List of works - Milena Cannella

Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations

scientific article

Impaired PGC-1alpha function in muscle in Huntington's disease.

scientific article published on 21 May 2009

Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course

scientific article

Low brain-derived neurotrophic factor (BDNF) levels in serum of Huntington's disease patients.

scientific article

Severe ultrastructural mitochondrial changes in lymphoblasts homozygous for Huntington disease mutation

scientific article published on 9 November 2005

Changes in mGlu5 receptor-dependent synaptic plasticity and coupling to homer proteins in the hippocampus of Ube3A hemizygous mice modeling angelman syndrome

scientific article

Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mG

scientific article published on 15 December 2010

Distinct brain volume changes correlating with clinical stage, disease progression rate, mutation size, and age at onset prediction as early biomarkers of brain atrophy in Huntington's disease

scientific article published in January 2009

Early defect of transforming growth factor β1 formation in Huntington's disease.

scientific article published on March 2011

Abnormal morphology of peripheral cell tissues from patients with Huntington disease

scientific article

Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1.

scientific article published on 19 November 2013

Riluzole protects Huntington disease patients from brain glucose hypometabolism and grey matter volume loss and increases production of neurotrophins.

scientific article published on 11 March 2009

N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors.

scientific article published on 23 October 2012

Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset

scientific article published on 01 February 2002

Onset and pre-onset studies to define the Huntington's disease natural history.

scientific article

Genotype-dependent priming to self- and xeno-cannibalism in heterozygous and homozygous lymphoblasts from patients with Huntington's disease

scientific article published on August 2006

Huntington disease in subjects from an Israeli Karaite community carrying alleles of intermediate and expanded CAG repeats in the HTT gene: Huntington disease or phenocopy?

scientific article published on 6 December 2008

The platelet maximum number of A2A-receptor binding sites (Bmax) linearly correlates with age at onset and CAG repeat expansion in Huntington's disease patients with predominant chorea.

scientific article published on 10 October 2005

Highly variable penetrance in subjects affected with cavernous cerebral angiomas (CCM) carrying novel CCM1 and CCM2 mutations.

scientific article

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system

scientific article published on 24 October 2017

Presymptomatic tests in Huntington's disease and dominant ataxias.

scientific article

Reduced activity of cortico-striatal fibres in the R6/2 mouse model of Huntington's disease.

scientific article

DNA instability in replicating Huntington's disease lymphoblasts

scientific article

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain

scientific article

Highly disabling cerebellar presentation in Huntington disease.

scientific article published in July 2003

CAG mutation effect on rate of progression in Huntington's disease.

scientific article

Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage.

scientific article published on 24 October 2015

Cavernous angiomas of the nervous system in Italy: clinical and genetic study

article

Dickkopf-3 Upregulates VEGF in Cultured Human Endothelial Cells by Activating Activin Receptor-Like Kinase 1 (ALK1) Pathway

scientific article published on 14 March 2017

De novo seven extra repeat expanded mutation in the PRNP gene in an Italian patient with early onset dementia.

scientific article published on 6 August 2007

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia.

scientific article published on 18 August 2017

Molecular medicine: predicting and preventing Huntington's disease.

scientific article published on 20 September 2008

Predictive testing for persons at risk for homozygosity for CAG expansion in the Huntington disease gene.

scientific article published in December 2003

Italian Huntington disease patients--data and tissue bank.

scientific article

De novo seven extra repeat expanded mutation in the PRNP gene in an Italian patient with early onset dementia.

scientific article published on 2 February 2009

Changes in the expression of genes encoding for mGlu4 and mGlu5 receptors and other regulators of the indirect pathway in acute mouse models of drug-induced parkinsonism.

scientific article published on 5 March 2015

Alterations in the α2 δ ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic/genetic generalized epilepsies.

scientific article

List of works by Milena Cannella

Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations

Impaired PGC-1alpha function in muscle in Huntington's disease.

Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course

Low brain-derived neurotrophic factor (BDNF) levels in serum of Huntington's disease patients.

Severe ultrastructural mitochondrial changes in lymphoblasts homozygous for Huntington disease mutation

Changes in mGlu5 receptor-dependent synaptic plasticity and coupling to homer proteins in the hippocampus of Ube3A hemizygous mice modeling angelman syndrome

Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mG

Distinct brain volume changes correlating with clinical stage, disease progression rate, mutation size, and age at onset prediction as early biomarkers of brain atrophy in Huntington's disease

Early defect of transforming growth factor β1 formation in Huntington's disease.

Abnormal morphology of peripheral cell tissues from patients with Huntington disease

Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1.

Riluzole protects Huntington disease patients from brain glucose hypometabolism and grey matter volume loss and increases production of neurotrophins.

N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors.

Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset

Onset and pre-onset studies to define the Huntington's disease natural history.

Genotype-dependent priming to self- and xeno-cannibalism in heterozygous and homozygous lymphoblasts from patients with Huntington's disease

Huntington disease in subjects from an Israeli Karaite community carrying alleles of intermediate and expanded CAG repeats in the HTT gene: Huntington disease or phenocopy?

The platelet maximum number of A2A-receptor binding sites (Bmax) linearly correlates with age at onset and CAG repeat expansion in Huntington's disease patients with predominant chorea.

Highly variable penetrance in subjects affected with cavernous cerebral angiomas (CCM) carrying novel CCM1 and CCM2 mutations.

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system

Presymptomatic tests in Huntington's disease and dominant ataxias.

Reduced activity of cortico-striatal fibres in the R6/2 mouse model of Huntington's disease.

DNA instability in replicating Huntington's disease lymphoblasts

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain

Highly disabling cerebellar presentation in Huntington disease.

CAG mutation effect on rate of progression in Huntington's disease.

Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage.

Cavernous angiomas of the nervous system in Italy: clinical and genetic study

Dickkopf-3 Upregulates VEGF in Cultured Human Endothelial Cells by Activating Activin Receptor-Like Kinase 1 (ALK1) Pathway

De novo seven extra repeat expanded mutation in the PRNP gene in an Italian patient with early onset dementia.

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia.

Molecular medicine: predicting and preventing Huntington's disease.

Predictive testing for persons at risk for homozygosity for CAG expansion in the Huntington disease gene.

Italian Huntington disease patients--data and tissue bank.

De novo seven extra repeat expanded mutation in the PRNP gene in an Italian patient with early onset dementia.

Changes in the expression of genes encoding for mGlu4 and mGlu5 receptors and other regulators of the indirect pathway in acute mouse models of drug-induced parkinsonism.

Alterations in the α2 δ ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic/genetic generalized epilepsies.