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List of works by Lakshminarayan M. Iyer

A TET homologue protein from Coprinopsis cinerea (CcTET) that biochemically converts 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine

scientific article published on 25 March 2014

A hemolytic pigment of Group B Streptococcus allows bacterial penetration of human placenta

scientific article

A multidomain adhesion protein family expressed in Plasmodium falciparum is essential for transmission to the mosquito

scientific article (publication date: 7 June 2004)

A new family of polymerases related to superfamily A DNA polymerases and T7-like DNA-dependent RNA polymerases

scientific article

A non-hemolytic Group B Streptococcus strain exhibits hypervirulence

scientific article published on 13 December 2017

A novel family of P-loop NTPases with an unusual phyletic distribution and transmembrane segments inserted within the NTPase domain

scientific article

A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems ⬇️

scientific article

A novel superfamily containing the beta-grasp fold involved in binding diverse soluble ligands

scientific article

A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey

scientific article

ALOG domains: provenance of plant homeotic and developmental regulators from the DNA-binding domain of a novel class of DIRS1-type retroposons

scientific article (publication date: 12 November 2012)

Adenine methylation in eukaryotes: Apprehending the complex evolutionary history and functional potential of an epigenetic modification

scientific article published on 12 December 2015

Adhesion molecules and other secreted host-interaction determinants in Apicomplexa: insights from comparative genomics

scientific article

Amidoligases with ATP-grasp, glutamine synthetase-like and acetyltransferase-like domains: synthesis of novel metabolites and peptide modifications of proteins

scientific article

Anatomy of the E2 ligase fold: implications for enzymology and evolution of ubiquitin/Ub-like protein conjugation

scientific article

Ancient conserved domains shared by animal soluble guanylyl cyclases and bacterial signaling proteins

scientific article

Assessment of penetrance and expressivity of RNAi-mediated silencing of the Arabidopsis phytoene desaturase gene

scientific article published in September 2005

BEN: a novel domain in chromatin factors and DNA viral proteins

scientific article

Bacterial GRAS domain proteins throw new light on gibberellic acid response mechanisms

scientific article

CHAPTER 11. The TET/JBP Family of Nucleic Acid Base-Modifying 2-Oxoglutarate and Iron-Dependent Dioxygenases

Classification and evolutionary history of the single-strand annealing proteins, RecT, Redbeta, ERF and RAD52

scientific article

Common origin of four diverse families of large eukaryotic DNA viruses

scientific article

Comparative analysis of apicomplexa and genomic diversity in eukaryotes

scientific article published on September 2004

Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling

scientific article published on 20 November 2015

Comparative genomic sequence analysis of the human and mouse cystic fibrosis transmembrane conductance regulator genes

scientific article

Comparative genomics and evolutionary trajectories of viral ATP dependent DNA-packaging systems

scientific article

Comparative genomics and structural biology of the molecular innovations of eukaryotes

scientific article

Comparative genomics of protists: new insights into the evolution of eukaryotic signal transduction and gene regulation

scientific article

Comparative genomics of the FtsK-HerA superfamily of pumping ATPases: implications for the origins of chromosome segregation, cell division and viral capsid packaging

scientific article published on 5 October 2004

Comparative genomics of transcription factors and chromatin proteins in parasitic protists and other eukaryotes

scientific article

Comparison of transcription regulatory interactions inferred from high-throughput methods: what do they reveal?

scientific article

Comprehensive analysis of combinatorial regulation using the transcriptional regulatory network of yeast

scientific article

Comprehensive classification of ABC ATPases and their functional radiation in nucleoprotein dynamics and biological conflict systems

scientific article published on 07 September 2020

Computational identification of novel biochemical systems involved in oxidation, glycosylation and other complex modifications of bases in DNA.

scientific article

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

scientific article

Corrigendum: The cyl Genes Reveal the Biosynthetic and Evolutionary Origins of the Group B Streptococcus Hemolytic Lipid, Granadaene

scientific article published on 25 February 2020

Detection of novel members, structure-function analysis and evolutionary classification of the 2H phosphoesterase superfamily

scientific article

Discovery of Novel DENN Proteins: Implications for the Evolution of Eukaryotic Intracellular Membrane Structures and Human Disease

scientific article published in 2012

Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains

scientific article

Diversification of AID/APOBEC-like deaminases in metazoa: multiplicity of clades and widespread roles in immunity.

scientific article

Diversity and Function of Adaptive Immune Receptors in a Jawless Vertebrate

scientific article

Diversity and evolution of chromatin proteins encoded by DNA viruses

scientific article published on 28 October 2009

Domain architectures of the Scm3p protein provide insights into centromere function and evolution

scientific article

Estimating the prevalence and regulatory potential of the telomere looping effect in yeast transcription regulation

scientific article

Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase

scientific article

Evolution of Eukaryotic Chromatin Proteins and Transcription Factors

Evolution of bacterial RNA polymerase: implications for large-scale bacterial phylogeny, domain accretion, and horizontal gene transfer

scientific article

Evolution of cell–cell signaling in animals: did late horizontal gene transfer from bacteria have a role?

scientific article

Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems

scientific article

Evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases and the origin of RNA polymerases

scientific article

Evolutionary convergence and divergence in archaeal chromosomal proteins and Chromo-like domains from bacteria and eukaryotes

scientific article published on 18 April 2018

Evolutionary genomics of nucleo-cytoplasmic large DNA viruses

scientific article

Expansions, diversification, and interindividual copy number variations of AID/APOBEC family cytidine deaminase genes in lampreys

scientific article published on 19 March 2018

Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors

scientific article

Functional Innovation in the Evolution of the Calcium-Dependent System of the Eukaryotic Endoplasmic Reticulum

scientific article published on 06 February 2020

Functional diversification of the RING finger and other binuclear treble clef domains in prokaryotes and the early evolution of the ubiquitin system

scientific article (publication date: July 2011)

GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer

scientific article published on 17 March 2021

Gene flow and biological conflict systems in the origin and evolution of eukaryotes

scientific article

Gene networks and chromatin and transcriptional regulation of the phaseolin promoter in Arabidopsis

scientific article published on 19 July 2013

Genomic donor cassette sharing during VLRA and VLRC assembly in jawless vertebrates

scientific article

HPC2 and ubinuclein define a novel family of histone chaperones conserved throughout eukaryotes ⬇️

scientific article

Highly-regulated, diversifying NTP-based biological conflict systems with implications for emergence of multicellularity

scientific article published on 26 February 2020

Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels

scientific article

Incarnation of classical pro- and eukaryotic mechanisms of mutagenesis in hypermutagenesis and immunity of vertebrates

Insights from the architecture of the bacterial transcription apparatus

scientific article (publication date: September 2012)

Intraproteomic networks: new forays into predicting interaction partners

scientific article

Isolation of DNA from the centromere of human chromosome 7 by microdissection

scientific article published on June 1, 1997

Lineage-specific expansions of TET/JBP genes and a new class of DNA transposons shape fungal genomic and epigenetic landscapes

scientific article

Multiple enzymatic activities of ParB/Srx superfamily mediate sexual conflict among conjugative plasmids

scientific article

MutL homologs in restriction-modification systems and the origin of eukaryotic MORC ATPases

scientific article

Mycobacterium tuberculosis Rv0991c Is a Redox-Regulated Molecular Chaperone

scientific article published on 25 August 2020

Natural history of eukaryotic DNA methylation systems

scientific article

Natural history of the E1-like superfamily: implication for adenylation, sulfur transfer, and ubiquitin conjugation

scientific article

Natural history of the eukaryotic chromatin protein methylation system

scientific article

Novel autoproteolytic and DNA-damage sensing components in the bacterial SOS response and oxidized methylcytosine-induced eukaryotic DNA demethylation systems

scientific article

Novel predicted peptidases with a potential role in the ubiquitin signaling pathway

scientific article

Origin and evolution of peptide-modifying dioxygenases and identification of the wybutosine hydroxylase/hydroperoxidase

scientific article

Origin and evolution of the archaeo-eukaryotic primase superfamily and related palm-domain proteins: structural insights and new members

scientific article

Plasmodium biology: genomic gleanings

scientific article

Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics

scientific article

Polyvalent Proteins, a Pervasive Theme in the Intergenomic Biological Conflicts of Bacteriophages and Conjugative Elements

scientific article

Predicted class-I aminoacyl tRNA synthetase-like proteins in non-ribosomal peptide synthesis

scientific article

Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids

scientific article

Presence of a classical RRM-fold palm domain in Thg1-type 3'- 5'nucleic acid polymerases and the origin of the GGDEF and CRISPR polymerase domains

scientific article

Proteasomal control of cytokinin synthesis protects Mycobacterium tuberculosis against nitric oxide

scientific journal article

Protein and DNA modifications: evolutionary imprints of bacterial biochemical diversification and geochemistry on the provenance of eukaryotic epigenetics

scientific article

Provenance of SET-domain histone methyltransferases through duplication of a simple structural unit.

scientific article

Quod erat demonstrandum? The mystery of experimental validation of apparently erroneous computational analyses of protein sequences

scientific article

Reconstructing the ubiquitin network: cross-talk with other systems and identification of novel functions

scientific article

Resilience of biochemical activity in protein domains in the face of structural divergence

scientific article

Scores of RINGS but No PHDs in Ubiquitin Signaling ⬇️

scientific article published on March 1, 2003

Selection of the lamprey VLRC antigen receptor repertoire

scientific article

Simultaneous sequencing of oxidized methylcytosines produced by TET/JBP dioxygenases in Coprinopsis cinerea

scientific article

Small but versatile: the extraordinary functional and structural diversity of the beta-grasp fold

scientific article

Structure and Evolution of Ubiquitin and Ubiquitin-Related Domains

Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen

scientific article

Ter-dependent stress response systems: novel pathways related to metal sensing, production of a nucleoside-like metabolite, and DNA-processing

scientific article

The ASCH superfamily: novel domains with a fold related to the PUA domain and a potential role in RNA metabolism

scientific article

The Anabaena sensory rhodopsin transducer defines a novel superfamily of prokaryotic small-molecule binding domains

scientific article

The DOMON domains are involved in heme and sugar recognition

scientific article

The HARE-HTH and associated domains: novel modules in the coordination of epigenetic DNA and protein modifications

scientific article

The HIRAN domain and recruitment of chromatin remodeling and repair activities to damaged DNA.

scientific article

The SWIRM domain: a conserved module found in chromosomal proteins points to novel chromatin-modifying activities

scientific article

The catalytic core of DEMETER guides active DNA demethylation in Arabidopsis

scientific article published on 13 August 2019

The catalytic domains of thiamine triphosphatase and CyaB-like adenylyl cyclase define a novel superfamily of domains that bind organic phosphates

scientific article

The cyl Genes Reveal the Biosynthetic and Evolutionary Origins of the Group B Streptococcus Hemolytic Lipid, Granadaene

scientific article published on 01 January 2019

The emergence of catalytic and structural diversity within the beta-clip fold

scientific article

The many faces of the helix-turn-helix domain: transcription regulation and beyond

scientific article (publication date: April 2005)

The natural history of ADP-ribosyltransferases and the ADP-ribosylation system

scientific article

The natural history of the WRKY-GCM1 zinc fingers and the relationship between transcription factors and transposons

scientific article (publication date: 2006)

The natural history of ubiquitin and ubiquitin-related domains

scientific article published on January 2012

The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like beta-grasp domains

scientific article

The two faces of Alba: the evolutionary connection between proteins participating in chromatin structure and RNA metabolism ⬇️

scientific article published on September 8, 2003

The unexpected provenance of components in eukaryotic nucleotide-excision-repair and kinetoplast DNA-dynamics from bacterial mobile elements

article

Transcription factors, chromatin proteins and the diversification of Hemiptera

scientific article published on 27 July 2015

Transposons to toxins: the provenance, architecture and diversification of a widespread class of eukaryotic effectors

scientific article

Two novel PIWI families: roles in inter-genomic conflicts in bacteria and Mediator-dependent modulation of transcription in eukaryotes

scientific article

Uncovering a hidden distributed architecture behind scale-free transcriptional regulatory networks

scientific article

Unexpected Evolution of Lesion-Recognition Modules in Eukaryotic NER and Kinetoplast DNA Dynamics Proteins from Bacterial Mobile Elements

scientific article published on 23 October 2018

Unraveling the biochemistry and provenance of pupylation: a prokaryotic analog of ubiquitination

scientific article

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