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List of works by M. Amélia Santos

A bis(3-hydroxy-4-pyridinone)-EDTA derivative as a strong chelator for M3+ hard metal ions: complexation ability and selectivity.

scientific article published on 9 June 2009

A family of hydroxypyrone ligands designed and synthesized as iron chelators.

scientific article published on 26 June 2013

A new tripodal kojic acid derivative for iron sequestration: Synthesis, protonation, complex formation studies with Fe3+, Al3+, Cu2+ and Zn2+, and in vivo bioassays

scientific article published on 06 February 2019

A new tripodal-3-hydroxy-4-pyridinone for iron and aluminium sequestration: synthesis, complexation and in vivo studies

A novel tripodal tris-hydroxypyrimidinone sequestering agent for trivalent hard metal ions: synthesis, complexation and in vivo studies

scientific article published on 06 December 2012

Alkylaryl-amino derivatives of 3-hydroxy-4-pyridinones as aluminium chelating agents with potential clinical application.

scientific article published in September 2003

An NMR study on the 6,6'-(2-(diethylamino)ethylazanediyl)bis(methylene)bis(5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) interaction with Al(III) and Zn(II) ions.

scientific article published on 2 February 2015

Arylamine–DNA adduct conformation in relation to mutagenesis

article

Bifunctional 3-hydroxy-4-pyridinone derivatives as potential pharmaceuticals: synthesis, complexation with Fe(III), Al(III) and Ga(III) and in vivo evaluation with 67Ga

Biologically relevant O,S-donor compounds. Synthesis, molybdenum complexation and xanthine oxidase inhibition.

scientific article published on 20 February 2008

Carbonic anhydrase inhibitors: Inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties

scientific article published on 08 January 2007

Chemistry and applications of metal complexes ⬇️

scientific article published on March 28, 2013

Combined chelation based on glycosyl-mono- and bis-hydroxypyridinones for aluminium mobilization: solution and biodistribution studies.

scientific article published on 15 August 2009

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

scientific article published on 22 February 2020

Design, synthesis and molecular modeling study of iminodiacetyl monohydroxamic acid derivatives as MMP inhibitors

scientific article published on 27 July 2006

Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease.

scientific article published on 24 May 2013

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's drug candidates

scientific article published on 01 December 2018

Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.

scientific article published in December 2008

Effect of substitution site upon the oxidation potentials of alkylanilines, the mutagenicities of N-hydroxyalkylanilines, and the conformations of alkylaniline-DNA adducts.

scientific article published in November 1997

Factors affecting the metal ion–hydroxamate interactions II: effect of the length of the connecting chain on the Fe(III), Mo(VI) and V(V) complexation of some new desferrioxamine B (DFB) model dihydroxamic acids

article

Hydroxy(thio)pyrone and hydroxy(thio)pyridinone iron chelators: physico-chemical properties and anti-oxidant activity.

scientific article

Hydroxypyri(mi)dine-Based Chelators as Antidotes of Toxicity Due to Aluminum and Actinides ⬇️

scientific article published on January 1, 2012

Iminodiacetyl-hydroxamate derivatives as metalloproteinase inhibitors: equilibrium complexation studies with Cu(II), Zn(II) and Ni(II).

scientific article published in December 2003

Interaction of folic acid and some matrix metalloproteinase (MMP) inhibitor folate-γ-hydroxamate derivatives with Zn(II) and human serum albumin.

scientific article

Methotrexate γ-hydroxamate derivatives as potential dual target antitumor drugs

scientific article published in 2007

Molecular recognition of guanosine and 2-acetylaminofluorene-modified guanosine. A comparative study

Molecular recognition of synthetic siderophore analogues: a study with receptor-deficient and fhu(A-B) deletion mutants of Escherichia coli

scientific article published on 01 September 1999

Multifunctional iron-chelators with protective roles against neurodegenerative diseases.

scientific article published on 13 March 2013

Multitemplate Alignment Method for the Development of a Reliable 3D-QSAR Model for the Analysis of MMP3 Inhibitors

article

N-Carboxyalkyl derivatives of 3-hydroxy-4-pyridinones: synthesis, complexation with Fe(III), Al(III) and Ga(III) and in vivo evaluation.

scientific article published in September 2002

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer's Disease

scientific article published on 07 February 2019

New hydroxypyridinone-functionalized sepharoses as sorbing agents for hard metal ions ⬇️

scientific article published on December 25, 2010

New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors.

scientific article published on 28 April 2010

New silica-immobilized hydroxypyrimidinone as sorbent of hard metal ions from aqueous fluids.

scientific article published in September 2005

New strong extrafunctionalizable tris(3,4-HP) and bis(3,4-HP) metal sequestering agents: synthesis, solution and in vivo metal chelation

scientific article published on 02 October 2019

New tris-3,4-HOPO lanthanide complexes as potential imaging probes: complex stability and magnetic properties

scientific article published on 07 January 2013

Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases.

scientific article published on 17 November 2011

Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease

scientific article published on 12 February 2018

Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer's Disease

scientific article published on 01 December 2020

Redox chemistry of low-pH forms of tetrahemic cytochrome c3

scientific article published in December 2006

Searching for new aluminium chelating agents: a family of hydroxypyrone ligands.

scientific article published on 18 October 2013

Speciation Studies of Bifunctional 3-Hydroxy-4-Pyridinone Ligands in the Presence of Zn2+ at Different Ionic Strengths and Temperatures

scientific article published on 12 November 2019

Synthesis, chelating properties towards gallium and biological evaluation of two N-substituted 3-hydroxy-4-pyridinones

scientific article published on 01 March 2000

Tacrine-deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug

scientific article published on 05 September 2018

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