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List of works by Kristopher A Sarosiek

A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Antiapoptotic Protein in Kidney Cancer

scientific article published in 2022

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity

scientific article published on 13 September 2020

BCL-XL directly modulates RAS signalling to favour cancer cell stemness.

scientific article published on 24 October 2017

BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response

scientific article

CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer

scientific article published in November 2016

Chemotherapy-treated cells go up in flames.

scientific article published in May 2017

Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition

scientific article published on 20 May 2016

Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL

scientific article published on 4 February 2016

Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL

scientific article published on 9 February 2017

Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics

scientific article published on 13 December 2016

Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas

scientific article published on December 2008

Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage.

scientific article published on 12 March 2018

Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma

scientific article

Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise.

scientific article published on 21 March 2016

Double trouble for CML

scientific article published on 01 April 2017

Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.

scientific article

Efficacy of bortezomib in a direct xenograft model of primary effusion lymphoma

scientific article

Epigenetics make transient states of cancer therapy resistance permanent.

scientific article

Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non-Small Cell Lung Cancer

scientific article published on 25 September 2018

Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers

scientific article published on 27 March 2014

HSF1 phase transition mediates stress adaptation and cell fate decisions

scientific article published on 03 February 2020

Inhibition of MAPKinase pathway sensitizes thyroid cancer cells to ABT-737 induced apoptosis.

scientific article published on March 2017

Interleukin 21 - its potential role in the therapy of B-cell lymphomas.

scientific article

Interleukin-4 distinctively modifies responses of germinal centre-like and activated B-cell-like diffuse large B-cell lymphomas to immuno-chemotherapy

scientific article published on 19 August 2009

Mitochondria: gatekeepers of response to chemotherapy

scientific article published on 21 September 2013

Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas.

scientific article

PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling

scientific article published on 20 August 2008

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy ⬇️

scientific article published on October 27, 2011

Radiation-Induced Cardiovascular Toxicity: Mechanisms, Prevention, and Treatment.

scientific article published on 20 March 2018

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

scientific article published on 01 March 2019

Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance

scientific article published on October 2013

T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6

scientific article

Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance

scientific article published in December 2016

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

scientific article published on 13 September 2018

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