Search filters

List of works by Ottavio Arancio

5-HT₄ receptor stimulation leads to soluble AβPPα production through MMP-9 upregulation

scientific article

A GluR1-cGKII interaction regulates AMPA receptor trafficking

scientific article published on November 2007

A Neuronal Microtubule-Interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer's Disease

article

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction.

scientific article

A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease

scientific article published on 29 April 2016

A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: Role of amyloid beta

scientific article published on 14 April 2014

A reliable way to detect endogenous murine β-amyloid

scientific article

A role for cGMP-dependent protein kinase II in AMPA receptor trafficking and synaptic plasticity

scientific article published on 4 July 2008

A role for tau in learning, memory and synaptic plasticity

scientific article published on 16 February 2018

A selective role for ARMS/Kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neurons

scientific article

A time course analysis of the electrophysiological properties of neurons differentiated from human induced pluripotent stem cells (iPSCs).

scientific article

A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment

scientific article

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

scientific article

ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction

scientific article published on 21 January 2005

APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant

scientific article

Abeta-dependent Inhibition of LTP in different intracortical circuits of the visual cortex: the role of RAGE

scientific article published on January 2009

Abolishing Tau cleavage by caspases at Aspartate421 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations

scientific article published on 08 August 2017

Activity-dependent long-term enhancement of transmitter release by presynaptic 3',5'-cyclic GMP in cultured hippocampal neurons.

scientific article published in July 1995

Acute Peroneal Compartmental Syndrome

scientific article published on 01 January 1985

Acute ethanol suppresses glutamatergic neurotransmission through endocannabinoids in hippocampal neurons

scientific article published on 15 September 2008

Acute vitreoretinal trauma and inflammation after traumatic brain injury in mice.

scientific article published on 26 February 2018

Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII

scientific journal article

Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits

scientific article

Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity

scientific article

Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling

scientific article

Amyloid-beta peptide inhibits activation of the nitric oxide/cGMP/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity.

scientific article published in July 2005

Amyloid-β Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory

scientific article published on 16 June 2017

Amyloid-β peptide: Dr. Jekyll or Mr. Hyde?

scientific article published on January 2013

An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss

scientific article

An isoform-selective p38α mitogen-activated protein kinase inhibitor rescues early entorhinal cortex dysfunctions in a mouse model of Alzheimer's disease

article

Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis

scientific article

BDNF-mediated neurotransmission relies upon a myosin VI motor complex

scientific journal article

Behavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines

scientific article

Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein

scientific article published on 12 July 2016

CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons

scientific article

Calpain inhibitors, a treatment for Alzheimer's disease: position paper

scientific article published in January 2003

Calpain inhibitors: a treatment for Alzheimer's disease

scientific article

Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease

scientific article

Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice.

scientific article

Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection

scientific article published on 10 December 2012

Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors

scientific article published on 8 January 2014

Characterization of a subpopulation of developing cortical interneurons from human iPSCs within serum-free embryoid bodies

scientific article

Congenital muscular dystrophy and cerebellar vermis agenesis in two brothers

scientific article published on 01 October 1988

Connectivity and circuitry in a dish versus in a brain

scientific article published on 4 June 2015

Correction to "A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction"

scientific article published on 16 July 2020

Correction: Abolishing Tau cleavage by caspases at Aspartate causes memory/synaptic plasticity deficits and pre-pathological Tau alterations

scientific article published on 31 August 2018

Corrigendum: Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease

scientific article published on 7 July 2015

Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1)

scientific article published on 25 October 2012

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

scientific article published on 21 September 2008

Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits

scientific article

Dendritic location of neural BC1 RNA ⬇️

scientific article published on March 15, 1991

Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy

scientific article

Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors

scientific article published on 22 July 2013

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

scientific article

Differential distribution of excitatory amino acid receptors on embryonic rat spinal cord neurons in culture.

scientific article published on April 1991

Dual Mechanism of Toxicity for Extracellular Injection of Tau Oligomers versus Monomers in Human Tau Mice

scientific article

Dynamin 1 is required for memory formation

scientific article

Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease.

scientific article published in January 2009

Early presynaptic changes during plasticity in cultured hippocampal neurons

scientific article published on 7 September 2006

EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment.

scientific article published on 7 June 2018

Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice

scientific article published on 7 October 2013

Effects of reinnervation with normal and tetrodotoxin-inactive nerves on resting membrane potential of rat skeletal muscle ⬇️

scientific article published on May 26, 1988

Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid

scientific article published on 18 December 2017

Electrophysiological profiles of induced neurons converted directly from adult human fibroblasts indicate incomplete neuronal conversion

scientific article

Endocannabinoid system: emerging role from neurodevelopment to neurodegeneration

scientific article

Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory

scientific article

Erratum to: A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease

scientific article published on 18 May 2016

Estimation of the mean from sums with unknown numbers of summands

scientific article published in September 2006

Excitatory synaptic connections onto rat hippocampal inhibitory cells may involve a single transmitter release site.

scientific article published in December 1994

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models

scientific article published on 07 January 2019

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

scientific article published on 20 January 2016

Familial autoimmune myasthenia gravis with different pathogenetic antibodies

scientific article

Fibrillar beta-amyloid impairs the late phase of long term potentiation

scientific article published in July 2006

Fibrillatory activity and other membrane changes in partially denervated muscles

article published in 1989

FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake

FoxO1 target Gpr17 activates AgRP neurons to regulate food intake

scientific article

Furoxans (1,2,5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents

scientific article

Glut4 expression defines an insulin-sensitive hypothalamic neuronal population

scientific article

Glutamate receptor agonist-induced inward currents in spinal dorsal horn neurons dissociated from the adult rat

scientific article published on 01 December 1991

Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia.

scientific article

Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer's Disease

scientific article

Increased neuronal PreP activity reduces Aβ accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse model

scientific article

Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease

scientific article

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

scientific article published on August 2008

Involvement of the nitric oxide pathway in synaptic dysfunction following amyloid elevation in Alzheimer's disease

scientific article published on January 2006

Is the amyloid hypothesis of Alzheimer's disease therapeutically relevant?

scientific article published on September 2012

Isolation and characterization of "Reprotoxin", a novel protein complex from Daboia russelii snake venom

scientific article published on 5 June 2008

LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

scientific article published on 11 July 2017

Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome

scientific journal article

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

scholarly article by Guomei Tang et al published September 2014 in Neuron

Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits

scientific article (publication date: 3 September 2014)

MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE.

scientific article

Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis

scientific article

Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease

scientific article

Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex

scientific article published in August 2010

Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer's Disease-Associated Presenilin 1 Mutation.

scientific article published on 14 September 2017

Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors

scientific article

Neuromodulatory Action of Picomolar Extracellular Aβ42 Oligomers on Presynaptic and Postsynaptic Mechanisms Underlying Synaptic Function and Memory

scientific article published on 24 May 2019

Neurotrophins, synaptic plasticity and dementia

scientific article

New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment

scientific article published on 13 August 2016

Nitric oxide acts as a retrograde messenger during long-term potentiation in cultured hippocampal neurons

scientific article published on 01 January 1996

Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons.

scientific article published in December 1996

Notoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation

scientific article

Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease

scientific article published on 17 October 2015

Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism

scientific article published on 6 April 2008

Oligomers of beta-amyloid peptide inhibit BDNF-induced arc expression in cultured cortical Neurons

scientific article published in December 2007

PDE5 Exists in Human Neurons and is a Viable Therapeutic Target for Neurologic Disease

scientific article published on 09 March 2016

PP2A methylation controls sensitivity and resistance to β-amyloid-induced cognitive and electrophysiological impairments

scientific article published on 7 March 2016

Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment

scientific article published on December 2004

Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model.

scientific article published in June 2009

Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits

scientific article

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

scientific article

Picomolar amyloid-β peptides enhance spontaneous astrocyte calcium transients

scientific article

Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits

scientific article published on 19 June 2017

Preparation of Tau Oligomers After the Protein Extraction from Bacteria and Brain Cortices

Preparation of oligomeric beta-amyloid 1-42 and induction of synaptic plasticity impairment on hippocampal slices

scientific article

Presynaptic CaMKII is necessary for synaptic plasticity in cultured hippocampal neurons

scientific article published in April 2004

Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice

scientific article published in June 2004

Protection against beta-amyloid induced abnormal synaptic function and cell death by Ginkgolide J

scientific article published on 20 July 2007

RAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environment

scientific article

RAGE mediates Aβ accumulation in a mouse model of Alzheimer's disease via modulation of β- and γ-secretase activity

scientific article published on 10 January 2018

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice

scientific article published on 30 September 2004

Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation.

scientific article published on 18 October 2001

Re-engineering a neuroprotective, clinical drug as a procognitive agent with high in vivo potency and with GABAA potentiating activity for use in dementia

scientific article published on 19 October 2015

Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction.

scientific article published on March 2008

Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation

scientific article published on August 2003

Reduced expression of the PP2A methylesterase, PME-1, or the PP2A methyltransferase, LCMT-1, alter sensitivity to beta-amyloid induced cognitive and electrophysiological impairments in mice

scientific article published on 24 April 2020

Reduced gliotransmitter release from astrocytes mediates tau-induced synaptic dysfunction in cultured hippocampal neurons.

scientific article published on 18 May 2017

Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides

scientific article

Reduction of synaptojanin 1 ameliorates synaptic and behavioral impairments in a mouse model of Alzheimer's disease

scientific article published on October 2012

Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease

scientific article

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation

scientific article

Reversal of long-term dendritic spine alterations in Alzheimer disease models

scientific article

Rodent models for Alzheimer's disease drug discovery.

scientific article

Role of Amyloid-β and Tau Proteins in Alzheimer’s Disease: Confuting the Amyloid Cascade

scientific article published on 01 January 2018

Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction

scientific journal article

SUMO and Alzheimer's disease

scientific article published on 25 August 2013

SUMO1 Affects Synaptic Function, Spine Density and Memory

scientific article

Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.

scientific article published on 29 March 2013

Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment

scientific article

Sub-efficacious doses of phosphodiesterase 4 and 5 inhibitors improve memory in a mouse model of Alzheimer's disease

scientific article published on 06 June 2018

Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade

scientific article published on 27 June 2019

Synaptic fatigue is more pronounced in the APP/PS1 transgenic mouse model of Alzheimer's disease

scientific article published in April 2005

Synaptic therapy in Alzheimer's disease: a CREB-centric approach

scientific article

Synaptic underpinnings of altered hippocampal function in glutaminase-deficient mice during maturation

scientific article

Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome

scientific journal article

Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease

scientific article

Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.

scientific article

Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger ⬇️

scientific article published on December 15, 1991

The ARMS/Kidins220 scaffold protein modulates synaptic transmission

scientific article

The ankyrin repeat-rich membrane spanning (ARMS)/Kidins220 scaffold protein is regulated by activity-dependent calpain proteolysis and modulates synaptic plasticity

scientific article

The distribution of excitatory amino acid receptors on acutely dissociated dorsal horn neurons from postnatal rats

scientific article published on 01 January 1993

The effect of amyloid-β peptide on synaptic plasticity and memory is influenced by different isoforms, concentrations, and aggregation status

scientific article published on 18 July 2018

The keystone of Alzheimer pathogenesis might be sought in Aβ physiology

scientific article

The schizophrenia susceptibility gene DTNBP1 modulates AMPAR synaptic transmission and plasticity in the hippocampus of juvenile DBA/2J mice

scientific article published on 07 December 2013

Time Course and Size of Blood-Brain Barrier Opening in a Mouse Model of Blast-Induced Traumatic Brain Injury

scientific article published on 28 September 2015

Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer's disease.

scientific article published on September 2016

Transitory l-carnitine depletion in rat skeletal muscle by d-carnitine

scientific article published on 01 March 1989

Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse.

scientific article

Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory

scientific article

Usefulness of behavioral and electrophysiological studies in transgenic models of Alzheimer's disease

scientific article

alpha-Synuclein produces a long-lasting increase in neurotransmitter release

scientific journal article

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia

scientific article

Paulina is supported by:

About Paulina

Help