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List of works by Wolfgang Sadee

5-Aza-2'-deoxycytidine and depsipeptide synergistically induce expression of BIK (BCL2-interacting killer).

scientific article published on 18 October 2006

6β-naltrexol, a peripherally selective opioid antagonist that inhibits morphine-induced slowing of gastrointestinal transit: an exploratory study

scientific article

A Novel In Vitro Human Granuloma Model of Sarcoidosis and Latent TB Infection

scientific article published on 9 June 2017

A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas

scientific article

A pharmacoproteomics study of the cancer cell line EKVX using capillary-LC/MS/MS.

scientific article published on September 2006

ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma

scientific article

Allele-Selective Transcriptome Recruitment to Polysomes Primed for Translation: Protein-Coding and Noncoding RNAs, and RNA Isoforms

scientific article published on 2 September 2015

Allelic mRNA expression of sortilin-1 (SORL1) mRNA in Alzheimer's autopsy brain tissues

scientific article published on 15 October 2008

Alveolar macrophages from tuberculosis patients display an altered inflammatory gene expression profile

scientific article published on 18 September 2017

Analyzing allele specific RNA expression using mixture models

scientific article published on August 2015

Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents

scientific article published on 11 October 2012

Association of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder

scientific article

Association study of the estrogen receptor gene ESR1 with postpartum depression--a pilot study

scientific article published on 07 August 2013

Biased Opioid Antagonists as Modulators of Opioid Dependence: Opportunities to Improve Pain Therapy and Opioid Use Management

scientific article published on 11 September 2020

Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies.

scientific article

Bridging material and biological sciences: the legacy of Hans Peter Merkle.

scientific article published in September 2013

CACNA1C gene polymorphisms, cardiovascular disease outcomes, and treatment response

scientific article published on 03 June 2009

CYP2D6 Genetic Variation and Beta-Blocker Maintenance Dose in Patients with Heart Failure

scientific article published on 8 February 2017

CYP3A4 intronic SNP rs35599367 (CYP3A4*22) alters RNA splicing

scientific article

CYP3A4/5 combined genotype analysis for predicting statin dose requirement for optimal lipid control ⬇️

scientific article published on January 1, 2013

Chemoinformatics analysis identifies cytotoxic compounds susceptible to chemoresistance mediated by glutathione and cystine/glutamate transport system xc-.

scientific article published on 17 March 2007

Chemoresistance to depsipeptide FK228 [(E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] is mediated by reversible MDR1 induction in human cancer cell lines

scientific article

Cholesteryl Ester Transfer Protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk

scientific article (publication date: 2012)

Cladograms with Path to Event (ClaPTE): a novel algorithm to detect associations between genotypes or phenotypes using phylogenies

scientific article

Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence

article

Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity

scientific article published on 28 August 2013

Conditional entropy in variation-adjusted windows detects selection signatures associated with expression quantitative trait loci (eQTLs).

scientific article published on 18 June 2015

DRD2/CHRNA5 interaction on prefrontal biology and physiology during working memory

scientific article

Design and implementation of a randomized controlled trial of genomic counseling for patients with chronic disease

scientific article

Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment

scientific article

Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene–gene–environment interaction ⬇️

scientific article published on January 22, 2013

Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder

scientific article

Efflux of depsipeptide FK228 (FR901228, NSC-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein 1.

scientific article

Elemental Ingredients in the Macrophage Cocktail: Role of ZIP8 in Host Response to Mycobacterium tuberculosis

scientific article published on 9 November 2017

Erratum to: Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles

scientific article

Expression and splicing of ABC and SLC transporters in the human blood-brain barrier measured with RNAseq

scientific article published on 7 February 2017

Expression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver

scientific article

Family-based clinical associations and functional characterization of the serotonin 2A receptor gene (HTR2A) in autism spectrum disorder

scientific article

Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene

scientific article published in 2009

Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition

scientific article

Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans

scientific article

Gene expression profiling of brain samples from patients with Lewy body dementia

scientific article published on 22 September 2016

Gene-gene-environment interactions between drugs, transporters, receptors, and metabolizing enzymes: Statins, SLCO1B1, and CYP3A4 as an example

scientific article published on 21 February 2013

Genetic variants affecting alternative splicing of human cholesteryl ester transfer protein

scientific article published on 3 January 2014

Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance

scientific article

Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure Response

scientific article published on January 2017

Genomic architecture of pharmacological efficacy and adverse events

scientific article

Genotyping panel for assessing response to cancer chemotherapy

scientific article

Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia

scientific article published on 12 August 2006

Human N-acetyltransferase 1 *10 and *11 alleles increase protein expression through distinct mechanisms and associate with sulfamethoxazole-induced hypersensitivity ⬇️

scientific article published on October 1, 2011

Individual and Combined Associations of Genetic Variants in CYP3A4, CYP3A5, and SLCO1B1 With Simvastatin and Simvastatin Acid Plasma Concentrations

scientific article published in July 2015

Institutional Profile: Program in Pharmacogenomics at the Ohio State University Medical Center ⬇️

scientific article published on May 1, 2012

Interactions Between Regulatory Variants in CYP7A1 (Cholesterol 7α-Hydroxylase) Promoter and Enhancer Regions Regulate CYP7A1 Expression

scientific article published on 01 October 2018

Intra- and interindividual variabilities of valacyclovir oral bioavailability and effect of coadministration of an hPEPT1 inhibitor

scientific article

Intronic Polymorphisms Affecting Alternative Splicing of Human Dopamine D2 Receptor Are Associated with Cocaine Abuse ⬇️

scientific article published on December 8, 2010

Intronic SNP in ESR1 encoding human estrogen receptor alpha is associated with brain ESR1 mRNA isoform expression and behavioral traits ⬇️

scientific article

KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST)

scientific article published on September 2007

Measuring cis-acting regulatory variants genome-wide: new insights into expression genetics and disease susceptibility

scientific article published on 22 December 2009

MicroRNA expression profiles for the NCI-60 cancer cell panel

scientific article published on 4 May 2007

MicroRNAs modulate the chemosensitivity of tumor cells

scientific article published on 9 January 2008

Missing heritability of common diseases and treatments outside the protein-coding exome

scientific article

Multiple Regulatory Variants Modulate Expression of 5-Hydroxytryptamine 2A Receptors in Human Cortex ⬇️

scientific article published on November 13, 2012

Nicotinic α5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms

scientific article

Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles

scientific article

Personalized Therapeutics and Pharmacogenomics: Integral to Personalized Health Care

scientific article

Pharmacogenomic Biomarkers: Validation Needed for both the Molecular Genetic Mechanism and Clinical Effect ⬇️

scientific article published on May 1, 2011

Pharmacogenomic testing: relevance in medical practice: why drugs work in some patients but not in others

scientific article

Pharmacogenomics of the RNA World: Structural RNA Polymorphisms in Drug Therapy ⬇️

scientific article published on February 2, 2011

Polymorphisms affecting gene regulation and mRNA processing: broad implications for pharmacogenetics

scientific article

Preferential Delivery of an Opioid Antagonist to the Fetal Brain in Pregnant Mice

scientific article published on 05 May 2016

Profiling solute carrier transporters in the human blood-brain barrier

scientific article published on 05 September 2013

Promoter polymorphisms in ACE (angiotensin I-converting enzyme) associated with clinical outcomes in hypertension

scientific article published on 22 October 2008

Protein therapeutics: new applications for pharmacogenetics

scientific article published on June 2006

RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles

scientific article published on 23 November 2015

Regulation of cholesteryl ester transfer protein expression by upstream polymorphisms: reduced expression associated with rs247616

scientific article published on August 2015

Regulatory Variants Modulate Protein Kinase C α (PRKCA) Gene Expression in Human Heart

scientific article published on 24 January 2017

Regulatory polymorphisms in CYP2C19 affecting hepatic expression

scientific article published on January 2013

Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity

scientific article

Response to paper by Kelly et al "The opioid receptor pharmacology of GSK1521498 compared to other ligands with different effects on compulsive reward-related behaviors" published in Psychopharmacology 232, 305-314, 2014.

scientific article published on 6 March 2015

Strategies and methods for research on sex differences in brain and behavior

scientific article

Synaptic Signaling and Aberrant RNA Splicing in Autism Spectrum Disorders ⬇️

scientific article published on January 26, 2011

The CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations

scientific article

The Making of a CYP3A Biomarker Panel for Guiding Drug Therapy

scientific article published on October 2012

The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Outcomes and Metrics of Pharmacogenetic Implementations Across Diverse Healthcare Systems.

scientific article

The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation

scientific article published on 19 March 2013

The epigenome, 4D nucleome and next-generation neuropsychiatric pharmacogenomics

scientific article

The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia

scientific article

Transporter and ion channel gene expression after Caco-2 cell differentiation using 2 different microarray technologies

scientific article published on 7 September 2004

Whole Transcriptome Profiling: An RNA-Seq Primer and Implications for Pharmacogenomics Research

scientific article published on 25 September 2017

Whole Transcriptome Sequencing Analyses Reveal Molecular Markers of Blood Pressure Response to Thiazide Diuretics

scientific article published on 22 November 2017

Whole transcriptome RNA-Seq allelic expression in human brain

scientific article (publication date: 22 August 2013)

mRNA Transcript Diversity Creates New Opportunities for Pharmacological Intervention ⬇️

scientific article published on February 7, 2012

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