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List of works by Jochen Prehn

"Preconditioning" with latrepirdine, an adenosine 5'-monophosphate-activated protein kinase activator, delays amyotrophic lateral sclerosis progression in SOD1(G93A) mice

scientific article published on 26 September 2014

'Mild mitochondrial uncoupling' induced protection against neuronal excitotoxicity requires AMPK activity.

scientific article published on 7 February 2012

9-Benzylidene-naphtho[2,3-b]thiophen-4-ones and benzylidene-9(10H)-anthracenones as novel tubulin interacting agents with high apoptosis-inducing activity.

scientific article published in August 2007

A high-fat jelly diet restores bioenergetic balance and extends lifespan in the presence of motor dysfunction and lumbar spinal cord motor neuron loss in TDP-43A315T mutant C57BL6/J mice.

scientific article published on 04 August 2016

A reverse-ELISA for the detection of TRIM28/KAP1 serum autoantibodies in colorectal cancer patients

scientific article published on 24 January 2012

A structured approach to the study of metabolic control principles in intact and impaired mitochondria

scientific article published on 05 January 2012

ALISSA: an automated live-cell imaging system for signal transduction analyses

scientific article

AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF

scientific article

AMPK preferentially depresses retrograde transport of axonal mitochondria during localised nutrient deprivation

scientific article published on 11 May 2020

AMP‐activated protein kinase (AMPK)–induced preconditioning in primary cortical neurons involves activation of MCL‐1 ⬇️

scientific article published on December 26, 2012

ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis

scientific article published on 26 February 2006

APOPTO-CELL--a simulation tool and interactive database for analyzing cellular susceptibility to apoptosis.

scientific article published on 19 January 2007

AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells

scientific article published on 22 December 2015

Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death

scientific article published on 01 June 2000

Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha.

scientific article

Activation of p53 and the pro-apoptotic p53 target gene PUMA during depolarization-induced apoptosis of chromaffin cells

scientific article

Active secretion of S100B from astrocytes during metabolic stress.

scientific article published on 19 June 2006

Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation.

scientific article published on 31 March 2010

Analysis of BH3-only proteins upregulated in response to oxygen/glucose deprivation in cortical neurons identifies Bmf but not Noxa as potential mediator of neuronal injury

scientific article

Analyzing proteasomal subunit expression reveals Rpt4 as a prognostic marker in stage II colorectal cancer

scientific article published on 08 November 2011

Angiogenin induces modifications in the astrocyte secretome: relevance to amyotrophic lateral sclerosis.

scientific article

Angiogenin protects motoneurons against hypoxic injury.

scientific article

Anti-apoptotic BCL-2 family proteins in acute neural injury

scientific article

Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: a review.

scientific article published on 06 January 2009

Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer ⬇️

scientific article published on April 24, 2012

Are NMDA or AMPA/kainate receptor antagonists more efficacious in the delayed treatment of excitotoxic neuronal injury?

scientific article published on 01 January 1995

BCL2 protein signalling determines acute responses to neoadjuvant chemoradiotherapy in rectal cancer.

scientific article published on 13 November 2014

BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus.

scientific article

BID Mediates Oxygen-Glucose Deprivation-Induced Neuronal Injury in Organotypic Hippocampal Slice Cultures and Modulates Tissue Inflammation in a Transient Focal Cerebral Ischemia Model without Changing Lesion Volume

scientific article published on 3 February 2016

Bax regulates neuronal Ca2+ homeostasis.

scientific article

Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo.

scientific article published on 31 December 2010

Bcl-w protects hippocampus during experimental status epilepticus.

scientific article

Bid Promotes K63-Linked Polyubiquitination of Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) and Sensitizes to Mutant SOD1-Induced Proinflammatory Signaling in Microglia.

scientific article published on March 2016

Bid and calpains cooperate to trigger oxaliplatin-induced apoptosis of cervical carcinoma HeLa cells.

scientific article published on 27 August 2009

Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects

scientific article

Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death.

scientific article

Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury

scientific journal article

Ca(2+)-induced inhibition of apoptosis in human SH-SY5Y neuroblastoma cells: degradation of apoptotic protease activating factor-1 (APAF-1).

scientific article

Calpains are downstream effectors of bax-dependent excitotoxic apoptosis.

scientific article published on February 2012

Caspase 6 has a protective role in SOD1(G93A) transgenic mice

scientific article

Caspase-3 cleavage and nuclear localization of caspase-activated DNase in human temporal lobe epilepsy

scientific article published on 01 April 2006

Central roles of apoptotic proteins in mitochondrial function.

scientific article published on 06 August 2012

Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression.

scientific article published in August 2002

Characterization of Puma-dependent and Puma-independent neuronal cell death pathways following prolonged proteasomal inhibition.

scientific article published on 4 October 2010

Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons.

scientific article published on 27 July 2006

Computational Analysis of AMPK-Mediated Neuroprotection Suggests Acute Excitotoxic Bioenergetics and Glucose Dynamics Are Regulated by a Minimal Set of Critical Reactions

scientific article published on 3 February 2016

Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus.

scientific article

Control of motoneuron survival by angiogenin.

scientific article

Cytoplasmic inclusions of Htt exon1 containing an expanded polyglutamine tract suppress execution of apoptosis in sympathetic neurons. ⬇️

scientific article

Deletion of Puma protects hippocampal neurons in a model of severe status epilepticus.

scientific article

Depletion of 14-3-3 zeta elicits endoplasmic reticulum stress and cell death, and increases vulnerability to kainate-induced injury in mouse hippocampal cultures.

scientific article published on 2 May 2008

Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death

scientific article

Dlk/ZIP kinase-induced apoptosis in human medulloblastoma cells: requirement of the mitochondrial apoptosis pathway

scientific article

Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death.

scientific article

Dynamics of intracellular oxygen in PC12 Cells upon stimulation of neurotransmission.

scientific article

Dynamics of outer mitochondrial membrane permeabilization during apoptosis.

scientific article published on 9 January 2009

Early loss of mammalian target of rapamycin complex 1 (mTORC1) signalling and reduction in cell size during dominant-negative suppression of hepatic nuclear factor 1-alpha (HNF1A) function in INS-1 insulinoma cells.

scientific article published on 24 October 2008

Effect of the N-methyl-D-aspartate NR2B subunit antagonist ifenprodil on precursor cell proliferation in the hippocampus

scientific article published on 27 January 2014

Effects of hepatocyte nuclear factor-1A and -4A on pancreatic stone protein/regenerating protein and C-reactive protein gene expression: implications for maturity-onset diabetes of the young.

scientific article published on 26 June 2013

Effects of serotonergic drugs in experimental brain ischemia: evidence for a protective role of serotonin in cerebral ischemia

scientific article published on 01 December 1993

Effects of transient focal cerebral ischemia in mice deficient in puma.

scientific article published on 13 January 2009

Elevated serum angiogenin levels in ALS.

scientific article published in November 2006

Elevation in plasma tRNA fragments precede seizures in human epilepsy

scientific article published on 30 April 2019

Endonuclease-G and the pathways to dopaminergic neurodegeneration: a question of location?

scientific article published on 25 October 2013

Endoplasmic reticulum stress-mediated upregulation of miR-29a enhances sensitivity to neuronal apoptosis.

scientific article published on 10 January 2016

Erratum to: Calnexin, an ER stress-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer.

scientific article published on 26 July 2016

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Expanding the substantial interactome of NEMO using protein microarrays

scientific article

Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na+/Ca2+ exchange

scientific article published on 13 June 2010

Fibroblast growth factor homologous factor 1 interacts with NEMO to regulate NF-κB signaling in neurons.

scientific article published on 24 October 2012

From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicine.

scientific article

Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists

scientific article published on 01 April 2022

Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome.

scientific article

Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release. ⬇️

scientific article

Glucose-starved cells do not engage in prosurvival autophagy

scientific article published on 6 September 2013

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

scientific article published on 17 April 2009

HCP: A Matlab package to create beautiful heatmaps with richly annotated covariates

scientific article published on 13 June 2019

Harnessing system models of cell death signalling for cytotoxic chemotherapy: towards personalised medicine approaches?

scientific article published on 30 January 2014

High levels of X-linked Inhibitor-of-Apoptosis Protein (XIAP) are indicative of radio chemotherapy resistance in rectal cancer.

scientific article published on 13 June 2015

Hippocampal transcriptome after status epilepticus in mice rendered seizure damage-tolerant by epileptic preconditioning features suppressed calcium and neuronal excitability pathways.

scientific article

Hsp27 binding to the 3'UTR of bim mRNA prevents neuronal death during oxidative stress-induced injury: a novel cytoprotective mechanism

scientific article

Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer.

scientific article

Hypothesis review: are clathrin-mediated endocytosis and clathrin-dependent membrane and protein trafficking core pathophysiological processes in schizophrenia and bipolar disorder? ⬇️

scientific article published on October 11, 2011

INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells. ⬇️

scientific article

Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival

scientific article

Imaging oxygen in neural cell and tissue models by means of anionic cell-permeable phosphorescent nanoparticles.

scientific article

In vivo bioluminescence imaging validation of a human biopsy-derived orthotopic mouse model of glioblastoma multiforme.

scientific article published in May 2013

Increased expression of microRNA-29a in ALS mice: functional analysis of its inhibition

scientific article published on 04 April 2014

Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme.

scientific article

Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models.

scientific article

KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia

scientific article

Latrepirdine is a potent activator of AMP-activated protein kinase and reduces neuronal excitability.

scientific article published on 22 October 2013

Low levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: Caspase-3 inhibition as a therapeutic approach

scientific article published on 4 February 2016

Marked diversity in the action of growth factors on N-methyl-D-aspartate-induced neuronal degeneration

scientific article published on 01 June 1996

Mathematical modelling of the mitochondrial apoptosis pathway.

scientific article published on 13 October 2010

Mechanistic interrogation of combination bevacizumab/dual PI3K/mTOR inhibitor response in glioblastoma implementing novel MR and PET imaging biomarkers

scientific article published on 15 March 2016

Method of calibration of a fluorescence microscope for quantitative studies.

scientific article

MicroRNA-224 is Readily Detectable in Urine of Individuals with Diabetes Mellitus and is a Potential Indicator of Beta-Cell Demise.

scientific article published on 23 June 2015

MicroRNAs 10a and 10b are potent inducers of neuroblastoma cell differentiation through targeting of nuclear receptor corepressor 2 ⬇️

scientific article published on January 7, 2011

Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance.

scientific article published in August 2007

Mitochondrial transmembrane potential and free radical production in excitotoxic neurodegeneration ⬇️

scientific article published on March 1, 1998

Modelling tumour cell proliferation from vascular structure using tissue decomposition into avascular elements

scientific article published on 4 May 2016

Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis

scientific article published on April 2014

Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)

scientific article published on 8 November 2006

Molecular Mechanisms in Amyotrophic Lateral Sclerosis: The Role of Angiogenin, a Secreted RNase.

scientific article published on 19 November 2012

Molecular imaging in the development of a novel treatment paradigm for glioblastoma (GBM): an integrated multidisciplinary commentary.

scientific article published on 20 June 2013

Motoneurons secrete angiogenin to induce RNA cleavage in astroglia.

scientific article published in April 2012

NMDA-induced injury of mouse organotypic hippocampal slice cultures triggers delayed neuroblast proliferation in the dentate gyrus: an in vitro model for the study of neural precursor cell proliferation.

scientific article published on 15 May 2010

NMDA‐induced superoxide production and neurotoxicity in cultured rat hippocampal neurons: role of mitochondria ⬇️

scientific article published on May 1, 1998

Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75.

scientific article published in January 2002

Neuronal apoptosis: BH3-only proteins the real killers?

scientific article

Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

scientific article

Opposing effects of transforming growth factor-beta 1 on glutamate neurotoxicity

scientific article published on 01 May 1994

Opposite effects of TGF-beta 1 on rapidly- and slowly-triggered excitotoxic injury.

scientific article published in March 1996

Paracrine control of tissue regeneration and cell proliferation by Caspase-3.

scientific article published on 11 July 2013

Patient-derived glioblastoma cells show significant heterogeneity in treatment responses to the inhibitor-of-apoptosis-protein antagonist birinapant

scientific article published on 10 December 2015

Proteasome inhibition can impair caspase-8 activation upon submaximal stimulation of apoptotic tumor necrosis factor-related apoptosis inducing ligand (TRAIL) signaling.

scientific article published on 9 March 2012

Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8.

scientific article

Protein macroarray profiling of serum autoantibodies in pseudoexfoliation glaucoma.

scientific article

Rapamycin protects against dominant negative-HNF1A-induced apoptosis in INS-1 cells.

scientific article

Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate.

scientific article published on 15 December 2006

Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway.

scientific article published on January 2005

Regulation of glucose transporter 3 surface expression by the AMP-activated protein kinase mediates tolerance to glutamate excitation in neurons.

scientific article

Role of 5'-adenosine monophosphate-activated protein kinase in cell survival and death responses in neurons.

scientific article published on 18 February 2011

Role of Smac in cephalostatin-induced cell death

scientific article published on 19 September 2008

S100B potently activates p65/c-Rel transcriptional complexes in hippocampal neurons: Clinical implications for the role of S100B in excitotoxic brain injury

scientific journal article

Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY) carriers from the third decade of life onward.

scientific article

Single-cell imaging of bioenergetic responses to neuronal excitotoxicity and oxygen and glucose deprivation

scientific article published in July 2014

Single-cell imaging of the heat-shock response in colon cancer cells suggests that magnitude and length rather than time of onset determines resistance to apoptosis.

scientific article published on 27 November 2013

Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation.

scientific article

System-based approaches as prognostic tools for glioblastoma

scientific article published on 12 November 2019

Systems analysis of BCL2 protein family interactions establishes a model to predict responses to chemotherapy.

scientific article published on January 2013

Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilization.

scientific article

Systems biology analysis identifies molecular determinants of chemotherapy-induced diarrhoea

scientific article published on 17 December 2019

Systems modelling methodology for the analysis of apoptosis signal transduction and cell death decisions.

scientific article published on 19 April 2013

TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling

scientific journal article

TOXI-SIM-A simulation tool for the analysis of mitochondrial and plasma membrane potentials.

scientific article published on 7 September 2008

Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer.

scientific article

The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis

scientific journal article

The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes.

scientific article published on 21 June 2014

The DAP kinase family of pro-apoptotic proteins: novel players in the apoptotic game.

scientific article

The amyloid precursor protein potentiates CHOP induction and cell death in response to ER Ca2+ depletion

scientific article published on 19 October 2006

The beta2-adrenoceptor agonist clenbuterol modulates Bcl-2, Bcl-xl and Bax protein expression following transient forebrain ischemia.

scientific article published in January 1999

The death associated protein (DAP) kinase homologue Dlk/ZIP kinase induces p19ARF- and p53-independent apoptosis.

scientific article published on January 2003

The esoteric roles of Bcl-2 family proteins in glucose homeostasis and cell survival.

scientific article published on 5 November 2015

The frequencies and clinical implications of mutations in 33 kinase-related genes in locally advanced rectal cancer: a pilot study.

scientific article

The indirect activation model of mitochondrial outer membrane permeabilisation (MOMP) initiation requires a trade-off between robustness in the absence of and sensitivity in the presence of stress ⬇️

scientific article published on September 1, 2013

The metabolic response to excitotoxicity - lessons from single-cell imaging.

scientific article published on 28 September 2014

Time-lapse imaging of p65 and IκBα translocation kinetics following Ca2+-induced neuronal injury reveals biphasic translocation kinetics in surviving neurons.

scientific article

Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate ⬇️

scientific article published on April 27, 2012

Unsupervised mitochondria segmentation using recursive spectral clustering and adaptive similarity models

scientific article published on 30 October 2013

Up-regulation of Bcl-xL in response to subtoxic beta-amyloid: role in neuronal resistance against apoptotic and oxidative injury.

scientific article

Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis.

scientific article

Validation of an imageable surgical resection animal model of Glioblastoma (GBM).

scientific article

Vascular regression precedes motor neuron loss in the FUS (1-359) ALS mouse model

scientific article published on 13 August 2019

Versatile Conjugated Polymer Nanoparticles for High-Resolution O2 Imaging in Cells and 3D Tissue Models.

scientific article

XIAP impairs Smac release from the mitochondria during apoptosis.

scientific article

Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via a mitochondria-mediated mechanism.

scientific article published on 24 March 2010

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