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List of works by Robert O. Ryan

31P-NMR study of the phospholipid moiety of lipophorin subspecies

scientific article published on September 22, 1992

A Two-step Binding Model of PCSK9 Interaction with the Low Density Lipoprotein Receptor ⬇️

scientific article published on December 11, 2010

A facile method for isolation of recombinant human apolipoprotein A-I from E. coli

scientific article

A molecular trigger of lipid binding-induced opening of a helix bundle exchangeable apolipoprotein

scientific article

A turbidimetric assay of lipid transfer activity

scientific article published on October 1, 1992

Aberrant hetero-disulfide bond formation by the hypertriglyceridemia-associated p.Gly185Cys APOA5 variant (rs2075291).

scientific article published on 14 August 2014

Alignment of the apolipophorin-III alpha-helices in complex with dimyristoylphosphatidylcholine. A unique spatial orientation

scientific article published on May 1995

All trans retinoic acid nanodisks enhance retinoic acid receptor mediated apoptosis and cell cycle arrest in mantle cell lymphoma

scientific article

All-trans-retinoic acid nanodisks

scientific article

Amphotericin B induces interdigitation of apolipoprotein stabilized nanodisk bilayers

scientific article

An N-terminal three-helix fragment of the exchangeable insect apolipoprotein apolipophorin III conserves the lipid binding properties of wild-type protein

scientific article published on March 2001

An insect lipoprotein hybrid helps to define the role of apolipophorin III.

scientific article

Anti-CD20 single chain variable antibody fragment-apolipoprotein A-I chimera containing nanodisks promote targeted bioactive agent delivery to CD20-positive lymphomas

scientific article published on 20 April 2015

ApoE enhances nanodisk-mediated curcumin delivery to glioblastoma multiforme cells

scientific article published on 24 July 2013

Apolipophorin III: a lipid-triggered molecular switch ⬇️

scientific article published on December 1, 2003

Apolipophorin III: role model apolipoprotein

scientific article

Apolipoprotein A-V N-terminal domain lipid interaction properties in vitro explain the hypertriglyceridemic phenotype associated with natural truncation mutants

scientific article published on 13 October 2009

Apolipoprotein A-V associates with intrahepatic lipid droplets and influences triglyceride accumulation

scientific article published on 11 February 2010

Apolipoprotein A-V association with intracellular lipid droplets

scientific article published on 25 April 2007

Apolipoprotein A-V deficiency enhances chylomicron production in lymph fistula mice

scientific article

Apolipoprotein A-V dependent modulation of plasma triacylglycerol: A puzzlement ⬇️

scientific article published on December 22, 2011

Apolipoprotein A-V gene therapy for disease prevention / treatment:a critical analysis

scientific article

Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family

scientific article

Apolipoprotein A-V is present in bile and its secretion increases with lipid absorption in Sprague-Dawley rats

scientific article

Apolipoprotein A-V-heparin interactions: implications for plasma lipoprotein metabolism

scientific article

Apolipoprotein A5: Extracellular and Intracellular Roles in Triglyceride Metabolism

scientific article published on 31 May 2015

Apolipoprotein E isoform-specific binding to the low-density lipoprotein receptor

scientific article

Apolipoprotein E: From lipid transport to neurobiology ⬇️

scientific article published on September 18, 2010

Arylphorin from Manduca sexta: carbohydrate structure and immunological studies

scientific article

Bacterial expression and site-directed mutagenesis of a functional recombinant apolipoprotein ⬇️

scientific article published on May 1, 1995

Bacterial overexpression, isotope enrichment, and NMR analysis of the N-terminal domain of human apolipoprotein E.

scientific article

Barth Syndrome: Connecting Cardiolipin to Cardiomyopathy

scientific article published on 9 January 2017

Binding of insect apolipophorin III to dimyristoylphosphatidylcholine vesicles. Evidence for a conformational change.

scientific article published on February 1994

Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells

scientific article

Biophysical studies on the lipid transfer particle from the hemolymph of the tobacco hornworm, Manduca sexta

scientific article published in July 1990

Biosynthesis of myristate in an aphid: involvement of a specific acylthioesterase

scientific article published in January 1982

Calorimetric and spectroscopic studies of the interaction of Manduca sexta apolipophorin III with zwitterionic, anionic, and nonionic lipids

scientific article published on April 1993

Cardiolipin and mitochondrial cristae organization

scientific article published on 20 March 2017

Changes in lipoprotein composition during larval-pupal metamorphosis of an insect, Manduca sexta

scientific article

Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation

scientific article

Characterization of low density lipoprotein receptor ligand interactions by fluorescence resonance energy transfer

scientific article published on 8 February 2006

Characterization of secondary structure and lipid binding behavior of N-terminal saposin like subdomain of human Wnt3a

scientific article published on 25 July 2017

Combined N- and C-terminal truncation of human apolipoprotein A-I yields a folded, functional central domain.

scientific article

Complete 1H, 15N, and 13C assignments of an exchangeable apolipoprotein, Locusta migratoria apolipophorin III.

scientific article published in January 2001

Conformational changes of an exchangeable apolipoprotein, apolipophorin III from Locusta migratoria, at low pH: correlation with lipid binding

scientific article published in June 2001

Conformational, thermodynamic, and stability properties of Manduca sexta apolipophorin III.

scientific article

Conversion of human low density lipoprotein into a very low density lipoprotein-like particle in vitro

scientific article

Curcumin homing to the nucleolus: mechanism for initiation of an apoptotic program

scientific article published on August 2014

Curcumin nanodisk-induced apoptosis in mantle cell lymphoma ⬇️

scientific article published on June 24, 2011

Curcumin nanodisks: formulation and characterization

scientific article published on October 2010

Differential lipid binding of truncation mutants of Galleria mellonella apolipophorin III.

scientific article published on July 2002

Displacement of apolipophorin III from the surface of low density lipophorin by human apolipoprotein A-I.

scientific article published in September 1991

Disulfide bond engineering to monitor conformational opening of apolipophorin III during lipid binding

scientific article published on October 1996

Domain swapping reveals that low density lipoprotein (LDL) type A repeat order affects ligand binding to the LDL receptor

scientific article published on 26 March 2009

Dynamics of insect lipophorin metabolism

scientific article published on October 1990

Effect of Amphotericin B Nanodisks on Leishmania major Infected Mice

scientific article

Effect of amphotericin B nanodisks on plant fungal diseases

scientific article published on 24 June 2011

Effect of apolipoprotein A-V on plasma triglyceride, lipoprotein size, and composition in genetically engineered mice

scientific article published on 3 December 2007

Effect of curcumin on amyloid-like aggregates generated from methionine-oxidized apolipoprotein A-I.

scientific article published on 10 January 2018

Effect of particle lipid content on the structure of insect lipophorins

scientific article

Effect of phospholipase C and apolipophorin III on the structure and stability of lipophorin subspecies

scientific article published on September 1994

Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families

scientific article

Evaluation of cardiolipin nanodisks as lipidreplacement therapy for Barth syndrome

scientific article published in November 2017

Exogenous cardiolipin localizes to mitochondria and prevents TAZ knockdown-induced apoptosis in myeloid progenitor cells

scientific article published on 9 July 2015

Expressed protein ligation using an N-terminal cysteine containing fragment generated in vivo from a pelB fusion protein

scientific article

Expressed protein ligation-mediated template protein extension ⬇️

scientific article published on April 1, 2012

Facilitated diacylglycerol exchange between insect hemolymph lipophorins. Properties of Manduca sexta lipid transfer particle

scientific article

Factors affecting the stability and conformation of Locusta migratoria apolipophorin III.

scientific article published in March 1994

Fluorescence studies of exchangeable apolipoprotein-lipid interactions. Superficial association of apolipophorin III with lipoprotein surfaces

scientific article published on January 1998

Fluorescence studies of lipid association-induced conformational adaptations of an exchangeable amphipathic apolipoprotein

scientific article published on October 1996

Functional similarities of human and chicken apolipoprotein A-I: dependence on secondary and tertiary rather than primary structure

scientific article published in April 2001

Gene Transfer of Apolipoprotein A-V Improves the Hypertriglyceridemic Phenotype of apoa5 (−/−) mice ⬇️

scientific article published on January 17, 2013

Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase

scientific article

Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons

scientific article

Helix orientation of the functional domains in apolipoprotein e in discoidal high density lipoprotein particles

scientific article

Hemolymph lipid transport

scientific article published in October 1994

Human apolipoprotein A-I liberated from high-density lipoprotein without denaturation

scientific article published on May 12, 1992

Human apolipoprotein E N-terminal domain displacement of apolipophorin III from insect low density lipophorin creates a receptor-competent hybrid lipoprotein

scientific article published on April 1999

Hydrogen/deuterium exchange kinetics of apolipophorin-III in lipid-free and phospholipid-bound states. An analysis by Fourier transform infrared spectroscopy

scientific article published on September 1996

Identification and localization of two distinct microenvironments for the diacylglycerol component of lipophorin particles by 13C NMR.

scientific article published on May 1995

Impact of apolipoprotein E on Alzheimer's disease

scientific article

Influence of apolipoprotein A-V on hepatocyte lipid droplet formation ⬇️

scientific article published on September 18, 2012

Influence of apolipoprotein A-V on the metabolic fate of triacylglycerol ⬇️

scientific article published on April 1, 2013

Insect apolipophorin III. Purification and properties

scientific article

Insect lipid transfer particle can facilitate net vectorial lipid transfer via a carrier-mediated mechanism ⬇️

scientific article published on July 15, 1992

Insect lipid transfer particle catalyzes bidirectional vectorial transfer of diacylglycerol from lipophorin to human low density lipoprotein

scientific article

Insect lipid transfer particle catalyzes diacylglycerol exchange between high-density and very-high-density lipoproteins ⬇️

scientific article published on September 2, 1988

Insight into Lipid Surface Recognition and Reversible Conformational Adaptations of an Exchangeable Apolipoprotein by Multidimensional Heteronuclear NMR Techniques ⬇️

scientific article published on July 18, 1997

Interaction of an exchangeable apolipoprotein with phospholipid vesicles and lipoprotein particles. Role of leucines 32, 34, and 95 in Locusta migratoria apolipophorin III.

scientific article published in July 1999

Interaction of locust apolipophorin III with lipoproteins and phospholipid vesicles: effect of glycosylation.

scientific article published on March 2000

Interhelical contacts are required for the helix bundle fold of apolipophorin III and its ability to interact with lipoproteins ⬇️

scientific article published on February 1, 1998

Intracellular lipid droplet targeting by apolipoprotein A-V requires the carboxyl-terminal segment

scientific article published on 30 April 2008

Intravenous Injection of Apolipoprotein A-V Reconstituted High-Density Lipoprotein Decreases Hypertriglyceridemia in apoav −/− Mice and Requires Glycosylphosphatidylinositol-Anchored High-Density Lipoprotein–Binding Protein 1 ⬇️

scientific article published on October 21, 2010

Isolation and characterization of recombinant murine Wnt3a

scientific article published on 8 November 2014

Lipid association-induced N- and C-terminal domain reorganization in human apolipoprotein E3.

scientific article published in August 2001

Lipid binding ability of human apolipoprotein E N-terminal domain isoforms: correlation with protein stability?

scientific article published in January 2003

Lipid binding of the exchangeable apolipoprotein apolipophorin III induces major changes in fluorescence properties of tryptophans 115 and 130.

scientific article published in June 2000

Lipid binding-induced conformational changes in the N-terminal domain of human apolipoprotein E.

scientific article

Lipid transfer between human plasma low-density lipoprotein and a triolein/phospholipid microemulsion catalyzed by insect hemolymph lipid transfer particle

scientific article

Lipid transfer particle catalyzes transfer of carotenoids between lipophorins of Bombyx mori

scientific article published on December 1998

Lipid transfer particle-catalyzed transfer of lipoprotein-associated diacylglycerol and long chain aliphatic hydrocarbons

scientific article

Lipid transfer particle-induced transformation of human high density lipoprotein into apolipoprotein A-I-deficient low density particles.

scientific article

Lipid transport biochemistry and its role in energy production

scientific article

Lipid-Protein Interactions in Nanodiscs: How to Enhance Stability

Lipid-bound Structure of an Apolipoprotein E-derived Peptide ⬇️

scientific article published on April 22, 2003

Lipid-induced extension of apolipoprotein E helix 4 correlates with low density lipoprotein receptor binding ability.

scientific article published in November 2006

Lipid-triggered conformational switch of apolipophorin III helix bundle to an extended helix organization

scientific article published on August 2002

Lipophorin of the larval honeybee, Apis mellifera L.

scientific article

Lipoprotein interconversions in an insect, Manduca sexta. Evidence for a lipid transfer factor in the hemolymph

scientific article

Local suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasis

scientific article

Manduca sexta lipid transfer particle acts upon a lipoprotein to catalyze lipid and apoprotein disproportionation

scientific article

Merck Frosst award lecture 1995. La conference Merck Frosst 1995. Structural studies of lipoproteins and their apolipoprotein components

scientific article published on January 1996

Metabolic annotation of 2-ethylhydracrylic acid

scientific article

Metabolic biology of 3-methylglutaconic acid-uria: a new perspective

scientific article

Modulation of the lipid binding properties of the N-terminal domain of human apolipoprotein E3.

scientific article

Molecular basis of exchangeable apolipoprotein function

scientific article

Molecular studies of pH-dependent ligand interactions with the low-density lipoprotein receptor

scientific article published on 11 October 2008

NMR evidence for a conformational adaptation of apolipophorin III upon lipid association

scientific article published on January 1998

NMR structure and dynamics of a receptor-active apolipoprotein E peptide

scientific article published on 29 May 2002

Nanobiotechnology applications of reconstituted high density lipoprotein ⬇️

scientific article published on December 1, 2010

Nanodisk-associated amphotericin B clears Leishmania major cutaneous infection in susceptible BALB/c mice

scientific article

Nanodisks derived from amphotericin B lipid complex

scientific article

Nanodisks protect amphotericin B from ultraviolet light and oxidation-induced damage

scientific article

Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution

scientific article published in December 2007

Nutlin-3a Nanodisks Induce p53 Stabilization and Apoptosis in a Subset of Cultured Glioblastoma Cells

scientific article published on 23 August 2017

On the origin of 3-methylglutaconic acid in disorders of mitochondrial energy metabolism

scientific article published on 18 April 2016

Optimized bacterial expression of human apolipoprotein A-I.

scientific article

Peptide stabilized amphotericin B nanodisks

scientific article published on 19 January 2007

Prevention of phospholipase-C induced aggregation of low density lipoprotein by amphipathic apolipoproteins

scientific article

Primary structure of locust flight muscle fatty acid binding protein

scientific article published on September 1, 1992

Protein-lipid interactions of apolipophorin-III, a model exchangeable amphipathic apolipoprotein ⬇️

scientific article published on August 1, 1997

Purification and properties of a predominantly female-specific protein from the hemolymph of the larva of the tobacco hornworm, Manduca sexta

scientific article

Purification and properties of a very high density lipoprotein from the hemolymph of the honeybee Apis mellifera

scientific article published in April 1987

Purification of very high density lipoproteins by differential density gradient ultracentrifugation

scientific article published in March 1987

Pyrene excimer fluorescence: a spatially sensitive probe to monitor lipid-induced helical rearrangement of apolipophorin III.

scientific article published on June 2000

Recombinant locust apolipophorin III: characterization and NMR spectroscopy ⬇️

scientific article published on July 31, 1998

Reconstituted high density lipoprotein enriched with the polyene antibiotic amphotericin B.

scientific article published on 28 November 2005

Replacement of helix 1' enhances the lipid binding activity of apoE3 N-terminal domain.

scientific article

Role of leucine zipper motif in apoE3 N-terminal domain lipid binding activity.

scientific article

Role of lipid transfer particle in transformation of lipophorin in insect oocytes

scientific article

Semisynthesis and segmental isotope labeling of the apoE3 N-terminal domain using expressed protein ligation

scientific article published on 19 December 2008

Spectroscopic and lipid binding studies on the amino and carboxyl terminal fragments of Locusta migratoria apolipophorin III.

scientific article published in September 1995

Spectroscopic characterization of the conformational adaptability of Bombyx mori apolipophorin III.

scientific article published on February 2000

Spectroscopic studies of amphotericin B solubilized in nanoscale bilayer membranes

scientific article published on 26 January 2006

Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway

scientific article published on 16 January 2018

Structural and binding characteristics of the carboxyl terminal fragment of apolipophorin III from Manduca sexta

scientific article published on November 1994

Structural basis for the conformational adaptability of apolipophorin III, a helix-bundle exchangeable apolipoprotein

scientific article

Structural studies of Manduca sexta lipid transfer particle with apolipoprotein-specific antibodies.

scientific article published on January 1995

Structure and interfacial properties of human apolipoprotein A-V

scientific article

Structure-function studies of human apolipoprotein A-V: a regulator of plasma lipid homeostasis

scientific article (publication date: 12 August 2003)

Structure-guided protein engineering modulates helix bundle exchangeable apolipoprotein properties

scientific article published on 8 April 2003

Studies of the morphology and structure of the plasma lipid transfer particle from the tobacco hornworm, Manduca sexta

scientific article

Targeting nanodisks via a single chain variable antibody--apolipoprotein chimera

scientific article published on 27 December 2008

The C terminus of apolipoprotein A-V modulates lipid-binding activity.

scientific article

The C-terminal domain of apolipoprotein A-I contains a lipid-sensitive conformational trigger

scientific article published in June 2003

The N-terminus of apolipoprotein A-V adopts a helix bundle molecular architecture

scientific article

The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons

scientific article

The carboxyl-terminal segment of apolipoprotein A-V undergoes a lipid-induced conformational change

scientific article published on June 2010

The ins (cell) and outs (plasma) of apolipoprotein A-V.

scientific article published on 2 December 2008

The role of apolipophorin III in in vivo lipoprotein interconversions in adult Manduca sexta.

scientific article

Wnt3a nanodisks promote ex vivo expansion of hematopoietic stem and progenitor cells

scientific article published on 23 August 2016

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