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List of works by Christophe Magnan

Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity

scientific article published on 15 August 2019

Adipocyte Glucocorticoid Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure

scientific article published on 19 November 2018

Adiponectin is required to mediate rimonabant-induced improvement of insulin sensitivity but not body weight loss in diet-induced obese mice

scientific article published on 11 February 2009

Alterations in the Serotonin and Dopamine Pathways by Cystathionine Beta Synthase Overexpression in Murine Brain

scientific article published on 20 September 2018

Altered activity of the autonomous nervous system as a determinant of the impaired beta-cell secretory response after protein-energy restriction in the rat.

scientific article published on August 1998

Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high-fat-diet-induced obesity.

scientific article published on 25 May 2012

Beta oxidation in the brain is required for the effects of non-esterified fatty acids on glucose-induced insulin secretion in rats.

scientific article published on 30 November 2004

Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity

scientific article published on 15 July 2008

Brain lipid sensing and nervous control of energy balance ⬇️

scientific article published on December 23, 2010

Brain lipid sensing and the neural control of energy balance

scientific article published on 25 September 2015

Brain lipoprotein lipase as a regulator of energy balance

scientific article

Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production

scientific article published on 24 June 2016

Characteristics and mechanisms of hypothalamic neuronal fatty acid sensing

scientific article published on 17 June 2009

Chronic free fatty acid infusion in rats results in insulin resistance but no alteration in insulin-responsive glucose transporter levels in skeletal muscle

scientific article published on 01 November 1996

Correction to: Establishing a Reproducible Murine Animal Model of Single Anastomosis Duodenoileal Bypass with Sleeve Gastrectomy (SADl-S)

scientific article published on 01 October 2018

Corrigendum to "Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome" [Free Radic. Biol. Med. 114 (2018) 122-130].

scientific article

Deregulation of hepatic insulin sensitivity induced by central lipid infusion in rats is mediated by nitric oxide

scientific article

Dietary supplementation with Agaricus blazei murill extract prevents diet-induced obesity and insulin resistance in rats

scientific article

Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding.

scientific article

Dietary triglycerides as signaling molecules that influence reward and motivation

scientific article published on 18 March 2016

Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity.

scientific article published on 14 July 2017

Dysregulation of energy homeostasis in mice overexpressing insulin-like growth factor-binding protein 6 in the brain

scientific journal article

Early changes in insulin secretion and action induced by high-fat diet are related to a decreased sympathetic tone.

scientific article published on 7 September 2004

Effects of maternal genotype and diet on offspring glucose and fatty acid-sensing ventromedial hypothalamic nucleus neurons

scientific article published on 26 August 2009

Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling

scientific article

Enhanced hypothalamic glucose sensing in obesity: alteration of redox signaling.

scientific article published on 06 July 2009

Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress

scientific article published on 01 October 2018

Exploring functional beta-cell heterogeneity in vivo using PSA-NCAM as a specific marker

scientific article published on 18 May 2009

F-DIO obesity-prone rat is insulin resistant before obesity onset

scientific article published on 5 May 2005

FAT/CD36: a major regulator of neuronal fatty acid sensing and energy homeostasis in rats and mice

scientific journal article

Farnesoid X Receptor Activation in Brain Alters Brown Adipose Tissue Function via the Sympathetic System

scientific article published on 01 January 2021

Fatty acid transporter CD36 mediates hypothalamic effect of fatty acids on food intake in rats

scientific article

Fostering improved human islet research: a European perspective

scientific article published on 13 June 2019

Free fatty acids and insulin resistance

scientific article

GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.

scientific article published on 30 September 2015

GLUT2 accumulation in enterocyte apical and intracellular membranes: a study in morbidly obese human subjects and ob/ob and high fat-fed mice

scientific article

GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice

scientific article published on 13 April 2009

Glucolipotoxicity impairs ceramide flow from the endoplasmic reticulum to the Golgi apparatus in INS-1 β-cells

scientific article

Glucose regulates proinsulin and prosomatostatin but not proglucagon messenger ribonucleic acid levels in rat pancreatic islets

scientific article published on 01 January 2000

Glucose-induced O₂ consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells

scientific article (publication date: 2012)

Hepatitis C virus induces a prediabetic state by directly impairing hepatic glucose metabolism in mice.

scientific article

Hippocampal lipoprotein lipase regulates energy balance in rodents

scientific article

Homocysteine Metabolism Pathway Is Involved in the Control of Glucose Homeostasis: A Cystathionine Beta Synthase Deficiency Study in Mouse

scientific article published on 25 May 2022

Hormonal counterregulation failure in rats is related to previous hyperglycaemia-hyperinsulinaemia

scientific article published on 01 February 1998

Hypoglycemia-activated GLUT2 neurons of the nucleus tractus solitarius stimulate vagal activity and glucagon secretion.

scientific article published in March 2014

Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning

scientific article

Hypothalamic integration of portal glucose signals and control of food intake and insulin sensitivity.

scientific article published on 18 June 2010

Identification of the Interactions Interference Between the PH and START Domain of CERT by Limonoid and HPA Inhibitors

scientific article published on 27 November 2020

Importance of the gut-brain axis in the control of glucose homeostasis

scientific article published on 20 September 2006

In vivo effects of glucose and insulin on secretion and gene expression of glucagon in rats

scientific article published on 01 December 1995

Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome.

scientific article published on 25 September 2017

Incretin effect of glucagon-like peptide 1 receptor agonist is preserved in presence of ABCC8/SUR1 mutation in β-cell

scientific article published on November 2012

Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats

scientific article published on 7 November 2017

Insulin internalizes GLUT2 in the enterocytes of healthy but not insulin-resistant mice.

scientific article published on 5 December 2007

Insulin, but not glucose lowering corrects the hyperglucagonemia and increased proglucagon messenger ribonucleic acid levels observed in insulinopenic diabetes

scientific article published on 01 November 1998

Interaction of low dose of fish oil and glucocorticoids on insulin sensitivity and lipolysis in healthy humans: A randomized controlled study.

scientific article published on 3 March 2016

Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms

scientific article

Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice

scientific article published in September 2008

Intestinal gluconeogenesis: key signal of central control of energy and glucose homeostasis

scientific article published on July 2009

Intracerebroventricular infusion of a triglyceride emulsion leads to both altered insulin secretion and hepatic glucose production in rats

scientific article published in November 2002

Intrauterine hyperglycemia increases insulin binding sites but not glucose transporter expression in discrete brain areas in term rat fetuses

scientific article

Involvement of the autonomic nervous system in the in vivo memory to glucose of pancreatic beta cell in rats.

scientific article

LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia

scientific article published on 31 January 2015

Laparoscopic Adjustable Gastric Banding: Predictive Factors for Weight Loss and Band Removal After More than 10 Years' Follow-Up in a Single University Unit

scientific article

Leptin receptor-deficient obese Zucker rats reduce their food intake in response to a systemic supply of calories from glucose

scientific article published in February 2003

Lipid sensing in the brain and regulation of energy balance

scientific article

Lipid-induced peroxidation in the intestine is involved in glucose homeostasis imbalance in mice

scientific article

Lipoprotein Lipase Expression in Hypothalamus Is Involved in the Central Regulation of Thermogenesis and the Response to Cold Exposure.

scientific article

Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice

scientific article published on 29 April 2017

Lixisenatide requires a functional gut-vagus nerve-brain axis to trigger insulin secretion in controls and type 2 diabetic mice

scientific article published on 02 August 2018

Long-Term Results After Laparoscopic Adjustable Gastric Banding for Morbid Obesity: 18-Year Follow-Up in a Single University Unit

scientific article

Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota.

scientific article published on 20 April 2018

Metabolic retroconversion of trimethylamineN-oxide and the gut microbiota

Metabolic sensing and the brain: who, what, where, and how?

scientific article

Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing

scientific article published on 27 November 2018

Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion.

scientific article published on 10 December 2008

Mitochondrial reactive oxygen species are required for hypothalamic glucose sensing.

scientific article published in July 2006

Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion

scientific article published on 26 January 2017

Multilevel control of glucose homeostasis by adenylyl cyclase 8.

scientific article

Multiple speckle exposure imaging for the study of blood flow changes induced by functional activation of barrel cortex and olfactory bulb in mice

scientific article published on 01 January 2019

Nervous glucose sensing regulates postnatal β cell proliferation and glucose homeostasis

scientific article published on 16 December 2013

Odor-Induced Neuronal Rhythms in the Olfactory Bulb Are Profoundly Modified in ob/ob Obese Mice

scientific article published on 19 January 2017

Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia

scientific article published on 07 July 2016

Overexpression of the DYRK1A Gene (Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) Induces Alterations of the Serotoninergic and Dopaminergic Processing in Murine Brain Tissues.

scientific article

Oxidative Stress Contributes to Aging by Enhancing Pancreatic Angiogenesis and Insulin Signaling

scientific article published on 01 February 2008

Palatability Can Drive Feeding Independent of AgRP Neurons

scientific article

Palatability Can Drive Feeding Independent of AgRP Neurons

scholarly article by Raphaël G Denis published in April 2017

Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents

scientific article

Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice.

scientific article published on 25 March 2017

Pancreatic beta-cell regeneration after 48-h glucose infusion in mildly diabetic rats is not correlated with functional improvement

scientific article published on 01 July 1998

Physiological and Pharmacological Mechanisms through which the DPP-4 Inhibitor Sitagliptin Regulates Glycemia in Mice

scientific article published on 14 June 2011

Physiological and pathophysiological implications of lipid sensing in the brain.

scientific article published on September 2014

Physiology and biochemistry of type 2 diabetes: A tribute to Dr Alain Ktorza

scientific article published on 10 November 2017

Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans

scientific article published in February 2017

Plasma triacylglycerols are biomarkers of β-cell function in mice and humans

scientific article published on 09 October 2021

Portal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet protein

scientific article published in November 2005

Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets.

scientific article

Psammomys obesus, a model for environment-gene interactions in type 2 diabetes

scientific article

Role of hypothalamic melanocortin system in adaptation of food intake to food protein increase in mice

scientific article

Roles of Sphingolipid Metabolism in Pancreatic β Cell Dysfunction Induced by Lipotoxicity

scientific article published on 20 June 2014

Rôle des acides gras dans le contrôle nerveux de la balance énergétique

S26948, a new specific peroxisome proliferator activated receptor gamma modulator improved in vivo hepatic insulin sensitivity in 48 h lipid infused rats.

scientific article published on 26 February 2009

Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores.

scientific article published on 28 January 2016

Targeting lipid sensing in the central nervous system: new therapy against the development of obesity and type 2 diabetes

scientific article published on 04 February 2013

Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes

scientific article published on 26 March 2015

The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse

scientific article published on 16 July 2020

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion

scientific article

The central nervous system at the core of the regulation of energy homeostasis

scientific article published on June 2009

The suppressor of cytokine signalling 2 (SOCS2) is a key repressor of insulin secretion.

scientific article published on 25 May 2010

The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathways

scientific article published on 02 September 2008

Unsaturated fatty acids disrupt Smad signaling in gonadotrope cells leading to inhibition of FSHβ gene expression.

scientific article published on 18 November 2013

Unsaturated fatty acids stimulate LH secretion via novel PKCepsilon and -theta in gonadotrope cells and inhibit GnRH-induced LH release

scientific article

Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion - A step towards precision medicine

scientific article published on 01 September 2019

Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats

scientific article published on 27 January 2015

Ventromedial hypothalamic nitric oxide production is necessary for hypoglycemia detection and counterregulation

scientific article

What can bariatric surgery teach us about the pathophysiology of type 2 diabetes?

scientific article published on December 2009

[Fatty acid sensors and neurologic control of energetic homeostasis]

scientific article published in January 2006

[Role of brain lipid sensing in nervous regulation of energy balance].

scientific article

mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes

scientific article published on 3 January 2008

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