List of works - Jaap D van Buul

A disintegrin and metalloprotease 10 is a novel mediator of vascular endothelial growth factor-induced endothelial cell function in angiogenesis and is associated with atherosclerosis.

scientific article published on 2 September 2010

A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1

scientific article published on 01 September 2015

A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1.

scientific article

A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis

scientific article published on 22 April 2015

Acid Sphingomyelinase-Derived Ceramide Regulates ICAM-1 Function during T Cell Transmigration across Brain Endothelial Cells

scientific article published on 23 November 2015

Actin-binding proteins differentially regulate endothelial cell stiffness, ICAM-1 function and neutrophil transmigration

scientific article published on 08 August 2014

Annexin A2 Limits Neutrophil Transendothelial Migration by Organizing the Spatial Distribution of ICAM-1.

scientific article

Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen

scientific article published in 2021

Class 3 semaphorins modulate the invasive capacity of rheumatoid arthritis fibroblast-like synoviocytes

scientific article published on 19 February 2018

Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation

scientific article

DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis

scientific article published on 12 February 2020

Diabetes mellitus induces bone marrow microangiopathy

scientific article

Double-Hit-Induced Leukocyte Extravasation Driven by Endothelial Adherens Junction Destabilization

scientific article published on 12 June 2020

Endothelial CD81 is a marker of early human atherosclerotic plaques and facilitates monocyte adhesion

scientific article published on 18 September 2008

Endothelial RhoB and RhoC are dispensable for leukocyte diapedesis and for maintaining vascular integrity during diapedesis

scientific article published on 29 September 2017

Endothelial adapter proteins in leukocyte transmigration.

scientific article published in April 2009

Endothelial junction regulation: a prerequisite for leukocytes crossing the vessel wall.

scientific article

Endothelial signaling by Ig-like cell adhesion molecules.

scientific article published on 21 June 2007

Erratum to: Unexpected arterial wall and cellular inflammation in patients with rheumatoid arthritis in remission using biological therapy: a cross-sectional study

scientific article published on 13 December 2016

F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling

scientific article

Filamin B mediates ICAM-1-driven leukocyte transendothelial migration.

scientific article

Flow-induced endothelial cell alignment requires the RhoGEF Trio as a scaffold protein to polarize active Rac1 distribution.

scientific article published on 17 May 2017

Functional re-expression of CCR7 on CMV-specific CD8+ T cells upon antigenic stimulation

scientific article published on 18 April 2005

Hematopoietic Stem And Progenitor Cells Use Podosomes To Transcellularly Home To The Bone Marrow

ICAM-1 clustering on endothelial cells recruits VCAM-1

scientific article published on 15 March 2010

ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration

scientific article published on 01 September 2007

In vivo imaging of enhanced leukocyte accumulation in atherosclerotic lesions in humans

scientific article published on 01 September 2014

Inflammation-Sensitive Myosin-X Functionally Supports Leukocyte Extravasation by Cdc42-Mediated ICAM-1-Rich Endothelial Filopodia Formation

scientific article published on 31 January 2018

Inhibition of GTPase Rac1 in endothelium by 6-mercaptopurine results in immunosuppression in nonimmune cells: new target for an old drug

scientific article published on 26 March 2014

Inside-out regulation of ICAM-1 dynamics in TNF-alpha-activated endothelium

scientific article

Interferon-Gamma Impairs Maintenance and Alters Hematopoietic Support of Bone Marrow Mesenchymal Stromal Cells.

scientific article published on 16 April 2018

Leukocyte Breaching of Endothelial Barriers: The Actin Link.

scientific article

Leukocyte transendothelial migration: A local affair.

scientific article

Leukocytes Crossing the Endothelium: A Matter of Communication.

scientific article

Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function

scientific article published on 26 May 2020

Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients ⬇️

scientific article published on December 14, 2011

Nuclear shape, protrusive behaviour and in vivo retention of human bone marrow mesenchymal stromal cells is controlled by Lamin-A/C expression

scientific article published on 07 October 2019

Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans ⬇️

scientific article published on 05 August 2016

P-glycoprotein regulates trafficking of CD8(+) T cells to the brain parenchyma

scientific article published on 16 January 2014

Plasminogen Activator Inhibitor-1 Controls Vascular Integrity by Regulating VE-Cadherin Trafficking

scientific article published on 29 December 2015

Real-time imaging of endothelial cell-cell junctions during neutrophil transmigration under physiological flow.

scientific article

Recruitment of Immune Cells into Inflamed Tissues: Consequences for Endothelial Barrier Integrity and Tissue Functionality

scientific article published on 17 February 2016

Rho GAPs and GEFs: controling switches in endothelial cell adhesion

scientific article

Rho-GTPase signaling in leukocyte extravasation: an endothelial point of view.

scientific article published on March 2014

RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration.

scientific article

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis ⬇️

scientific article published in Nature

Small Rho GTPase-mediated actin dynamics at endothelial adherens junctions.

scientific article published on 29 January 2016

Sphingosine-1-phosphate receptor 3 mediates sphingosine-1-phosphate induced release of weibel-palade bodies from endothelial cells.

scientific article

The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models

scientific article published on 21 October 2020

The Ins and Outs of Small GTPase Rac1 in the Vasculature.

scientific article published on 02 June 2015

The N-terminal DH-PH domain of Trio induces cell spreading and migration by regulating lamellipodia dynamics in a Rac1-dependent fashion

scientific article published on 6 January 2012

The Rho-GEF Trio regulates a novel pro-inflammatory pathway through the transcription factor Ets2.

scientific article

The Rho-guanine nucleotide exchange factor Trio controls leukocyte transendothelial migration by promoting docking structure formation.

scientific article

The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis

scientific article

The many faces of the guanine-nucleotide exchange factor trio.

scientific article published on 17 October 2012

The presence of alpha-catenin in the VE-cadherin complex is required for efficient transendothelial migration of leukocytes

scientific article published on 9 November 2009

The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation

scientific article

Trading spaces: Rap, Rac, and Rho as architects of transendothelial migration.

scientific article

Transglutaminase activity regulates atherosclerotic plaque composition at locations exposed to oscillatory shear stress

scientific article published on 07 August 2012

Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis

scientific article

Two CGD Families with a Hypomorphic Mutation in the Activation Domain of p67(phox)

scientific article published on June 2014

Unexpected arterial wall and cellular inflammation in patients with rheumatoid arthritis in remission using biological therapy: a cross-sectional study.

scientific article published on 21 May 2016

List of works by Jaap D van Buul

A disintegrin and metalloprotease 10 is a novel mediator of vascular endothelial growth factor-induced endothelial cell function in angiogenesis and is associated with atherosclerosis.

A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1

A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1.

A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis

Acid Sphingomyelinase-Derived Ceramide Regulates ICAM-1 Function during T Cell Transmigration across Brain Endothelial Cells

Actin-binding proteins differentially regulate endothelial cell stiffness, ICAM-1 function and neutrophil transmigration

Annexin A2 Limits Neutrophil Transendothelial Migration by Organizing the Spatial Distribution of ICAM-1.

Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen

Class 3 semaphorins modulate the invasive capacity of rheumatoid arthritis fibroblast-like synoviocytes

Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation

DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis

Diabetes mellitus induces bone marrow microangiopathy

Double-Hit-Induced Leukocyte Extravasation Driven by Endothelial Adherens Junction Destabilization

Endothelial CD81 is a marker of early human atherosclerotic plaques and facilitates monocyte adhesion

Endothelial RhoB and RhoC are dispensable for leukocyte diapedesis and for maintaining vascular integrity during diapedesis

Endothelial adapter proteins in leukocyte transmigration.

Endothelial junction regulation: a prerequisite for leukocytes crossing the vessel wall.

Endothelial signaling by Ig-like cell adhesion molecules.

Erratum to: Unexpected arterial wall and cellular inflammation in patients with rheumatoid arthritis in remission using biological therapy: a cross-sectional study

F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling

Filamin B mediates ICAM-1-driven leukocyte transendothelial migration.

Flow-induced endothelial cell alignment requires the RhoGEF Trio as a scaffold protein to polarize active Rac1 distribution.

Functional re-expression of CCR7 on CMV-specific CD8+ T cells upon antigenic stimulation

Hematopoietic Stem And Progenitor Cells Use Podosomes To Transcellularly Home To The Bone Marrow

ICAM-1 clustering on endothelial cells recruits VCAM-1

ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration

In vivo imaging of enhanced leukocyte accumulation in atherosclerotic lesions in humans

Inflammation-Sensitive Myosin-X Functionally Supports Leukocyte Extravasation by Cdc42-Mediated ICAM-1-Rich Endothelial Filopodia Formation

Inhibition of GTPase Rac1 in endothelium by 6-mercaptopurine results in immunosuppression in nonimmune cells: new target for an old drug

Inside-out regulation of ICAM-1 dynamics in TNF-alpha-activated endothelium

Interferon-Gamma Impairs Maintenance and Alters Hematopoietic Support of Bone Marrow Mesenchymal Stromal Cells.

Leukocyte Breaching of Endothelial Barriers: The Actin Link.

Leukocyte transendothelial migration: A local affair.

Leukocytes Crossing the Endothelium: A Matter of Communication.

Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function

Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients ⬇️

Nuclear shape, protrusive behaviour and in vivo retention of human bone marrow mesenchymal stromal cells is controlled by Lamin-A/C expression

Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans ⬇️

P-glycoprotein regulates trafficking of CD8(+) T cells to the brain parenchyma

Plasminogen Activator Inhibitor-1 Controls Vascular Integrity by Regulating VE-Cadherin Trafficking

Real-time imaging of endothelial cell-cell junctions during neutrophil transmigration under physiological flow.

Recruitment of Immune Cells into Inflamed Tissues: Consequences for Endothelial Barrier Integrity and Tissue Functionality

Rho GAPs and GEFs: controling switches in endothelial cell adhesion

Rho-GTPase signaling in leukocyte extravasation: an endothelial point of view.

RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration.

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis ⬇️

Small Rho GTPase-mediated actin dynamics at endothelial adherens junctions.

Sphingosine-1-phosphate receptor 3 mediates sphingosine-1-phosphate induced release of weibel-palade bodies from endothelial cells.

The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models

The Ins and Outs of Small GTPase Rac1 in the Vasculature.

The N-terminal DH-PH domain of Trio induces cell spreading and migration by regulating lamellipodia dynamics in a Rac1-dependent fashion

The Rho-GEF Trio regulates a novel pro-inflammatory pathway through the transcription factor Ets2.

The Rho-guanine nucleotide exchange factor Trio controls leukocyte transendothelial migration by promoting docking structure formation.

The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis

The many faces of the guanine-nucleotide exchange factor trio.

The presence of alpha-catenin in the VE-cadherin complex is required for efficient transendothelial migration of leukocytes

The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation

Trading spaces: Rap, Rac, and Rho as architects of transendothelial migration.

Transglutaminase activity regulates atherosclerotic plaque composition at locations exposed to oscillatory shear stress

Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis

Two CGD Families with a Hypomorphic Mutation in the Activation Domain of p67(phox)

Unexpected arterial wall and cellular inflammation in patients with rheumatoid arthritis in remission using biological therapy: a cross-sectional study.