List of works - Ralf Schmid

Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life

scientific article published on 05 October 2020

Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma.

scientific article published on 30 March 2017

Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide.

scientific article published on 28 January 2016

Generation and characterization of brain lipid-binding protein promoter-based transgenic mouse models for the study of radial glia.

scientific article published on March 2006

Genomic profiles of low-grade murine gliomas evolve during progression to glioblastoma.

scientific article published on 7 April 2017

Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease.

scientific article published on 6 May 2010

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins

scientific article

Modeling astrocytoma pathogenesis in vitro and in vivo using cortical astrocytes or neural stem cells from conditional, genetically engineered mice

scientific article published on 12 August 2014

Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex

scientific journal article

PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition

scientific article published in PLoS ONE

Radiation Sensitivity in a Preclinical Mouse Model of Medulloblastoma Relies on the Function of the Intrinsic Apoptotic Pathway

scientific article published on 13 April 2016

Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model.

scientific article published on 13 June 2016

Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B