List of works by Enrico Petretto

A Bayesian Approach for Analysis of Whole-Genome Bisulfite Sequencing Data Identifies Disease-Associated Changes in DNA Methylation

scientific article

A gene harvest revealing the archeology and complexity of human disease

scientific article

A new essential hypertension susceptibility locus on chromosome 2p24-p25, detected by genomewide search

scientific article published on 12 September 2002

A predictive computational framework for direct reprogramming between human cell types

scientific article

A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation

scientific article published on 01 December 2019

A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target

scientific article published in Nature Communications

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

scientific article published on 8 September 2010

A trans-eQTL network regulates osteoclast multinucleation and bone mass

scientific article published on 19 June 2020

Adrenal gland tumorigenesis after gonadectomy in mice is a complex genetic trait driven by epistatic loci

scientific article published on 15 November 2007

An embryonic system to assess direct and indirect Wnt transcriptional targets

scientific article published on 11 September 2017

Author Correction: WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling

scientific article published on 09 September 2019

Bayesian detection of expression quantitative trait loci hot spots

scientific article published on 16 September 2011

Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture

scientific article published in Nature Communications

Broad regulation of gene isoform expression by Wnt signaling in cancer

scientific article published on 10 September 2019

Brugada syndrome genetics is associated with phenotype severity

scientific article published on 21 November 2020

Cell Type of Origin Dictates the Route to Pluripotency.

scientific article published in December 2017

Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk

scientific article published on 17 January 2018

Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1β synthesis in macrophages

scientific article

Common signalling pathways in macrophage and osteoclast multinucleation

scientific article published on 05 June 2018

Computational methods for direct cell conversion

scientific article

Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation

article

Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans

scientific article

Culturing functional pancreatic islets on α5-laminins and curative transplantation to diabetic mice.

scientific article published on 27 March 2018

Determining signalling nodes for apoptosis by a genetic high-throughput screen

scientific article

ESS++: a C++ objected-oriented algorithm for Bayesian stochastic search model exploration

scientific article published on 13 January 2011

Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function

scientific article

EpiMogrify Models H3K4me3 Data to Identify Signaling Molecules that Improve Cell Fate Control and Maintenance

scientific article published on 06 October 2020

Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis.

scientific article

Ethnicity-Specific Skeletal Muscle Transcriptional Signatures and Their Relevance to Insulin Resistance in Singapore

scientific article published on 01 February 2019

EvoTol: a protein-sequence based evolutionary intolerance framework for disease-gene prioritization

scientific article published on 29 December 2014

Expression QTLs Mapping and Analysis: A Bayesian Perspective

scientific article published on January 2017

Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia

scientific article published on 11 February 2013

FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity

scientific article published on 21 May 2007

FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans.

scientific article published on 4 February 2011

From integrative genomics to systems genetics in the rat to link genotypes to phenotypes

scientific article

GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm

scientific article

Genetic analysis of the cardiac methylome at single nucleotide resolution in a model of human cardiovascular disease

scientific article

Genetic influences on brain gene expression in rats selected for tameness and aggression

scientific article

Genetic mapping and positional cloning

scientific article published on January 2010

Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat

scientific article published on 26 January 2017

Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat

scientific article published on 25 July 2013

Genome-wide analysis of differential RNA editing in epilepsy.

scientific article

Genome-wide co-expression analysis in multiple tissues

scientific article

Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation

scientific article

Genome-wide meta-analysis associates GPSM1 with type 2 diabetes, a plausible gene involved in skeletal muscle function

scientific article published on 21 January 2020

Heritability and demographic analyses in the large isolated population of Val Borbera suggest advantages in mapping complex traits genes

scientific article

Heritability and tissue specificity of expression quantitative trait loci

scientific article

IL-11 is a crucial determinant of cardiovascular fibrosis.

scientific article

Identification of Ceruloplasmin as a Gene that Affects Susceptibility to Glomerulonephritis Through Macrophage Function.

scientific article

Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet.

scientific article

Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension

scientific article

Impulsivity is a heritable trait in rodents and associated with a novel quantitative trait locus on chromosome 1

scientific article published on 21 April 2020

Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs

scientific article

Influence of shear stress magnitude and direction on atherosclerotic plaque composition

scientific article

Insight into the genetics of hypertension, a core component of the metabolic syndrome

scientific article published on July 2008

Integrated gene expression profiling and linkage analysis in the rat.

scientific article published on 12 June 2006

Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass

scientific article

Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat.

scientific article published on 16 August 2011

Integrated systems-genetic analyses reveal a network target for delaying glioma progression

scientific article published on 17 August 2019

Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease.

scientific article published on 13 February 2005

Integrating phosphoproteome and transcriptome reveals new determinants of macrophage multinucleation

scientific article published on 22 December 2014

Integrative genomics in cardiovascular medicine

scientific article published on 27 September 2012

Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants

scientific article

Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease

scientific article published on 23 April 2019

In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors

scientific article published on 01 March 2019

In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors

scientific article published on 01 May 2020

JunD/AP1 regulatory network analysis during macrophage activation in a rat model of crescentic glomerulonephritis

scientific article

Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory disease

scientific article published on 14 August 2014

Leveraging gene co-expression networks to pinpoint the regulation of complex traits and disease, with a focus on cardiovascular traits

scientific article published on 19 August 2013

MT-HESS: an efficient Bayesian approach for simultaneous association detection in OMICS datasets, with application to eQTL mapping in multiple tissues

scientific article

MWASTools: an R/Bioconductor package for metabolome-wide association studies.

scientific article published on 26 July 2017

Macrophage epoxygenase determines a profibrotic transcriptome signature

scientific article

Mapping genetic determinants of coronary microvascular remodeling in the spontaneously hypertensive rat.

scientific article published on 30 November 2012

Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy.

scientific article published in November 2017

MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy--comparison with human epileptic samples.

scientific article

Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly

scientific article published on 11 March 2020

Multi-tissue analysis of co-expression networks by higher-order generalized singular value decomposition identifies functionally coherent transcriptional modules

scientific article published on 2 January 2014

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.

scientific article published on 14 September 2017

New insights into the genetic control of gene expression using a Bayesian multi-tissue approach

scientific article

No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases

article

Not all isolates are equal: linkage disequilibrium analysis on Xq13.3 reveals different patterns in Sardinian sub-populations

article

Optimisation of laboratory methods for whole transcriptomic RNA analyses in human left ventricular biopsies and blood samples of clinical relevance

scientific article published on 14 March 2019

Rare and common epilepsies converge on a shared gene regulatory network providing opportunities for novel antiepileptic drug discovery.

scientific article

Repeatability of published microarray gene expression analyses

scientific article

Response to: 'M-CSF and GM-CSF monocyte-derived macrophages in systemic sclerosis: the two sides of the same coin?' by Lescoat et al

scientific article published on 09 March 2018

Signalling pathways drive heterogeneity of ground state pluripotency

Single cell expression quantitative trait loci and complex traits

scientific article

Sleeve gastrectomy rapidly enhances islet function independently of body weight

scientific article published on 21 March 2019

Striking differentiation of sub-populations within a genetically homogeneous isolate (Ogliastra) in Sardinia as revealed by mtDNA analysis

scientific article

Systems Genetics Approaches in Rat Identify Novel Genes and Gene Networks Associated With Cardiac Conduction

scientific article published on 01 November 2018

Systems Genetics as a Tool to Identify Master Genetic Regulators in Complex Disease

scientific article published on January 2017

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes

scientific article published on 28 November 2017

Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus

scientific article

Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease

scientific article published on 21 December 2015

Systems genetics identifies a macrophage cholesterol network associated with physiological wound healing

article

Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans

scientific article published on 31 October 2012

Temporal dynamics of Wnt-dependent transcriptome reveals an oncogenic Wnt/MYC/ribosome axis

scientific article published on 12 November 2018

The State of Systems Genetics in 2017.

scientific article

The effect of reactor geometry on frontal polymerization spin modes

scientific article published on 01 March 2002

The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance

scientific article

Transcriptional Networks of Microglia in Alzheimer's Disease and Insights into Pathogenesis

scientific article published on 12 October 2019

Transcriptional network analysis for the regulation of left ventricular hypertrophy and microvascular remodeling

scientific article published on 09 August 2013

Transcriptional signature in microglia associated with Aβ plaque phagocytosis

scientific article published on 21 May 2021

Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function.

scientific article

Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects

scientific article published on 01 February 2019

Unique regulatory properties of mesangial cells are genetically determined in the rat.

scientific article published on 24 October 2014

WGBSSuite: simulating whole-genome bisulphite sequencing data and benchmarking differential DNA methylation analysis tools

scientific article

WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling

scientific article published on 09 August 2019

Wars2 is a determinant of angiogenesis.

scientific article

Web-based Gene Pathogenicity Analysis (WGPA): a web platform to interpret gene pathogenicity from personal genome data

scientific article

Whole-Genome Sequencing of Finnish Type 1 Diabetic Siblings Discordant for Kidney Disease Reveals DNA Variants associated with Diabetic Nephropathy

scientific article published on 09 January 2020

Widespread repression of gene expression in cancer by a Wnt/β-catenin/MAPK pathway

scientific article published on 17 November 2020

Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation

scientific article published on 22 October 2020

ZBTB17 ( MIZ1 ) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure

article

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