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List of works by John Simms

A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures

scientific article

A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors.

scientific article published in January 2005

Agonist-specific requirement for a glutamate in transmembrane helix 1 of the oxytocin receptor ⬇️

scientific article published on December 3, 2010

Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.

scientific article

An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology

scientific article published on 17 May 2016

An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist

scientific article (publication date: December 2003)

Characterization of the structure of RAMP1 by mutagenesis and molecular modeling

scientific article published on 21 April 2006

Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allostery.

scientific article published on 28 January 2015

Diverse Functional Motifs within the Three Intracellular Loops of the CGRP1Receptor†

scientific article published in October 2006

Evidence that interaction between conserved residues in transmembrane helices 2, 3, and 7 are crucial for human VPAC1 receptor activation

scientific article published on 23 June 2010

Functional characterisation of G protein-coupled receptors

scientific article published in September 2018

Heterodimers and family-B GPCRs: RAMPs, CGRP and adrenomedullin

scientific article published in November 2004

Homology modeling of GPCRs.

scientific article published in January 2009

Improving virtual screening of G protein-coupled receptors via ligand-directed modeling.

scientific article published on 13 November 2017

Lifting the lid on GPCRs: the role of extracellular loops

scientific article published on March 2012

Ligand Binding and Activation of the CGRP Receptor

scientific article published on 4 September 2009

Ligand binding and activation of the CGRP receptor.

scientific article

Membrane proteins by accident or design.

scientific article published on December 2013

Modulating receptor function through RAMPs: can they represent drug targets in themselves?

scientific article published on 16 January 2009

Photoaffinity Cross-Linking and Unnatural Amino Acid Mutagenesis Reveal Insights into Calcitonin Gene-Related Peptide Binding to the Calcitonin Receptor-like Receptor/Receptor Activity-Modifying Protein 1 (CLR/RAMP1) Complex

scientific article published on 13 July 2018

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations ⬇️

scientific article published on March 11, 2013

Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation.

scientific article

RAMPs and CGRP receptors

scientific article published on January 2012

RAMPs as Drug Targets ⬇️

scientific article published on January 1, 2012

Receptor activity modifying proteins and their potential as drug targets

scientific article published on January 2010

Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs.

scientific article published on 10 July 2017

Relative Antagonism of Mutants of the CGRP Receptor Extracellular Loop 2 Domain (ECL2) Using a Truncated Competitive Antagonist (CGRP8-37): Evidence for the Dual Involvement of ECL2 in the Two-Domain Binding Model

scientific article published on 10 July 2017

Relative domain folding and stability of a membrane transport protein.

scientific article

Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function.

scientific article published on 6 December 2011

Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation

scientific article published on 6 December 2011

Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor

scientific article published on 14 May 2015

Structure-function analysis of RAMP1 by alanine mutagenesis

scientific article published in January 2009

Structure-function analysis of RAMP1-RAMP3 chimeras.

scientific article published in January 2010

Structure–Function Studies of Muscarinic Acetylcholine Receptors ⬇️

scientific article published on January 1, 2012

Systematic analysis of the entire second extracellular loop of the V(1a) vasopressin receptor: key residues, conserved throughout a G-protein-coupled receptor family, identified.

scientific article published on 2 April 2007

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

scientific article

The second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expression

scientific article published on 17 November 2005

Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach

scientific article published on 29 May 2017

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