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List of works by Lorella Pasquinucci

(+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects

scientific article

(2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist

scientific article published on 18 February 2019

An LP1 analogue, selective MOR agonist with a peculiar pharmacological profile, used to scrutiny the ligand binding domain.

scientific article published on 30 August 2016

Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand

scientific article

Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells.

scientific article published on 15 October 2010

Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review

scientific article published on 17 February 2018

Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review

scientific article published on 07 June 2018

Bivalent opioid peptides synthesized from μ selective monomers display preferential selectivity for δ receptors

CCB, a novel specific kappa opioid agonist, which discriminates between opioid and sigma 1 recognition sites.

scientific article published in January 1995

Design and synthesis of new bifunctional sigma-1 selective ligands with antioxidant activity.

scientific article published on 19 March 2013

Development of novel LP1-based analogues with enhanced delta opioid receptor profile.

scientific article published on 11 July 2017

Differential scanning calorimetry approach to investigate the transfer of the multitarget opioid analgesic LP1 to biomembrane model.

scientific article

Evaluation of N-substituent structural variations in opioid receptor profile of LP1.

scientific article

Evaluation of N-substitution in 6,7-benzomorphan compounds.

scientific article published on 9 June 2010

Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist

scientific article published on 23 March 2020

Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy.

scientific article

In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations.

scientific article published on 27 February 2018

Multitarget Opioid/Non-opioid Ligands: A Potential Approach in Pain Management

scientific article

Multitarget opioid ligands in pain relief: New players in an old game

scientific article

New bifunctional antioxidant/σ1 agonist ligands: Preliminary chemico-physical and biological evaluation

scientific article

Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties

scientific article published on 21 April 2011

Progress in the development of more effective and safer analgesics for pain management

scientific article published on 16 September 2019

Resveratrol-Loaded Lipid Nanocarriers: Correlation between In Vitro Occlusion Factor and In Vivo Skin Hydrating Effect.

scientific article published on 10 December 2017

Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles

scientific article published on 21 October 2017

Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation

scientific article published on 25 January 2019

Specific kappa opioid receptor agonists.

scientific article

Substituted 1-phenyl-2-cyclopropylmethylamines with high affinity and selectivity for sigma sites

scientific article published on 01 June 2000

Synthesis and Structure-Activity Relationships of (-)-cis-N-Normetazocine-Based LP1 Derivatives.

scientific article published on 5 May 2018

Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists.

scientific article published on 16 March 2018

The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation.

scientific article

The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment

scientific article published on 9 November 2011

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