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List of works by Gilles Lambert

A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes

scientific article

A hemorrhagic transformation model of mechanical stroke therapy with acute hyperglycemia in mice

scientific article published on 26 December 2017

ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice

scientific article

Acute hypertriglyceridaemia in humans increases the triglyceride content and decreases the anti-inflammatory capacity of high density lipoproteins.

scientific article published on 21 November 2008

Adiposity blunts the positive relationship of thyrotropin with proprotein convertase subtilisin-kexin type 9 levels in euthyroid subjects.

scientific article published on February 2013

Analysis of glomerulosclerosis and atherosclerosis in lecithin cholesterol acyltransferase-deficient mice.

scientific article published on 7 February 2001

Apolipoprotein A-IV is regulated by nutritional and metabolic stress: involvement of glucocorticoids, HNF-4 alpha, and PGC-1 alpha.

scientific article published on 23 August 2006

Beyond LDL cholesterol, a new role for PCSK9.

scientific article published in July 2010

Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody.

scientific article published on 15 September 2015

Characterization of the First PCSK9 Gain of Function Homozygote

scientific article published in November 2015

Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux.

scientific article

Displacement of apo A-I from HDL by apo A-II or its C-terminal helix promotes the formation of pre-beta1 migrating particles and decreases LCAT activation.

scientific article published in August 1998

Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis.

scientific article

Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice.

scientific article

Effect of atorvastatin, cholesterol ester transfer protein inhibition, and diabetes mellitus on circulating proprotein subtilisin kexin type 9 and lipoprotein(a) levels in patients at high cardiovascular risk.

scientific article published on 12 October 2017

Effects of Extended-Release Nicotinic Acid on Apolipoprotein (a) Kinetics in Hypertriglyceridemic Patients

scientific article published on 09 July 2015

Elevated plasma PCSK9 level is equally detrimental for patients with nonfamilial hypercholesterolemia and heterozygous familial hypercholesterolemia, irrespective of low-density lipoprotein receptor defects

scientific article published on 12 March 2014

Emerging Cardiovascular Disease Biomarkers and Incident Diabetes Mellitus Risk in Statin-Treated Patients With Coronary Artery Disease (from the Treating to New Targets [TNT] Study).

scientific article published on 29 May 2016

Evaluation of androgenic activity of nutraceutical-derived steroids using mammalian and yeast in vitro androgen bioassays

scientific article published on 18 February 2011

Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor.

scientific article published on 22 June 2006

Fenofibrate concomitantly decreases serum proprotein convertase subtilisin/kexin type 9 and very-low-density lipoprotein particle concentrations in statin-treated type 2 diabetic patients

scientific article published on September 2010

Fenofibrate decreases plasma ceramide in type 2 diabetes patients: A novel marker of CVD?

scientific article published on 9 May 2017

HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells

scientific article

Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c

scientific article

Hepatic lipase deficiency decreases the selective uptake of HDL-cholesteryl esters in vivo

scientific article published on 01 May 2000

Hepatic lipase promotes the selective uptake of high density lipoprotein-cholesteryl esters via the scavenger receptor B1.

scientific article published on July 1999

Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease

scientific article published on July 2008

Homozygous Familial Hypercholesterolemia Patients With Identical Mutations Variably Express the LDLR (Low-Density Lipoprotein Receptor): Implications for the Efficacy of Evolocumab

scientific article published on 28 December 2017

Identification and characterization of two non-secreted PCSK9 mutants associated with familial hypercholesterolemia in cohorts from New Zealand and South Africa

scientific article

Intestinal cholesterol absorption and NPC1-L1

scientific article

Key aspects of PCSK9 inhibition beyond LDL lowering

scientific article published on 01 December 2018

Kinetics of plasma apolipoprotein E isoforms by LC-MS/MS: a pilot study

scientific article published on 14 March 2018

Kinetics of prebeta1 HDL and alphaHDL in type II diabetic patients

scientific article published on 01 January 2006

Lipid-Free Apolipoprotein A-I and Discoidal Reconstituted High-Density Lipoproteins Differentially Inhibit Glucose-Induced Oxidative Stress in Human Macrophages

article published in 2011

Lipid-binding properties of synthetic peptide fragments of human apolipoprotein A-II

scientific article published on 01 December 1996

Low levels of low-density lipoprotein-C associated with proprotein convertase subtilisin kexin 9 inhibition do not increase the risk of hemorrhagic transformation

scientific article published on 14 August 2014

Nonenzymatic glycation impairs the antiinflammatory properties of apolipoprotein A-I.

scientific article

Normalization of low-density lipoprotein receptor expression in receptor defective homozygous familial hypercholesterolemia by inhibition of PCSK9 with alirocumab

scientific article published on 24 November 2014

One-year Clinical Outcome after Primary Stenting for Trans-Atlantic Inter-Society Consensus (TASC) C and D Femoropopliteal Lesions (The STELLA “STEnting Long de L'Artère fémorale superficielle” Cohort) ⬇️

scientific article published on August 21, 2012

Overexpression of human apolipoprotein A-II in mice induces hypertriglyceridemia due to defective very low density lipoprotein hydrolysis

scientific article published on 01 April 1999

PCSK9 Association With Lipoprotein(a)

scientific article published on 27 April 2016

PCSK9 Modulates the Secretion But Not the Cellular Uptake of Lipoprotein(a) Ex Vivo: An Effect Blunted by Alirocumab.

scientific article published in October 2016

PCSK9 and lipoprotein (a) levels are two predictors of coronary artery calcification in asymptomatic patients with familial hypercholesterolemia.

scientific article published on 27 August 2016

PCSK9 inhibition in LDL cholesterol reduction: genetics and therapeutic implications of very low plasma lipoprotein levels.

scientific article

PCSK9 inhibition with alirocumab reduces lipoprotein(a) levels in nonhuman primates by lowering apolipoprotein(a) production rate

scientific article published on 31 May 2018

PCSK9 inhibitors.

scientific article published on 09 April 2015

PCSK9: a new gene involved in familial hypercholesteremia

scientific article published in December 2004

PCSK9: a promising therapeutic target for dyslipidemias?

scientific article published on 17 February 2006

Peroxisome proliferator-activated receptor beta/delta regulates very low density lipoprotein production and catabolism in mice on a Western diet.

scientific article published on 4 March 2004

Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment.

scientific article

Plasma PCSK9 levels and clinical outcomes in the TNT (Treating to New Targets) trial: a nested case-control study

article

Plasma PCSK9 measurement by liquid chromatography-Tandem mass spectrometry and comparison with conventional ELISA.

scientific article

Plasma levels of PCSK9 and phenotypic variability in familial hypercholesterolemia

scientific article published on 27 February 2012

Plasma lipoprotein-associated phospholipase A2 is inversely correlated with proprotein convertase subtilisin-kexin type 9

scientific article published on 31 January 2012

Plasma proprotein convertase subtilisin-kexin type 9 does not change during 24h insulin infusion in healthy subjects and type 2 diabetic patients

scientific article published on 02 November 2010

Plasma proprotein convertase subtilisin-kexin type 9 is predominantly related to intermediate density lipoproteins

scientific article published on 26 March 2014

Proprotein Convertase Subtilisin Kexin Type 9 Inhibition for Autosomal Recessive Hypercholesterolemia-Brief Report.

scientific article

Proprotein convertase subtilisin/kexin type 9 inhibition.

scientific article published on December 2012

Proprotein convertase subtilisin–kexin type 9 is elevated in proteinuric subjects: Relationship with lipoprotein response to antiproteinuric treatment ⬇️

scientific article published on November 29, 2012

Ras/mitogen-activated protein kinase (MAPK) signaling modulates protein stability and cell surface expression of scavenger receptor SR-BI.

scientific article

Relationship of plasma apolipoprotein M with proprotein convertase subtilisin-kexin type 9 levels in non-diabetic subjects

scientific article published on 03 November 2010

Relationship of proprotein convertase subtilisin-kexin type 9 levels with resistin in lean and obese subjects ⬇️

scientific article published on July 15, 2012

Severe decrease in high-density lipoprotein cholesterol with the combination of fibrates and ezetimibe: A case series

scientific article published on 2 November 2016

The 5A apolipoprotein A-I mimetic peptide displays antiinflammatory and antioxidant properties in vivo and in vitro.

scientific article

The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice

scientific article

The C-terminal helix of human apolipoprotein AII promotes the fusion of unilamellar liposomes and displaces apolipoprotein AI from high-density lipoproteins

scientific article published on 01 April 1998

The PCSK9 decade ⬇️

scientific article published on July 17, 2012

The complexity of lipoprotein (a) lowering by PCSK9 monoclonal antibodies.

scientific article published on February 2017

The farnesoid X-receptor is an essential regulator of cholesterol homeostasis

scientific journal article

The impact of LDLR function on fibroblast growth factor 21 levels.

scientific article published on 3 June 2015

Unravelling the functional significance of PCSK9.

scientific article

Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells

scientific journal article

[Arterial heterogeneity]

scientific article published on 16 November 2012

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