List of works - Matthew D Disney

A Designed Small Molecule Inhibitor of a Non-Coding RNA Sensitizes HER2 Negative Cancers to Herceptin

scientific article published on 06 February 2019

A Toxic RNA Templates the Synthesis of Its Own Fluorogenic Inhibitor by Using a Bio-orthogonal Tetrazine Ligation in Cells and Tissues

scientific article published on 17 June 2020

A cross-linking approach to map small molecule-RNA binding sites in cells

scientific article published on 02 April 2019

A general fragment-based approach to identify and optimize bioactive ligands targeting RNA

scientific article published on 14 December 2020

Bleomycin Can Cleave an Oncogenic Noncoding RNA.

scientific article

Computational Investigation of RNA A-Bulges Related to the Microtubule-Associated Protein Tau Causing Frontotemporal Dementia and Parkinsonism

scientific article published on 02 January 2019

Defining RNA-Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA

scientific article

Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10

scientific article

Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold-small molecule interactions

scientific article published on 24 August 2020

Design of small molecules targeting RNA structure from sequence

scientific article published on 16 September 2020

Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing

scientific article published on 04 May 2020

How We Think about Targeting RNA with Small Molecules

scientific article published on 26 March 2020

Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules.

scientific article

Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects

scientific article

Optimization of the Linker Domain in a Dimeric Compound that Degrades an r(CUG) Repeat Expansion in Cells

scientific article published on 13 July 2020

Precise Small Molecule Degradation of a Noncoding RNA Identifies Cellular Binding Sites and Modulates an Oncogenic Phenotype

scientific article published on 30 October 2018

Precise Targeted Cleavage of a r(CUG) Repeat Expansion in Cells by Using a Small-Molecule-Deglycobleomycin Conjugate

scientific article published on 18 March 2020

Precise small-molecule recognition of a toxic CUG RNA repeat expansion.

scientific article

Progress toward the development of the small molecule equivalent of small interfering RNA

scientific article published on 06 February 2020

Selective Small Molecule Recognition of RNA Base Pairs

scientific article published on 31 July 2018

Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit.

scientific article published on 27 February 2017

Small Molecule Targeted Recruitment of a Nuclease to RNA

scientific article published on 24 May 2018

Small molecule recognition of disease-relevant RNA structures

scientific article published on 25 September 2020

Small molecule targeting of RNA structures in neurological disorders

scientific article published on 09 April 2019

Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer

scientific article published on 21 January 2020

Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD

scientific article published on 16 November 2020

Structure and Dynamics of RNA Repeat Expansions That Cause Huntington's Disease and Myotonic Dystrophy Type 1.

scientific article published on 15 June 2017

Structure-Specific Cleavage of an RNA Repeat Expansion with a Dimeric Small Molecule Is Advantageous over Sequence-Specific Recognition by an Oligonucleotide

scientific article published on 13 January 2020

Target-Directed Approaches for Screening Small Molecules against RNA Targets

scientific article published on 18 May 2020

Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands

scientific article published on 01 April 2020

Targeting RNA with Small Molecules To Capture Opportunities at the Intersection of Chemistry, Biology, and Medicine

scientific article published on 19 April 2019

The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology

scientific article published on 10 July 2019

Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA

scientific article published on 03 January 2020

Using Genome Sequence to Enable the Design of Medicines and Chemical Probes.

scientific article published on 11 January 2018

List of works by Matthew D Disney

A Designed Small Molecule Inhibitor of a Non-Coding RNA Sensitizes HER2 Negative Cancers to Herceptin

A Toxic RNA Templates the Synthesis of Its Own Fluorogenic Inhibitor by Using a Bio-orthogonal Tetrazine Ligation in Cells and Tissues

A cross-linking approach to map small molecule-RNA binding sites in cells

A general fragment-based approach to identify and optimize bioactive ligands targeting RNA

Bleomycin Can Cleave an Oncogenic Noncoding RNA.

Computational Investigation of RNA A-Bulges Related to the Microtubule-Associated Protein Tau Causing Frontotemporal Dementia and Parkinsonism

Defining RNA-Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA

Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10

Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold-small molecule interactions

Design of small molecules targeting RNA structure from sequence

Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing

How We Think about Targeting RNA with Small Molecules

Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules.

Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects

Optimization of the Linker Domain in a Dimeric Compound that Degrades an r(CUG) Repeat Expansion in Cells

Precise Small Molecule Degradation of a Noncoding RNA Identifies Cellular Binding Sites and Modulates an Oncogenic Phenotype

Precise Targeted Cleavage of a r(CUG) Repeat Expansion in Cells by Using a Small-Molecule-Deglycobleomycin Conjugate

Precise small-molecule recognition of a toxic CUG RNA repeat expansion.

Progress toward the development of the small molecule equivalent of small interfering RNA

Selective Small Molecule Recognition of RNA Base Pairs

Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit.

Small Molecule Targeted Recruitment of a Nuclease to RNA

Small molecule recognition of disease-relevant RNA structures

Small molecule targeting of RNA structures in neurological disorders

Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer

Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD

Structure and Dynamics of RNA Repeat Expansions That Cause Huntington's Disease and Myotonic Dystrophy Type 1.

Structure-Specific Cleavage of an RNA Repeat Expansion with a Dimeric Small Molecule Is Advantageous over Sequence-Specific Recognition by an Oligonucleotide

Target-Directed Approaches for Screening Small Molecules against RNA Targets

Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands

Targeting RNA with Small Molecules To Capture Opportunities at the Intersection of Chemistry, Biology, and Medicine

The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology

Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA

Using Genome Sequence to Enable the Design of Medicines and Chemical Probes.