List of works - Michael J Harms

Arginine residues at internal positions in a protein are always charged ⬇️

scientific article published on November 11, 2011

Coevolution of the Toll-Like Receptor 4 Complex with Calgranulins and Lipopolysaccharide

scientific article published on 21 February 2018

Conservation of specificity in two low-specificity proteins.

scientific article published on 14 December 2017

Detecting High-Order Epistasis in Nonlinear Genotype-Phenotype Maps

scientific article (publication date: March 2017)

Enzymes emerge by upcycling

scientific article published on 01 June 2018

Evolution of minimal specificity and promiscuity in steroid hormone receptors

scientific article

Evolution of multifunctionality through a pleiotropic substitution in the innate immune protein S100A9

scientific article published on 07 April 2020

Evolutionary biochemistry: revealing the historical and physical causes of protein properties.

scientific article

Evolutionary trend toward kinetic stability in the folding trajectory of RNases H.

scientific article

Exploring the Evolutionary History of Kinetic Stability in the α-Lytic Protease Family

scientific article published on 12 January 2021

High-order epistasis shapes evolutionary trajectories

scientific article

Historical contingency and its biophysical basis in glucocorticoid receptor evolution.

scientific article

How sequence defines structure: a crystallographic map of DNA structure and conformation.

scientific article

Human S100A5 binds Ca2+ and Cu2+ independently

scientific article published on 22 November 2017

Identification and Characterization of Zebrafish Tlr4 Coreceptor Md-2

scientific article published on 20 January 2021

Inferring a complete genotype-phenotype map from a small number of measured phenotypes

scientific article published on 29 September 2020

Learning Peptide Recognition Rules for a Low-Specificity Protein

scientific article published on 26 September 2020

Molecular ensembles make evolution unpredictable.

scientific article published on 23 October 2017

Multiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family

scientific article

Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor

scientific article

Resurrection of an Urbilaterian U1A/U2B″/SNF protein

scientific article published on 22 June 2013

Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty.

scientific article published on 30 October 2016

The thermostability and specificity of ancient proteins

scientific article

Thermodynamic system drift in protein evolution

scientific article

Tracing the evolution of novel features of human Toll-like receptor 4

scientific article published on 03 June 2019

Were Ancestral Proteins Less Specific?

scientific article published on 01 May 2021

pytc: Open-Source Python Software for Global Analyses of Isothermal Titration Calorimetry Data.

scientific article published on 5 April 2018

List of works by Michael J Harms

Arginine residues at internal positions in a protein are always charged ⬇️

Coevolution of the Toll-Like Receptor 4 Complex with Calgranulins and Lipopolysaccharide

Conservation of specificity in two low-specificity proteins.

Detecting High-Order Epistasis in Nonlinear Genotype-Phenotype Maps

Enzymes emerge by upcycling

Evolution of minimal specificity and promiscuity in steroid hormone receptors

Evolution of multifunctionality through a pleiotropic substitution in the innate immune protein S100A9

Evolutionary biochemistry: revealing the historical and physical causes of protein properties.

Evolutionary trend toward kinetic stability in the folding trajectory of RNases H.

Exploring the Evolutionary History of Kinetic Stability in the α-Lytic Protease Family

High-order epistasis shapes evolutionary trajectories

Historical contingency and its biophysical basis in glucocorticoid receptor evolution.

How sequence defines structure: a crystallographic map of DNA structure and conformation.

Human S100A5 binds Ca2+ and Cu2+ independently

Identification and Characterization of Zebrafish Tlr4 Coreceptor Md-2

Inferring a complete genotype-phenotype map from a small number of measured phenotypes

Learning Peptide Recognition Rules for a Low-Specificity Protein

Molecular ensembles make evolution unpredictable.

Multiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family

Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor

Resurrection of an Urbilaterian U1A/U2B″/SNF protein

Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty.

The thermostability and specificity of ancient proteins

Thermodynamic system drift in protein evolution

Tracing the evolution of novel features of human Toll-like receptor 4

Were Ancestral Proteins Less Specific?

pytc: Open-Source Python Software for Global Analyses of Isothermal Titration Calorimetry Data.

pytc: a python package for analysis of Isothermal Titration Calorimetry experiments