List of works - Connie Jackaman

Actin nemaline myopathy mouse reproduces disease, suggests other actin disease phenotypes and provides cautionary note on muscle transgene expression

scientific article

Aged neutrophils accumulate in lymphoid tissues from healthy elderly mice and infiltrate T and B cell zones.

scientific article published on 30 March 2018

Aging and cancer: The role of macrophages and neutrophils.

scientific article published on 5 April 2017

Are macrophages, myeloid derived suppressor cells and neutrophils mediators of local suppression in healthy and cancerous tissues in aging hosts?

scientific article

Blood-brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment.

scientific article

CD40-activated B cells contribute to mesothelioma tumor regression.

scientific article published on 13 July 2010

CD8 cytotoxic T cell responses to dominant tumor-associated antigens are profoundly weakened by aging yet subdominant responses retain functionality and expand in response to chemotherapy

article

Chemotherapy broadens the range of tumor antigens seen by cytotoxic CD8(+) T cells in vivo.

scientific article

Deliberately provoking local inflammation drives tumors to become their own protective vaccine site.

scientific article published on 29 September 2008

Dissociated flexor digitorum brevis myofiber culture system--a more mature muscle culture system.

scientific article

Elderly dendritic cells respond to LPS/IFN-γ and CD40L stimulation despite incomplete maturation.

scientific article published on 13 April 2018

Ex vivo expression of chemokine receptors on cells surrounding cutaneous nerves in patients with HIV-associated sensory neuropathy

scientific article published on 12 December 2017

Functional endogenous cytotoxic T lymphocytes are generated to multiple antigens co-expressed by progressing tumors; after intra-tumoral IL-2 therapy these effector cells eradicate established tumors

scientific article published on 11 November 2005

IL-2 intratumoral immunotherapy enhances CD8+ T cells that mediate destruction of tumor cells and tumor-associated vasculature: a novel mechanism for IL-2.

scientific article published on November 2003

IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice.

scientific article published on 19 April 2014

Intratumoral interleukin-2/agonist CD40 antibody drives CD4+ -independent resolution of treated-tumors and CD4+ -dependent systemic and memory responses.

scientific article published on 15 October 2011

Intratumoral poly-N-acetyl glucosamine-based polymer matrix provokes a prolonged local inflammatory response that, when combined with IL-2, induces regression of malignant mesothelioma in a murine model.

scientific article published on July 2005

Lipid-laden partially-activated plasmacytoid and CD4(-)CD8α(+) dendritic cells accumulate in tissues in elderly mice

scientific article

Local effector failure in mesothelioma is not mediated by CD4+ CD25+ T-regulator cells.

scientific article

Macrophage Depletion in Elderly Mice Improves Response to Tumor Immunotherapy, Increases Anti-tumor T Cell Activity and Reduces Treatment-Induced Cachexia

scientific article published on 06 November 2018

Mesothelioma tumor cells modulate dendritic cell lipid content, phenotype and function

scientific article

Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules.

scientific article

Mouse models of dominant ACTA1 disease recapitulate human disease and provide insight into therapies

scientific article published on 08 February 2011

Multiple Osmotic Stress Responses in Acidihalobacter prosperus Result in Tolerance to Chloride Ions.

scientific article

Murine mesothelioma induces locally-proliferating IL-10(+)TNF-α(+)CD206(-)CX3CR1(+) M3 macrophages that can be selectively depleted by chemotherapy or immunotherapy

scientific article published on 22 April 2016

Novel application of flow cytometry: determination of muscle fiber types and protein levels in whole murine skeletal muscles and heart

scientific article published on 01 December 2007

Rapid copper acquisition by developing murine mesothelioma: decreasing bioavailable copper slows tumor growth, normalizes vessels and promotes T cell infiltration

scientific article

Rescue of skeletal muscle alpha-actin-null mice by cardiac (fetal) alpha-actin

scientific article published on 25 May 2009

Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice.

scientific article published on 27 March 2013

The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy

article

List of works by Connie Jackaman

Actin nemaline myopathy mouse reproduces disease, suggests other actin disease phenotypes and provides cautionary note on muscle transgene expression

Aged neutrophils accumulate in lymphoid tissues from healthy elderly mice and infiltrate T and B cell zones.

Aging and cancer: The role of macrophages and neutrophils.

Are macrophages, myeloid derived suppressor cells and neutrophils mediators of local suppression in healthy and cancerous tissues in aging hosts?

Blood-brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment.

CD40-activated B cells contribute to mesothelioma tumor regression.

CD8 cytotoxic T cell responses to dominant tumor-associated antigens are profoundly weakened by aging yet subdominant responses retain functionality and expand in response to chemotherapy

Chemotherapy broadens the range of tumor antigens seen by cytotoxic CD8(+) T cells in vivo.

Deliberately provoking local inflammation drives tumors to become their own protective vaccine site.

Dissociated flexor digitorum brevis myofiber culture system--a more mature muscle culture system.

Elderly dendritic cells respond to LPS/IFN-γ and CD40L stimulation despite incomplete maturation.

Ex vivo expression of chemokine receptors on cells surrounding cutaneous nerves in patients with HIV-associated sensory neuropathy

Functional endogenous cytotoxic T lymphocytes are generated to multiple antigens co-expressed by progressing tumors; after intra-tumoral IL-2 therapy these effector cells eradicate established tumors

IL-2 intratumoral immunotherapy enhances CD8+ T cells that mediate destruction of tumor cells and tumor-associated vasculature: a novel mechanism for IL-2.

IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice.

Intratumoral interleukin-2/agonist CD40 antibody drives CD4+ -independent resolution of treated-tumors and CD4+ -dependent systemic and memory responses.

Intratumoral poly-N-acetyl glucosamine-based polymer matrix provokes a prolonged local inflammatory response that, when combined with IL-2, induces regression of malignant mesothelioma in a murine model.

Lipid-laden partially-activated plasmacytoid and CD4(-)CD8α(+) dendritic cells accumulate in tissues in elderly mice

Local effector failure in mesothelioma is not mediated by CD4+ CD25+ T-regulator cells.

Macrophage Depletion in Elderly Mice Improves Response to Tumor Immunotherapy, Increases Anti-tumor T Cell Activity and Reduces Treatment-Induced Cachexia

Mesothelioma tumor cells modulate dendritic cell lipid content, phenotype and function

Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules.

Mouse models of dominant ACTA1 disease recapitulate human disease and provide insight into therapies

Multiple Osmotic Stress Responses in Acidihalobacter prosperus Result in Tolerance to Chloride Ions.

Murine mesothelioma induces locally-proliferating IL-10(+)TNF-α(+)CD206(-)CX3CR1(+) M3 macrophages that can be selectively depleted by chemotherapy or immunotherapy

Novel application of flow cytometry: determination of muscle fiber types and protein levels in whole murine skeletal muscles and heart

Rapid copper acquisition by developing murine mesothelioma: decreasing bioavailable copper slows tumor growth, normalizes vessels and promotes T cell infiltration

Rescue of skeletal muscle alpha-actin-null mice by cardiac (fetal) alpha-actin

Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice.

The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy