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List of works by Ludwig Dubois

A longitudinal evaluation of partial lung irradiation in mice by using a dedicated image-guided small animal irradiator

scientific article published on 4 September 2014

Combining hypoxia-activated prodrugs and radiotherapy in silico: Impact of treatment scheduling and the intra-tumoural oxygen landscape

scientific article published on 03 August 2020

Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

scientific article published on 12 June 2011

Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series

scientific article published on 01 December 2020

Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure

article

EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition

scientific article

Epigenetics in radiotherapy: where are we heading?

scientific article published on 23 May 2014

HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells

scientific article published on 12 January 2019

How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models

scientific article

Hypoxia PET Imaging with [18F]-HX4-A Promising Next-Generation Tracer

scientific article published on 22 May 2020

Hypoxia-Activated Prodrug Derivatives of Carbonic Anhydrase Inhibitors in Benzenesulfonamide Series: Synthesis and Biological Evaluation

scientific article published on 18 May 2020

Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials

scientific article published on 18 January 2019

Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response

scientific article published on 29 June 2009

Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model

scientific article published on 16 July 2009

Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors

scientific article published on 14 May 2007

Immunotherapy as sensitizer for local radiotherapy

scientific article published on 30 October 2020

Inhibition of 4E-BP1 sensitizes U87 glioblastoma xenograft tumors to irradiation by decreasing hypoxia tolerance

scientific article published in March 2009

Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes

scientific article published on 01 December 2018

PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS.

scientific article published on 7 March 2013

PET imaging of zirconium-89 labelled cetuximab: A phase I trial in patients with head and neck and lung cancer

scientific article published on 21 December 2016

Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506

scientific article published on 8 October 2021

Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.

scientific article published on 14 June 2011

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

scientific article published on April 2009

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

scientific article

The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment

scientific article published on 16 July 2009

The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses.

scientific article published on 16 January 2018

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

scientific article

Use of a Luciferase-Expressing Orthotopic Rat Brain Tumor Model to Optimize a Targeted Irradiation Strategy for Efficacy Testing with Temozolomide

scientific article published on 15 June 2020

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