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List of works by Anthony Tak-Cheung Chan

A broadly adaptive array of dose-constraint templates for planning of intensity-modulated radiation therapy for advanced T-stage nasopharyngeal carcinoma

scientific article published on 24 January 2009

A multicenter phase II trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine®) and gemcitabine in advanced non-small-cell lung cancer with pharmacokinetic evaluation using peripheral blood mononuclear cells

scientific article published on 12 September 2007

A novel 19q13 nucleolar zinc finger protein suppresses tumor cell growth through inhibiting ribosome biogenesis and inducing apoptosis but is frequently silenced in multiple carcinomas

scientific article published on 07 June 2012

A novel compound 6D-offset simulating phantom and quality assurance program for stereotactic image-guided radiation therapy system

scientific article published on 4 November 2014

A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors

scientific article

A phase II study of patients with metastatic or locoregionally recurrent nasopharyngeal carcinoma and evaluation of plasma Epstein-Barr virus DNA as a biomarker of efficacy.

scientific article

A prospective randomized study of chemotherapy adjunctive to definitive radiotherapy in advanced nasopharyngeal carcinoma

scientific article published on 01 October 1995

A randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma.

scientific article

A randomized trial on addition of concurrent-adjuvant chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma

article

A recombinant modified vaccinia ankara vaccine encoding Epstein-Barr Virus (EBV) target antigens: a phase I trial in UK patients with EBV-positive cancer

scientific article

A split-organ delineation approach for dose optimisation for intensity-modulated radiotherapy for advanced T-stage nasopharyngeal carcinoma

scientific article published on 26 November 2007

Accelerated fractionation radiotherapy and late intensification with 2 intra-arterial cisplatin infusions for locally advanced head and neck squamous cell carcinoma

scientific article published on 01 July 2010

Activity of the MEK inhibitor selumetinib (AZD6244; ARRY-142886) in nasopharyngeal cancer cell lines.

scientific article published on 8 May 2012

Addition of bevacizumab to standard chemoradiation for locoregionally advanced nasopharyngeal carcinoma (RTOG 0615): a phase 2 multi-institutional trial.

scientific article published on 15 December 2011

Adjuvant chemoradiation for gastric cancer: experience in the Chinese population

scientific article published on 16 April 2007

Advanced proteomic technologies for cancer biomarker discovery

scientific article

An RNA-directed nucleoside anti-metabolite, 1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl)cytosine (ECyd), elicits antitumor effect via TP53-induced Glycolysis and Apoptosis Regulator (TIGAR) downregulation.

scientific article published on 26 February 2010

Anti-invasion, anti-proliferation and anoikis-sensitization activities of lapatinib in nasopharyngeal carcinoma cells.

scientific article published on 23 June 2010

Application of the international prognostic index in a study of Chinese patients with non-Hodgkin's lymphoma and a high incidence of primary extranodal lymphoma

scientific article published on 01 June 1998

Assessment of proliferating cell nuclear antigen in nasopharyngeal carcinoma tissue and its relation to clinical findings

scientific article published on 01 January 1997

Automated extraction protocol for quantification of SARS-coronavirus RNA in serum: an evaluation study.

scientific article

Barriers to clinical trial recruitment in head and neck cancer

scientific article

CD4 and CD8 T cell responses to tumour-associated Epstein-Barr virus antigens in nasopharyngeal carcinoma patients.

scientific article published in July 2008

CD4+ T-cell responses to Epstein-Barr virus nuclear antigen EBNA1 in Chinese populations are highly focused on novel C-terminal domain-derived epitopes.

scientific article published on August 2006

CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis.

scientific article

Carbamazepine-induced lymphadenopathy mimicking Ki-1 (CD30+) T-cell lymphoma

scientific article published on 01 February 1997

Case of chlorambucil-induced seizure

scientific article published on 01 October 2006

Chemoradiotherapy with or without panitumumab in patients with unresected, locally advanced squamous-cell carcinoma of the head and neck (CONCERT-1): a randomised, controlled, open-label phase 2 trial

scientific article published on 15 January 2015

Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients.

scientific article published in January 2006

Clinical recommendations for defining platinum unsuitable head and neck cancer patient populations on chemoradiotherapy: A literature review

scientific article

Clinical significance of frizzled homolog 3 protein in colorectal cancer patients

scientific article

Clinical studies of immunomodulatory activities of Yunzhi-Danshen in patients with nasopharyngeal carcinoma

scientific article published on 01 October 2006

Comparison of Protocols for Extracting Circulating DNA and RNA from Maternal Plasma

scientific article published on 01 November 2005

Complete small bowel obstruction caused by metastasis from primary nasopharyngeal carcinoma ⬇️

scientific article published on July 22, 2009

Comprehensive proteomic profiling identifies serum proteomic signatures for detection of hepatocellular carcinoma and its subtypes

scientific article published on 01 May 2003

Consensus recommendations for management of head and neck cancer in Asian countries: a review of international guidelines.

scientific article published on 04 July 2013

Controversies in the systemic treatment of nasopharyngeal carcinoma

scientific article published on 17 February 2014

Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma.

scientific article

Current treatment of nasopharyngeal carcinoma ⬇️

scientific article published on 01 September 2011

DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers

scientific article published on 20 January 2009

Dose–response relationship of nasopharyngeal carcinoma above conventional tumoricidal level: A study by the Hong Kong nasopharyngeal carcinoma study group (HKNPCSG)

scientific article published on 19 April 2006

Dosimetric comparison of intensity-modulated stereotactic radiotherapy with other stereotactic techniques for locally recurrent nasopharyngeal carcinoma

scientific article published on 10 April 2010

EBV latent membrane proteins (LMPs) 1 and 2 as immunotherapeutic targets: LMP-specific CD4+ cytotoxic T cell recognition of EBV-transformed B cell lines.

scientific article published on February 2008

Early tumour response and treatment toxicity after hyperfractionated radiotherapy in nasopharyngeal carcinoma

scientific article published on 01 March 1996

Effect of age and disease on taste perception

scientific article published on 01 July 2004

Effects of patupilone (epothilone B; EPO906), a novel chemotherapeutic agent, in hepatocellular carcinoma: an in vitro study.

scientific article

Eight-signature classifier for prediction of nasopharyngeal [corrected] carcinoma survival

scientific article published on 24 October 2011

Enhancement of local control in locally advanced node-positive nasopharyngeal carcinoma by adjunctive chemotherapy.

scientific article published in January 1999

Epigenetic disruption of interferon-gamma response through silencing the tumor suppressor interferon regulatory factor 8 in nasopharyngeal, esophageal and multiple other carcinomas.

scientific article

Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting β-catenin and AKT signaling but frequently methylated in common carcinomas

scientific article published on 25 October 2013

Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors.

scientific article

Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.

scholarly article

Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: a multicentre immunohistochemical study in the Asia-Pacific region

scientific article published on 01 August 2002

Extranodal extension is a criterion for poor outcome in patients with metastatic nodes from cancer of the nasopharynx

scientific article published on 24 November 2018

FEZF2 , a novel 3p14 tumor suppressor gene, represses oncogene EZH2 and MDM2 expression and is frequently methylated in nasopharyngeal carcinoma ⬇️

scientific article published on May 14, 2013

False-negative rate of abdominal sonography for detecting hepatocellular carcinoma in patients with hepatitis B and elevated serum alpha-fetoprotein levels

scientific article published on 01 August 2004

Gemcitabine: a game changer in nasopharyngeal carcinoma.

scientific article published on 23 August 2016

Genome-wide expression analysis using microarray identified complex signaling pathways modulated by hypoxia in nasopharyngeal carcinoma.

scientific article published on 22 February 2007

Germ cell tumors express a specific alpha-fetoprotein variant detectable by isoelectric focusing

scientific article published on 01 April 1995

HLA-A11-restricted epitope polymorphism among Epstein-Barr virus strains in the highly HLA-A11-positive Chinese population: incidence and immunogenicity of variant epitope sequences.

scientific article published on November 2003

High-density lipoprotein cholesterol as a predictor of poor survival in patients with nasopharyngeal carcinoma.

scientific article published on 03 February 2016

How Successful Is High-Dose (≥60 GY) Reirradiation Using Mainly External Beams in Salvaging Local Failures of Nasopharyngeal Carcinoma? ⬇️

scientific article published on March 1, 1998

Human Leukocyte Antigen (HLA) A*1101-Restricted Epstein-Barr Virus-Specific T-cell Receptor Gene Transfer to Target Nasopharyngeal Carcinoma.

scientific article published on 24 February 2015

Hypoxia-targeting by tirapazamine (TPZ) induces preferential growth inhibition of nasopharyngeal carcinoma cells with Chk1/2 activation.

scientific article

Increased incidence of tongue cancer after primary radiotherapy for nasopharyngeal carcinoma--the possibility of radiation carcinogenesis

scientific article published on 01 February 1999

Investigational drugs for nasopharyngeal carcinoma

scientific article

Isoelectric focusing of alphafetoprotein in patients with hepatocellular carcinoma--frequency of specific banding patterns at non-diagnostic serum levels.

scientific article published on April 1996

KRAB zinc finger protein ZNF382 is a proapoptotic tumor suppressor that represses multiple oncogenes and is commonly silenced in multiple carcinomas.

scientific article published on 3 August 2010

Liver resection after irinotecan, 5-fluorouracil, and folinic acid for patients with unresectable colorectal liver metastases: a multicenter phase II study by the Cancer Therapeutic Research Group.

scientific article published in January 2005

Longitudinal colour doppler study of superficial lymph nodes in non-Hodgkin's lymphoma patients on chemotherapy

scientific article published on 01 February 2000

Lung metastasis alone in nasopharyngeal carcinoma: A relatively favorable prognostic group

scientific article published on 01 July 2004

Management of Nasopharyngeal Carcinoma: Current Practice and Future Perspective.

scientific article published on 08 September 2015

Management of the neck after chemoradiotherapy for head and neck cancers in Asia: consensus statement from the Asian Oncology Summit 2009.

scientific article

Multicenter, phase II study of cetuximab in combination with carboplatin in patients with recurrent or metastatic nasopharyngeal carcinoma.

scientific article

Nasal lymphoma: results of local radiotherapy with or without chemotherapy

scientific article published on 01 July 1997

Nasopharyngeal Cancers: Which Method Should be Used to Measure these Irregularly Shaped Tumors on Cross-Sectional Imaging?

scientific article published on 21 May 2007

Nasopharyngeal cancer: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up

scientific article published on 01 October 2012

Nasopharyngeal cancer: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up

scientific article published on 01 May 2010

Nasopharyngeal cancer: ESMO Clinical Recommendations for diagnosis, treatment and follow-up

scientific article published on 01 May 2008

Nasopharyngeal carcinoma

scientific article published on 01 July 2002

Nasopharyngeal carcinoma

scientific article published on 01 October 2010

Nasopharyngeal carcinoma

scientific article published on 28 August 2015

Nasopharyngeal carcinoma

scientific article published on 06 June 2019

Nasopharyngeal carcinoma: relationship between invasion of the prevertebral space and distant metastases.

scientific article

Nuclear beta-catenin expression is rare and its potential association with short survival in colorectal signet-ring cell carcinoma.

scientific article

OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation.

scientific article

Pathogenesis and treatment of nasopharyngeal carcinoma.

scientific article

Pharmacoproteomics study of cetuximab in nasopharyngeal carcinoma.

scientific article published on December 2006

Phase II randomized study comparing the toxicity profile of gemcitabine plus cisplatin with gemcitabine plus oral etoposide in the treatment of advanced non-small cell lung cancer.

scientific article

Phase II study of TAS-106 in patients with platinum-failure recurrent or metastatic head and neck cancer and nasopharyngeal cancer.

scientific article published on 18 April 2013

Phase II study of Temodal in the treatment of patients with advanced nasopharyngeal carcinoma

scientific article published on 01 January 1998

Preclinical evaluation of ribociclib and its synergistic effect in combination with alpelisib in non-keratinizing nasopharyngeal carcinoma.

scientific article

Preclinical evaluation of sunitinib as single agent or in combination with chemotherapy in nasopharyngeal carcinoma.

scientific article

Preclinical evaluation of the PI3K-mTOR dual inhibitor PF-04691502 as a novel therapeutic drug in nasopharyngeal carcinoma.

scientific article published on 24 August 2013

Preclinical evaluation of the mTOR-PI3K inhibitor BEZ235 in nasopharyngeal cancer models.

scientific article published on 14 September 2013

Preliminary results of a randomized study (NPC-9902 Trial) on therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally advanced nasopharyngeal carcinoma

scientific article published in September 2006

Primary mediastinal malignant germ cell tumour. Single institution experience in Chinese patients and correlation with specific alpha-fetoprotein bends.

scientific article published on January 1996

Prospective validation of serum CYFRA 21-1, beta-2-microglobulin, and ferritin levels as prognostic markers in patients with nonmetastatic nasopharyngeal carcinoma undergoing radiotherapy.

scientific article published in August 2004

Pseudomembranous colitis complicating chemotherapy

scientific article published on 01 January 1992

Radiotherapy for nasopharyngeal carcinoma--transition from two-dimensional to three-dimensional methods.

scientific article

Randomized phase II trial of concurrent cisplatin-radiotherapy with or without neoadjuvant docetaxel and cisplatin in advanced nasopharyngeal carcinoma

scientific article published on 8 December 2008

Rapid healing of an indolent leg ulcer with topical rhGM-CSF

scientific article published on 01 June 1996

Relationship between pretreatment level of plasma Epstein-Barr virus DNA, tumor burden, and metabolic activity in advanced nasopharyngeal carcinoma.

scientific article published in November 2006

Retrospective study of the incidence and patterns of arterial and venous thrombosis in Chinese versus African American patients with multiple myeloma.

scientific article

Reverse phase protein array identifies novel anti-invasion mechanisms of YC-1.

scientific article published on 30 October 2009

Study of serum haptoglobin and its glycoforms in the diagnosis of hepatocellular carcinoma: a glycoproteomic approach

scientific article published on 01 October 2006

Survival outcome of patients with nasopharyngeal carcinoma with first local failure: A study by the Hong Kong Nasopharyngeal Carcinoma Study Group

scientific article published on 01 May 2005

Systemic approach to improving treatment outcome in nasopharyngeal carcinoma: current and future directions.

scientific article published on 21 May 2008

Systemic therapy for hepatocellular carcinoma: cytotoxic chemotherapy, targeted therapy and immunotherapy.

scientific article published on 31 January 2008

Systemic treatment strategies and therapeutic monitoring for advanced nasopharyngeal carcinoma.

scientific article

Targeting tumor hypoxia in nasopharyngeal carcinoma.

scientific article

The cost of palliative care for hepatocellular carcinoma in Hong Kong.

scientific article published in January 2001

The epigenetic modifier PRDM5 functions as a tumor suppressor through modulating WNT/β-catenin signaling and is frequently silenced in multiple tumors.

scientific article

The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/β-catenin signaling and silenced in common carcinomas ⬇️

scientific article published on December 5, 2011

The impact of 18F-FDG PET/CT on assessment of nasopharyngeal carcinoma at diagnosis.

scientific article published in April 2008

The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation.

scientific article published on 24 July 2006

The metalloprotease ADAMTS8 displays antitumor properties through antagonizing EGFR-MEK-ERK signaling and is silenced in carcinomas by CpG methylation

scientific article published on November 2013

The role of chemotherapy in the management of nasopharyngeal carcinoma ⬇️

scientific article published on March 15, 1998

The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling and is frequently silenced in nasopharyngeal carcinoma.

scientific article published on 15 April 2010

Transcriptional profiling of tumor biopsies in oncology trials--a 'window' of opportunity for evaluating new drugs in nasopharyngeal cancer?

scientific article published on 01 November 2006

Treatment of nasopharyngeal carcinoma with intensity-modulated radiotherapy: The Hong Kong experience

scientific article published on 01 December 2004

Treatment outcomes of nasopharyngeal carcinoma in modern era after intensity modulated radiotherapy (IMRT) in Hong Kong: A report of 3328 patients (HKNPCSG 1301 study).

scientific article published on 12 December 2017

Tumor-specific methylation of the 8p22 tumor suppressor gene DLC1 is an epigenetic biomarker for Hodgkin, nasal NK/T-cell and other types of lymphomas.

scientific article published on 15 January 2007

Update in antiepidermal growth factor receptor therapy in the management of metastatic colorectal cancer.

scientific article published on 09 April 2009

Update on the management and therapeutic monitoring of advanced nasopharyngeal cancer.

scientific article published on December 2008

WNT5A antagonizes WNT/β-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma.

scientific article published on 7 September 2010

WNT5A exhibits tumor-suppressive activity through antagonizing the Wnt/beta-catenin signaling, and is frequently methylated in colorectal cancer.

scientific article published on January 2008

What Is the Best Treatment of Locally Advanced Nasopharyngeal Carcinoma? An Individual Patient Data Network Meta-Analysis.

scientific article

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