List of works - Frank Verhaegen

A CT based correction method for speed of sound aberration for ultrasound based image guided radiotherapy.

scientific article published in May 2011

A CT-based analytical dose calculation method for HDR 192Ir brachytherapy.

scientific article published in September 2009

A combined dose calculation and verification method for a small animal precision irradiator based on onboard imaging

scientific article published on 01 July 2012

A comparison of the relative biological effectiveness of low energy electronic brachytherapy sources in breast tissue: a Monte Carlo study.

scientific article published on 16 December 2015

A comprehensive system for dosimetric commissioning and Monte Carlo validation for the small animal radiation research platform.

scientific article published on 18 August 2009

A fast three‐dimensional gamma evaluation using a GPU utilizing texture memory for on‐the‐fly interpolations ⬇️

scientific article published on July 1, 2011

A framework for inverse planning of beam-on times for 3D small animal radiotherapy using interactive multi-objective optimisation.

scientific article

A generic TG-186 shielded applicator for commissioning model-based dose calculation algorithms for high-dose-rate 192 Ir brachytherapy.

scientific article

A generic high-dose rate (192)Ir brachytherapy source for evaluation of model-based dose calculations beyond the TG-43 formalism

scientific article

A medical image-based graphical platform -- features, applications and relevance for brachytherapy

scientific article published on 26 August 2014

A novel approach to EPID-based 3D volumetric dosimetry for IMRT and VMAT QA

scientific article published on 22 May 2018

A novel data management platform to improve image-guided precision preclinical biological research

scientific article published on 11 October 2018

A novel rectal applicator for contact radiotherapy with HDR 192Ir sources

scientific article published on 16 August 2018

A novel system for commissioning brachytherapy applicators: example of a ring applicator

scientific article published on 15 September 2017

A novel time dependent gamma evaluation function for dynamic 2D and 3D dose distributions

scientific article published on 17 September 2014

A review of treatment planning for precision image-guided photon beam pre-clinical animal radiation studies

scientific article published on 12 March 2014

A simulation study on proton computed tomography (CT) stopping power accuracy using dual energy CT scans as benchmark.

scientific article published on 29 July 2015

A systematic review comparing radiation toxicity after various endorectal techniques

article

A validated tumor control probability model based on a meta-analysis of low, intermediate, and high-risk prostate cancer patients treated by photon, proton, or carbon-ion radiotherapy.

scientific article published on February 2016

ALGEBRA: ALgorithm for the heterogeneous dosimetry based on GEANT4 for BRAchytherapy.

scientific article published on 9 May 2012

Accuracy of dose calculations on kV cone beam CT images of lung cancer patients.

scientific article published on November 2016

Active Breathing Control in Combination With Ultrasound Imaging: A Feasibility Study of Image Guidance in Stereotactic Body Radiation Therapy of Liver Lesions ⬇️

scientific article published on October 8, 2012

Altered protein turnover signaling and myogenesis during impaired recovery of inflammation-induced muscle atrophy in emphysematous mice

scientific article published on 17 July 2018

An image guided small animal radiation therapy platform (SmART) to monitor glioblastoma progression and therapy response

scientific article published on 7 July 2015

An orthotopic non-small cell lung cancer model for image-guided small animal radiotherapy platforms

scientific article published on 30 November 2018

Analysis of dose perturbation factors of a NACP-02 ionization chamber in clinical electron beams.

scientific article published on 19 December 2008

Application of single- and dual-energy CT brain tissue segmentation to PET monitoring of proton therapy.

scientific article

Automated Computed Tomography-Ultrasound Cross-Modality 3-D Contouring Algorithm for Prostate

scientific article published on 21 July 2015

Automated patient-specific transperineal ultrasound probe setups for prostate cancer patients undergoing radiotherapy

scientific article published on 14 June 2018

Automatic multiatlas based organ at risk segmentation in mice

scientific article published on 25 July 2018

Calcifications in low-dose rate prostate seed brachytherapy treatment: post-planning dosimetry and predictive factors.

scientific article published on 20 February 2015

Calculation of relative biological effectiveness of a low-energy electronic brachytherapy source

scientific article published on 26 November 2008

Comparison of TG-43 and TG-186 in breast irradiation using a low energy electronic brachytherapy source.

scientific article

Comparison of proton therapy treatment planning for head tumors with a pencil beam algorithm on dual and single energy CT images.

scientific article published in January 2016

Complementary use of bioluminescence imaging and contrast-enhanced micro-computed tomography in an orthotopic brain tumor model.

scientific article

Consequences of Intermodality Registration Errors for Intramodality 3D Ultrasound IGRT.

scientific article published on 5 June 2015

Corrigendum to A systematic review comparing radiation toxicity after various endorectal techniques, by Verrijssen et al., Brachytherapy. 2019 Jan - Feb;18(1):71-86.e5

scientific article published on 01 May 2019

Critical assessment of intramodality 3D ultrasound imaging for prostate IGRT compared to fiducial markers.

scientific article published in July 2013

Deriving concentrations of oxygen and carbon in human tissues using single- and dual-energy CT for ion therapy applications.

scientific article published on 8 July 2013

Deriving effective atomic numbers from DECT based on a parameterization of the ratio of high and low linear attenuation coefficients

scientific article published on 11 September 2013

Design of and technical challenges involved in a framework for multicentric radiotherapy treatment planning studies.

scientific article

Detection of anatomical changes in lung cancer patients with 2D time-integrated, 2D time-resolved and 3D time-integrated portal dosimetry: a simulation study.

scientific article published on 5 June 2017

Development and validation of a treatment planning system for small animal radiotherapy: SmART-Plan.

scientific article published on 31 October 2013

Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure

article

Dose distribution for gynecological brachytherapy with dose accumulation between insertions: Feasibility study.

scientific article published on 13 May 2016

Dose painting by dynamic irradiation delivery on an image-guided small animal radiotherapy platform

scientific article published on 12 February 2019

Dose perturbation due to catheter materials in high-dose-rate interstitial (192)Ir brachytherapy.

scientific article published on 10 June 2014

Dose rate mapping of VMAT treatments.

scientific article

Dose reduction in LDR brachytherapy by implanted prostate gold fiducial markers

scientific article published on 01 March 2012

Dose specification for ¹⁹²Ir high dose rate brachytherapy in terms of dose-to-water-in-medium and dose-to-medium-in-medium.

scientific article published on 26 May 2015

Dose to tissue medium or water cavities as surrogate for the dose to cell nuclei at brachytherapy photon energies.

scientific article

Dose to water versus dose to medium from cavity theory applied to small animal irradiation with kilovolt x-rays

scientific article published on 14 August 2019

Dosimetric consequences of misalignment and realignment in prostate 3DCRT using intramodality ultrasound image guidance.

scientific article

Dosimetric evolution of the breast electron boost target using 3D ultrasound imaging.

scientific article published on 28 June 2010

Dual-energy CT for automatic organs-at-risk segmentation in brain-tumor patients using a multi-atlas and deep-learning approach

scientific article published on 11 March 2019

ESTRO ACROP: Technology for precision small animal radiotherapy research: Optimal use and challenges.

scientific article published on 18 December 2017

Efficient scatter distribution estimation and correction in CBCT using concurrent Monte Carlo fitting.

scientific article

Evaluation of a novel triple-channel radiochromic film analysis procedure using EBT2.

scientific article

Evofosfamide sensitizes esophageal carcinomas to radiation without increasing normal tissue toxicity

scientific article published on 17 August 2019

Exploring the feasibility of a clinical proton beam with an adaptive aperture for pre-clinical research

scientific article published on 07 November 2018

Factors influencing the accuracy of beam range estimation in proton therapy using prompt gamma emission.

scientific article published on 22 July 2014

First clinical results of adaptive radiotherapy based on 3D portal dosimetry for lung cancer patients with atelectasis treated with volumetric-modulated arc therapy (VMAT).

scientific article published on 3 September 2013

HDR 192Ir source speed measurements using a high speed video camera

scientific article published in January 2015

High dose rate and flattening filter free irradiation can be safely implemented in clinical practice

scientific article

How efficient is translational research in radiation oncology? The example of a large Dutch academic radiation oncology department

scientific article published on 27 June 2016

In vivo dosimetry for gynaecological brachytherapy using a novel position sensitive radiation detector: feasibility study

scientific article published on 01 April 2012

Influence of breast composition and interseed attenuation in dose calculations for post-implant assessment of permanent breast 103Pd seed implant

scientific article published on 29 July 2010

Influence of the jaw tracking technique on the dose calculation accuracy of small field VMAT plans.

scientific article

Influence of trace elements in human tissue in low-energy photon brachytherapy dosimetry.

scientific article published on 16 May 2012

Interfractional trend analysis of dose differences based on 2D transit portal dosimetry.

scientific article published on 21 September 2012

Is integrated transit planar portal dosimetry able to detect geometric changes in lung cancer patients treated with volumetric modulated arc therapy?

scientific article published on 16 July 2015

Layered mass geometry: a novel technique to overlay seeds and applicators onto patient geometry in Geant4 brachytherapy simulations.

scientific article published on 14 September 2012

Magnitude of speed of sound aberration corrections for ultrasound image guided radiotherapy for prostate and other anatomical sites.

scientific article

Measured vs simulated portal images for low MU fields on three accelerator types: possible consequences for 2D portal dosimetry

scientific article published on 01 December 2012

Measurement of absorbed dose to water around an electronic brachytherapy source. Comparison of two dosimetry systems: lithium formate EPR dosimeters and radiochromic EBT2 film

scientific article published on 23 April 2015

Mechanical evaluation of the Bravos afterloader system for HDR brachytherapy

scientific article published on 18 July 2019

Modern clinical research: How rapid learning health care and cohort multiple randomised clinical trials complement traditional evidence based medicine.

scientific article published on 23 September 2015

Monte Carlo calculation of the dose perturbations in a dual-source HDR/PDR afterloader treatment unit.

scientific article published in July 2016

Monte Carlo calculations of positron emitter yields in proton radiotherapy.

scientific article published on 7 March 2012

Monte Carlo dosimetry of high dose rate gynecologic interstitial brachytherapy.

scientific article

Monte Carlo proton dose calculations using a radiotherapy specific dual-energy CT scanner for tissue segmentation and range assessment

scientific article published on 29 May 2018

Monte Carlo study of LDR seed dosimetry with an application in a clinical brachytherapy breast implant.

scientific article

Monte Carlo study on the sensitivity of prompt gamma imaging to proton range variations due to interfractional changes in prostate cancer patients.

scientific article published on 18 November 2015

Multi-institutional dosimetric and geometric commissioning of image-guided small animal irradiators

scientific article published in March 2014

Murine vs human tissue compositions: implications of using human tissue compositions for photon energy absorption in mice

scientific article published on 30 November 2018

NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma. ⬇️

scientific article published on 10 May 2016

On the determination of planning target margins due to motion for mice lung tumours using a four-dimensional MOBY phantom

scientific article published on 20 July 2018

On the sensitivity of α/β prediction to dose calculation methodology in prostate brachytherapy.

scientific article published in February 2014

On the significance of density-induced speed of sound variations on US-guided radiotherapy.

scientific article

On the use of an analytic source model for dose calculations in precision image-guided small animal radiotherapy.

scientific article published on 25 April 2013

Online pretreatment verification of high-dose rate brachytherapy using an imaging panel

scientific article

Optimizing dual energy cone beam CT protocols for preclinical imaging and radiation research

scientific article

Patient-specific Monte Carlo dose calculations for high-dose-rate endorectal brachytherapy with shielded intracavitary applicator.

scientific article published in November 2008

Preclinical Assessment of Efficacy of Radiation Dose Painting Based on Intratumoral FDG-PET Uptake

scientific article published on 14 August 2015

Prostate postbrachytherapy seed distribution: comparison of high-resolution, contrast-enhanced, T1- and T2-weighted endorectal magnetic resonance imaging versus computed tomography: initial experience: in regard to BLOCH et al. (Int J Radiat Oncol B

scientific article

Quantifying the effect of seed orientation in postplanning dosimetry of low-dose-rate prostate brachytherapy.

scientific article published in October 2014

Report of the Task Group 186 on model-based dose calculation methods in brachytherapy beyond the TG-43 formalism: current status and recommendations for clinical implementation.

scientific article published on October 2012

Review of ultrasound image guidance in external beam radiotherapy part II: intra-fraction motion management and novel applications

scientific article published on 22 March 2016

Review of ultrasound image guidance in external beam radiotherapy: I. Treatment planning and inter-fraction motion management.

scientific article

Revisiting the single-energy CT calibration for proton therapy treatment planning: a critical look at the stoichiometric method

scientific article published on 26 November 2018

SU-E-J-195: Dosimetric Consequences of Metal Prosthesis in Prostate 3D CRT by Using Monte Carlo Dose Calculation Method.

scientific article published in June 2012

SU-E-J-51: Interfractional Trend Analysis of Dose Discrepancies Based on 2D Portal Dosimetry.

scientific article published in June 2012

SU-F-BRCD-04: Efficient Scatter Distribution Estimation and Correction in CBCT Using Concurrent Monte Carlo Fitting.

scientific article published on June 2012

Sensitivity of low energy brachytherapy Monte Carlo dose calculations to uncertainties in human tissue composition.

scientific article published in October 2010

Should dose from small fields be limited for dose verification procedures?: uncertainty versus small field dose in VMAT treatments

scientific article published on 16 October 2018

Simulation of pseudo-CT images based on deformable image registration of ultrasound images: A proof of concept for transabdominal ultrasound imaging of the prostate during radiotherapy

scientific article published in April 2016

Simulation study on potential accuracy gains from dual energy CT tissue segmentation for low-energy brachytherapy Monte Carlo dose calculations.

scientific article

Small animal image-guided radiotherapy

scientific article published in January 2017

Small animal image-guided radiotherapy: status, considerations and potential for translational impact

scientific article

Small animal radiotherapy research platforms.

scientific article published on 26 May 2011

Spatial frequency spectrum of the x-ray scatter distribution in CBCT projections

scientific article

SpekCalc: a program to calculate photon spectra from tungsten anode x-ray tubes

scientific article published on 01 September 2009

Technical Note: Relative proton stopping power estimation from virtual monoenergetic images reconstructed from dual-layer computed tomography

scientific article published on 19 February 2019

Technical note: cone beam CT imaging for 3D image guided brachytherapy for gynecological HDR brachytherapy.

scientific article published in May 2011

The Use of Ultrasound Imaging in the External Beam Radiotherapy Workflow of Prostate Cancer Patients.

scientific article

The contribution from transit dose for (192)Ir HDR brachytherapy treatments.

scientific article published on 14 March 2014

The effect of different image reconstruction techniques on pre-clinical quantitative imaging and dual-energy CT

scientific article published on 07 November 2018

The effects of compensator and imaging geometry on the distribution of x-ray scatter in CBCT

scientific article published on 24 January 2011

The impact of dual energy CT imaging on dose calculations for pre-clinical studies.

scientific article published on 21 November 2017

The influence of respiratory motion on dose delivery in a mouse lung tumour irradiation using the 4D MOBY phantom.

scientific article published on 14 September 2016

The influence of tissue composition uncertainty on dose distributions in brachytherapy

scientific article published on 7 February 2018

The use of tetrahedral mesh geometries in Monte Carlo simulation of applicator based brachytherapy dose distributions

scientific article published on 11 September 2014

Time dependent pre-treatment EPID dosimetry for standard and FFF VMAT.

scientific article published on 4 August 2014

Time-Resolved Versus Integrated Transit Planar Dosimetry for Volumetric Modulated Arc Therapy: Patient-Specific Dose Differences During Treatment, a Proof of Principle

scientific article published on 10 December 2015

Time-of-flight neutron rejection to improve prompt gamma imaging for proton range verification: a simulation study

scientific article published on 21 September 2012

Time-resolved versus time-integrated portal dosimetry: the role of an object's position with respect to the isocenter in volumetric modulated arc therapy.

scientific article published on 9 May 2016

Tissue modeling schemes in low energy breast brachytherapy.

scientific article published on 21 October 2011

Towards a Clinical Decision Support System for External Beam Radiation Oncology Prostate Cancer Patients: Proton vs. Photon Radiotherapy? A Radiobiological Study of Robustness and Stability.

scientific article published on 18 February 2018

Tumour and normal tissue radiobiology in mouse models: how close are mice to mini-humans?

scientific article published on 9 September 2016

Validation and uncertainty analysis of a pre-treatment 2D dose prediction model.

scientific article published on 26 November 2017

Weekly kilovoltage cone-beam computed tomography for detection of dose discrepancies during (chemo)radiotherapy for head and neck cancer

scientific article published on 29 July 2015

What is the degree of innovation routinely implemented in Dutch radiotherapy centres? A multicentre cross-sectional study.

scientific article published on 23 September 2016

What is the impact of innovation on output in healthcare with a special focus on treatment innovations in radiotherapy? A literature review.

scientific article published on 06 August 2017

What level of accuracy is achievable for preclinical dose painting studies on a clinical irradiation platform?

scientific article published on 21 April 2015

List of works by Frank Verhaegen

A CT based correction method for speed of sound aberration for ultrasound based image guided radiotherapy.

A CT-based analytical dose calculation method for HDR 192Ir brachytherapy.

A combined dose calculation and verification method for a small animal precision irradiator based on onboard imaging

A comparison of the relative biological effectiveness of low energy electronic brachytherapy sources in breast tissue: a Monte Carlo study.

A comprehensive system for dosimetric commissioning and Monte Carlo validation for the small animal radiation research platform.

A fast three‐dimensional gamma evaluation using a GPU utilizing texture memory for on‐the‐fly interpolations ⬇️

A framework for inverse planning of beam-on times for 3D small animal radiotherapy using interactive multi-objective optimisation.

A generic TG-186 shielded applicator for commissioning model-based dose calculation algorithms for high-dose-rate 192 Ir brachytherapy.

A generic high-dose rate (192)Ir brachytherapy source for evaluation of model-based dose calculations beyond the TG-43 formalism

A medical image-based graphical platform -- features, applications and relevance for brachytherapy

A novel approach to EPID-based 3D volumetric dosimetry for IMRT and VMAT QA

A novel data management platform to improve image-guided precision preclinical biological research

A novel rectal applicator for contact radiotherapy with HDR 192Ir sources

A novel system for commissioning brachytherapy applicators: example of a ring applicator

A novel time dependent gamma evaluation function for dynamic 2D and 3D dose distributions

A review of treatment planning for precision image-guided photon beam pre-clinical animal radiation studies

A simulation study on proton computed tomography (CT) stopping power accuracy using dual energy CT scans as benchmark.

A systematic review comparing radiation toxicity after various endorectal techniques

A validated tumor control probability model based on a meta-analysis of low, intermediate, and high-risk prostate cancer patients treated by photon, proton, or carbon-ion radiotherapy.

ALGEBRA: ALgorithm for the heterogeneous dosimetry based on GEANT4 for BRAchytherapy.

Accuracy of dose calculations on kV cone beam CT images of lung cancer patients.

Active Breathing Control in Combination With Ultrasound Imaging: A Feasibility Study of Image Guidance in Stereotactic Body Radiation Therapy of Liver Lesions ⬇️

Altered protein turnover signaling and myogenesis during impaired recovery of inflammation-induced muscle atrophy in emphysematous mice

An image guided small animal radiation therapy platform (SmART) to monitor glioblastoma progression and therapy response

An orthotopic non-small cell lung cancer model for image-guided small animal radiotherapy platforms

Analysis of dose perturbation factors of a NACP-02 ionization chamber in clinical electron beams.

Application of single- and dual-energy CT brain tissue segmentation to PET monitoring of proton therapy.

Automated Computed Tomography-Ultrasound Cross-Modality 3-D Contouring Algorithm for Prostate

Automated patient-specific transperineal ultrasound probe setups for prostate cancer patients undergoing radiotherapy

Automatic multiatlas based organ at risk segmentation in mice

Calcifications in low-dose rate prostate seed brachytherapy treatment: post-planning dosimetry and predictive factors.

Calculation of relative biological effectiveness of a low-energy electronic brachytherapy source

Comparison of TG-43 and TG-186 in breast irradiation using a low energy electronic brachytherapy source.

Comparison of proton therapy treatment planning for head tumors with a pencil beam algorithm on dual and single energy CT images.

Complementary use of bioluminescence imaging and contrast-enhanced micro-computed tomography in an orthotopic brain tumor model.

Consequences of Intermodality Registration Errors for Intramodality 3D Ultrasound IGRT.

Corrigendum to A systematic review comparing radiation toxicity after various endorectal techniques, by Verrijssen et al., Brachytherapy. 2019 Jan - Feb;18(1):71-86.e5

Critical assessment of intramodality 3D ultrasound imaging for prostate IGRT compared to fiducial markers.

Deriving concentrations of oxygen and carbon in human tissues using single- and dual-energy CT for ion therapy applications.

Deriving effective atomic numbers from DECT based on a parameterization of the ratio of high and low linear attenuation coefficients

Design of and technical challenges involved in a framework for multicentric radiotherapy treatment planning studies.

Detection of anatomical changes in lung cancer patients with 2D time-integrated, 2D time-resolved and 3D time-integrated portal dosimetry: a simulation study.

Development and validation of a treatment planning system for small animal radiotherapy: SmART-Plan.

Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure

Dose distribution for gynecological brachytherapy with dose accumulation between insertions: Feasibility study.

Dose painting by dynamic irradiation delivery on an image-guided small animal radiotherapy platform

Dose perturbation due to catheter materials in high-dose-rate interstitial (192)Ir brachytherapy.

Dose rate mapping of VMAT treatments.

Dose reduction in LDR brachytherapy by implanted prostate gold fiducial markers

Dose specification for ¹⁹²Ir high dose rate brachytherapy in terms of dose-to-water-in-medium and dose-to-medium-in-medium.

Dose to tissue medium or water cavities as surrogate for the dose to cell nuclei at brachytherapy photon energies.

Dose to water versus dose to medium from cavity theory applied to small animal irradiation with kilovolt x-rays

Dosimetric consequences of misalignment and realignment in prostate 3DCRT using intramodality ultrasound image guidance.

Dosimetric evolution of the breast electron boost target using 3D ultrasound imaging.

Dual-energy CT for automatic organs-at-risk segmentation in brain-tumor patients using a multi-atlas and deep-learning approach

ESTRO ACROP: Technology for precision small animal radiotherapy research: Optimal use and challenges.

Efficient scatter distribution estimation and correction in CBCT using concurrent Monte Carlo fitting.

Evaluation of a novel triple-channel radiochromic film analysis procedure using EBT2.

Evofosfamide sensitizes esophageal carcinomas to radiation without increasing normal tissue toxicity

Exploring the feasibility of a clinical proton beam with an adaptive aperture for pre-clinical research

Factors influencing the accuracy of beam range estimation in proton therapy using prompt gamma emission.

First clinical results of adaptive radiotherapy based on 3D portal dosimetry for lung cancer patients with atelectasis treated with volumetric-modulated arc therapy (VMAT).

HDR 192Ir source speed measurements using a high speed video camera

High dose rate and flattening filter free irradiation can be safely implemented in clinical practice

How efficient is translational research in radiation oncology? The example of a large Dutch academic radiation oncology department

In vivo dosimetry for gynaecological brachytherapy using a novel position sensitive radiation detector: feasibility study

Influence of breast composition and interseed attenuation in dose calculations for post-implant assessment of permanent breast 103Pd seed implant

Influence of the jaw tracking technique on the dose calculation accuracy of small field VMAT plans.

Influence of trace elements in human tissue in low-energy photon brachytherapy dosimetry.

Interfractional trend analysis of dose differences based on 2D transit portal dosimetry.

Is integrated transit planar portal dosimetry able to detect geometric changes in lung cancer patients treated with volumetric modulated arc therapy?

Layered mass geometry: a novel technique to overlay seeds and applicators onto patient geometry in Geant4 brachytherapy simulations.

Magnitude of speed of sound aberration corrections for ultrasound image guided radiotherapy for prostate and other anatomical sites.

Measured vs simulated portal images for low MU fields on three accelerator types: possible consequences for 2D portal dosimetry

Measurement of absorbed dose to water around an electronic brachytherapy source. Comparison of two dosimetry systems: lithium formate EPR dosimeters and radiochromic EBT2 film

Mechanical evaluation of the Bravos afterloader system for HDR brachytherapy

Modern clinical research: How rapid learning health care and cohort multiple randomised clinical trials complement traditional evidence based medicine.

Monte Carlo calculation of the dose perturbations in a dual-source HDR/PDR afterloader treatment unit.

Monte Carlo calculations of positron emitter yields in proton radiotherapy.