Search filters

List of works by Christoph Rader

"One, if by land, and two, if by sea": bispecific antibodies join the revolution

scientific article published on 01 February 2019

A CD19/CD3 bispecific antibody for effective immunotherapy of chronic lymphocytic leukemia in the ibrutinib era.

scientific article

A Sortase A Programmable Phage Display Format for Improved Panning of Fab Antibody Libraries

article

A chemical adaptor system designed to link a tumor-targeting device with a prodrug and an enzymatic trigger

scientific article published on 01 January 2003

A direct interaction of axonin-1 with NgCAM-related cell adhesion molecule (NrCAM) results in guidance, but not growth of commissural axons.

scientific article

A human monoclonal antibody drug and target discovery platform for B-cell chronic lymphocytic leukemia based on allogeneic hematopoietic stem cell transplantation and phage display.

scientific article published on 10 August 2009

A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy

scientific article published in September 2003

A new immunochemical strategy for triple-negative breast cancer therapy

scientific article

A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease

scientific article

A novel high-affinity human monoclonal antibody to mesothelin.

scientific article

A phage display approach for rapid antibody humanization: designed combinatorial V gene libraries.

scientific article

Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications

scientific article published on 19 March 2020

Aldolase antibody activation of prodrugs of potent aldehyde-containing cytotoxics for selective chemotherapy

scientific article published on October 2004

An Engineered Arginine Residue of Unusual pH-Sensitive Reactivity Facilitates Site-Selective Antibody Conjugation

scientific article published on 23 March 2021

An IgG1-like bispecific antibody targeting CD52 and CD20 for the treatment of B-cell malignancies

scientific article published on 24 August 2018

An engineered selenocysteine defines a unique class of antibody derivatives

scholarly article

Analysis of cell-cell contact mediated by Ig superfamily cell adhesion molecules.

scientific article published on 2 December 2013

Analysis of cell-cell contact mediated by Ig superfamily cell adhesion molecules.

scientific article published on August 2001

Angucyclines and Angucyclinones from Streptomyces sp. CB01913 Featuring C-Ring Cleavage and Expansion ⬇️

scientific article published on 3 September 2015

Antibody conjugation via one and two C-terminal selenocysteines.

scientific article published on 10 June 2013

Antibody libraries in drug and target discovery.

scientific article

Application of a trifunctional reactive linker for the construction of antibody-drug hybrid conjugates

scientific article

Application of strain-promoted azide-alkyne cycloaddition and tetrazine ligation to targeted Fc-drug conjugates.

scientific article

Assessment of reagents for selenocysteine conjugation and the stability of selenocysteine adducts

scientific article published on 17 May 2016

Axonin-1/TAG-1 mediates cell-cell adhesion by a cis-assisted trans-interaction.

scientific article

Bispecific antibodies in cancer immunotherapy

scientific article published on 13 December 2019

Bortezomib resistance in mantle cell lymphoma is associated with plasmacytic differentiation

scientific article

CAR T cells targeting αvβ3 integrin are effective against advanced cancer in preclinical models

scientific article published on 10 July 2018

Carlos F. Barbas III (1964-2014): Visionary at the interface of chemistry and biology

scientific article published on August 2014

Characterization of TnmH as an O-Methyltransferase Revealing In-sights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy to Prepare Antibody-Tiancimycin Conjugates

scientific article published on 13 July 2020

Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devices.

scientific article

Chemical biology: How to minimalize antibodies

scientific article published on February 2015

Chemically Programmed Bispecific Antibodies in Diabody Format

scientific article published on 21 July 2016

Chemically programmable and switchable CAR-T therapy

scientific article published on 24 April 2020

Chemically programmed antibodies.

scientific article published on 11 March 2014

Chemically programmed bispecific antibodies that recruit and activate T cells

scientific article

Chemically programmed monoclonal antibodies for cancer therapy: adaptor immunotherapy based on a covalent antibody catalyst.

scientific article

Chimeric Antigen Receptor Library Screening Using a Novel NF-κB/NFAT Reporter Cell Platform

scientific article published on 20 November 2018

Chimeric Rabbit/Human Fab Antibodies Against the Hepatitis B e-antigen and Their Potential Applications in Assay, Characterization and Therapy.

scientific article

Chimeric rabbit/human Fab and IgG specific for members of the Nogo-66 receptor family selected for species cross-reactivity with an improved phage display vector

scientific article

Cloning, expression, and purification of monoclonal antibodies in scFv-Fc format

scientific article published on 01 January 2012

Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis

scientific article published on 13 September 2018

Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals

scholarly article

Conventional and Chemically Programmed Asymmetric Bispecific Antibodies Targeting Folate Receptor 1

scientific article published on 21 August 2019

DARTs take aim at BiTEs

scientific article published on 01 April 2011

Discovery of ammosesters by mining the Streptomyces uncialis DCA2648 genome revealing new insight into ammosamide biosynthesis ⬇️

scientific article published on 18 March 2021

Discrete clusters of axonin-1 and NgCAM at neuronal contact sites: facts and speculations on the regulation of axonal fasciculation.

scientific article

Dual-mechanistic antibody-drug conjugate via site-specific selenocysteine/cysteine conjugation

scientific article published on 24 October 2019

E. coli expression and purification of Fab antibody fragments

scientific article

Engineered production of cancer targeting peptide (CTP)-containing C-1027 in Streptomyces globisporus and biological evaluation

scientific article

Engineering Dual Variable Domains for the Generation of Site-Specific Antibody-Drug Conjugates

scientific article published on 01 January 2019

From catalytic asymmetric synthesis to the transcriptional regulation of genes: in vivo and in vitro evolution of proteins.

scientific article

From rabbit antibody repertoires to rabbit monoclonal antibodies

scientific article published on 24 March 2017

Generation and characterization of a chimeric rabbit/human Fab for co-crystallization of HIV-1 Rev.

scientific article

Generation and characterization of a recombinant human CCR5-specific antibody. A phage display approach for rabbit antibody humanization.

scientific article

Generation and selection of rabbit antibody libraries by phage display

scientific article

Generation and validation of structurally defined antibody-siRNA conjugates

scientific article published on 29 April 2020

Generation of human Fab antibody libraries: PCR amplification and assembly of light- and heavy-chain coding sequences.

scientific article

Generation of human Fab libraries for phage display.

scientific article

Generation of human scFv antibody libraries: PCR amplification and assembly of light- and heavy-chain coding sequences.

scientific article

Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual antagonistic and agonistic activity

scientific article

Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne. ⬇️

scientific article published on 31 October 2017

Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates

scientific article

Harnessing the fcμ receptor for potent and selective cytotoxic therapy of chronic lymphocytic leukemia.

scientific article

Human Serum Albumin Domain I Fusion Protein for Antibody Conjugation.

scientific article published on 26 September 2016

Human/mouse cross-reactive anti-VEGF receptor 2 recombinant antibodies selected from an immune b9 allotype rabbit antibody library.

scientific article

IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for High Risk Sarcomas.

scientific article published on 14 July 2015

Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade

scientific article published on 01 December 2020

Implications of the HIV-1 Rev dimer structure at 3.2 A resolution for multimeric binding to the Rev response element

scientific article

Improving the serum stability of site-specific antibody conjugates with sulfone linkers

scientific article

In vivo activity in a catalytic antibody-prodrug system: Antibody catalyzed etoposide prodrug activation for selective chemotherapy

scientific article published on 12 June 2001

Integrin alpha(v)beta3 targeted therapy for Kaposi's sarcoma with an in vitro evolved antibody

scientific article

Integrin alphaIIbbeta3-specific synthetic human monoclonal antibodies and HCDR3 peptides that potently inhibit platelet aggregation

scientific article published on 19 December 2003

Intradiabodies, bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors.

scientific article

Isolation of human prostate cancer cell reactive antibodies using phage display technology.

scientific article

Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase-dependent pathway

scientific article

Lipid-directed vinculin dimerization

scientific article published on 24 April 2015

Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting

scientific article published on 01 March 2019

Mechanisms of CNS myelin inhibition: evidence for distinct and neuronal cell type specific receptor systems.

scientific article published on January 2008

Mining Naïve Rabbit Antibody Repertoires by Phage Display for Monoclonal Antibodies of Therapeutic Utility

scientific article published on 14 August 2017

Mining human antibody repertoires

scientific article

Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNI-Fc, a novel antagonist of CNS myelin inhibition

scientific journal article

Molecularly defined antibody conjugation through a selenocysteine interface

scientific article

Monoclonal antibodies targeting cell surface deposited complement fragment C3d potentiate cancer immunotherapy and eliminate antigen loss variants.

scientific article published on 4 November 2015

Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2

scientific article

Mutations from bat ACE2 orthologs markedly enhance ACE2-Fc neutralization of SARS-CoV-2

scientific article published on 30 June 2020

Neurite fasciculation mediated by complexes of axonin-1 and Ng cell adhesion molecule

scientific article

Neutralization of Burkholderia pseudomallei protease by Fabs generated through phage display

scientific article

New chemical adaptor unit designed to release a drug from a tumor targeting device by enzymatic triggering.

scientific article published in April 2004

Overview on concepts and applications of Fab antibody fragments

scientific article

Phage display of combinatorial antibody libraries.

scientific article published on August 1997

Phenotypic knockout of VEGF-R2 and Tie-2 with an intradiabody reduces tumor growth and angiogenesis in vivo

scientific article

Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1

scientific article published on 29 May 2018

Prodrugs of dynemicin analogs for selective chemotherapy mediated by an aldolase catalytic Ab.

scholarly article

ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo

scientific article published on 29 April 2015

ROR1-targeted delivery of miR-29b induces cell cycle arrest and therapeutic benefit in vivo in a CLL mouse model

scientific article published on 31 May 2019

Rabbit immune repertoires as sources for therapeutic monoclonal antibodies: the impact of kappa allotype-correlated variation in cysteine content on antibody libraries selected by phage display

scientific article

Rabbit models of human diseases for diagnostics and therapeutics development

article

Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells

scientific article published on 25 April 2013

Recognition of antigen-specific B-cell receptors from chronic lymphocytic leukemia patients by synthetic antigen surrogates

scientific article

Redirecting cytotoxic T cells with chemically programmed antibodies

scientific article published on 02 November 2020

Restricted cell surface expression of receptor tyrosine kinase ROR1 in pediatric B-lineage acute lymphoblastic leukemia suggests targetability with therapeutic monoclonal antibodies

scientific article

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

scientific article published on 26 November 2020

Safety of targeting ROR1 for cancer immunotherapy with chimeric antigen receptor-modified T cells in a primate model

scientific article published on 6 November 2014

Safety of targeting ROR1 in primates with chimeric antigen receptor-modified T cells

scientific article

Selection of apoptotic cell specific human antibodies from adult bone marrow

scientific article (publication date: 2014)

Selection of human Fab libraries by phage display

scientific article

Siglec-6 on Chronic Lymphocytic Leukemia Cells Is a Target for Post-Allogeneic Hematopoietic Stem Cell Transplantation Antibodies

scholarly article by Jing Chang et al published September 2018 in Cancer immunology research

Site-Selective Antibody Functionalization via Orthogonally Reactive Arginine and Lysine Residues

scientific article published on 20 June 2019

Site-Specific Antibody-Drug Conjugates in Triple Variable Domain Fab Format

scientific article published on 14 May 2020

Site-Specific Dual Antibody Conjugation via Engineered Cysteine and Selenocysteine Residues.

scientific article published on 10 July 2015

Site-Specific Lysine Arylation as an Alternative Bioconjugation Strategy for Chemically Programmed Antibodies and Antibody-Drug Conjugates

scientific article published on 01 November 2019

Six-packed antibodies punch better

scientific article published on 01 September 2019

Small molecule drug activity in melanoma models may be dramatically enhanced with an antibody effector

scientific article published on 01 September 2006

Stable and Potent Selenomab-Drug Conjugates.

scientific article published on 09 March 2017

Strain Prioritization and Genome Mining for Enediyne Natural Products

scientific article (publication date: 20 December 2016)

Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation.

scholarly article

Tagging the Untaggable: A Difluoroalkyl-Sulfinate Ketone-Based Reagent for Direct C-H Functionalization of Bioactive Heteroarenes

scientific article published on 5 August 2016

Targeting Stereotyped B Cell Receptors from Chronic Lymphocytic Leukemia Patients with Synthetic Antigen Surrogates

scientific article published on 5 February 2016

Targeting malignant B cells with an immunotoxin against ROR1

scientific article

Targeting the Fcμ-receptor in chronic lymphocytic leukemia with a novel IgM-derived antibody-drug conjugate

scientific article published on 7 November 2013

Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody

scientific article published on 01 February 2005

The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor.

scientific article

The New Zealand black mouse as a model for the development and progression of chronic lymphocytic leukemia

scientific article

The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein

scientific journal article

The axonally secreted cell adhesion molecule, axonin-1. Primary structure, immunoglobulin-like and fibronectin-type-III-like domains and glycosyl-phosphatidylinositol anchorage

scientific article published on March 1, 1992

The contactin-related protein FAR-2 defines purkinje cell clusters and labels subpopulations of climbing fibers in the developing cerebellum.

scientific article published in July 2001

The gene of chicken axonin-1. Complete structure and analysis of the promoter.

scientific article published on February 1995

The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity.

scientific article

The rabbit antibody repertoire as a novel source for the generation of therapeutic human antibodies.

scientific article

Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies

scientific article

Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia

scientific article

Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia.

scientific article

Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task

scientific article published on April 2000

Utilization of Selenocysteine for Site-Specific Antibody Conjugation.

scientific article published on January 2017

cDNA cloning, structural features, and eucaryotic expression of human TAG-1/axonin-1

scientific article

Paulina is supported by:

About Paulina

Help