List of works by Sylvain Lesné

A specific amyloid-beta protein assembly in the brain impairs memory

scientific journal article published in 2006. 14 July 2022 Editor’s Note: readers are advised to use caution when using results reported therein.

Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

scientific article

Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity

scientific article published on 29 March 2005

Amyloid plaques and amyloid-beta oligomers: an ongoing debate.

scientific article

Angiopoietin-1-induced PI3-kinase activation prevents neuronal apoptosis.

scientific article

Beta-amyloid modulation of synaptic transmission and plasticity

scientific article published on October 2007

Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons

scientific article published on 11 July 2018

Brain amyloid-β oligomers in ageing and Alzheimer's disease

scientific article

Breaking the Code of Amyloid-β Oligomers

scientific article

Cellular prion protein and class-specific Aβ oligomers mediate plaque-associated cytopathology in a mouse model of Alzheimer’s disease

Cognitive effects of cell-derived and synthetically derived Aβ oligomers

scientific article

Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity

scientific article published in March 2008

Detecting aβ*56 oligomers in brain tissues.

scientific article published in January 2011

Discrete pools of oligomeric amyloid-β track with spatial learning deficits in a mouse model of Alzheimer amyloidosis.

scientific article published on 14 December 2017

Does transforming growth factor-beta (TGF-beta) act as a neuroprotective agent in cerebral ischemia?

scientific article published in January 2003

Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease

scientific article published on 10 May 2016

Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of AD.

scientific article

Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease

scientific article

Increased expression of transforming growth factor-beta after cerebral ischemia in the baboon: an endogenous marker of neuronal stress?

scientific article published in July 2001

Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.

scholarly article

Ischemia-Induced Interleukin-6 as a Potential Endogenous Neuroprotective Cytokine against NMDA Receptor-Mediated Excitoxicity in the Brain

scientific article published on 01 June 2000

Live discussion: Amyloid-beta degradation: the forgotten half of Alzheimer's disease. 12 September 2002.

scientific article published in December 2003

NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production.

scientific article

Oligomers of the amyloid-beta protein disrupt working memory: confirmation with two behavioral procedures.

scientific article published on 08 June 2008

Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers

scientific article published in December 2006

Plaque-bearing mice with reduced levels of oligomeric amyloid-beta assemblies have intact memory function.

scientific article

Reduced brain tissue perfusion in TGF-beta 1 transgenic mice showing Alzheimer's disease-like cerebrovascular abnormalities

scientific article

Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

scientific article

Smad3-dependent induction of plasminogen activator inhibitor-1 in astrocytes mediates neuroprotective activity of transforming growth factor-beta 1 against NMDA-induced necrosis

scientific article

Soluble Aβ oligomer production and toxicity

scientific article published on 28 November 2011

Soluble Conformers of Aβ and Tau Alter Selective Proteins Governing Axonal Transport

scientific article published on September 2016

Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk

scientific article published on 30 May 2020

Soluble α-synuclein is a novel modulator of Alzheimer's disease pathophysiology

scientific article

Sp1 and Smad transcription factors co-operate to mediate TGF-beta-dependent activation of amyloid-beta precursor protein gene transcription.

scientific article published on October 2004

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

scientific article published on 06 June 2019

The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation.

scientific article

The complex PrP(c)-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease

scientific article published on November 2012

Toxic oligomer species of amyloid-β in Alzheimer's disease, a timing issue.

scientific article

Transforming growth factor alpha-induced expression of type 1 plasminogen activator inhibitor in astrocytes rescues neurons from excitotoxicity.

scientific article

Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice

scientific article published on 7 March 2003

Transforming growth factor-beta and ischemic brain injury ⬇️

scientific article published on October 1, 2003

Transforming growth factor-beta1-modulated cerebral gene expression

scientific article published in September 2002

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