List of works - Barbara Campanini

A novel Bim-BH3-derived Bcl-XL inhibitor: biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity

scientific article published on 20 October 2008

A two-step process controls the formation of the bienzyme cysteine synthase complex

scientific article

ATP binding to human serine racemase is cooperative and modulated by glycine

scientific article

Activation of an anti-bacterial toxin by the biosynthetic enzyme CysK: mechanism of binding, interaction specificity and competition with cysteine synthase.

scientific article published on 18 August 2017

Asymmetry of the active site loop conformation between subunits of glutamate-1-semialdehyde aminomutase in solution

scientific article published on 31 July 2013

Birth of a pathway for sulfur metabolism in early amniote evolution

scientific article published on 29 June 2020

Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action

scientific article published on 21 October 2019

Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction

scientific article published on 31 March 2022

Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target

scientific article

Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR.

scientific article published on 31 August 2016

Design and synthesis of trans-2-substituted-cyclopropane-1-carboxylic acids as the first non-natural small molecule inhibitors of O-acetylserine sulfhydrylase

article by Laura Amori et al published 2012 in MedChemComm

Design of O -Acetylserine Sulfhydrylase Inhibitors by Mimicking Nature

scientific article

Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand-based drug design

scientific article published on 01 December 2018

Dynamics of green fluorescent protein mutant2 in solution, on spin-coated glasses, and encapsulated in wet silica gels

scientific article published on May 2002

Effect of the point mutation H148G on GFPmut2 unfolding kinetics by fluorescence spectroscopy

scientific article published on 13 April 2011

Enhanced Green Fluorescent Protein (GFP) fluorescence after polyelectrolyte caging

scientific article published in October 2006

Environment effects on the oscillatory unfolding kinetics of GFP.

scientific article

Evidence of discrete substates and unfolding pathways in green fluorescent protein

scientific article

Expanding the chemical space of human serine racemase inhibitors

scientific article published on 4 August 2015

Exploring O-acetylserine sulfhydrylase-B isoenzyme from Salmonella typhimurium by fluorescence spectroscopy

scientific article published on 16 October 2010

Fine tuning of the active site modulates specificity in the interaction of O-acetylserine sulfhydrylase isozymes with serine acetyltransferase

scientific article published on 19 September 2012

GFP-mut2 proteins in trehalose-water matrixes: spatially heterogeneous protein-water-sugar structures

scientific article published on 6 April 2007

Glutamine 89 is a key residue in the allosteric modulation of human serine racemase activity by ATP.

scientific article published on 13 June 2018

Green fluorescent protein ground states: the influence of a second protonation site near the chromophore

scientific article

Human kynurenine aminotransferase II - reactivity with substrates and inhibitors

scholarly article by Elisabetta Passera published in April 2011

Human serine racemase is inhibited by glyceraldehyde 3-phosphate, but not by glyceraldehyde 3-phosphate dehydrogenase

scientific article published on 21 September 2020

Human serine racemase is nitrosylated at multiple sites.

scientific article published on 30 January 2018

Identification of the structural determinants for the stability of substrate and aminoacrylate external Schiff bases in O-acetylserine sulfhydrylase-A.

scientific article published in July 2010

Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor

scientific article published on 13 February 2020

Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives

scholarly article by Nina Franko et al published December 2018 in Journal of Enzyme Inhibition and Medicinal Chemistry

Inhibitors of the sulfur assimilation pathway in bacterial pathogens as enhancers of antibiotic therapy.

scientific article

Insight into GFPmut2 pH Dependence by Single Crystal Microspectrophotometry and X-ray Crystallography

scientific article published on 17 September 2018

Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets.

scientific article published on 26 February 2018

Interaction of human hemoglobin and semi-hemoglobins with the Staphylococcus aureus hemophore IsdB: a kinetic and mechanistic insight

scientific article published on 09 December 2019

Interaction of serine acetyltransferase with O-acetylserine sulfhydrylase active site: evidence from fluorescence spectroscopy

scientific article published on 29 June 2005

Iron Metabolism at the Interface between Host and Pathogen: From Nutritional Immunity to Antibacterial Development

scientific article published on 20 March 2020

Isozyme-specific ligands for O-acetylserine sulfhydrylase, a novel antibiotic target

scientific article

Kinetics of acid-induced spectral changes in the GFPmut2 chromophore

scientific article published in January 2005

Magnesium and calcium ions differentially affect human serine racemase activity and modulate its quaternary equilibrium toward a tetrameric form.

scientific article published on 9 January 2017

Modulation of Escherichia coli serine acetyltransferase catalytic activity in the cysteine synthase complex

scientific article published on 24 March 2017

Moonlighting O-acetylserine sulfhydrylase: New functions for an old protein

scientific article

Nanoscale dynamical investigation of the hemoglobin complex with the bacterial protein IsdB: is their interaction stabilized by catch bonds?

scientific article published in 2024

Off to a slow start: Analyzing lag phases and accelerating rates in steady-state enzyme kinetics

scientific article published on 24 January 2020

Oxygen Delivery by Allosteric Effectors of Hemoglobin, Blood Substitutes, and Plasma Expanders

Photoinduced millisecond switching kinetics in the GFPMut2 E222Q mutant.

scientific article

Rational Design, Synthesis, and Preliminary Structure-Activity Relationships of α-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella typhimurium O-Acetylserine Sulfhydrylase

scientific article published on 19 February 2016

Refining the structure-activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms

scholarly article by Joana Magalhães et al published December 2019 in Journal of Enzyme Inhibition and Medicinal Chemistry

Regulation of human serine racemase activity and dynamics by halides, ATP and malonate

article

Role of histidine 148 in stability and dynamics of a highly fluorescent GFP variant

scientific article published on 26 January 2013

Serine racemase: a key player in neuron activity and in neuropathologies

scientific article published on June 2013

Single Amino Acid Replacement Makes Aequorea victoria Fluorescent Proteins Reversibly Photoswitchable

scientific article published on 13 January 2010

Singlet oxygen photosensitisation by GFP mutants: oxygen accessibility to the chromophore

scientific article

Stimulated emission properties of fluorophores by CW-STED single molecule spectroscopy

scientific article

Structural insight into the interaction of O-acetylserine sulfhydrylase with competitive, peptidic inhibitors by saturation transfer difference-NMR.

scientific article

Structural stability of green fluorescent proteins entrapped in polyelectrolyte nanocapsules

scientific article

Structure and single crystal spectroscopy of Green Fluorescent Proteins.

scientific article

Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes

scientific article

Study of DNA binding and bending by Bacillus subtilis GabR, a PLP-dependent transcription factor

scientific article

Sulfur mobilization in cyanobacteria: the catalytic mechanism of L-cystine C-S lyase (C-DES) from synechocystis

scientific article

Surface-exposed tryptophan residues are essential for O-acetylserine sulfhydrylase structure, function, and stability

scientific article

The Energy Landscape of Human Serine Racemase

The allosteric interplay between S-nitrosylation and glycine binding controls the activity of human serine racemase

scientific article published on 29 November 2020

The multifaceted pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase

scientific article published on 28 April 2011

Tracking unfolding and refolding of single GFPmut2 molecules

scientific article

Unfolding of Green Fluorescent Protein mut2 in wet nanoporous silica gels.

scientific article

Unfolding of pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase probed by time-resolved tryptophan fluorescence.

scientific article

Voltage regulation of single green fluorescent protein mutants

scientific article published on 5 October 2006

List of works by Barbara Campanini

A novel Bim-BH3-derived Bcl-XL inhibitor: biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity

A two-step process controls the formation of the bienzyme cysteine synthase complex

ATP binding to human serine racemase is cooperative and modulated by glycine

Activation of an anti-bacterial toxin by the biosynthetic enzyme CysK: mechanism of binding, interaction specificity and competition with cysteine synthase.

Asymmetry of the active site loop conformation between subunits of glutamate-1-semialdehyde aminomutase in solution

Birth of a pathway for sulfur metabolism in early amniote evolution

Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action

Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction

Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target

Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR.

Design and synthesis of trans-2-substituted-cyclopropane-1-carboxylic acids as the first non-natural small molecule inhibitors of O-acetylserine sulfhydrylase

Design of O -Acetylserine Sulfhydrylase Inhibitors by Mimicking Nature

Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand-based drug design

Dynamics of green fluorescent protein mutant2 in solution, on spin-coated glasses, and encapsulated in wet silica gels

Effect of the point mutation H148G on GFPmut2 unfolding kinetics by fluorescence spectroscopy

Enhanced Green Fluorescent Protein (GFP) fluorescence after polyelectrolyte caging

Environment effects on the oscillatory unfolding kinetics of GFP.

Evidence of discrete substates and unfolding pathways in green fluorescent protein

Expanding the chemical space of human serine racemase inhibitors

Exploring O-acetylserine sulfhydrylase-B isoenzyme from Salmonella typhimurium by fluorescence spectroscopy

Fine tuning of the active site modulates specificity in the interaction of O-acetylserine sulfhydrylase isozymes with serine acetyltransferase

GFP-mut2 proteins in trehalose-water matrixes: spatially heterogeneous protein-water-sugar structures

Glutamine 89 is a key residue in the allosteric modulation of human serine racemase activity by ATP.

Green fluorescent protein ground states: the influence of a second protonation site near the chromophore

Human kynurenine aminotransferase II - reactivity with substrates and inhibitors

Human serine racemase is inhibited by glyceraldehyde 3-phosphate, but not by glyceraldehyde 3-phosphate dehydrogenase

Human serine racemase is nitrosylated at multiple sites.

Identification of the structural determinants for the stability of substrate and aminoacrylate external Schiff bases in O-acetylserine sulfhydrylase-A.

Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor

Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives

Inhibitors of the sulfur assimilation pathway in bacterial pathogens as enhancers of antibiotic therapy.

Insight into GFPmut2 pH Dependence by Single Crystal Microspectrophotometry and X-ray Crystallography

Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets.

Interaction of human hemoglobin and semi-hemoglobins with the Staphylococcus aureus hemophore IsdB: a kinetic and mechanistic insight

Interaction of serine acetyltransferase with O-acetylserine sulfhydrylase active site: evidence from fluorescence spectroscopy

Iron Metabolism at the Interface between Host and Pathogen: From Nutritional Immunity to Antibacterial Development

Isozyme-specific ligands for O-acetylserine sulfhydrylase, a novel antibiotic target

Kinetics of acid-induced spectral changes in the GFPmut2 chromophore

Magnesium and calcium ions differentially affect human serine racemase activity and modulate its quaternary equilibrium toward a tetrameric form.

Modulation of Escherichia coli serine acetyltransferase catalytic activity in the cysteine synthase complex

Moonlighting O-acetylserine sulfhydrylase: New functions for an old protein

Nanoscale dynamical investigation of the hemoglobin complex with the bacterial protein IsdB: is their interaction stabilized by catch bonds?

Off to a slow start: Analyzing lag phases and accelerating rates in steady-state enzyme kinetics

Oxygen Delivery by Allosteric Effectors of Hemoglobin, Blood Substitutes, and Plasma Expanders

Photoinduced millisecond switching kinetics in the GFPMut2 E222Q mutant.

Rational Design, Synthesis, and Preliminary Structure-Activity Relationships of α-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella typhimurium O-Acetylserine Sulfhydrylase

Refining the structure-activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms

Regulation of human serine racemase activity and dynamics by halides, ATP and malonate

Role of histidine 148 in stability and dynamics of a highly fluorescent GFP variant

Serine racemase: a key player in neuron activity and in neuropathologies

Single Amino Acid Replacement Makes Aequorea victoria Fluorescent Proteins Reversibly Photoswitchable

Singlet oxygen photosensitisation by GFP mutants: oxygen accessibility to the chromophore

Stimulated emission properties of fluorophores by CW-STED single molecule spectroscopy

Structural insight into the interaction of O-acetylserine sulfhydrylase with competitive, peptidic inhibitors by saturation transfer difference-NMR.

Structural stability of green fluorescent proteins entrapped in polyelectrolyte nanocapsules

Structure and single crystal spectroscopy of Green Fluorescent Proteins.

Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes

Study of DNA binding and bending by Bacillus subtilis GabR, a PLP-dependent transcription factor

Sulfur mobilization in cyanobacteria: the catalytic mechanism of L-cystine C-S lyase (C-DES) from synechocystis

Surface-exposed tryptophan residues are essential for O-acetylserine sulfhydrylase structure, function, and stability

The Energy Landscape of Human Serine Racemase

The allosteric interplay between S-nitrosylation and glycine binding controls the activity of human serine racemase

The multifaceted pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase

Tracking unfolding and refolding of single GFPmut2 molecules

Unfolding of Green Fluorescent Protein mut2 in wet nanoporous silica gels.

Unfolding of pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase probed by time-resolved tryptophan fluorescence.

Voltage regulation of single green fluorescent protein mutants