Search filters

List of works by Chung-Jung Tsai

'Latent drivers' expand the cancer mutational landscape

scientific article published on 05 February 2015

'Pathway drug cocktail': targeting Ras signaling based on structural pathways

scientific article published on 15 August 2013

A New View of Pathway-Driven Drug Resistance in Tumor Proliferation

scientific article published on 25 February 2017

A New View of Ras Isoforms in Cancers

scientific article

A broad view of scaffolding suggests that scaffolding proteins can actively control regulation and signaling of multienzyme complexes through allostery

scientific article published on 03 January 2013

A hierarchical protein folding scheme based on the building block folding model.

scientific article

A new, structurally nonredundant, diverse data set of protein-protein interfaces and its implications

scientific article

A unified convention for biological assemblies with helical symmetry

scientific article

A unified view of "how allostery works"

scientific article (publication date: February 2014)

Allo-network drugs: harnessing allostery in cellular networks

scientific article published on 16 September 2011

Allosteric activation of RAF in the MAPK signaling pathway

scientific article published on 27 July 2018

Allosteric conformational barcodes direct signaling in the cell

scientific article published on September 2013

Allosteric post-translational modification codes

scientific article published on 08 August 2012

Allostery in Its Many Disguises: From Theory to Applications

scientific article published on 07 February 2019

Allostery in disease and in drug discovery

scientific article

Allostery modulates the beat rate of a cardiac pacemaker

scientific article

Allostery without a conformational change? Revisiting the paradigm.

scientific article

Allostery: absence of a change in shape does not imply that allostery is not at play

scientific article published on 29 February 2008

Analysis of ordered and disordered protein complexes reveals structural features discriminating between stable and unstable monomers

scientific article

Are Parallel Proliferation Pathways Redundant?

scientific article published on 25 April 2020

Autoinhibition can identify rare driver mutations and advise pharmacology

scientific article published on 22 November 2019

Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: a comprehensive review underscoring the challenges in pharmacological intervention

scientific article published on 29 September 2018

Calmodulin and IQGAP1 activation of PI3Kα and Akt in KRAS, HRAS and NRAS-driven cancers

scientific article published on 30 October 2017

Calmodulin and PI3K Signaling in KRAS Cancers

scientific article published on 18 February 2017

Comparison of protein fragments identified by limited proteolysis and by computational cutting of proteins

scientific article published on July 2002

Computational Structural Biology: Successes, Future Directions, and Challenges

Correction: Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers

scientific article published on 12 June 2019

Designing a nanotube using naturally occurring protein building blocks

scientific article published on 28 April 2006

Does Ras Activate Raf and PI3K Allosterically?

scientific article published on 15 November 2019

Dynamic Protein Allosteric Regulation and Disease

scientific article published on 01 January 2019

Dynamic allostery: linkers are not merely flexible

scientific article published on July 2011

Emerging Allosteric Mechanism of EGFR Activation in Physiological and Pathological Contexts

scientific article published on 28 May 2019

Energy landscape of amyloidogenic peptide oligomerization by parallel-tempering molecular dynamics simulation: significant role of Asn ladder

scientific article

Extended disordered proteins: targeting function with less scaffold

scientific article (publication date: February 2003)

Free energy diagrams for protein function

scientific article published on 06 February 2014

Gene-specific transcription activation via long-range allosteric shape-shifting

scientific article published on October 2011

HMI-PRED: A Web Server for Structural Prediction of Host-Microbe Interactions Based on Interface Mimicry

scientific article published on 13 February 2020

Hierarchical protein folding pathways: a computational study of protein fragments.

scientific article

Hollow core of Alzheimer's Abeta42 amyloid observed by cryoEM is relevant at physiological pH.

scientific article

How do transcription factors select specific binding sites in the genome?

scientific article published in November 2009

In silico protein design by combinatorial assembly of protein building blocks

scientific article published on October 2004

Independent and core pathways in oncogenic KRAS signaling

scientific article published on 7 July 2016

Insights into amyloid structural formation and assembly through computational approaches

scientific article

Interface-Based Structural Prediction of Novel Host-Pathogen Interactions

scientific article published on 01 January 2019

Intra-molecular chaperone: the role of the N-terminal in conformational selection and kinetic control

scientific article published on 4 February 2009

Intrinsic protein disorder in oncogenic KRAS signaling

scientific article

Is Nanoclustering essential for all oncogenic KRas pathways? Can it explain why wild-type KRas can inhibit its oncogenic variant?

scientific article published on 4 January 2018

K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?

scientific article published on 12 February 2016

Maximal stabilities of reversible two-state proteins

scientific article published in April 2002

Mechanisms of transcription factor selectivity

scientific article published on 13 January 2010

Multiple conformational selection and induced fit events take place in allosteric propagation.

scientific article published on 31 October 2013

Mutational analysis and allosteric effects in the HIV-1 capsid protein carboxyl-terminal dimerization domain

scientific article published on February 2009

Nanostructure design using protein building blocks enhanced by conformationally constrained synthetic residues

scientific article

Oligomerization and nanocluster organization render specificity

scientific article

Oncogenic K-Ras4B Dimerization Enhances Downstream Mitogen-activated Protein Kinase Signaling

scientific article published on 10 January 2020

Oncogenic KRAS signaling and YAP1/β-catenin: Similar cell cycle control in tumor initiation

scientific article published on 4 April 2016

Oncogenic KRas mobility in the membrane and signaling response.

scientific article published on 27 February 2018

Oncogenic Ras Isoforms Signaling Specificity at the Membrane

scientific article published on 22 December 2017

Oncoviruses Can Drive Cancer by Rewiring Signaling Pathways Through Interface Mimicry

scientific article published on 15 November 2019

Pathogen mimicry of host protein-protein interfaces modulates immunity

scientific article

Phosphorylation and Driver Mutations in PI3Kα and PTEN Autoinhibition

scientific article published on 07 December 2020

Precision medicine review: rare driver mutations and their biophysical classification

article

Prediction of Host-Pathogen Interactions for Helicobacter pylori by Interface Mimicry and Implications to Gastric Cancer

scientific article

Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation

scientific article published on 23 October 2015

Principles of Shape-Driven Nanostructure Design via Self-Assembly of Protein Building Blocks

Principles of allosteric interactions in cell signaling

scientific article

Principles of nanostructure design with protein building blocks

scientific article

Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms ⬇️

scientific article

Protein ensembles link genotype to phenotype.

scientific article published on 20 June 2019

Protein-protein interaction networks: how can a hub protein bind so many different partners?

scientific article published on December 2009

RASSF5: An MST activator and tumor suppressor in vivo but opposite in vitro

scientific article published on 16 September 2016

Ras assemblies and signaling at the membrane

scientific article published on 04 February 2020

Reducing the computational complexity of protein folding via fragment folding and assembly

scientific article published in June 2003

Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers

article

Self-assembly of fused homo-oligomers to create nanotubes

scientific article published on January 2008

Structural host-microbiota interaction networks

scientific article

Structural stability and dynamics of an amyloid-forming peptide GNNQQNY from the yeast prion sup-35.

scientific article

Structure by design: from single proteins and their building blocks to nanostructures

scientific article

Symmetry-based self-assembled nanotubes constructed using native protein structures: the key role of flexible linkers

scientific article published in April 2011

Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima

scientific article published on 12 August 2008

TRAF3 signaling: Competitive binding and evolvability of adaptive viral molecular mimicry.

scientific article published on 18 May 2016

Tandem Domains with Tuned Interactions Are a Powerful Biological Design Principle

scientific article published on 30 November 2015

Temperature range of thermodynamic stability for the native state of reversible two-state proteins

scientific article

The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway

scientific article

The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas

scientific article

The Mystery of Rap1 Suppression of Oncogenic Ras

scientific article published on 02 March 2020

The Role of Allostery in the Termination of Second Messenger Signaling

scientific article

The design of covalent allosteric drugs

scientific article

The different ways through which specificity works in orthosteric and allosteric drugs

scientific article published in January 2012

The dynamic mechanism of RASSF5 and MST kinase activation by Ras.

scientific article published on 15 February 2017

The free energy landscape in translational science: how can somatic mutations result in constitutive oncogenic activation?

scientific article

The hydrophobic effect: a new insight from cold denaturation and a two-state water structure

scientific article

The implications of higher (or lower) success in secondary structure prediction of chain fragments

scientific article published on August 2005

The molecular basis of targeting protein kinases in cancer therapeutics

scientific article published on 04 May 2013

The origin of allosteric functional modulation: multiple pre-existing pathways

scientific article published on August 2009

The stability and dynamics of the human calcitonin amyloid peptide DFNKF

scientific article

The structural basis for cancer treatment decisions

scientific article

The underappreciated role of allostery in the cellular network.

scientific article

Thermal unfolding molecular dynamics simulation of Escherichia coli dihydrofolate reductase: thermal stability of protein domains and unfolding pathway

scientific article published on February 2002

Unraveling structural mechanisms of allosteric drug action

scientific article published on 14 April 2014

Why Are Some Driver Mutations Rare?

scientific article published on 05 November 2019

Why does binding of proteins to DNA or proteins to proteins not necessarily spell function?

scientific article

Paulina is supported by:

About Paulina

Help