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List of works by Rafael Moreno-Sanchez

A web-based multimedia spatial information system to document Aedes aegypti breeding sites and dengue fever risk along the US-Mexico border

scientific article

Accumulation of arsenic, lead, copper, and zinc, and synthesis of phytochelatins by indigenous plants of a mining impacted area.

scientific article

Activation of methanogenesis by cadmium in the marine archaeon Methanosarcina acetivorans.

scientific article

Activation of pyruvate dehydrogenase complex by Ca2+ in intact heart, cardiac myocytes, and cardiac mitochondria

scientific article published on 01 January 1989

Air-adapted Methanosarcina acetivorans shows high methane production and develops resistance against oxygen stress

scientific article

Anti-mitochondrial therapy in human breast cancer multi-cellular spheroids

scientific article published on 27 November 2012

Assessment of the low inhibitory specificity of oxamate, aminooxyacetate and dichloroacetate on cancer energy metabolism.

scientific article

Bio-recovery of non-essential heavy metals by intra- and extracellular mechanisms in free-living microorganisms

scientific article published on 13 May 2016

Biochemistry and Physiology of Heavy Metal Resistance and Accumulation in Euglena.

scientific article published on January 2017

Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

scientific article published on 21 December 2009

Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi

scientific article published on 11 November 2017

Cadmium accumulation in the chloroplast of Euglena gracilis

scientific article published on 01 June 2002

Cadmium removal by Euglena gracilis is enhanced under anaerobic growth conditions.

scientific article published on 11 February 2015

Canonical and new generation anticancer drugs also target energy metabolism.

scientific article published on 04 May 2014

Cardiotoxicity of copper-based antineoplastic drugs casiopeinas is related to inhibition of energy metabolism.

scientific article published on 26 July 2005

Casiopeina II-gly and bromo-pyruvate inhibition of tumor hexokinase, glycolysis, and oxidative phosphorylation.

scientific article

Cd2+ resistance mechanisms in Methanosarcina acetivorans involve the increase in the coenzyme M content and induction of biofilm synthesis.

scientific article published on 25 July 2013

Cd2+ transport and storage in the chloroplast of Euglena gracilis

scientific article published on 01 January 2005

Celecoxib inhibits mitochondrial O2 consumption, promoting ROS dependent death of murine and human metastatic cancer cells via the apoptotic signalling pathway

scientific article published on 23 May 2018

Cell wall composition affects Cd2+ accumulation and intracellular thiol peptides in marine red algae

scientific article published on 11 November 2006

Characterization of an aldehyde dehydrogenase from Euglena gracilis

scientific article published in January 2006

Characterization of oxidative phosphorylation in the colorless chlorophyte Polytomella sp. Its mitochondrial respiratory chain lacks a plant-like alternative oxidase.

scientific article published in July 2002

Chromium uptake, retention and reduction in photosynthetic Euglena gracilis.

scientific article published on 17 March 2009

Control and regulation of the pyrophosphate-dependent glucose metabolism in Entamoeba histolytica

scientific article published on 14 February 2019

Control of cellular proliferation by modulation of oxidative phosphorylation in human and rodent fast-growing tumor cells

scientific article published on 31 March 2006

Control of glutathione and phytochelatin synthesis under cadmium stress. Pathway modeling for plants

scientific article published on 25 August 2005

Control of oxidative phosphorylation in AS-30D hepatoma mitochondria.

scientific article published in March 1993

Control of oxidative phosphorylation in mitochondria, cells and tissues ⬇️

scientific article published on January 1, 1991

Control of superoxide production in mitochondria from maize mesocotyls.

scientific article published in July 2004

Control of the NADPH supply and GSH recycling for oxidative stress management in hepatoma and liver mitochondria

scientific article published on 24 July 2018

Control of the NADPH supply for oxidative stress handling in cancer cells

scientific article

Cytosol-mitochondria transfer of reducing equivalents by a lactate shuttle in heterotrophic Euglena.

scientific article

Determining and understanding the control of flux. An illustration in submitochondrial particles of how to validate schemes of metabolic control

scientific article published on 01 September 1999

Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase

scientific article published on 01 May 2006

Drug Target Selection for Trypanosoma cruzi Metabolism by Metabolic Control Analysis and Kinetic Modeling

scientific article published on 01 January 2019

Drug target validation of the trypanothione pathway enzymes through metabolic modelling

scientific article published on 4 April 2012

Dual regulation of energy metabolism by p53 in human cervix and breast cancer cells

scientific article published in October 2015

Early carbon mobilization and radicle protrusion in maize germination

scientific article published on 18 May 2012

Editorial: Metabolic Plasticity of Cancer

scientific article published on 23 October 2020

Editorial: The Bioenergetics of Cancer, the Warburg Hypothesis and the Mitochondrial Function

scientific article published on 01 January 2013

Efflux of chromate by Pseudomonas aeruginosa cells expressing the ChrA protein

scientific article

Emergence of the silicon human and network targeting drugs

article

Energy Metabolism Drugs Block Triple Negative Breast Metastatic Cancer Cell Phenotype

scientific article published on 23 May 2018

Energy metabolism in tumor cells

scientific article

Energy metabolism transition in multi-cellular human tumor spheroids.

scientific article published on July 2008

Enhanced Heavy Metal Tolerance in Two Strains of Photosynthetic Euglena gracilis by Preexposure to Mercury or Cadmium

scientific article published on 01 February 1998

Enhanced alternative oxidase and antioxidant enzymes under Cd(2+) stress in Euglena

scientific article published on 25 September 2007

Entamoeba histolytica: kinetic and molecular evidence of a previously unidentified pyruvate kinase.

scientific article published in January 2004

Erratum to: Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death

scholarly article published in Pharmaceutical Research

Experimental validation of metabolic pathway modeling

scientific article published on 28 May 2008

FruBPase II and ADP-PFK1 are involved in the modulation of carbon flow in the metabolism of carbohydrates in Methanosarcina acetivorans

scientific article published on 22 May 2019

Functional and metabolic implications of biotin deficiency for the rat heart

scientific article published on 27 September 2008

GPI/AMF inhibition blocks the development of the metastatic phenotype of mature multi-cellular tumor spheroids.

scientific article

Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity

scientific article published on 28 May 2019

Gene cloning and biochemical characterization of an alcohol dehydrogenase from Euglena gracilis

scientific article published in November 2008

Glycolysis in Entamoeba histolytica. Biochemical characterization of recombinant glycolytic enzymes and flux control analysis.

scientific article published in April 2005

Glycolysis in Ustilago maydis.

scientific article

HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression

scientific article published on 05 June 2013

HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms.

scientific article published on August 2009

HPI/AMF inhibition halts the development of the aggressive phenotype of breast cancer stem cells

scientific article published on 22 June 2017

Heart Metabolic Disturbances in Cardiovascular Diseases ⬇️

scientific article published on March 1, 2003

Hitting the Bull's-Eye in Metastatic Cancers-NSAIDs Elevate ROS in Mitochondria, Inducing Malignant Cell Death.

scientific article

Hypoglycemia Enhances Epithelial-Mesenchymal Transition and Invasiveness, and Restrains the Warburg Phenotype, in Hypoxic HeLa Cell Cultures and Microspheroids.

scientific article published on 23 September 2016

Identification of a metabolic and canonical biomarker signature in Mexican HR+/HER2-, triple positive and triple-negative breast cancer patients.

scientific article published on 25 September 2014

Impairment of glucose metabolism and energy transfer in the rat heart

scientific article published in July 2003

In vivo identification of the steps that control energy metabolism and survival of Entamoeba histolytica

scientific article published on 21 November 2014

Increased synthesis of α-tocopherol, paramylon and tyrosine by Euglena gracilis under conditions of high biomass production ⬇️

scientific article published on September 21, 2010

Induction of CYP1A1 and CYP2E1 in rat liver by histamine: binding and kinetic studies.

scientific article published on 13 April 2007

Inhibition of Non-flux-Controlling Enzymes Deters Cancer Glycolysis by Accumulation of Regulatory Metabolites of Controlling Steps

scientific article published on 23 September 2016

Inhibition of substrate oxidation in mitochondria by the peripheral-type benzodiazepine receptor ligand AHN 086

scientific article published on 01 May 1991

Inhibitors of succinate: quinone reductase/Complex II regulate production of mitochondrial reactive oxygen species and protect normal cells from ischemic damage but induce specific cancer cell death.

scientific article published on 24 August 2011

Isolation and characterization of gallium resistant Pseudomonas aeruginosa mutants.

scientific article published on 6 August 2013

Kinetic and thermodynamic characterization of adenylyl cyclase from Euglena gracilis.

scientific article

Kinetic mechanism and metabolic role of pyruvate phosphate dikinase from Entamoeba histolytica

scientific article published on 14 October 2004

Kinetic modeling can describe in vivo glycolysis in Entamoeba histolytica

scientific article published on 01 September 2007

Kinetic modeling of glucose central metabolism in hepatocytes and hepatoma cells

scientific article published on 23 July 2020

Kinetics of transport and phosphorylation of glucose in cancer cells.

scientific article

Marine Archaeon Methanosarcina acetivorans Enhances Polyphosphate Metabolism Under Persistent Cadmium Stress

scientific article published on 24 October 2019

Mercury pretreatment selects an enhanced cadmium-accumulating phenotype in Euglena gracilis.

scientific article published on 9 May 2003

Mercury uptake and removal by Euglena gracilis.

scientific article published in September 2000

Metabolic Control Analysis for Drug Target Prioritization in Trypanosomatids

scientific article published on 01 January 2020

Metabolic Control Theory

scientific article published in 2013

Metabolic changes induced by cold stress in rat liver mitochondria.

scientific article

Metabolic control analysis indicates a change of strategy in the treatment of cancer

scientific article published on 25 June 2010

Metabolic control analysis of the Trypanosoma cruzi peroxide detoxification pathway identifies tryparedoxin as a suitable drug target

scientific article published on 30 October 2014

Metabolic control analysis: a tool for designing strategies to manipulate metabolic pathways.

scientific article published on January 2008

Mitochondrial bound hexokinase activity as a preventive antioxidant defense: steady-state ADP formation as a regulatory mechanism of membrane potential and reactive oxygen species generation in mitochondria.

scientific article

Mitochondrial free fatty acid β-oxidation supports oxidative phosphorylation and proliferation in cancer cells.

scientific article published on 11 June 2015

Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II

scientific article

Modeling cancer glycolysis

scientific article published on 24 November 2010

Modeling cancer glycolysis under hypoglycemia, and the role played by the differential expression of glycolytic isoforms.

scientific article published in July 2014

Modulation of 2-oxoglutarate dehydrogenase and oxidative phosphorylation by Ca2+ in pancreas and adrenal cortex mitochondria

scientific article published on 01 June 1995

Modulation of 2-oxoglutarate dehydrogenase complex by inorganic phosphate, Mg(2+), and other effectors

scientific article published on 01 July 2000

Modulation of oxidative phosphorylation by Mg2+ in rat heart mitochondria

scientific article published on 01 April 1998

Molecular basis of the unusual catalytic preference for GDP/GTP in Entamoeba histolytica 3-phosphoglycerate kinase.

scientific article published in April 2009

Molecular mechanism for the selective impairment of cancer mitochondrial function by a mitochondrially targeted vitamin E analogue

scientific article published on 22 May 2012

Molecular mechanisms of resistance to heavy metals in the protist Euglena gracilis.

scientific article published on August 2007

Multi-biomarker pattern for tumor identification and prognosis

scientific article published on October 2011

Multisite control of the Crabtree effect in ascites hepatoma cells.

scientific article published in April 2001

Mutant p53 downregulates oxidative phosphorylation and upregulates glycolysis under normoxia and hypoxia in human cervix cancer cells

scientific article published on 10 September 2018

Non-Steroidal Anti-Inflammatory Drugs Increase Cisplatin, Paclitaxel, and Doxorubicin Efficacy against Human Cervix Cancer Cells

scientific article published on 15 December 2020

Novel mitochondrial alcohol metabolizing enzymes of Euglena gracilis

scientific article published on 21 July 2011

On the mechanism by which 6-ketocholestanol protects mitochondria against uncoupling-induced Ca2+ efflux

scientific article published on 01 February 1996

On the protection by inorganic phosphate of calcium-induced membrane permeability transition

scientific article published on 01 December 1997

Oxidative phosphorylation as a target to arrest malignant neoplasias.

scientific article published on January 2011

Oxidative phosphorylation is impaired by prolonged hypoxia in breast and possibly in cervix carcinoma

scientific article published on 21 July 2010

Oxidative phosphorylation supported by an alternative respiratory pathway in mitochondria from Euglena

scientific article published on 01 April 2000

Oxidized ATM protein kinase is a new signal transduction player that regulates glycolysis in CAFs as well as tumor growth and metastasis

scientific article published on 04 March 2019

PPARs, metabolic syndrome and cardiac diseases

scientific article

Phosphofructokinase type 1 kinetics, isoform expression, and gene polymorphisms in cancer cells

scientific article

Phosphorylation of the spinach chloroplast 24 kDa RNA-binding protein (24RNP) increases its binding to petD and psbA 3′ untranslated regions

scientific article published on 19 April 2006

Physiological Role of Glutamate Dehydrogenase in Cancer Cells

scientific article published on 09 April 2020

Physiological role of rhodoquinone in Euglena gracilis mitochondria

scientific article published on 4 November 2005

Phytochelatin-cadmium-sulfide high-molecular-mass complexes of Euglena gracilis

scientific article published on 01 December 2006

Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde-alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica.

scientific article published on 12 July 2010

Reactive oxygen species are generated by the respiratory complex II--evidence for lack of contribution of the reverse electron flow in complex I.

scientific article published on 7 January 2013

Removal, accumulation and resistance to chromium in heterotrophic Euglena gracilis

scientific article published on 23 July 2011

Repurposing drugs as pro-oxidant redox modifiers to eliminate cancer stem cells and improve the treatment of advanced stage cancers

scientific article published on 20 May 2019

Resveratrol inhibits cancer cell proliferation by impairing oxidative phosphorylation and inducing oxidative stress

scientific article published on 13 March 2019

Role of Aldehyde Dehydrogenases in Physiopathological Processes

scientific article published on 25 January 2019

Role of protonatable groups of bovine heart bc1 complex in ubiquinol binding and oxidation ⬇️

scientific article published on November 1, 2001

Roles of acetyl-CoA synthetase (ADP-forming) and acetate kinase (PPi-forming) in ATP and PPi supply in Entamoeba histolytica

scientific article

Short-chain chromate ion transporter proteins from Bacillus subtilis confer chromate resistance in Escherichia coli.

scientific article published on 6 July 2009

Simultaneous Cd2+, Zn2+, and Pb2+ uptake and accumulation by photosynthetic Euglena gracilis

scientific article published on 23 September 2006

Structural and functional changes in heart mitochondria from sucrose-fed hypertriglyceridemic rats.

scientific article

Substrate oxidation and ATP supply in AS-30D hepatoma cells

scientific article published on 01 March 2000

Sulfate uptake in photosynthetic Euglena gracilis. Mechanisms of regulation and contribution to cysteine homeostasis.

scientific article published on 18 May 2012

Sulfite and membrane energization induce two different active states of the Paracoccus denitrificans F0F1-ATPase

scientific article published on 01 February 2000

Sulfur assimilation and glutathione metabolism under cadmium stress in yeast, protists and plants

scientific article

Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II.

scientific article published on 17 February 2009

Targeting Trypanothione Metabolism in Trypanosomatid Human Parasites ⬇️

scientific article published on December 1, 2010

Targeting of cancer energy metabolism.

scientific article published on January 2009

The 2-oxoglutarate supply exerts significant control on the lysine synthesis flux in Saccharomyces cerevisiae.

scientific article published on 13 September 2013

The Lys20 homocitrate synthase isoform exerts most of the flux control over the lysine synthesis pathway in Saccharomyces cerevisiae

scientific article published on 29 September 2011

The Membrane-bound L- and D-lactate dehydrogenase activities in mitochondria from Euglena gracilis.

scientific article published in June 2001

The Pb-hyperaccumulator aquatic fern Salvinia minima Baker, responds to Pb(2+) by increasing phytochelatins via changes in SmPCS expression and in phytochelatin synthase activity

scientific article published on 12 November 2008

The Warburg Hypothesis and the ATP Supply In Cancer Cells Is Oxidative Phosphorylation impaired in malignant neoplasias?

scientific article published on June 2012

The alternative respiratory pathway of euglena mitochondria.

scientific article published in October 2004

The bacterial-like lactate shuttle components from heterotrophic Euglena gracilis.

scientific article published in September 2005

The bifunctional aldehyde-alcohol dehydrogenase controls ethanol and acetate production in Entamoeba histolytica under aerobic conditions

scientific article published on 28 November 2012

The bioenergetics of cancer: is glycolysis the main ATP supplier in all tumor cells?

scientific article published on March 2009

The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy

scientific article published on 02 March 2010

The mitochondrial membrane permeability transition induced by inorganic phosphate or inorganic arsenate. A comparative study

scientific article published on 01 May 1997

The nutritional status of Methanosarcina acetivorans regulates glycogen metabolism and gluconeogenesis and glycolysis fluxes.

scientific article

Thiol peptides induction in the seagrass Thalassia testudinum (Banks ex König) in response to cadmium exposure.

scientific article published on 7 September 2007

Tight binding of inhibitors to bovine bc1 complex is independent of the Rieske protein redox state. Consequences for semiquinone stabilization in the quinol oxidation site.

scientific article published on 2 October 2002

Time-course development of the Cd2+ hyper-accumulating phenotype in Euglena gracilis.

scientific article published on 21 October 2005

Toxic effects of Cr(VI) and Cr(III) on energy metabolism of heterotrophic Euglena gracilis.

scientific article published on 24 August 2010

Toxic effects of copper-based antineoplastic drugs (Casiopeinas) on mitochondrial functions.

scientific article published on June 2003

Transcriptional Regulation of Energy Metabolism in Cancer Cells

scientific article published on 09 October 2019

Understanding the cancer cell phenotype beyond the limitations of current omics analyses

scientific article published on 29 September 2015

Who controls the ATP supply in cancer cells? Biochemistry lessons to understand cancer energy metabolism

scientific article published on 07 February 2014

Zn-bis-glutathionate is the best co-substrate of the monomeric phytochelatin synthase from the photosynthetic heavy metal-hyperaccumulator Euglena gracilis

scientific article published on 24 January 2014

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