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List of works by Johannes P van Leeuwen

1,25-dihydroxyvitamin D(3)-independent stimulatory effect of estrogen on the expression of ECaC1 in the kidney.

scientific article

11beta-Hydroxysteroid dehydrogenase expression and glucocorticoid synthesis are directed by a molecular switch during osteoblast differentiation.

scientific article

1Alpha,25-(OH)2D3 acts in the early phase of osteoblast differentiation to enhance mineralization via accelerated production of mature matrix vesicles.

scientific article

1α,25-dihydroxyvitamin D3 stimulates activin A production to fine-tune osteoblast-induced mineralization.

scientific article published on November 2013

5-HIAA excretion is not associated with bone metabolism in carcinoid syndrome patients.

scientific article

A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells

scientific article published on 29 January 2012

A central dinucleotide within vitamin D response elements modulates DNA binding and transactivation by the vitamin D receptor in cellular response to natural and synthetic ligands

scientific article

A comparison of UVb compact lamps in enabling cutaneous vitamin D synthesis in growing bearded dragons.

scientific article published on 27 April 2017

A cross-sectional study on biochemical parameters of bone turnover and vitamin d metabolites in healthy dutch children and young adults.

scientific article

A human vitamin D receptor mutation causes rickets and impaired Th1/Th17 responses

scientific article published on 6 September 2014

A new concept underlying stem cell lineage skewing that explains the detrimental effects of thiazolidinediones on bone.

scientific article published on May 2010

A role for subchondral bone changes in the process of osteoarthritis; a micro-CT study of two canine models.

scientific article

A small molecule approach to engineering vascularized tissue.

scientific article

ADAMTS5-/- mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage and subchondral bone changes

scientific article published on 17 October 2008

Activin A suppresses osteoblast mineralization capacity by altering extracellular matrix (ECM) composition and impairing matrix vesicle (MV) production.

scientific article published on 17 June 2013

Adverse Effects of Diabetes Mellitus on the Skeleton of Aging Mice

scientific article published on 18 September 2015

Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6

scientific article published on 16 May 2006

Age-related skeletal dynamics and decrease in bone strength in DNA repair deficient male trichothiodystrophy mice

scientific article (publication date: 2012)

An Age-Dependent Interaction with Leptin Unmasks Ghrelin's Bone-Protective Effects ⬇️

scientific article published on June 14, 2012

Analysis of osteoarthritis in a mouse model of the progeroid human DNA repair syndrome trichothiodystrophy.

scientific article

Anti-tumor effects of 1,25-dihydroxyvitamin D3 and vitamin D analogs.

scientific article

Antiestrogens inhibit in vitro bone resorption stimulated by 1,25-dihydroxyvitamin D3 and the vitamin D3 analogs EB1089 and KH1060

scientific article published on 01 February 1995

Basic techniques in human mesenchymal stem cell cultures: differentiation into osteogenic and adipogenic lineages, genetic perturbations, and phenotypic analyses.

scientific article

Bidirectional regulation of the 1,25-dihydroxyvitamin D3 receptor by phorbol ester-activated protein kinase-C in osteoblast-like cells: interaction with adenosine 3',5'-monophosphate-induced up-regulation of the 1,25-dihydroxyvitamin D3 receptor

scientific article published on April 1, 1992

Bioinformatics-based selection of a model cell type for in vitro biomaterial testing.

scientific article published on 28 April 2013

Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice

scientific article published on 04 August 2011

Bone mineral density and vertebral fracture history are associated with incident and progressive radiographic knee osteoarthritis in elderly men and women: the Rotterdam Study

scientific article published on 01 October 2005

Bone resorption inhibitor alendronate normalizes the reduced bone thickness of TRPV5(-/-) mice.

scientific article published in November 2008

Calcifying vascular smooth muscle cells and osteoblasts: independent cell types exhibiting extracellular matrix and biomineralization-related mimicries.

scientific article

Cancer and bone: a complex complex

scientific article

Cartilage damage pattern in relation to subchondral plate thickness in a collagenase-induced model of osteoarthritis

scientific article published on 27 September 2007

Characterization of vitamin D-deficient klotho(-/-) mice: do increased levels of serum 1,25(OH)2D3 cause disturbed calcium and phosphate homeostasis in klotho(-/-) mice?

scientific article published on 09 July 2012

Collagen I derived recombinant protein microspheres as novel delivery vehicles for bone morphogenetic protein-2.

scientific article published in December 2017

Common Genetic Variation of the Low-Density Lipoprotein Receptor-Related Protein 5 and 6 Genes Determines Fracture Risk in Elderly White Men

article

Comparative proteomic profiling of human osteoblast-derived extracellular matrices identifies proteins involved in mesenchymal stromal cell osteogenic differentiation and mineralization

scientific article published on 8 March 2017

Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathway

scientific article

Consequences of vitamin D receptor gene polymorphisms for growth inhibition of cultured human peripheral blood mononuclear cells by 1, 25-dihydroxyvitamin D3

scientific article published on 01 February 2000

Consequences of vitamin D receptor regulation for the 1,25-dihydroxyvitamin D3-induced 24-hydroxylase activity in osteoblast-like cells: initiation of the C24-oxidation pathway

scientific article published on 01 March 1997

Cyclical etidronate in the prevention of bone loss in corticosteroid-treated primary biliary cirrhosis. A prospective, controlled pilot study

scientific article published on 01 February 1997

Decreased oxygen tension lowers reactive oxygen species and apoptosis and inhibits osteoblast matrix mineralization through changes in early osteoblast differentiation.

scientific article published on April 2012

Design principles of nuclear receptor signaling: how complex networking improves signal transduction.

scientific article

Detection of sequence variability of the collagen type IIalpha 1 3' variable number of tandem repeat

scientific article published on 01 November 2000

Development of osteoarthritic features in estrogen receptor knockout mice.

scientific article published on 17 April 2009

Dexamethasone in osteogenic medium strongly induces adipocyte differentiation of mouse bone marrow stromal cells and increases osteoblast differentiation.

scientific article

Dietary 135-fold cholecalciferol supplementation severely disturbs the endochondral ossification in growing dogs.

scientific article published in May 2003

Differential Genetic Effects of ESR1 Gene Polymorphisms on Osteoporosis Outcomes

scientific article published in The Journal of the American Medical Association

Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells.

scientific article published on November 1997

Distinct conformations of vitamin D receptor/retinoid X receptor-alpha heterodimers are specified by dinucleotide differences in the vitamin D-responsive elements of the osteocalcin and osteopontin genes

scientific article published on 01 November 1996

Distinct effects on the conformation of estrogen receptor alpha and beta by both the antiestrogens ICI 164,384 and ICI 182,780 leading to opposite effects on receptor stability

scientific article published on 01 July 1999

EVpedia: a community web portal for extracellular vesicles research

scientific article

Editorial: Launch of Biochemistry and Biophysics Reports.

scientific article published on 15 April 2015

Effect of calcium and cholecalciferol supplementation on several parameters of calcium status in plasma and urine of captive Asian (Elephas maximus) and African elephants (Loxodonta africana).

scientific article

Effects of dexamethasone-loaded PLGA microspheres on human fetal osteoblasts.

scientific article

Effects of vitamin D3 supplementation and UVb exposure on the growth and plasma concentration of vitamin D3 metabolites in juvenile bearded dragons (Pogona vitticeps).

scientific article published on 4 March 2010

Estrogen modulates iodoacetate-induced gene expression in bovine cartilage explants.

scientific article published in May 2010

Estrogen receptor polymorphism predicts the onset of natural and surgical menopause

scientific article published on 01 September 1999

Evidence for multiple peroxisome proliferator-activated receptor gamma transcripts in bone: fine-tuning by hormonal regulation and mRNA stability.

scientific article

Evidence of vitamin D and interferon‐β cross‐talk in human osteoblasts with 1α,25‐dihydroxyvitamin D3 being dominant over interferon‐β in stimulating mineralization ⬇️

scientific article published on September 1, 2012

Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms.

scientific article published on 19 July 2016

Extracellular vesicles: specialized bone messengers.

scientific article published on 22 May 2014

Fibroblast growth factor-2 in serum-free medium is a potent mitogen and reduces dedifferentiation of human ear chondrocytes in monolayer culture.

scientific article

Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study

scientific article published on 01 January 2004

GPM6B regulates osteoblast function and induction of mineralization by controlling cytoskeleton and matrix vesicle release ⬇️

scientific article published on September 1, 2011

Genetic manipulation of the ghrelin signaling system in male mice reveals bone compartment specificity of acylated and unacylated ghrelin in the regulation of bone remodeling

scientific article published on 25 July 2014

Ghrelin and bone.

scientific article published on January 2008

Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a

scientific article

High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam Study

scientific article published on 11 January 2013

High content imaging in the screening of biomaterial-induced MSC behavior.

scientific article published on 23 November 2012

Homocysteine levels and the risk of osteoporotic fracture

scientific article

Hydroxychloroquine affects bone resorption both in vitro and in vivo.

scientific article published on 30 May 2017

Hydroxychloroquine decreases human MSC-derived osteoblast differentiation and mineralization in vitro.

scientific article

Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice.

scientific article

IFNβ impairs extracellular matrix formation leading to inhibition of mineralization by effects in the early stage of human osteoblast differentiation.

scientific article

Identification of Three Early Phases of Cell-Fate Determination during Osteogenic and Adipogenic Differentiation by Transcription Factor Dynamics

scientific article published on 16 March 2017

Identification of acid-sensing ion channels in bone.

scientific article published in November 2005

Identification of microRNAs in Human Plasma

scientific article published on 01 January 2015

Immunolocalization and quantification of noncollagenous bone matrix proteins in methylmethacrylate-embedded adult human bone in combination with histomorphometry.

scientific article published on April 1998

In vitro cytotoxicity evaluation of porous TiO₂-Ag antibacterial coatings for human fetal osteoblasts.

scientific article

Induction of ornithine decarboxylase activity in isolated chicken osteoblasts by parathyroid hormone: the role of cAMP and calcium

scientific article published on 01 July 1988

Inhibition of insulin- and insulin-like growth factor-I-stimulated growth of human breast cancer cells by 1,25-dihydroxyvitamin D3 and the vitamin D3 analogue EB1089

scientific article published on 01 May 1996

Interaction between the vitamin D receptor gene and collagen type Ialpha1 gene in susceptibility for fracture.

scientific article

Interaction between vitamin D receptor genotype and estrogen receptor alpha genotype influences vertebral fracture risk.

scientific article published in August 2003

Intrinsic differentiation potential of adolescent human tendon tissue: an in-vitro cell differentiation study.

scientific article

Iodothyronine deiodinase enzyme activities in bone.

scientific article published on 04 April 2008

Klotho prevents renal calcium loss.

scientific article published on 27 August 2009

Lack of associations between serum leptin, a polymorphism in the gene for the beta 3-adrenergic receptor and glucose tolerance in the Dutch population.

scientific article published in August 1998

Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism.

scientific article published on 18 April 2016

Mechanical control of human osteoblast apoptosis and proliferation in relation to differentiation.

scientific article published on 21 January 2003

Mechanism and function of high vitamin D receptor levels in genetic hypercalciuric stone-forming rats.

scientific article published on 29 November 2004

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.

scientific article published on 10 September 2016

MicroRNA functions in osteogenesis and dysfunctions in osteoporosis

scientific article published on June 2013

Modulation by epidermal growth factor of the basal 1,25(OH)2D3 receptor level and the heterologous up-regulation of the 1,25(OH)2D3 receptor in clonal osteoblast-like cells.

scientific article published on July 1991

Modulation of responsiveness to cAMP stimulating agonists by phorbol ester in fetal rat osteoblasts.

scientific article

Modulatory function of protein kinase C in the activation of ornithine decarboxylase and in cAMP production in rat osteoblasts

scientific article published on 01 March 1989

Molecular characterization of human osteoblast-derived extracellular vesicle mRNA using next-generation sequencing.

scientific article published on 24 March 2017

Nell-1, HMGB1 and CCN2 enhance migration and vasculogenesis, but not osteogenic differentiation compared to BMP2.

scientific article published on 2 May 2017

Novel Compound Heterozygous Mutations in the CYP27B1 Gene Lead to Pseudovitamin D-Deficient Rickets

scientific article published in July 2016

Opposing actions of rosiglitazone and resveratrol on mineralization in human vascular smooth muscle cells

scientific article published on 28 July 2011

Osteoarthritis induction leads to early and temporal subchondral plate porosity in the tibial plateau of mice: an in vivo microfocal computed tomography study.

scientific article published in September 2011

Osteoblast differentiation and control by vitamin D and vitamin D metabolites.

scientific article published in January 2004

Osteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cells

scientific article published on 02 September 2016

Osteoclastogenic capacity of peripheral blood mononuclear cells is not different between women with and without osteoporosis.

scientific article published on 11 November 2016

Oxygen-induced transcriptional dynamics in human osteoblasts are most prominent at the onset of mineralization.

scientific article published on September 2013

Paracrine Signaling by Extracellular Vesicles via Osteoblasts

scientific article

Population analysis of the collagen type IIα1 3′ variable number of tandem repeat polymorphism by heteroduplex genotyping ⬇️

scientific article published on May 1, 1998

Preliminary validation of assays to measure parameters of calcium metabolism in captive Asian and African elephants in western Europe.

scientific article

Proteomic analysis of human osteoblastic cells: relevant proteins and functional categories for differentiation.

scientific article

Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth

scientific article

Regulation of 1,25-dihydroxyvitamin D3 receptor gene expression by parathyroid hormone and cAMP-agonists

scientific article published on June 30, 1992

Regulation of osteocalcin production and bone resorption by 1,25-dihydroxyvitamin D3 in mouse long bones: interaction with the bone-derived growth factors TGF-beta and IGF-I.

scientific article

Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women

scientific article published on 01 April 1998

Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5

scientific article

Role of calcium and cAMP in heterologous up-regulation of the 1,25-dihydroxyvitamin D3 receptor in an osteoblast cell line.

scientific article published on April 1990

Role of extracellular calcium in the regulation of 1,25-dihydroxyvitamin D3 formation in cultured human keratinocytes

scientific article published on 01 March 1994

Role of protein kinase C (PKC) in bone resorption: effect of the specific PKC inhibitor 1-alkyl-2-methylglycerol

scientific article published on May 15, 1992

Serum Phosphate Is Associated With Fracture Risk: The Rotterdam Study and MrOS.

scientific article published on 8 February 2017

Spatiotemporal proliferation of human stromal cells adjusts to nutrient availability and leads to stanniocalcin-1 expression in vitro and in vivo

scientific article published on 15 May 2015

Stimulation of osteogenic differentiation in human osteoprogenitor cells by pulsed electromagnetic fields: an in vitro study.

scientific article

Stretch-induced modulation of matrix metalloproteinases in mineralizing osteoblasts via extracellular signal-regulated kinase-1/2.

scientific article published on July 2006

Supporting data of spatiotemporal proliferation of human stromal cells adjusts to nutrient availability and leads to stanniocalcin-1 expression in vitro and in vivo

scientific article

Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss. ⬇️

scientific article published on 22 June 2009

Systems biology towards life in silico: mathematics of the control of living cells.

scientific article published on 16 February 2008

TNF blockade requires 1,25(OH)2D3 to control human Th17-mediated synovial inflammation ⬇️

scientific article published on January 4, 2012

TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk.

scientific article published on 29 September 2013

The catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men

scientific article published on 15 May 2007

The collagen Ia1 SP1 polymorphism is associated with differences in ultrasound transmission velocity in the calcaneus in postmenopausal women

scientific article published on 27 May 2002

The diet of free-roaming Australian Central Bearded Dragons (Pogona vitticeps).

scientific article

The effect of vitamin D supplementation on the bone mineral density of the femoral neck is associated with vitamin D receptor genotype

scientific article published on 01 August 1997

The effects of MC903 on 1,25-(OH)2D3 receptor binding, 24-hydroxylase activity and in vitro bone resorption ⬇️

scientific article published on August 1, 1991

The importance of oestrogens in males.

scientific article

The transient receptor potential channel TRPV6 is dynamically expressed in bone cells but is not crucial for bone mineralization in mice.

scientific article

The vitamin D analog ZK191784 normalizes decreased bone matrix mineralization in mice lacking the calcium channel TRPV5.

scientific article published in February 2013

Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio

scientific article published on 18 November 2014

Transforming growth factor beta-induced dissociation between vitamin D receptor level and 1,25-dihydroxyvitamin D3 action in osteoblast-like cells.

scientific article published on July 1994

UV exposure inhibits intestinal tumor growth and progression to malignancy in intestine-specific Apc mutant mice kept on low vitamin D diet

scientific article published on 05 June 2014

Understanding Age-Induced Cortical Porosity in Women: The Accumulation and Coalescence of Eroded Cavities Upon Existing Intracortical Canals Is the Main Contributor.

scientific article published on 29 November 2017

Understanding age-induced cortical porosity in women: Is a negative BMU balance in quiescent osteons a major contributor?

scientific article published on 18 September 2018

Unraveling the human bone microenvironment beyond the classical extracellular matrix proteins: a human bone protein library.

scientific article

Using the Connectivity Map to discover compounds influencing human osteoblast differentiation.

scientific article published in December 2017

Vitamin D and gene networks in human osteoblasts.

scientific article published on 09 April 2014

Vitamin D endocrine system and osteoblasts.

scientific article published on 05 February 2014

Vitamin D endocrinology of bone mineralization.

scientific article

Vitamin D receptor genotype is associated with radiographic osteoarthritis at the knee.

scientific article published on July 1997

Vitamin D: a modulator of cell proliferation and differentiation.

scientific article published on December 1990

Wnt signaling acts and is regulated in a human osteoblast differentiation dependent manner.

scientific article published on May 2008

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