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List of works by Michael S Pepper

8-prenylnaringenin, a novel phytoestrogen, inhibits angiogenesis in vitro and in vivo.

scientific article published in April 2004

A comparative study on the anti-angiogenic effects of DNA-damaging and cytoskeletal-disrupting agents.

scientific article published on 12 February 2009

AMLprofiler: A Diagnostic and Prognostic Microarray for Acute Myeloid Leukemia.

scientific article

ASSAf consensus study on the ethical, legal and social implications of genetics and genomics in South Africa

scientific article published in 2018

Active-site inactivated FVIIa decreases thrombosis and necrosis in a random skin flap model of acute ischemia.

scientific article

Adipocyte and adipogenesis.

scientific article published on 14 June 2013

Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways

scientific article published on 16 June 2020

Altered expression of platelet factor 4 and basic fibroblast growth factor correlates with the inhibition of tumor growth in mice

scientific article

An in vitro and in vivo study on the properties of hollow polycaprolactone cell-delivery particles

scientific article published on 03 July 2018

Application of the AMLprofiler Diagnostic Microarray in the South African Setting.

scientific article published on 7 November 2017

Author Correction: Establishment and equilibrium levels of deleterious mutations in large populations

scientific article published on 17 March 2020

Barriers to Implementing Clinical Pharmacogenetics Testing in Sub-Saharan Africa. A Critical Review

scientific article published on 26 August 2020

Basic fibroblast growth factor increases junctional communication and connexin 43 expression in microvascular endothelial cells.

scientific article

Biocompatibility and biodegradation of protein microparticle and film scaffolds made from kafirin (sorghum prolamin protein) subcutaneously implanted in rodent models

scientific article

Biotechnology Innovators To Convene in Cape Town, South Africa: Pharmacogenetics and Precision Medicine Conference (April 7-9, 2016).

scientific article

Biphasic effect of transforming growth factor-beta 1 on in vitro angiogenesis

scientific article published on 01 February 1993

Both TNF receptors are required for direct TNF-mediated cytotoxicity in microvascular endothelial cells

scientific article published on 01 November 1998

Bovine microvascular endothelial cells immortalized with human telomerase

scientific article published on 01 May 2006

C-C chemokine receptor type five (CCR5): An emerging target for the control of HIV infection.

scientific article published on 26 May 2013

CRISPR-Cas: Revolutionising genome engineering

scientific article published on August 2016

Cardiovascular pharmacogenetics.

scientific article

Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2

scientific journal article

Chondrocytes inhibit endothelial sprout formation in vitro: evidence for involvement of a transforming growth factor-beta

scientific article published on 01 January 1991

Chromogranin A alters ductal morphogenesis and increases deposition of basement membrane components by mammary epithelial cells in vitro.

scientific article published on June 1999

Circulating and imaging markers for angiogenesis.

scientific article published on 17 October 2008

Comparison of human platelet lysate alternatives using expired and freshly isolated platelet concentrates for adipose-derived stromal cell expansion.

scientific article published on 19 March 2018

Constituting a public umbilical cord blood bank in South Africa.

scientific article published on 26 January 2015

Could we offer mitochondrial donation or similar assisted reproductive technology to South African patients with mitochondrial DNA disease?

scientific article published on 2 February 2016

Curbing stem cell tourism in South Africa.

scientific article published on 14 May 2013

Cystic Fibrosis in the African Diaspora

scientific article published on 21 November 2016

Cystic fibrosis in South Africa: A changing diagnostic paradigm

article

Cystic fibrosis on the African continent.

scientific article

Cytochrome P450 pharmacogenetics in African populations.

scientific article published on 16 April 2013

Deoxyribonucleic Acid Damage and Repair: Capitalizing on Our Understanding of the Mechanisms of Maintaining Genomic Integrity for Therapeutic Purposes.

scientific article published on 11 April 2018

Differential expression of gap junction connexins in endocrine and exocrine glands

scientific article published on 01 November 1993

Dissecting the role of matrix metalloproteinases (MMP) and integrin alpha(v)beta3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-Type 1-MMP and alpha(v)beta3 are critical.

scientific article

Downregulation of vascular endothelial-cadherin expression is associated with an increase in vascular tumor growth and hemorrhagic complications

scientific article published on 01 June 2005

Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis

scientific article published on 6 December 2017

Elevated levels of angiogenic cytokines in the plasma of cancer patients.

scientific article

Endothelial cells of the human microvasculature express epidermal fatty acid-binding protein

scientific article

Establishing a public umbilical cord blood stem cell bank for South Africa: an enquiry into public acceptability

scientific article

Establishment and equilibrium levels of deleterious mutations in large populations

scientific article published on 17 July 2019

Ets 1 is expressed in capillary blood vessels but not in lymphatics

scientific article published on 01 August 2003

Evaluation of predictiveCYP2C19genotyping assays relative to measured phenotype in a South African cohort

scientific article published on 05 August 2015

Exporting DNA - striking a balance between preventing exploitation and promoting innovation.

scientific article published on 30 January 2017

Expression and localization of VEGF-C and VEGFR-3 in glioblastomas and haemangioblastomas.

scientific article published in May 2006

Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D, and their receptor VEGFR-3, during different stages of cervical carcinogenesis

scientific article published on 01 December 2003

Expression of vascular endothelial growth factor in digestive neuroendocrine tumours

scientific article published on 01 February 1998

FGF-2 promotes disassembly of actin cytoskeleton and shape changes in murine vascular cells.

scientific article published on March 2001

Factors Influencing the Umbilical Cord Blood Stem Cell Industry: An Evolving Treatment Landscape

scientific article published on 18 May 2018

Familial predisposition to tufted angioma: identification of blood and lymphatic vascular components.

scientific article published in May 2003

Fate of systemically and locally administered adipose-derived mesenchymal stromal cells and their effect on wound healing

scientific article published on 15 October 2019

Fibroblast-Derived Extracellular Matrix Induces Chondrogenic Differentiation in Human Adipose-Derived Mesenchymal Stromal/Stem Cells in Vitro

scientific article published on 03 August 2016

Gender and sexual diversity--changing paradigms in an ever-changing world

scientific article published on 14 September 2015

Genistein, a dietary-derived inhibitor of in vitro angiogenesis

scientific article

Genome-wide analysis of gene expression during adipogenesis in human adipose-derived stromal cells reveals novel patterns of gene expression during adipocyte differentiation

scientific article published on 19 April 2016

Genomic sovereignty and the African promise: mining the African genome for the benefit of Africa ⬇️

scientific article published on April 6, 2012

HLA typing: Conventional techniques v. next-generation sequencing.

scientific article published on 16 December 2015

Haemangiomas are formed by cells expressing high levels of alphavbeta3 integrin and lacking acetylated LDL uptake.

scientific article published on June 2004

Hemangiomas - current therapeutic strategies ⬇️

scientific article published on January 1, 2011

Hereditary vascular anomalies: new insights into their pathogenesis.

scientific article published in July 2004

Heterogeneity of smooth muscle cell populations cultured from pig coronary artery

scientific article published on 01 July 2002

Homing properties of mesenchymal stromal cells.

scientific article

Human Leukocyte Antigen Diversity: A Southern African Perspective

scientific article published in 2015

Human Leukocyte Antigen-A, B, C, DRB1, and DQB1 Allele and Haplotype Frequencies in a Subset of 237 Donors in the South African Bone Marrow Registry.

scientific article

Human adipose derived mesenchymal stromal cells transduced with GFP lentiviral vectors: assessment of immunophenotype and differentiation capacity in vitro

scientific article published on 27 January 2016

Human lymphatic endothelial cells express multiple functional TLRs.

scientific article

Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemia

scientific article

IL-20 activates human lymphatic endothelial cells causing cell signalling and tube formation

scientific article published on 9 March 2009

IL-27 Inhibits Lymphatic Endothelial Cell Proliferation by STAT1-Regulated Gene Expression

article

Identification of transcription factors potentially involved in human adipogenesis in vitro

scientific article

Immunohistochemical quantification of lymph vessels, VEGF-C and VEGF receptor 3 in human sarcomas

scientific article published on 01 July 2006

Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy: a pilot study.

scientific article published on 28 March 2017

Implications of direct-to-consumer whole-exome sequencing in South Africa.

scientific article published on 12 January 2016

In vitro angiogenic and proteolytic properties of bovine lymphatic endothelial cells

scientific article published on 01 February 1994

In vivo modulation of connexin 43 gene expression and junctional coupling of pancreatic B-cells

scientific article published on 01 February 1991

Induction of angiogenesis in vitro by vanadate, an inhibitor of phosphotyrosine phosphatases

scientific article published on 01 March 1988

Induction of epithelial branching tubulogenesis in vitro ⬇️

scientific article published on November 1, 1997

Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1.

scientific article

Inhibition of endothelial wound repair by dominant negative connexin inhibitors.

scientific article published on April 2001

Inhibition of hemangioma development in a syngeneic mouse model correlates with bcl-2 suppression and the inhibition of Akt kinase activity ⬇️

scientific article published on December 25, 2011

Introduction of the AmpliChip CYP450 Test to a South African cohort: a platform comparative prospective cohort study

scientific article

Involvement of the VEGF receptor 3 in tubular morphogenesis demonstrated with a human anti-human VEGFR-3 monoclonal antibody that antagonizes receptor activation by VEGF-C.

scientific article published on 18 May 2004

Junctional communication is induced in migrating capillary endothelial cells.

scientific article

Lectin-deficient TNF mutants display comparable anti-tumour but reduced pro-metastatic potential as compared to the wild-type molecule

scientific article published on 01 February 2001

Lentivector Knockdown of CCR5 in Hematopoietic Stem and Progenitor Cells Confers Functional and Persistent HIV-1 Resistance in Humanized Mice

scientific article published on 22 April 2015

Lessons Learned from Somatic Cell Nuclear Transfer

scientific article published on 27 March 2020

Literature watch. FOXC2 haploinsufficient mice are a model for human autosomal dominant lymphedema-distichiasis syndrome.

scientific article

Lymphangiogenesis and lymph node microdissemination

scientific article published on 01 July 2001

Lymphangiogenesis in human gynaecological cancers.

scientific article

Lymphatic endothelial cells: establishment of primaries and characterization of established lines.

scientific article published in January 2009

Lymphatic vessel density and vascular endothelial growth factor-C expression correlate with malignant behavior in human pancreatic endocrine tumors.

scientific article published in October 2004

Manipulating angiogenesis. From basic science to the bedside.

scientific article

Membrane proteases in focus

scientific article published in Nature

Membrane-type-1 matrix metalloproteinase confers tumorigenicity on nonmalignant epithelial cells.

scientific article

Mesenchymal cells potentiate vascular endothelial growth factor-induced angiogenesis in vitro

scientific article published on 01 November 2002

Microscopy: an art?

scientific article published on 01 February 2002

Mitochondrial transfer: Implications for assisted reproductive technologies

scientific article

Mixed arterio-venous insufficiency in random skin flaps in the rat: is the application of medicinal leeches beneficial?

scientific article

Modulation of bovine microvascular endothelial cell proteolytic properties by inhibitors of angiogenesis

scientific article published on 01 August 1994

Molecular characterization of lymphatic endothelial cells.

scientific article

Mutations in C-C chemokine receptor type 5 (CCR5) in South African individuals.

scientific article published on August 2013

Novel flow cytometric approach for the detection of adipocyte subpopulations during adipogenesis.

scientific article published on February 2016

Novel tempeh (fermented soyabean) isoflavones inhibit in vivo angiogenesis in the chicken chorioallantoic membrane assay.

scientific article published in March 2005

Obesity in South Africa.

scientific article published on November 2006

Opportunities and barriers to establishing a cell therapy programme in South Africa.

scientific article published on 29 May 2013

Ownership and human tissue - the legal conundrum: A response to Jordaan's critique.

scientific article published on 27 February 2017

PDGF-BB increases endothelial migration on cord movements during angiogenesis in vitro

scientific article published on 01 March 1997

Partial relief from the regulatory vacuum involving human tissues through enactment of chapter 8 of the National Health Act and regulations thereto.

scientific article published on 28 June 2012

Pediatric medulloblastoma: prognostic value of p53, bcl-2, Mib-1, and microvessel density.

scientific article published in January 1999

Persistent ischemia impairs myofibroblast development in wound granulation tissue: a new model of delayed wound healing

scientific article published on 01 November 2007

Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort

scientific article published on 27 October 2015

Pharmacogenetics of CYP2B6, CYP2A6 and UGT2B7 in HIV treatment in African populations: focus on efavirenz and nevirapine.

scientific article

Pharmacogenomic Research in South Africa: Lessons Learned and Future Opportunities in the Rainbow Nation.

scientific article published on September 2011

Pharmacogenomics and Global Precision Medicine in the Context of Adverse Drug Reactions: Top 10 Opportunities and Challenges for the Next Decade

scientific article

Pharmacogenomics for infectious diseases in sub-Saharan Africa: Successes and opportunities.

scientific article published on 7 May 2016

Phorbol ester induces cultured endothelial cells to invade a fibrin matrix in the presence of fibrinolytic inhibitors.

scientific article published in September 1987

Phytoestrogens and inhibition of angiogenesis.

scientific article

Pilot social feasibility study for the establishment of a public human umbilical cord blood stem cell bank in South Africa.

scientific article

Plasminogen activator expression in rat arterial smooth muscle cells depends on their phenotype and is modulated by cytokines.

scientific article published in June 1998

Plasminogen activator inhibitor-1 is induced in microvascular endothelial cells by a chondrocyte-derived transforming growth factor-beta

scientific article published on 01 April 1991

Plasminogen activator inhibitor-1 is induced in migrating endothelial cells

scientific article published on October 1, 1992

Polymorphisms in the endothelial nitric oxide synthase gene and the tendency for aneurysm rupture

scientific article published on 01 March 2005

Positive and Negative Regulation of Angiogenesis: From Cell Biology to the Clinic ⬇️

scientific article published on January 1, 1996

Posttranscriptional stimulation of endothelial cell matrix metalloproteinases 2 and 1 by endothelioma cells.

scientific article published on August 2000

Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro

scientific article published on 01 December 1992

Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation.

scientific article published on 30 January 2013

Priority pharmacogenetics for the African continent: focus on CYP450.

scientific article published on February 2014

Progresses towards safe and efficient gene therapy vectors

scientific article

Proteolytic balance and capillary morphogenesis ⬇️

scientific article published on December 2, 1990

Quantitative plasma analysis using automated online solid-phase extraction with column switching LC-MS/MS for characterising cytochrome P450 2D6 and 2C19 metabolism.

scientific article published on 13 April 2011

Reactive Oxygen Species and NOX Enzymes Are Emerging as Key Players in Cutaneous Wound Repair

scientific article

Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia.

scientific article published in October 1998

Regulation of vascular endothelial growth factor receptor-2 (Flk-1) expression in vascular endothelial cells.

scientific article published in June 1998

Response of bovine endothelial cells to FGF-2 and VEGF is dependent on their site of origin: Relevance to the regulation of angiogenesis

article

Retinoic acid regulates arterial smooth muscle cell proliferation and phenotypic features in vivo and in vitro through an RARalpha-dependent signaling pathway

scientific article published on 01 June 1999

Risperidone-associated adverse drug reactions and CYP2D6 polymorphisms in a South African cohort

scientific article published on 14 May 2015

Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis.

scientific article

Side Population: Its Use in the Study of Cellular Heterogeneity and as a Potential Enrichment Tool for Rare Cell Populations

scientific article published on 06 December 2018

Signalling properties of an HIV-encoded angiogenic peptide mimicking vascular endothelial growth factor activity.

scientific article published on February 2001

Single-Cell Transcriptome Analysis of Human Adipose-Derived Stromal Cells Identifies a Contractile Cell Subpopulation

scientific article published on 28 April 2021

Social Media and COVID-19—Perceptions and Public Deceptions of Ivermectin, Colchicine and Hydroxychloroquine: Lessons for Future Pandemics

scientific article published on 25 March 2022

Special Issue - Pharmacogenomics & personalized medicine, Journal of Applied and Translational Genomics

scientific article published on 6 November 2013

Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion.

scientific article published on 20 April 2017

Tetracycline-regulated expression of VEGF-A in beta cells induces angiogenesis: improvement of engraftment following transplantation.

scientific article published on January 2006

The Effect of Early Rounds of ex vivo Expansion and Cryopreservation on the Adipogenic Differentiation Capacity of Adipose-Derived Stromal/Stem Cells

scientific article published on 04 November 2019

The Role of Pref-1 during Adipogenic Differentiation: An Overview of Suggested Mechanisms

scientific article published on 09 June 2020

The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer.

scientific article

The effect of medium supplementation and serial passaging on the transcriptome of human adipose-derived stromal cells expanded in vitro

scientific article published on 14 August 2019

The role of reactive oxygen species in mesenchymal stem cell adipogenic and osteogenic differentiation: a review

scientific article

The state of gene therapy research in Africa, its significance and implications for the future.

scientific article

Transforming growth factor beta 1 down-regulates vascular endothelial growth factor receptor 2/flk-1 expression in vascular endothelial cells.

scientific article

Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro ⬇️

scientific article published on August 1, 1990

Understanding the Implications of Mitochondrial DNA Variation in the Health of Black Southern African Populations: The 2014 Workshop

scientific article published on 01 May 2015

Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells

scientific article

Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells ⬇️

scientific article published on December 16, 1991

Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-C(deltaNdeltaC)- and VEGF-A-induced angiogenesis in vitro

scientific journal article

Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells

scientific article published on 01 April 1995

Vascular endothelial growth factor is increased in devascularized rat islets of Langerhans in vitro

scientific article published on 01 February 1997

Visualizing function in the tumor-associated lymphatic system.

scientific article

Wharton's Jelly-Derived Mesenchymal Stromal Cells and Fibroblast-Derived Extracellular Matrix Synergistically Activate Apoptosis in a p21-Dependent Mechanism in WHCO1 and MDA MB 231 Cancer Cells In Vitro

scientific article published on 10 January 2016

Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans.

scientific article published on 12 December 2017

alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitro.

scientific article

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