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List of works by Timothy Luke Denning

A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage.

scientific article

A(₂B)AR expression in non-immune cells plays an important role in the development of murine colitis

scientific article

Acquired alkylating drug resistance of a human ovarian carcinoma cell line is unaffected by altered levels of pro- and anti-apoptotic proteins.

scientific article

Adenosine triphosphate energizes intestinal T(H)17 cells.

scientific article published on 22 January 2009

Advances in understanding the interaction between the gut microbiota and adaptive mucosal immune responses ⬇️

scientific article published on April 12, 2010

CD98 siRNA-loaded nanoparticles decrease hepatic steatosis in mice

scientific article published on 17 November 2016

CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice

scientific article

Compromised Intestinal Epithelial Barrier Induces Adaptive Immune Compensation that Protects from Colitis ⬇️

scientific article published on September 13, 2012

Contribution of Mesenteric Lymph Nodes and GALT to the Intestinal Foxp3+ Regulatory T-Cell Compartment.

scientific article published on May 2016

Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage

scientific article

Differential induction of interleukin-10 and interleukin-12 in dendritic cells by microbial toll-like receptor activators and skewing of T-cell cytokine profiles.

scientific article

Division of labor, plasticity, and crosstalk between dendritic cell subsets.

scientific article published on 21 December 2007

ERK1-/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis.

scientific article

Effects of MF59 Adjuvant on Induction of Isotype-Switched IgG Antibodies and Protection after Immunization with T-Dependent Influenza Virus Vaccine in the Absence of CD4+ T Cells

scientific article published on 25 May 2016

Enhanced immune responses by skin vaccination with influenza subunit vaccine in young hosts.

scientific article published on 2 March 2015

Expression of IL-10 receptors on epithelial cells from the murine small and large intestine.

scientific article

Fab'-bearing siRNA TNFα-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis.

scientific article published on 5 May 2014

Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization.

scientific article

Harnessing regulatory T cells for the treatment of inflammatory bowel disease.

scientific article published on June 2015

Hepatic stellate cells preferentially induce Foxp3+ regulatory T cells by production of retinoic acid.

scientific article published on 28 January 2013

IFNγ-induced suppression of β-catenin signaling: evidence for roles of Akt and 14.3.3ζ.

scientific article

IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria.

scientific article

IL-36γ Protects against Severe Influenza Infection by Promoting Lung Alveolar Macrophage Survival and Limiting Viral Replication

scientific article published on 30 May 2018

IL-36γ Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses.

scientific article

IL-36γ signaling controls the induced regulatory T cell-Th9 cell balance via NFκB activation and STAT transcription factors.

scientific article published on 22 March 2017

Intestinal Antigen-Presenting Cells: Key Regulators of Immune Homeostasis and Inflammation

scientific article

Isolation and characterization of dendritic cells and macrophages from the mouse intestine.

scientific article published on 21 May 2012

Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit

scientific article

Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses

scientific article published on 16 September 2007

Macrophage Isolation from the Mouse Small and Large Intestine.

scientific article published on January 2016

Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling

scientific article published on 7 August 2017

Matrix metalloproteinase MMP9 maintains epithelial barrier function and preserves mucosal lining in colitis associated cancer

scientific article published on 17 October 2017

Moving Beyond the Mouse: Key New Insight Into Human Colonic Dendritic Cells

scientific article published on 25 November 2015

Negative selection of T cells by Helicobacter pylori as a model for bacterial strain selection by immune evasion.

scientific article

Neutrophil-derived JAML inhibits repair of intestinal epithelial injury during acute inflammation.

scientific article published on 12 March 2014

Neutrophils enlist IL-22 to restore order in the gut

scientific article published on 19 July 2013

Oxidative stress induces the expression of Fas and Fas ligand and apoptosis in murine intestinal epithelial cells

scientific article published on 01 December 2002

Phenotypic and functional profiling of mouse intestinal antigen presenting cells.

scientific article published on 17 April 2015

Pulmonary antigen encounter regulates the establishment of tissue-resident CD8 memory T cells in the lung airways and parenchyma.

scientific article published on 16 February 2018

Segmented filamentous bacteria shape intestinal immunity

scientific article published on 25 May 2010

Segmented filamentous bacteria-induced immune responses: a balancing act between host protection and autoimmunity

article

Small intestinal intraepithelial TCRγδ+ T lymphocytes are present in the premature intestine but selectively reduced in surgical necrotizing enterocolitis

scientific article

Specific microbiota-induced intestinal Th17 differentiation requires MHC class II but not GALT and mesenteric lymph nodes

scientific article

Staphylococcal enterotoxin B stimulates expansion of autoreactive T cells that induce apoptosis in intestinal epithelial cells: regulation of autoreactive responses by IL-10

scientific article published on 01 March 2000

TNFα gene silencing mediated by orally targeted nanoparticles combined with interleukin-22 for synergistic combination therapy of ulcerative colitis

article

Targeting intestinal inflammation with CD98 siRNA/PEI-loaded nanoparticles.

scientific article published on 12 September 2013

Tbet and IL-36γ cooperate in therapeutic DC-mediated promotion of ectopic lymphoid organogenesis in the tumor microenvironment.

scientific article published on 28 April 2017

The Wnt antagonist Dkk1 regulates intestinal epithelial homeostasis and wound repair.

scientific article published on 25 March 2011

The role of the vascular dendritic cell network in atherosclerosis

scientific article published on 03 April 2013

Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota ⬇️

scientific article published on April 28, 2013

Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity.

scientific article published on March 2009

Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18

scientific article

Wound repair: role of immune-epithelial interactions

scientific article

Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance.

scientific article

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