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List of works by Niranjan Y Sardesai

A DNA vaccine delivered by dermal electroporation fully protects cynomolgus macaques against Lassa fever

scientific article published on 18 October 2017

A Novel DNA Vaccine Platform Enhances Neo-antigen-like T Cell Responses against WT1 to Break Tolerance and Induce Anti-tumor Immunity.

scientific article published on 22 February 2017

A Synthetic DNA, Multi-Neoantigen Vaccine Drives Predominately MHC Class I CD8+ T-cell Responses, Impacting Tumor Challenge

scientific article published on 24 January 2019

A heterologous prime/boost vaccination strategy enhances the immunogenicity of therapeutic vaccines for hepatitis C virus.

scientific article published on 17 June 2013

A highly optimized DNA vaccine confers complete protective immunity against high-dose lethal lymphocytic choriomeningitis virus challenge.

scientific article

A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques

scientific article

A multi-head intradermal electroporation device allows for tailored and increased dose DNA vaccine delivery to the skin

scientific article

A multi-head intradermal electroporation device allows for tailored and increased dose DNA vaccine delivery to the skin.

scientific article published in January 2015

A novel prototype device for electroporation-enhanced DNA vaccine delivery simultaneously to both skin and muscle.

scientific article published in January 2011

A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates

scientific article

Activated CD4+CCR5+ T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques.

scientific article

Adventures of a vaccinologist entrepreneur.

scientific article published on January 2014

Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques

scientific article

An Enhanced Synthetic Multiclade DNA Prime Induces Improved Cross-Clade-Reactive Functional Antibodies when Combined with an Adjuvanted Protein Boost in Nonhuman Primates.

scientific article

An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model

scientific article published on 21 September 2017

An optimized SIV DNA vaccine can serve as a boost for Ad5 and provide partial protection from a high-dose SIVmac251 challenge ⬇️

scientific article published on March 8, 2012

An optimized, synthetic DNA vaccine encoding the toxin A and toxin B receptor binding domains of Clostridium difficile induces protective antibody responses in vivo

scientific article

Analysis of the potential for HIV-1 Vpr as an anti-cancer agent.

scientific article published on March 2009

Broad cross-protective anti-hemagglutination responses elicited by influenza microconsensus DNA vaccine

scientific article published on 31 October 2017

Chemokine-adjuvanted electroporated DNA vaccine induces substantial protection from simian immunodeficiency virus vaginal challenge

scientific article

Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy.

scientific article

Co-delivery of PSA and PSMA DNA vaccines with electroporation induces potent immune responses.

scientific article

Comparative analysis of immune responses induced by vaccination with SIV antigens by recombinant Ad5 vector or plasmid DNA in rhesus macaques.

scientific article

Comparison of immune responses generated by optimized DNA vaccination against SIV antigens in mice and macaques

scientific article

Comparison of intradermal and intramuscular delivery followed by in vivo electroporation of SIV Env DNA in macaques.

scientific article published on 28 June 2013

Construction of coordinatively saturated rhodium complexes containing appended peptides.

scientific article

Control of Heterologous Simian Immunodeficiency Virus SIV Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques

scientific article published on 17 July 2018

DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections.

scientific article published on 6 July 2017

DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV.

scientific article published on 12 October 2016

DNA Vaccine-Induced Long-Lasting Cytotoxic T Cells Targeting Conserved Elements of Human Immunodeficiency Virus Gag Are Boosted Upon DNA or Recombinant Modified Vaccinia Ankara Vaccination

scholarly article by Xintao Hu published in September 2018

DNA and protein co-immunization improves the magnitude and longevity of humoral immune responses in macaques

scientific article

DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge

scientific article published on 28 January 2013

DNA vaccination protects mice against Zika virus-induced damage to the testes

scientific article

DNA vaccine cocktail expressing genotype A and C HBV surface and consensus core antigens generates robust cytotoxic and antibody responses in mice and Rhesus macaques.

scientific article published on 6 December 2013

DNA vaccines 2010: A gumbo of accomplishment and excitement in New Orleans

scientific article published on 16 July 2011

DNA vaccines targeting heavy chain C-terminal fragments of Clostridium botulinum neurotoxin serotypes A, B, and E induce potent humoral and cellular immunity and provide protection from lethal toxin challenge

scientific article

Detection of newly diagnosed bladder cancer, bladder cancer recurrence and bladder cancer in patients with hematuria using quantitative rt-PCR of urinary survivin.

scientific article published on 26 January 2007

Development of a novel DNA SynCon tetravalent dengue vaccine that elicits immune responses against four serotypes.

scientific article

Direct transfection of dendritic cells in the epidermis after plasmid delivery enhanced by surface electroporation.

scientific article

Dose-dependent inhibition of Gag cellular immunity by Env in SIV/HIV DNA vaccinated macaques

scientific article

Effects of the immunomodulator, VGX-1027, in endotoxin-induced uveitis in Lewis rats.

scientific article published on 08 September 2008

Efficient 50S ribosome-catalyzed peptide bond synthesis with an aminoacyl minihelix.

scientific article published on September 1999

Electroporation delivery of DNA vaccines: prospects for success ⬇️

scientific article published on April 27, 2011

Enhanced Efficacy of a Codon-Optimized DNA Vaccine Encoding the Glycoprotein Precursor Gene of Lassa Virus in a Guinea Pig Disease Model When Delivered by Dermal Electroporation.

scientific article published on 18 July 2013

Functional analysis of peptide motif for RNA microhelix binding suggests new family of RNA-binding domains

scientific article

Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques

article

HIV-1 Env DNA vaccine plus protein boost delivered by EP expands B- and T-cell responses and neutralizing phenotype in vivo

scientific article

HIV-1 p24(gag) derived conserved element DNA vaccine increases the breadth of immune response in mice

scientific article

Hepatitis C virus NS3/NS4A DNA vaccine induces multiepitope T cell responses in rhesus macaques mimicking human immune responses [corrected]

scientific article published on 27 September 2011

Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens

scientific article

High antibody and cellular responses induced to HIV-1 clade C envelope following DNA vaccines delivered by electroporation.

scientific article

Highly optimized DNA vaccine targeting human telomerase reverse transcriptase stimulates potent antitumor immunity.

scientific article

How will diagnostics create new opportunities for prophylactic and therapeutic vaccines?: 2011 Phacilitate Vaccine Forum, Washington DC Day 2, afternoon plenary session—January 25, 2011.

scientific article published in June 2011

Human papillomavirus therapeutic vaccines: targeting viral antigens as immunotherapy for precancerous disease and cancer.

scientific article published on March 2013

Humoral immunity induced by mucosal and/or systemic SIV-specific vaccine platforms suggests novel combinatorial approaches for enhancing responses

scientific article

IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques

scientific article published on 16 August 2012

Immunogenicity of a novel engineered HIV-1 clade C synthetic consensus-based envelope DNA vaccine

scientific article

Immunogenicity of a novel enhanced consensus DNA vaccine encoding the leptospiral protein LipL45

scientific article

Immunogenicity of novel consensus-based DNA vaccines against Chikungunya virus

scientific article

In vitro inhibition of enterobacteria-reactive CD4+CD25- T cells and suppression of immunoinflammatory colitis in mice by the novel immunomodulatory agent VGX-1027.

scientific article published on 17 February 2008

In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine

scientific article

Inducing humoral and cellular responses to multiple sporozoite and liver-stage malaria antigens using exogenous plasmid DNA.

scientific article published on 29 July 2013

Induction of robust cellular immunity against HPV6 and HPV11 in mice by DNA vaccine encoding for E6/E7 antigen.

scientific article

Influenza A vaccines using linear expression cassettes delivered via electroporation afford full protection against challenge in a mouse model ⬇️

scientific article published on March 8, 2012

Intradermal DNA vaccination enhanced by low-current electroporation improves antigen expression and induces robust cellular and humoral immune responses.

scientific article

Intramuscular delivery of heterodimeric IL-15 DNA in macaques produces systemic levels of bioactive cytokine inducing proliferation of NK and T cells

scientific article

Introduction to DNA vaccines – Las Vegas

scientific article published on 01 February 2010

Long-term programming of antigen-specific immunity from gene expression signatures in the PBMC of rhesus macaques immunized with an SIV DNA vaccine

scientific article (publication date: 2011)

MESOMARK: a potential test for malignant pleural mesothelioma

scientific article

Mesothelin variant 1 is released from tumor cells as a diagnostic marker.

scientific article published on May 2006

Multivalent Smallpox DNA Vaccine Delivered by Intradermal Electroporation Drives Protective Immunity in Nonhuman Primates Against Lethal Monkeypox Challenge ⬇️

scientific article published on January 1, 2011

Novel and enhanced anti-melanoma DNA vaccine targeting the tyrosinase protein inhibits myeloid-derived suppressor cells and tumor growth in a syngeneic prophylactic and therapeutic murine model

scientific article published on 14 November 2014

Novel prostate cancer immunotherapy with a DNA-encoded anti-prostate-specific membrane antigen monoclonal antibody.

scientific article published on 17 August 2017

Novel synthetic plasmid and Doggybone DNA vaccines induce neutralizing antibodies and provide protection from lethal influenza challenge in mice

scientific article

OA05-02. Analysis of DNA compared to Ad5 vaccination, as single and mixed modalities, demonstrates robust induction of cellular immune responses in macaques

article

Optimization of electroporation-enhanced intradermal delivery of DNA vaccine using a minimally invasive surface device

scientific article

Optimized in vivo transfer of small interfering RNA targeting dermal tissue using in vivo surface electroporation.

scientific article

P02-02. Analysis of antigen specific degranulation potentials using IL-12 or IL-28B during HIV DNA Vaccination.

scientific article published on 22 October 2009

P03-11. DNA vaccination with IL-12 lowers viral replication following SIVmac251 challenge.

scientific article published on 22 October 2009

P19-46. Co-delivery of mucosal chemokine plasmids in a systemically delivered DNA vaccine elicits systemic and mucosal immune responses in mice and macaques.

scientific article published on 22 October 2009

Piezoelectric permeabilization of mammalian dermal tissue for in vivo DNA delivery leads to enhanced protein expression and increased immunogenicity.

scientific article published in January 2011

Plasmodium inui Infection Reduces the Efficacy of a Simian Immunodeficiency Virus DNA Vaccine in a Rhesus Macaque Model Through Alteration of the Vaccine-Induced Immune Response ⬇️

scientific article published on June 12, 2012

Protective immunity to H7N9 influenza viruses elicited by synthetic DNA vaccine.

scientific article

Protocols for Developing Novel Chikungunya Virus DNA Vaccines.

scientific article published on January 2016

Prototype development and preclinical immunogenicity analysis of a novel minimally invasive electroporation device.

scientific article

Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus.

scientific article

Recombinant rubella vectors elicit SIV Gag-specific T cell responses with cytotoxic potential in rhesus macaques.

scientific article

Safety and Immunogenicity of PENNVAX®-G DNA Prime Administered by Biojector® 2000 or CELLECTRA® Electroporation Device with Modified Vaccinia Ankara-CMDR Boost

scientific article published on 2 September 2017

Safety and comparative immunogenicity of an HIV-1 DNA vaccine in combination with plasmid interleukin 12 and impact of intramuscular electroporation for delivery

scientific article published on 08 July 2013

Safety, bioavailability, and pharmacokinetics of VGX-1027-A novel oral anti-inflammatory drug in healthy human subjects

scientific article

Skin Transfection Patterns and Expression Kinetics of Electroporation-Enhanced Plasmid Delivery Using the CELLECTRA-3P, a Portable Next-Generation Dermal Electroporation Device

scientific article published on 29 July 2015

Strong HCV NS3/4a, NS4b, NS5a, NS5b-specific cellular immune responses induced in Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine.

scientific article

Synthetic consensus HIV-1 DNA induces potent cellular immune responses and synthesis of granzyme B, perforin in HIV infected individuals

scientific article

The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production.

scientific article published on 7 January 2013

Tolerability of intramuscular and intradermal delivery by CELLECTRA(®) adaptive constant current electroporation device in healthy volunteers

scientific article published on 04 June 2013

Unique Th1/Th2 Phenotypes Induced during Priming and Memory Phases by Use of Interleukin-12 (IL-12) or IL-28B Vaccine Adjuvants in Rhesus Macaques ⬇️

scientific article published on August 4, 2010

VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus

article

Vaccination with synthetic constructs expressing cytomegalovirus immunogens is highly T cell immunogenic in mice.

scientific article published on November 2012

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