List of works - Damien J Downes

A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker

scientific article published on 21 June 2021

Characterization of the mutagenic spectrum of 4-nitroquinoline 1-oxide (4-NQO) in Aspergillus nidulans by whole genome sequencing

scientific article

Dual DNA binding and coactivator functions of Aspergillus nidulans TamA, a Zn(II)2Cys6 transcription factor

scientific article published on 07 May 2014

Duplication and Functional Divergence of Branched-Chain Amino Acid Biosynthesis Genes in Aspergillus nidulans

scientific article published on 22 June 2021

Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development

scientific article published on 09 February 2022

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia

scientific article published on 4 September 2017

Enhancers predominantly regulate gene expression during differentiation via transcription initiation

scientific article published on 03 February 2021

Fra-1 regulates its target genes via binding to remote enhancers without exerting major control on chromatin architecture in triple negative breast cancers

scientific article published on 01 March 2021

Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo

scientific article published on 7 February 2017

High-Throughput Genotyping of CRISPR/Cas Edited Cells in 96-Well Plates

scientific article published on 01 August 2018

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale

scientific article published on 22 January 2021

Hypoxia induces transcriptional and translational downregulation of the type I interferon (IFN) pathway in multiple cancer cell types

scientific article published on 28 October 2020

Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus

scientific article published on 04 November 2021

Impaired DNA demethylation of C/EBP sites causes premature aging

scientific article published on 08 June 2018

Low-input Capture-C: A Chromosome Conformation Capture Assay to Analyze Chromatin Architecture in Small Numbers of Cells

scientific article published in December 2017

Multiple nuclear localization signals mediate nuclear localization of the GATA transcription factor AreA

scientific article published on 21 February 2014

Reactivation of a developmentally silenced embryonic globin gene

scientific article published on 21 July 2021

Regulation of the NADP-glutamate dehydrogenase gene gdhA in Aspergillus nidulans by the Zn(II)2Cys6 transcription factor LeuB

article

Robust detection of chromosomal interactions from small numbers of cells using low-input Capture-C.

scientific article published on 23 November 2017

Spatial differentiation of gene expression in Aspergillus niger colony grown for sugar beet pulp utilization.

scientific article published on 28 August 2015

Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.

scientific article published on 24 July 2017

List of works by Damien J Downes