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List of works by Richard W Groen

A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization.

scientific article published on 13 May 2017

A bioluminescence imaging based in vivo model for preclinical testing of novel cellular immunotherapy strategies to improve the graft-versus-myeloma effect.

scientific article

Accessory cells of the microenvironment protect multiple myeloma from T-cell cytotoxicity through cell adhesion-mediated immune resistance.

scientific article published on 4 September 2013

Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma

scientific article

CD38 as a therapeutic target for adult acute myeloid leukemia and T-cell acute lymphoblastic leukemia

scientific article published on 06 September 2018

CD38-targeting antibodies in multiple myeloma: mechanisms of action and clinical experience

scientific article published on 21 February 2018

Combined CD28 and 4-1BB Costimulation Potentiates Affinity-tuned Chimeric Antigen Receptor-engineered T Cells

scientific article published on 12 April 2019

Decoding the pathophysiology and the genetics of multiple myeloma to identify new therapeutic targets

scientific article published on October 2013

Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival.

scientific article published on 6 April 2011

Eradication of medullary multiple myeloma by CD4+ cytotoxic human T lymphocytes directed at a single minor histocompatibility antigen

scientific article published on 09 November 2010

Establishing human leukemia xenograft mouse models by implanting human bone marrow-like scaffold-based niches

scientific article published on 12 October 2016

Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma.

scientific article

Genetically engineered mesenchymal stromal cells produce IL-3 and TPO to further improve human scaffold-based xenograft models

scientific article published on 26 April 2017

Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells ⬇️

scientific article published on February 4, 2013

Illegitimate WNT pathway activation by beta-catenin mutation or autocrine stimulation in T-cell malignancies.

scientific article published in September 2008

Lenalidomide for the treatment of relapsed and refractory multiple myeloma.

scientific article

Liposomal dexamethasone inhibits tumor growth in an advanced human-mouse hybrid model of multiple myeloma

scientific article published on 22 January 2019

Modeling BCR-ABL and MLL-AF9 leukemia in a human bone marrow-like scaffold-based xenograft model

scientific article published on 29 April 2016

Non-canonical PRC1.1 Targets Active Genes Independent of H3K27me3 and Is Essential for Leukemogenesis.

scientific article published on 30 December 2015

Optimal selection of natural killer cells to kill myeloma: the role of HLA-E and NKG2A

scientific article published on 29 April 2015

PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation

scientific article published on 05 August 2019

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.

scientific article published on 09 January 2014

Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma.

scientific article published on 8 February 2016

Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib

scientific article

Preclinical activity of the oral proteasome inhibitor MLN9708 in Myeloma bone disease.

scientific article published on 31 January 2014

Preclinical evidence for an effective therapeutic activity of FL118, a novel survivin inhibitor, in patients with relapsed/refractory multiple myeloma

scientific article published on 31 January 2020

Realgar nanoparticles versus ATO arsenic compounds induce in vitro and in vivo activity against multiple myeloma.

scientific article

Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma ⬇️

scientific article published on May 31, 2012

Sepantronium bromide (YM155) improves daratumumab-mediated cellular lysis of multiple myeloma cells by abrogation of bone marrow stromal cell-induced resistance.

scientific article published on 5 May 2016

Targeting EXT1 reveals a crucial role for heparan sulfate in the growth of multiple myeloma.

scientific article

The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor-Mediated Cross-Linking

scientific article published on 17 June 2016

Upregulation of CD38 expression on multiple myeloma cells by all-trans retinoic acid improves the efficacy of daratumumab.

scientific article published on 15 May 2015

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