List of works - Paul Simons

A role for APP in Wnt signalling links synapse loss with β-amyloid production

scientific article published on 20 September 2018

A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.

scientific article

Adeno-associated virus serotypes 7 and 8 outperform serotype 9 in expressing atheroprotective human apoE3 from mouse skeletal muscle.

scientific article published on 23 May 2010

Amyloid persistence in decellularized liver: biochemical and histopathological characterization.

scientific article published on 8 December 2015

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil. ⬇️

scientific article

C-reactive protein is essential for innate resistance to pneumococcal infection

scientific article

Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β 2 -Microglobulin

scientific article

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

scientific article

Exon skipping of hepatic APOB pre-mRNA with splice-switching oligonucleotides reduces LDL cholesterol in vivo. ⬇️

scientific article

Loss of phosphatidylinositol 4-kinase 2alpha activity causes late onset degeneration of spinal cord axons

scientific article

Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity.

scientific article published on 14 June 2009

Oligonucleotide-directed gene-editing technology: mechanisms and future prospects.

scientific article published on 10 February 2012

Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity.

scientific article published on 15 July 2009

Pathogenetic mechanisms of amyloid A amyloidosis.

scientific article published on 19 August 2013

Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo

scientific article published on February 2016

Reducing β-amyloid by inhibition of BACE1: how low should you go?

scientific article published in April 2015

Screening for mutations in the phosphatidylinositol 4-kinase 2-alpha gene in autosomal recessive hereditary spastic paraplegia.

scientific article

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice

scientific article

The IGF-I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscle

scientific article

The effects of short-term JNK inhibition on the survival and growth of aged sympathetic neurons.

scientific article published on 5 July 2016

Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells

scientific article published on 11 April 2016

Validation of oligonucleotide-mediated gene editing.

scientific article

List of works by Paul Simons

A role for APP in Wnt signalling links synapse loss with β-amyloid production

A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.

Adeno-associated virus serotypes 7 and 8 outperform serotype 9 in expressing atheroprotective human apoE3 from mouse skeletal muscle.

Amyloid persistence in decellularized liver: biochemical and histopathological characterization.

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil. ⬇️

C-reactive protein is essential for innate resistance to pneumococcal infection

Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β 2 -Microglobulin

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

Exon skipping of hepatic APOB pre-mRNA with splice-switching oligonucleotides reduces LDL cholesterol in vivo. ⬇️

Loss of phosphatidylinositol 4-kinase 2alpha activity causes late onset degeneration of spinal cord axons

Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity.

Oligonucleotide-directed gene-editing technology: mechanisms and future prospects.

Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity.

Pathogenetic mechanisms of amyloid A amyloidosis.

Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo

Reducing β-amyloid by inhibition of BACE1: how low should you go?

Screening for mutations in the phosphatidylinositol 4-kinase 2-alpha gene in autosomal recessive hereditary spastic paraplegia.

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice

The IGF-I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscle

The effects of short-term JNK inhibition on the survival and growth of aged sympathetic neurons.

Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells

Validation of oligonucleotide-mediated gene editing.