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List of works by Kay L Double

A Proposed Mechanism for Neurodegeneration in Movement Disorders Characterized by Metal Dyshomeostasis and Oxidative Stress

scientific article published on 31 May 2018

A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice

scientific article (publication date: 2010)

Accumulation of dysfunctional SOD1 protein in Parkinson's disease is not associated with mutations in the SOD1 gene.

scientific article published on 19 October 2017

Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease.

scientific article

Amyotrophic lateral sclerosis-like superoxide dismutase 1 proteinopathy is associated with neuronal loss in Parkinson's disease brain

scientific article published on 19 May 2017

Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease

scientific article

Arguments for the use of dopamine receptor agonists in clinical and preclinical Parkinson's disease

scientific article

Brain iron pathways and their relevance to Parkinson's disease.

scientific article

Cell loss in the nucleus basalis is related to regional cortical atrophy in Alzheimer's disease.

scientific article published on June 1997

Comparative Study of Metal Quantification in Neurological Tissue Using Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry Imaging and X-ray Fluorescence Microscopy

scientific article published on 9 June 2015

Copper dyshomoeostasis in Parkinson's disease: implications for pathogenesis and indications for novel therapeutics

scientific article published on April 2016

Copper pathology in vulnerable brain regions in Parkinson's disease

scientific article published on 2 October 2013

Decline in Proliferation and Immature Neuron Markers in the Human Subependymal Zone during Aging: Relationship to EGF- and FGF-Related Transcripts

scientific article

Differential effects of human neuromelanin and synthetic dopamine melanin on neuronal and glial cells.

scientific article published on 31 August 2005

Dolichol is the major lipid component of human substantia nigra neuromelanin.

scientific article

Dopamine receptor agonists in current clinical use: comparative dopamine receptor binding profiles defined in the human striatum

scientific article (publication date: October 2003)

Dopamine receptor agonists in the therapy of Parkinson's disease.

scientific article published on 29 December 2003

Dopamine receptors in the substantia nigra are involved in the regulation of muscle tone.

scientific article

Effect of age on proliferation-regulating factors in human adult neurogenic regions

scientific article published on 28 September 2010

Effects of inactivation of D1 dopamine receptors on stereotypic and thermic responses to quinpirole (LY 171555).

scientific article published in July 1990

Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model.

scientific article published on 20 June 2013

Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers.

scientific article

Evidence for specific phases in the development of human neuromelanin

article

Evidence for specific phases in the development of human neuromelanin.

scientific article

Expression of stereotyped behaviour requires stimulation of nigral D1 dopamine receptors.

scientific article published on May 1995

Functional effects of neuromelanin and synthetic melanin in model systems.

scientific article

GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area.

scientific article published in August 2012

Hand function is impaired in healthy older adults at risk of Parkinson's disease

scientific article published on 3 May 2014

Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease.

scientific article published on 24 July 2014

Identifying severely atrophic cortical subregions in Alzheimer's disease.

scientific article published in October 2003

Identifying the pattern of olfactory deficits in Parkinson disease using the brief smell identification test

scientific article

Impaired iron homeostasis in Parkinson's disease.

scientific article

In vitro studies of ferritin iron release and neurotoxicity.

scientific article published in June 1998

Influence of neuromelanin on oxidative pathways within the human substantia nigra

scientific article

Intracellular chemical imaging of the developmental phases of human neuromelanin using synchrotron X-ray microspectroscopy.

scientific article

Investigation of the lipid component of neuromelanin.

scientific article

Iron and dopamine: a toxic couple.

scientific article published on 8 March 2016

Iron in the Parkinsonian substantia nigra.

scientific article published in March 1997

Iron-binding characteristics of neuromelanin of the human substantia nigra.

scientific article published in August 2003

Language-associated cortical regions are proportionally larger in the female brain

scientific article

Levels of glial cell line-derived neurotrophic factor are decreased, but fibroblast growth factor 2 and cerebral dopamine neurotrophic factor are increased in the hippocampus in Parkinson's disease

scientific article published on 14 June 2019

Localization of copper and copper transporters in the human brain.

scientific article published in January 2013

Low Serum Progranulin Predicts the Presence of Mutations: A Prospective Study

scientific article published on 01 January 2010

Meta-Analysis of Copper and Iron in Parkinson's Disease Brain and Biofluids

scientific article published on 31 December 2019

Neural degeneration in Parkinson's disease.

scientific article

Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease

scientific article

Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson's disease

scientific article

Neuromelanin-bound ferric iron as an experimental model of dopaminergic neurodegeneration in Parkinson's disease.

scientific article published on 27 June 2008

Neuronal vulnerability in Parkinson's disease.

scientific article published on January 2012

New face of neuromelanin.

scientific article published on January 2006

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

scientific article published on 20 August 2019

Pathophysiology of transcranial sonography signal changes in the human substantia nigra.

scientific article published on January 2010

Pigmentation in the human brain and risk of Parkinson's disease.

scientific article

Potential sources of increased iron in the substantia nigra of parkinsonian patients

scientific article published in January 2006

Putative presynaptic dopamine dysregulation in schizophrenia is supported by molecular evidence from post-mortem human midbrain

scientific article published on 17 January 2017

Quantitative electromyographic changes following modification of central dopaminergic transmission.

scientific article published in February 1993

Reducing the burden of neurological disease and mental illness

scientific article published in May 2017

Reduction in IGF1 mRNA in the Human Subependymal Zone During Aging

scientific article published on 01 February 2019

Regional brain atrophy in idiopathic parkinson's disease and diffuse Lewy body disease

scientific article

Regional specificity of brain atrophy in Huntington's disease.

scientific article published in December 1998

Role of iron in 6-hydroxydopamine neurotoxicity

scientific article

Simultaneous structural and elemental nano-imaging of human brain tissue

scientific article published on 10 August 2020

Strategies for the protection of dopaminergic neurons against neurotoxicity.

scientific article

Structural Characteristics of Human Substantia Nigra Neuromelanin and Synthetic Dopamine Melanins

scientific article published on 01 December 2000

Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain.

scientific article

Substantia nigra echomorphology and motor cortex excitability.

scientific article published on 29 January 2010

Substantia nigra echomorphology in the healthy very old: Correlation with motor slowing.

scientific article published in December 2006

Tension-referenced measures of gastrocnemius slack length and stiffness in Parkinson's disease.

scientific article published on 11 March 2016

Testosterone induces molecular changes in dopamine signaling pathway molecules in the adolescent male rat nigrostriatal pathway

scientific article

Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra

scientific article

The industrial chemical Tinuvin 123 does not induce dopaminergic neurotoxicity in C57Bl/6 mice

scientific article published on 01 January 2000

The relevance of iron in the pathogenesis of Parkinson's disease.

scientific article published on March 2004

Topography of brain atrophy during normal aging and Alzheimer's disease.

scientific article published in July 1996

Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease.

scientific article published on 24 August 2012

Upper limb function is normal in patients with restless legs syndrome (Willis-Ekbom Disease).

scientific article published on 18 July 2014

Using Sepia melanin as a PD model to describe the binding characteristics of neuromelanin - A critical review

scientific article

Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra

scientific article

White matter loss in healthy ageing: A postmortem analysis

scientific article published on 20 February 2008

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