List of works - Adam Daïch

A domino N-amidoacylation/aldol-type condensation approach to the synthesis of the topo-I inhibitor Rosettacin and derivatives

scientific article published on 07 February 2008

Access to 3-spiroindolizines containing an isoindole ring through intra-molecular arylation of spiro-N-acyliminium species: a new family of potent farnesyltransferase inhibitors

scientific article published on 01 March 2019

Acid-catalysed formation of tricyclic N,S-acetals in imidazolinone series based on the use of the unprecedented N-acyliminium ion cascade reaction involving transposition, heterocyclisation and pi-cyclisation.

scientific article published on 4 October 2005

An alkaloid, two conjugate sesquiterpenes and a phenylpropanoid from Pachypodanthium confine Engl. and Diels

scientific article published on 01 June 2007

Asymmetric Synthesis and Binding Study of New Long-Chain HPA-12 Analogues as Potent Ligands of the Ceramide Transfer Protein CERT.

scientific article published on 31 March 2016

CIAT with simultaneous epimerization at two stereocenters. Synthesis of substituted beta-methyl-alpha-homophenylalanines

scientific article published on 23 November 2006

Chemistry and Biology of HPAs: A Family of Ceramide Trafficking Inhibitors.

scientific article published on 15 September 2016

Competitive intramolecular C-C vs. C-O bond coupling reactions toward C6 ring-fused 2-pyridone synthesis

scientific article published on 15 March 2016

Design and semisynthesis of new herbicide as 1,2,3-triazole derivatives of the natural maslinic acid

scientific article published on 20 July 2018

Development of SECheM Concept for Isolation and Chemical Modification of Gossypol Directly from Cienfuegosia digitata.

scientific article

Domino Process Optimized via ab Initio Study for an Alternative Access to Bicyclic Lactams ⬇️

scientific article published on June 28, 2011

Eaton's reagent-mediated domino π-cationic arylations of aromatic carboxylic acids to Iasi-red polymethoxylated polycyclic aromatic hydrocarbons: products with unprecedented biological activities as tubulin polymerization inhibitors.

scientific article

Expedient and practical synthesis of CERT-dependent ceramide trafficking inhibitor HPA-12 and its analogues

scientific article published on 25 February 2011

From Conventional Lewis Acids to Heterogeneous Montmorillonite K10, Eco-friendly Plant-based Catalysts used as Green Lewis Acids

scientific article published on 6 February 2018

General and versatile entry to 4,5-fused polycyclic imidazolones systems. Use of the tandem transposition/pi-cyclization of N-acyliminium species

scientific article published on 01 July 2006

Highly Enantioselective Semisynthesis of (+)/(-)-Gossypol Schiff Base Derivatives from Ground Plant Material

scientific article published on 11 July 2019

Identification of novel CERT ligands as potential ceramide trafficking inhibitors.

scientific article

Impact of Functional Groups on the Copper-Initiated N-Arylation of 5-Functionalized Pyrrolidin-2-ones and Their Vinylogues

Intermolecular and intramolecular alpha-amidoalkylation reactions using bismuth triflate as the catalyst

scientific article published on 23 January 2007

Metal-Free Cascade Approach toward Polysubstituted Indolizines from Chromone-Based Michael Acceptors.

scientific article

New Efficient Eco-Friendly Supported Catalysts for the Synthesis of Amides with Antioxidant and Anti-Inflammatory Properties

scientific article published on 12 February 2020

New and expeditious tandem sequence aza-Michael/intramolecular nucleophilic substitution route to substituted gamma-lactams: synthesis of the tricyclic core of (+/-)-martinellines.

scientific article

New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities.

scientific article

Original Mitsunobu-Triggered Sequence Involved in a One-Pot Domino Process toward Tetracyclic Systems Bearing a Bis-N,O-acetal Junction.

scientific article published on 7 September 2016

Phenyliodine(III) Diacetate/I2 -Mediated Domino Approach for Pyrrolo[1,4]Thiazines and 1,4-Thiazines by a One-Pot Morin Rearrangement of N,S-Acetals

scientific article published on 08 April 2019

Phytochemical and biological studies of Atriplex inflata f. Muell.: isolation of secondary bioactive metabolites.

scientific article published on 2 May 2017

Pi-aromatic and sulfur nucleophilic partners in cationic pi-cyclizations: intramolecular amidoalkylation and thioamidoalkylation cyclization via omega-carbinol lactams(1, 2).

scientific article published in June 2001

Simple access to highly functional bicyclic γ- and δ-lactams: origins of chirality transfer to contiguous tertiary/quaternary stereocenters assessed by DFT.

scientific article published on 18 December 2014

Structure and Mechanism Revision of a Catalyzed Cyclization of Benzaldehyde Bearing Alkyne-Nitrile.

scientific article published on 6 September 2017

Structure-Based Kinetic Control in a Domino Process: A Powerful Tool Toward Molecular Diversity in Chromone Series.

scientific article

Synthesis and sequential diastereoselective incorporation of hydroxyl groups into hexahydrofuro[3,2-f]indolizin-7(2H)-one to give mono-, di- and tetra-hydroxyfuroindolizidines

scientific article published on 05 August 2020

Synthesis of highly functionalized pyrrolidines as tunable templates for the direct access to (±)-coerulescine and the tricyclic core of martinellines.

scientific article

Tandem Michael addition/amino-nitrile cyclization from 2-formyl-1,4-DHP in the synthesis of novel dihydroindolizine-based compounds.

scientific article published in November 2006

The CERT antagonist HPA-12: first practical synthesis and individual binding evaluation of the four stereoisomers.

scientific article

List of works by Adam Daïch

A domino N-amidoacylation/aldol-type condensation approach to the synthesis of the topo-I inhibitor Rosettacin and derivatives

Access to 3-spiroindolizines containing an isoindole ring through intra-molecular arylation of spiro-N-acyliminium species: a new family of potent farnesyltransferase inhibitors

Acid-catalysed formation of tricyclic N,S-acetals in imidazolinone series based on the use of the unprecedented N-acyliminium ion cascade reaction involving transposition, heterocyclisation and pi-cyclisation.

An alkaloid, two conjugate sesquiterpenes and a phenylpropanoid from Pachypodanthium confine Engl. and Diels

Asymmetric Synthesis and Binding Study of New Long-Chain HPA-12 Analogues as Potent Ligands of the Ceramide Transfer Protein CERT.

CIAT with simultaneous epimerization at two stereocenters. Synthesis of substituted beta-methyl-alpha-homophenylalanines

Chemistry and Biology of HPAs: A Family of Ceramide Trafficking Inhibitors.

Competitive intramolecular C-C vs. C-O bond coupling reactions toward C6 ring-fused 2-pyridone synthesis

Design and semisynthesis of new herbicide as 1,2,3-triazole derivatives of the natural maslinic acid

Development of SECheM Concept for Isolation and Chemical Modification of Gossypol Directly from Cienfuegosia digitata.

Domino Process Optimized via ab Initio Study for an Alternative Access to Bicyclic Lactams ⬇️

Eaton's reagent-mediated domino π-cationic arylations of aromatic carboxylic acids to Iasi-red polymethoxylated polycyclic aromatic hydrocarbons: products with unprecedented biological activities as tubulin polymerization inhibitors.

Expedient and practical synthesis of CERT-dependent ceramide trafficking inhibitor HPA-12 and its analogues

From Conventional Lewis Acids to Heterogeneous Montmorillonite K10, Eco-friendly Plant-based Catalysts used as Green Lewis Acids

General and versatile entry to 4,5-fused polycyclic imidazolones systems. Use of the tandem transposition/pi-cyclization of N-acyliminium species

Highly Enantioselective Semisynthesis of (+)/(-)-Gossypol Schiff Base Derivatives from Ground Plant Material

Identification of novel CERT ligands as potential ceramide trafficking inhibitors.

Impact of Functional Groups on the Copper-Initiated N-Arylation of 5-Functionalized Pyrrolidin-2-ones and Their Vinylogues

Intermolecular and intramolecular alpha-amidoalkylation reactions using bismuth triflate as the catalyst

Metal-Free Cascade Approach toward Polysubstituted Indolizines from Chromone-Based Michael Acceptors.

New Efficient Eco-Friendly Supported Catalysts for the Synthesis of Amides with Antioxidant and Anti-Inflammatory Properties

New and expeditious tandem sequence aza-Michael/intramolecular nucleophilic substitution route to substituted gamma-lactams: synthesis of the tricyclic core of (+/-)-martinellines.

New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities.

Original Mitsunobu-Triggered Sequence Involved in a One-Pot Domino Process toward Tetracyclic Systems Bearing a Bis-N,O-acetal Junction.

Phenyliodine(III) Diacetate/I2 -Mediated Domino Approach for Pyrrolo[1,4]Thiazines and 1,4-Thiazines by a One-Pot Morin Rearrangement of N,S-Acetals

Phytochemical and biological studies of Atriplex inflata f. Muell.: isolation of secondary bioactive metabolites.

Pi-aromatic and sulfur nucleophilic partners in cationic pi-cyclizations: intramolecular amidoalkylation and thioamidoalkylation cyclization via omega-carbinol lactams(1, 2).

Simple access to highly functional bicyclic γ- and δ-lactams: origins of chirality transfer to contiguous tertiary/quaternary stereocenters assessed by DFT.

Structure and Mechanism Revision of a Catalyzed Cyclization of Benzaldehyde Bearing Alkyne-Nitrile.

Structure-Based Kinetic Control in a Domino Process: A Powerful Tool Toward Molecular Diversity in Chromone Series.

Synthesis and sequential diastereoselective incorporation of hydroxyl groups into hexahydrofuro[3,2-f]indolizin-7(2H)-one to give mono-, di- and tetra-hydroxyfuroindolizidines

Synthesis of highly functionalized pyrrolidines as tunable templates for the direct access to (±)-coerulescine and the tricyclic core of martinellines.

Tandem Michael addition/amino-nitrile cyclization from 2-formyl-1,4-DHP in the synthesis of novel dihydroindolizine-based compounds.

The CERT antagonist HPA-12: first practical synthesis and individual binding evaluation of the four stereoisomers.

The Reactivity of Enantiopure (S )-6-Oxopipecolic Acid and Corresponding Pyridoisoquinolines Under Acidic Conditions

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction