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List of works by Hideyuki Saya

A human cancer xenograft model utilizing normal pancreatic duct epithelial cells conditionally transformed with defined oncogenes.

scientific article published on 24 May 2014

A stem cell medium containing neural stimulating factor induces a pancreatic cancer stem-like cell-enriched population

scientific article

ALK(R1275Q) perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN.

scientific article published in February 2016

APCCDH1 Targets MgcRacGAP for Destruction in the Late M Phase ⬇️

scientific article published on May 16, 2013

Acquired expression of NFATc1 downregulates E-cadherin and promotes cancer cell invasion.

scientific article published on 28 June 2013

Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells.

scientific article published on 5 April 2017

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.

scientific article

An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics

scientific journal article

An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment

scientific article published on 19 December 2018

Anti-tumor effect against human cancer xenografts by a fully human monoclonal antibody to a variant 8-epitope of CD44R1 expressed on cancer stem cells

scientific article (publication date: 2012)

Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases

scientific article

Application of clotrimazole via a novel controlled release device provides potent retinal protection.

scientific article published on 3 September 2015

Arsenic trioxide sensitizes glioblastoma to a myc inhibitor.

scientific article published on 3 June 2015

Author Correction: CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake

scientific article published on 03 April 2020

Blocking COX-2 induces apoptosis and inhibits cell proliferation via the Akt/survivin- and Akt/ID3 pathway in low-grade-glioma.

scientific article published on 10 March 2017

Breast cancer stem cells.

scientific article published on 06 October 2009

BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells.

scientific article

CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis.

scientific article

CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence.

scientific article published on 18 June 2013

CD44 variant 9 is a potential biomarker of tumor initiating cells predicting survival outcome in hepatitis C virus-positive patients with resected hepatocellular carcinoma.

scientific article published on 16 February 2016

CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake.

scientific article published on 12 February 2018

CD44 variant-dependent regulation of redox balance in EGFR mutation-positive non-small cell lung cancer: A target for treatment.

scientific article

CD44s regulates the TGF-β-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma

scientific article published on 02 May 2012

CD44s signals the acquisition of the mesenchymal phenotype required for anchorage-independent cell survival in hepatocellular carcinoma.

scientific article published on 3 December 2013

Calcitriol exerts an anti-tumor effect in osteosarcoma by inducing the endoplasmic reticulum stress response

scientific article published on 23 June 2017

Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori-Infected CAPZA1-Overexpressing Cells

scientific article published on 27 May 2019

Characteristics of glioma stem cells ⬇️

scientific article published on April 13, 2013

Complexity of cancer stem cells ⬇️

scientific article published on December 17, 2012

Concise Review: Stem Cells and Epithelial-Mesenchymal Transition in Cancer: Biological Implications and Therapeutic Targets.

scientific article published on 2 June 2016

Convection-enhanced delivery of sulfasalazine prolongs survival in a glioma stem cell brain tumor model

scientific article published on 19 September 2017

Correction: Arsenic Trioxide Sensitizes Glioblastoma to a Myc Inhibitor.

scientific article published on 16 February 2016

Correction: LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C.

scientific article published on 10 April 2015

DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/CCdh1 in Senescent Cells ⬇️

scientific article published on December 15, 2011

Development of Highly Selective Fluorescent Probe Enabling Flow-Cytometric Isolation of ALDH3A1-Positive Viable Cells.

scientific article published on 15 December 2016

Development of a functional thyroid model based on an organoid culture system.

scientific article published on 19 February 2018

Development of an ErbB4 monoclonal antibody that blocks neuregulin-1-induced ErbB4 activation in cancer cells.

scientific article published on 9 January 2016

Development of mouse models of malignant phyllodes tumors by transplantation of syngeneic mammary gland cells expressing mutant H-Ras

scientific article published on 23 September 2016

Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis

scientific article published on 23 June 2016

Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205).

scientific article published on 7 April 2016

Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma

scientific article published on 17 September 2020

Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality.

scientific article published on 19 December 2017

Dynamic changes in CD44v-positive cells after preoperative anti-HER2 therapy and its correlation with pathologic complete response in HER2-positive breast cancer

scientific article published on 4 January 2018

Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression.

scientific article published on 9 July 2015

EGFR promotes glioma progression by regulating xCT and GluN2B-containing NMDA receptor signaling

scientific article published on 05 November 2018

Effectiveness of plasma treatment on gastric cancer cells.

scientific article

Endothelial-Mesenchymal Transition Drives Expression of CD44 Variant and xCT in Pulmonary Hypertension

scientific article published on 01 September 2019

Endothelium-induced three-dimensional invasion of heterogeneous glioma initiating cells in a microfluidic coculture platform

scientific article published on 28 July 2017

EpCAM expression in the prostate cancer makes the difference in the response to growth factors

scientific article published on 2 December 2013

Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines.

scientific article published on 31 March 2016

Establishment of HRAS(G12V) transgenic medaka as a stable tumor model for in vivo screening of anticancer drugs

scientific article

Establishment of a choriocarcinoma model from immortalized normal extravillous trophoblast cells transduced with HRASV12

scientific article

Establishment of pten knockout medaka with transcription activator-like effector nucleases (TALENs) as a model of PTEN deficiency disease

scientific article published on 20 October 2017

Experimental therapies: Investigator-initiated cancer trials with INDs for approval in Japan

scientific article published on 01 March 2010

Expression of CD24 is associated with HER2 expression and supports HER2-Akt signaling in HER2-positive breast cancer cells.

scientific article

Expression of TNF-α and CD44 is implicated in poor prognosis, cancer cell invasion, metastasis and resistance to the sunitinib treatment in clear cell renal cell carcinomas.

scientific article

Expression profiles of carcinosarcoma of the uterine corpus—are these similar to carcinoma or sarcoma? ⬇️

scientific article published on November 10, 2011

FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia.

scientific article published on 31 January 2017

Fibroblast growth factor-2 is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma.

scientific article published on 6 January 2012

Functional analysis of a novel glioma antigen, EFTUD1.

scientific article

Functional analysis of the DEPDC1 oncoantigen in malignant glioma and brain tumor initiating cells.

scientific article published on 29 May 2017

Functional role of CD44v-xCT system in the development of spasmolytic polypeptide-expressing metaplasia.

scientific article

GANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development.

scientific article published on 9 January 2016

Gene expression profile of a newly established choriocarcinoma cell line, iC3-1, compared to existing choriocarcinoma cell lines and normal placenta.

scientific article published on 28 November 2012

Generation of heterozygous fibrillin-1 mutant cloned pigs from genome-edited foetal fibroblasts

scientific article

Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors

scientific article published on 04 March 2019

Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma

scientific article published on 13 September 2019

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival.

scientific article published on 19 April 2018

HER2 Heterogeneity Is Associated with Poor Survival in HER2-Positive Breast Cancer

scientific article published on 24 July 2018

Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma.

scientific article

IGF1 Receptor Signaling Regulates Adaptive Radioprotection in Glioma Stem Cells ⬇️

scientific article published on April 1, 2013

IGF2 preserves osteosarcoma cell survival by creating an autophagic state of dormancy that protects cells against chemotherapeutic stress.

scientific article published on October 2014

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

scientific article published on 01 August 2019

Identification of CD44 as a cell surface marker for Müller glia precursor cells.

scientific article published on 19 November 2010

Identification of kit-ligand a as the Gene Responsible for the Medaka Pigment Cell Mutant few melanophore

scientific article published on 07 January 2020

Identification of novel small compounds that restore E-cadherin expression and inhibit tumor cell motility and invasiveness.

scientific article

Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin.

scientific article published on 17 September 2009

Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry

scientific article published on 11 November 2014

In vivo assessment of cancerous tumors using boron doped diamond microelectrode

scientific article

In vivo pH monitoring using boron doped diamond microelectrode and silver needles: application to stomach disorder diagnosis.

scientific article published on 19 November 2013

Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer.

scientific article published on 19 January 2012

Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression.

scientific article published on June 2017

Inhibiting xCT Improves 5-Fluorouracil Resistance of Gastric Cancer Induced by CD44 Variant 9 Expression

scientific article published on 01 November 2018

Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor.

scientific article published on 10 October 2011

Ink4a/Arf(-/-) and HRAS(G12V) transform mouse mammary cells into triple-negative breast cancer containing tumorigenic CD49f(-) quiescent cells.

scientific article published on 04 February 2013

Ink4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis.

scientific article

Integrated analysis identifies different metabolic signatures for tumor-initiating cells in a murine glioblastoma model.

scientific article published on 23 May 2014

Invasion precedes tumor mass formation in a malignant brain tumor model of genetically modified neural stem cells

scientific article

Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation.

scientific article published on 11 December 2013

Isolation of All CD44 Transcripts in Human Epidermis and Regulation of Their Expression by Various Agents

scientific article

Katanin p60 contributes to microtubule instability around the midbody and facilitates cytokinesis in rat cells

scientific article (publication date: 2013)

LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development.

scientific article published on 30 June 2016

LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C.

scientific article

LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression

scientific article

Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor‐negative breast cancer ⬇️

scientific article published on August 24, 2011

Lysyl Oxidase Is Induced by Cell Density-Mediated Cell Cycle Suppression via RB-E2F1-HIF-1α Axis ⬇️

scientific article published on November 30, 2012

MIF Maintains the Tumorigenic Capacity of Brain Tumor-Initiating Cells by Directly Inhibiting p53.

scientific article published on 15 March 2016

Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation

scientific article published on 6 December 2013

Mad2 inhibits the mitotic kinesin MKlp2 ⬇️

scientific article published on December 13, 2010

Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model.

scientific article

Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model.

scientific article published on 2 September 2017

Methotrexate inhibits osteoclastogenesis by decreasing RANKL-induced calcium influx into osteoclast progenitors

scientific article published on 23 July 2015

Modeling phenotypes of malignant gliomas

scientific article

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

scientific article published on 20 August 2018

Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells.

scientific article published on 31 January 2012

Molecular Biology of Glioma ⬇️

scientific article published on January 1, 2012

Molecular and cellular mechanisms underlying brain metastasis of breast cancer

scientific article published on 13 May 2020

Multiple café au lait spots in familial patients with MAP2K2 mutation.

scientific article

Myeloid Differentiation Factor 88 Signaling in Bone Marrow-Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment.

scientific article

NKX2.2 suppresses self-renewal of glioma-initiating cells.

scientific article published on 17 December 2010

Neuroprotective effects of memantine via enhancement of autophagy

scientific article published on 17 August 2019

Novel strategies for cancer stem cells.

scientific article

Oncogenicity of L-type amino-acid transporter 1 (LAT1) revealed by targeted gene disruption in chicken DT40 cells: LAT1 is a promising molecular target for human cancer therapy.

scientific article published on March 2011

Organotypic brain explant culture as a drug evaluation system for malignant brain tumors.

scientific article

Periostin Is a Key Niche Component for Wound Metastasis of Melanoma.

scientific article published on 17 June 2015

Periostin antisense oligonucleotide suppresses bleomycin-induced formation of a lung premetastatic niche for melanoma.

scientific article published on 2 March 2018

Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407).

scientific article published on 2 May 2017

Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer.

scientific article published on July 2017

Potential of sulfasalazine as a therapeutic sensitizer for CD44 splice variant 9-positive urogenital cancer

scientific article published on 4 April 2016

Prospects for new lung cancer treatments that target EMT signaling

scientific article published on 27 September 2017

Proteome profiling reveals gender differences in the composition of human serum.

scientific article

Pyruvate kinase M2: multiple faces for conferring benefits on cancer cells.

scientific article published on October 2012

RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis.

scientific article published on 22 January 2017

ROCK Inhibition Induces Terminal Adipocyte Differentiation and Suppresses Tumorigenesis in Chemoresistant Osteosarcoma Cells

scientific article published on 16 April 2019

Reciprocal control of G1-phase progression is required for Th-POK/Runx3-mediated CD4/8 thymocyte cell fate decision.

scientific article published on 26 September 2012

Recurrent Spindle Cell Carcinoma Shows Features of Mesenchymal Stem Cells

scientific article published in February 2018

Redox regulation in stem-like cancer cells by CD44 variant isoforms.

scientific article published on 21 January 2013

Reducing Inflammatory Cytokine Production from Renal Collecting Duct Cells by Inhibiting GATA2 Ameliorates Acute Kidney Injury.

scientific article published on 14 August 2017

Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation

scientific article published on 26 February 2014

Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs

scientific article

Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma

scientific article

Ropinirole hydrochloride remedy for amyotrophic lateral sclerosis - Protocol for a randomized, double-blind, placebo-controlled, single-center, and open-label continuation phase I/IIa clinical trial (ROPALS trial)

scientific article published on 26 July 2019

Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche

scientific journal article

Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity

scientific article published on 31 October 2016

Stat3 as a potential therapeutic target for rheumatoid arthritis.

scientific article published on 8 September 2017

Statins decrease lung inflammation in mice by upregulating tetraspanin CD9 in macrophages.

scientific article

Sulfasalazine could modulate the CD44v9-xCT system and enhance cisplatin-induced cytotoxic effects in metastatic bladder cancer

scientific article published on 01 March 2019

Sulfasalazine, a therapeutic agent for ulcerative colitis, inhibits the growth of CD44v9(+) cancer stem cells in ulcerative colitis-related cancer.

scientific article published on 5 January 2016

Synergistic antiproliferative effect of imatinib and adriamycin in platelet-derived growth factor receptor-expressing osteosarcoma cells

scientific article published on 26 May 2015

Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells

scientific article published on 18 September 2018

T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease

scientific article published on 18 October 2018

TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells.

scientific article published on 26 August 2013

TNFα promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state.

scientific article published on 16 December 2013

TSPAN2 is involved in cell invasion and motility during lung cancer progression.

scientific article published on 13 April 2014

Targeting Aurora B to the equatorial cortex by MKlp2 is required for cytokinesis

scientific article

The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells ⬇️

scientific article published on January 11, 2013

The Arf/p53 Protein Module, Which Induces Apoptosis, Down-regulates Histone H2AX to Allow Normal Cells to Survive in the Presence of Anti-cancer Drugs ⬇️

scientific article published on March 27, 2013

The DNA topoisomerase II inhibitor amsacrine as a novel candidate adjuvant in a model of glaucoma filtration surgery

scientific article published on 17 December 2019

The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-)

scientific article published on 15 March 2016

The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.

scientific article

The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress.

scientific article published on 23 February 2011

The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer

scientific article

The inhibitor of apoptosis protein Livin confers resistance to Fas-mediated immune cytotoxicity in refractory lymphoma

scientific article published on 14 September 2020

The insulin-PI3K-Rac1 axis contributes to terminal adipocyte differentiation through regulation of actin cytoskeleton dynamics

scientific article published on 29 January 2020

The use of next-generation sequencing in molecular diagnosis of neurofibromatosis type 1: a validation study.

scientific article

Therapeutic potential of tranilast for the treatment of chronic graft-versus-host disease in mice

scientific article published in PLoS ONE

Therapeutic strategies targeting cancer stem cells

scientific article

Three-dimensional culture of sebaceous gland cells revealing the role of prostaglandin E2-induced activation of canonical Wnt signaling.

scientific article published on 13 August 2013

Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells.

scientific article published on 17 April 2018

Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction.

scientific article

Tumor-specific interendothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness

scientific article published on 01 March 2022

Tumour resistance in induced pluripotent stem cells derived from naked mole-rats.

scientific article

Up-regulation of Imp3 confers in vivo tumorigenicity on murine osteosarcoma cells.

scientific article

Variant CD44 expression is enriching for a cell population with cancer stem cell-like characteristics in human lung adenocarcinoma.

scientific article

Variant isoforms of CD44 expression in upper tract urothelial cancer as a predictive marker for recurrence and mortality.

scientific article published on 25 April 2016

Variant isoforms of CD44 involves acquisition of chemoresistance to cisplatin and has potential as a novel indicator for identifying a cisplatin-resistant population in urothelial cancer.

scientific article published on 31 January 2018

Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy

scientific article published on 22 November 2019

Visualization of spatiotemporal dynamics of human glioma stem cell invasion

scientific article published on 06 May 2019

ZEB1 expression is a potential indicator of invasive endometriosis.

scientific article

cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes.

scientific article published on 3 May 2013

cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells.

scientific article published on 27 June 2017

xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma.

scientific article published on 14 January 2013

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