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List of works by Bernard Le Bonniec

A motif within the N-terminal domain of TSP-1 specifically promotes the proangiogenic activity of endothelial colony-forming cells

scientific article published on 14 July 2012

Association rate constants rationalise the pharmacodynamics of apixaban and rivaroxaban

scientific article published on 12 March 2015

Characterization of the P2' and P3' specificities of thrombin using fluorescence-quenched substrates and mapping of the subsites by mutagenesis

scientific article published on 01 June 1996

Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes

scientific article published in October 2003

Contribution of interactions with the core domain of hirudin to the stability of its complex with thrombin.

scientific article published on March 1994

Control of the coagulation system by serpins. Getting by with a little help from glycosaminoglycans

scientific article

Determination of the P1', P2' and P3' subsite-specificity of factor Xa.

scientific article

Electrostatic steering and ionic tethering in the formation of thrombin-hirudin complexes: the role of the thrombin anion-binding exosite-I

scientific article published on 01 April 2001

Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model.

scientific article published in January 2012

Evaluation of recombinant activated factor VII, prothrombin complex concentrate, and fibrinogen concentrate to reverse apixaban in a rabbit model of bleeding and thrombosis.

scientific article published on 6 August 2013

Functional identification of t-PA in crude and purified systems

scientific article published on 01 January 1988

Gestational age-related patterns of AMOT methylation are revealed in preterm infant endothelial progenitors

scientific article published on 16 October 2017

Glu192-->Gln substitution in thrombin yields an enzyme that is effectively inhibited by bovine pancreatic trypsin inhibitor and tissue factor pathway inhibitor.

scientific article

Identification of thrombin residues that modulate its interactions with antithrombin III and alpha 1-antitrypsin

scientific article published on 01 September 1995

Inherited factor VII deficiency: identification of two novel mutations (A191V and T239P) in the catalytic domain.

scientific article

Inhibitory mechanism of serpins. Identification of steps involving the active-site serine residue of the protease

scientific article published on 01 January 1997

Interaction of thrombin des-ETW with antithrombin III, the Kunitz inhibitors, thrombomodulin and protein C. Structural link between the autolysis loop and the Tyr-Pro-Pro-Trp insertion of thrombin ⬇️

scientific article published on September 25, 1992

Intrinsic specificity of the reactive site loop of alpha1-antitrypsin, alpha1-antichymotrypsin, antithrombin III, and protease nexin I

scientific article published on 01 June 1997

Large-Scale Chromatin Immunoprecipitation with Promoter Sequence Microarray Analysis of the Interaction of the NSs Protein of Rift Valley Fever Virus with Regulatory DNA Regions of the Host Genome ⬇️

scientific article published on August 15, 2012

Lonomia obliqua caterpillar spicules trigger human blood coagulation via activation of factor X and prothrombin

scientific article published on March 1, 1998

Low molecular weight fucoidan and heparin enhance the basic fibroblast growth factor-induced tube formation of endothelial cells through heparan sulfate-dependent alpha6 overexpression.

scientific article published in September 2003

Mapping of the catalytic groove preferences of factor Xa reveals an inadequate selectivity for its macromolecule substrates.

scientific article

Mapping of the thrombin des-ETW conformation by using site-directed mutants of hirudin. Evidence for the induction of nonlocal modifications by mutagenesis

scientific article published on 01 April 1994

Molecular determinants of the mechanism underlying acceleration of the interaction between antithrombin and factor Xa by heparin pentasaccharide

scientific article published on 19 February 2002

Multimodal assessment of non-specific hemostatic agents for apixaban reversal

scientific article published on 05 February 2015

Platelet factor 4 (CXCL4) seals blood clots by altering the structure of fibrin.

scientific article published on 7 November 2006

Protein C activation.

scientific article published on January 1993

Proteolytic derivatives of thrombin

scientific article published on 01 January 1986

Pulsed cavitational therapy using high-frequency ultrasound for the treatment of deep vein thrombosis in an in vitro model of human blood clot

scientific article published on 20 October 2017

Recombinant activated factor VII and prothrombin complex concentrates have different effects on bleeding and arterial thrombosis in the haemodiluted rabbit

scientific article published on 18 January 2012

Recombinant activated factor VII does not reduce bleeding in rabbits treated with aspirin and clopidogrel

scientific article published on 20 July 2010

Role of the P2 residue in determining the specificity of serpins

scientific article published on 01 September 1996

The VKOR target for warfarin identified

scientific article

The dual role of thrombin's anion-binding exosite-I in the recognition and cleavage of the protease-activated receptor 1

scientific article published on 01 January 2001

The elusive role of the potential factor X cation-binding exosite-1 in substrate and inhibitor interactions.

scientific article published on 28 October 2003

The gamma-carboxyglutamic acid domain of anticoagulant protein S is involved in activated protein C cofactor activity, independently of phospholipid binding.

scientific article published on 12 August 2004

The response to thrombin of human neutrophils: evidence for two novel receptors

scientific article published on 01 September 1995

The role of Glu(192) in the allosteric control of the S(2)' and S(3)' subsites of thrombin

scientific article published on 01 January 2000

The role of calcium ions in factor X activation by thrombin E192Q

scientific article published on 01 April 1992

The role of thrombin's Tyr-Pro-Pro-Trp motif in the interaction with fibrinogen, thrombomodulin, protein C, antithrombin III, and the Kunitz inhibitors

scientific article published on 01 September 1993

The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin

scientific article published on June 1997

Thrombin Glu-39 restricts the P'3 specificity to nonacidic residues

scientific article published on 01 July 1991

Thrombin bound to a fibrin clot confers angiogenic and haemostatic properties on endothelial progenitor cells

scientific article

Thrombin generation test: A reliable tool to evaluate the pharmacodynamics of vitamin K antagonist rodenticides in rats

scientific article published on 15 February 2018

Thrombin-activable factor X re-establishes an intrinsic amplification in tenase-deficient plasmas.

scientific article

Thrombomodulin modulates the mitogenic response to thrombin of human umbilical vein endothelial cells

scientific article published on 01 April 1998

Ticagrelor reversal: in vitro assessment of four haemostatic agents

scientific article

Topology of the stable serpin-protease complexes revealed by an autoantibody that fails to react with the monomeric conformers of antithrombin

scientific article published on 01 February 1999

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