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List of works by David M. Clarke

A salt bridge in intracellular loop 2 is essential for folding of human p-glycoprotein.

scientific article

Benzbromarone Stabilizes ΔF508 CFTR at the Cell Surface ⬇️

scientific article published on May 3, 2011

Chalcogenopyrylium Compounds as Modulators of the ATP-Binding Cassette Transporters P-Glycoprotein (P-gp/ABCB1) and Multidrug Resistance Protein 1 (MRP1/ABCC1)

article

Corrector VX-809 stabilizes the first transmembrane domain of CFTR.

scientific article published on 5 July 2013

Cysteines introduced into extracellular loops 1 and 4 of human P-glycoprotein that are close only in the open conformation spontaneously form a disulfide bond that inhibits drug efflux and ATPase activity.

scientific article

Drug rescue distinguishes between different structural models of human P-glycoprotein

scientific article published on 2 October 2013

Human P-glycoprotein contains a greasy ball-and-socket joint at the second transmission interface.

scientific article published on 03 June 2013

Identification of the distance between the homologous halves of P-glycoprotein that triggers the high/low ATPase activity switch.

scientific article published on 12 February 2014

Locking intracellular helices 2 and 3 together inactivates human P-glycoprotein.

scientific article published on 25 November 2013

Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein.

scientific article published on 26 October 2015

P-glycoprotein ATPase activity requires lipids to activate a switch at the first transmission interface.

scientific article published on 2 March 2016

Tariquidar inhibits P-glycoprotein drug efflux but activates ATPase activity by blocking transition to an open conformation

scientific article

The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoprotein

scientific article published on 18 May 2015

The cystic fibrosis V232D mutation inhibits CFTR maturation by disrupting a hydrophobic pocket rather than formation of aberrant interhelical hydrogen bonds.

scientific article published on 9 January 2014

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