List of works - Nicholas Brindle

A transcriptional regulator of osteogenesis expressed in calcifying atherosclerotic plaques ⬇️

scientific article published on 01 November 2001

ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1

scientific article

An in vitro model of aneurysmal disease: effect of leukocyte infiltration and shear stress on MMP production within the arterial wall

scientific article published on 01 November 1996

Aneurysmal smooth muscle cells exhibit increased matrix metalloproteinase-2 production in vitro

scientific article published on 01 November 1996

Angiogenesis and the atherosclerotic carotid plaque: an association between symptomatology and plaque morphology

scientific article published on 01 August 1999

Angiogenic revascularisation in ischaemic disease. Molecular techniques hold promise, though they are still some way off.

scientific article published on June 1999

Angiopoietin-2 stimulates migration of endothelial progenitors and their interaction with endothelium

scientific article published on 01 October 2005

Anti-(insulin receptor) monoclonal antibody-stimulated tyrosine phosphorylation in cells transfected with human insulin receptor cDNA ⬇️

scientific article published on June 15, 1990

Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets.

scientific article

Development of an Orthogonal Tie2 Ligand Resistant to Inhibition by Ang2

article

Directed evolution of an angiopoietin-2 ligand trap by somatic hypermutation and cell surface display

scientific article published on 8 October 2013

Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface

scientific article

Elastase-induced matrix degradation in arterial organ cultures: an in vitro model of aneurysmal disease

scientific article published on 01 October 1996

Evidence for heterotypic interaction between the receptor tyrosine kinases TIE-1 and TIE-2.

scientific article

Expression of two alternative splice forms of the insulin-like growth factor-I gene in human vascular endothelial cells

scientific article published on 01 March 1993

Functional analysis of a mutant form of the receptor tyrosine kinase Tie2 causing venous malformations.

scientific article published on 29 October 2004

Growth factors in endothelial regeneration.

scientific article

High glucose and elevated fatty acids suppress signaling by the endothelium protective ligand angiopoietin-1.

scientific article published on 15 January 2010

Inhibition of rabbit aortic smooth muscle cell proliferation by selective inhibitors of protein kinase C ⬇️

scientific article published on April 1, 1995

Involvement of protein tyrosine kinases in regulation of endothelial cell organization by basement membrane proteins

scientific article published on 01 December 1996

Molecular control of angiopoietin signalling ⬇️

scientific article published on December 1, 2011

Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2

scientific article

Mutant Tie2 causing venous malformation signals through Shc

scientific article published on 30 May 2006

Noninvasive augmentation of microvessel number in patients with peripheral vascular disease

scientific article published on 01 December 2003

Platelet-derived growth factor receptor expression does not accompany morphological differentiation of macrovascular endothelial cells in vitro

scientific article published on 01 November 1995

Potential roles of metalloprotease mediated ectodomain cleavage in signaling by the endothelial receptor tyrosine kinase Tie-1

scientific article published on 01 July 1999

Priming of human neutrophils by tumour necrosis factor-alpha and substance P is associated with tyrosine phosphorylation

scientific article published on 01 February 1995

Rational design and protein engineering of growth factors for regenerative medicine and tissue engineering.

scientific article published on August 2009

Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2.

scientific article

Regulation of Angiopoietin Signalling by Soluble Tie2 Ectodomain and Engineered Ligand Trap

scientific article published on 16 June 2017

Regulation of Insulin-Like Growth Factor-1 Expression in Vascular Endothelial Cells by the Inflammatory Cytokine Interleukin-1 ⬇️

scientific article published on May 1, 1998

Signaling and functions of angiopoietin-1 in vascular protection.

scientific article

Suppression of triglyceride secretion by epinephrine in isolated rat hepatocytes

scientific article published on 01 November 1986

The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling protein-2 by angiopoietin-1

scientific article

The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2.

scientific article

The endothelial receptor tyrosine kinase tie-1 is upregulated by hypoxia and vascular endothelial growth factor.

scientific article published in February 1998

The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling

scientific article

The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines

scientific article published on 01 October 2007

Tyrosine phosphorylation of proteins during "priming" of neutrophils

scientific article published on 01 November 1993

Using experimental evolution to probe molecular mechanisms of protein function.

scientific article

Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases.

scientific article published on 17 April 2009

Vascular endothelial growth factor and angiopoietins in neurovascular regeneration and protection following stroke.

scientific article

Vascular endothelial growth factor modulates the Tie-2:Tie-1 receptor complex.

scientific article published in March 2002

Vascular surgical society of great britain and ireland: angiogenesis and the atherosclerotic carotid plaque: association between symptomatology and plaque morphology

scientific article published on 01 May 1999

Vasodilator-stimulated phosphoprotein is involved in stress-fiber and membrane ruffle formation in endothelial cells

scientific article published on 01 September 2000

α-adrenergic suppression of very-low-density-lipoprotein triacylglycerol secretion by isolated rat hepatocytes ⬇️

scientific article published on March 1, 1988

List of works by Nicholas Brindle

A transcriptional regulator of osteogenesis expressed in calcifying atherosclerotic plaques ⬇️

ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1

An in vitro model of aneurysmal disease: effect of leukocyte infiltration and shear stress on MMP production within the arterial wall

Aneurysmal smooth muscle cells exhibit increased matrix metalloproteinase-2 production in vitro

Angiogenesis and the atherosclerotic carotid plaque: an association between symptomatology and plaque morphology

Angiogenic revascularisation in ischaemic disease. Molecular techniques hold promise, though they are still some way off.

Angiopoietin-2 stimulates migration of endothelial progenitors and their interaction with endothelium

Anti-(insulin receptor) monoclonal antibody-stimulated tyrosine phosphorylation in cells transfected with human insulin receptor cDNA ⬇️

Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets.

Development of an Orthogonal Tie2 Ligand Resistant to Inhibition by Ang2

Directed evolution of an angiopoietin-2 ligand trap by somatic hypermutation and cell surface display

Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface

Elastase-induced matrix degradation in arterial organ cultures: an in vitro model of aneurysmal disease

Evidence for heterotypic interaction between the receptor tyrosine kinases TIE-1 and TIE-2.

Expression of two alternative splice forms of the insulin-like growth factor-I gene in human vascular endothelial cells

Functional analysis of a mutant form of the receptor tyrosine kinase Tie2 causing venous malformations.

Growth factors in endothelial regeneration.

High glucose and elevated fatty acids suppress signaling by the endothelium protective ligand angiopoietin-1.

Inhibition of rabbit aortic smooth muscle cell proliferation by selective inhibitors of protein kinase C ⬇️

Involvement of protein tyrosine kinases in regulation of endothelial cell organization by basement membrane proteins

Molecular control of angiopoietin signalling ⬇️

Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2

Mutant Tie2 causing venous malformation signals through Shc

Noninvasive augmentation of microvessel number in patients with peripheral vascular disease

Platelet-derived growth factor receptor expression does not accompany morphological differentiation of macrovascular endothelial cells in vitro

Potential roles of metalloprotease mediated ectodomain cleavage in signaling by the endothelial receptor tyrosine kinase Tie-1

Priming of human neutrophils by tumour necrosis factor-alpha and substance P is associated with tyrosine phosphorylation

Rational design and protein engineering of growth factors for regenerative medicine and tissue engineering.

Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2.

Regulation of Angiopoietin Signalling by Soluble Tie2 Ectodomain and Engineered Ligand Trap

Regulation of Insulin-Like Growth Factor-1 Expression in Vascular Endothelial Cells by the Inflammatory Cytokine Interleukin-1 ⬇️

Signaling and functions of angiopoietin-1 in vascular protection.

Suppression of triglyceride secretion by epinephrine in isolated rat hepatocytes

The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling protein-2 by angiopoietin-1

The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2.

The endothelial receptor tyrosine kinase tie-1 is upregulated by hypoxia and vascular endothelial growth factor.

The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling

The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines

Tyrosine phosphorylation of proteins during "priming" of neutrophils

Using experimental evolution to probe molecular mechanisms of protein function.

Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases.

Vascular endothelial growth factor and angiopoietins in neurovascular regeneration and protection following stroke.

Vascular endothelial growth factor modulates the Tie-2:Tie-1 receptor complex.

Vascular surgical society of great britain and ireland: angiogenesis and the atherosclerotic carotid plaque: association between symptomatology and plaque morphology

Vasodilator-stimulated phosphoprotein is involved in stress-fiber and membrane ruffle formation in endothelial cells

α-adrenergic suppression of very-low-density-lipoprotein triacylglycerol secretion by isolated rat hepatocytes ⬇️