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List of works by Sebastian Nijman

A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer.

scientific article published on 25 September 2011

A reversible gene trap collection empowers haploid genetics in human cells

scientific article published on 25 August 2013

A thesaurus of genetic variation for interrogation of repetitive genomic regions

scientific article

An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B.

scientific article published on 18 July 2011

Comparison of genetic variants in matched samples using thesaurus annotation.

scientific article published on 5 November 2015

Exploiting epigenetic vulnerabilities for cancer therapeutics

scientific article published on 12 February 2014

Functional drug-gene interactions in lung cancer.

scientific article published on April 2012

Functional genomics to uncover drug mechanism of action.

scientific article

Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity

scientific article

Identification of oncostatin M as a STAT5-dependent mediator of bone marrow remodeling in KIT D816V-positive systemic mastocytosis

scientific article

Light-assisted small-molecule screening against protein kinases.

scientific article published on 12 October 2015

Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse

scientific article

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line

scientific article

NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation

scientific article published on 29 September 2014

Parallel reverse genetic screening in mutant human cells using transcriptomics

scientific article published on August 2016

Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway

scientific article published on 15 September 2020

Synthetic lethal vulnerabilities of cancer

scientific article

Synthetic lethality: General principles, utility and detection using genetic screens in human cells ⬇️

scientific article published on November 19, 2010

TOPS: a versatile software tool for statistical analysis and visualization of combinatorial gene-gene and gene-drug interaction screens

scientific article

Targeting a cell state common to triple-negative breast cancers

scientific article

Ubiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1

scientific article

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