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List of works by René de Waal Malefyt

A canine model of cutaneous late-phase reactions: prednisolone inhibition of cellular and cytokine responses.

scientific article published in February 2006

A clinical biomarker assay to quantitate thymic stromal lymphopoietin in human plasma at sub-pg/ml level.

scientific article published on January 2015

Aberrant tissue positioning of metallophilic macrophages in the thymus of XCL1-deficient mice

scientific article published on 29 April 2014

Activation of a myelin basic protein-specific human T cell clone by antigen-presenting cells from rhesus monkeys

scientific article published on 01 September 1995

An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors

scientific article published on December 1993

Biological properties of interleukin 10

scientific article published on 01 July 1992

Biomarkers of Disease and Treatment in Murine and Cynomolgus Models of Chronic Asthma ⬇️

scientific article published on July 10, 2012

Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease

scientific article published on 16 February 2012

Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Non-Human Primates of the Anti-PD-1 Antibody Pembrolizumab

scientific article published on 30 March 2020

CD2/LFA-3 or LFA-1/ICAM-1 but not CD28/B7 interactions can augment cytotoxicity by virus-specific CD8+ cytotoxic T lymphocytes.

scientific article published on February 1993

Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL-10-/- mice and Rag-2-/- mice reconstituted with CD4+CD45RBhigh T cells

scientific article published on 01 May 2001

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

scientific article

Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3

scientific article

Co-stimulation of T cells results in distinct IL-10 and TNF-α cytokine profiles dependent on binding to ICAM-1, ICAM-2 or ICAM-3

scientific article published on 01 July 1999

Correction: Defining the Roles of IFN-γ and IL-17A in Inflammation and Protection against Helicobacter pylori Infection

scientific article published on 6 November 2015

Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells.

scientific article published in December 2007

Development and function of TH17 cells in health and disease

scientific article published on May 2009

Development, cytokine profile and function of human interleukin 17-producing helper T cells

scientific article (publication date: September 2007)

Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis ⬇️

scientific article published on February 11, 2011

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

scientific article

Do human TH1 and TH2 CD4+ clones exist? ⬇️

scientific article published on January 1, 1991

Early production of thymic stromal lymphopoietin precedes infiltration of dendritic cells expressing its receptor in allergen-induced late phase cutaneous responses in atopic subjects

article

Effects of interleukin 4 on monocyte functions: comparison to interleukin 13.

scientific article published on October 1993

Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation.

scientific article published on 21 March 2011

Epicutaneous application of house dust mite induces thymic stromal lymphopoietin in nonlesional skin of patients with atopic dermatitis.

scientific article

Establishment of engineered cell-based assays mediating LAG3 and PD1 immune suppression enables potency measurement of blocking antibodies and assessment of signal transduction

scientific article published on 7 February 2018

Expression patterns of IL-10 ligand and receptor gene families provide leads for biological characterization.

scientific article published on May 2004

From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited

scientific article published on December 2008

Functional characterization of human IL-10.

scientific article

GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells

scientific article

Glucocorticoid-Induced TNF Receptor Family-Related Protein Ligand is Requisite for Optimal Functioning of Regulatory CD4(+) T Cells

scientific article published on 03 February 2014

Glucocorticoid-Induced Tumor Necrosis Factor Receptor Family-Related Protein Regulates CD4+T Cell–Mediated Colitis in Mice ⬇️

scientific article published on December 6, 2011

Glucocorticoid-induced TNF receptor family-related protein ligand regulates the migration of monocytes to the inflamed intestine

scientific journal article

High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.

scientific article

Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria

scientific article

Human Th17 cells comprise heterogeneous subsets including IFN-gamma-producing cells with distinct properties from the Th1 lineage

scientific article published on 28 May 2010

Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells

scientific article

Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.

scientific article

Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion.

scientific article published on 29 February 2004

IL-12 and IL-23: master regulators of innate and adaptive immunity.

scientific article

IL-12 transiently induces IFN-gamma transcription and protein synthesis in human CD4+ allergen-specific Th2 T cell clones

scientific article published on 01 July 1994

IL-13 induces proliferation and differentiation of human B cells activated by the CD40 ligand ⬇️

scientific article published on June 1, 1993

IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion Injury.

scientific article

IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritis

scientific article

IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18.

scientific article

IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization

scientific article published on 22 August 2016

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis

scientific article

IL-27 and IFN-αSignal via Stat1 and Stat3 and Induce T-Bet and IL-12Rβ2 in Naive T Cells ⬇️

scientific article published on September 1, 2003

IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells

scientific article published in May 2009

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

scientific article (publication date: June 2002)

IL-33 promotes innate IFN-γ production and modulates dendritic cell response in LCMV-induced hepatitis in mice

scientific article published on 7 August 2015

In contrast to their murine counterparts, normal human keratinocytes and human epidermoid cell lines A431 and HaCaT fail to express IL-10 mRNA and protein

scientific article published on 01 January 1997

In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

scientific article

Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13

scientific article published on 01 October 2004

Interleukin 10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary mixed lymphocyte cultures

scientific article published on 01 December 1992

Interleukin 10 inhibits transforming growth factor-beta (TGF-beta) synthesis required for osteogenic commitment of mouse bone marrow cells.

scientific article published on February 1994

Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.

scientific article

Interleukin-10

scientific article

Interleukin-10 down-regulates MHC class II alphabeta peptide complexes at the plasma membrane of monocytes by affecting arrival and recycling.

scientific article published in December 1997

Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice

scientific article published on October 2008

Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.

scientific article

Interleukin-19: a constituent of the regulome that controls antigen presenting cells in the lungs and airway responses to microbial products

scientific article (publication date: 2011)

Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells.

scientific article published on May 2004

Modelling asthma in macaques: longitudinal changes in cellular and molecular markers

scientific article published on 22 July 2010

Molecular regulation of Th2 immunity by dendritic cells.

scientific article

Multiple sclerosis. Immunomodulatory effects of human astrocytes on T cells

scientific article published on 01 December 1994

Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2-/- (TRUC) mice.

scientific article

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

scientific article

Pulmonary arterial remodeling induced by a Th2 immune response

scientific article published on 28 January 2008

Reciprocal control of T helper cell and dendritic cell differentiation

scientific article published on 01 February 1999

Selective development of a strong Th2 cytokine profile in high-risk children who develop atopy: risk factors and regulatory role of IFN-gamma, IL-4 and IL-10

scientific article published on 01 July 2001

Signaling Lymphocyte Activation Molecule Regulates Development of Colitis in Mice ⬇️

scientific article published on September 6, 2012

T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis

scientific article

The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains

scientific article

The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS).

scientific article

Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis.

scientific article published on 21 July 2013

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

scientific article

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