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List of works by Christophe Sirac

A mouse model recapitulating human monoclonal heavy chain deposition disease evidences the relevance of proteasome inhibitor therapy.

scientific article

A plasma cell differentiation quality control ablates B cell clones with biallelic Ig rearrangements and truncated Ig production

scientific article

AID-induced remodeling of immunoglobulin genes and B cell fate

scientific article

Al amyloidosis

scientific article

Animal models of monoclonal immunoglobulin-related renal diseases.

scientific article

B-cell receptor signal strength influences terminal differentiation.

scientific article

Comprehensive molecular characterization of a heavy chain deposition disease case

scientific article published on 19 July 2018

Cross talk between immunoglobulin heavy-chain transcription and RNA surveillance during B cell development.

scientific article published on 28 October 2011

Efficient AID targeting of switch regions is not sufficient for optimal class switch recombination.

scientific article

Fanconi's syndrome induced by a monoclonal Vkappa3 light chain in Waldenstrom's macroglobulinemia

scientific article published on 01 April 2005

Immunologic basis for the rare occurrence of true nonsecretory plasma cell dyscrasias.

scientific article published on 20 May 2004

Impaired Lysosomal Function Underlies Monoclonal Light Chain-Associated Renal Fanconi Syndrome

scientific article

Interallelic Class Switch Recombination Contributes Significantly to Class Switching in Mouse B Cells

scientific article published on 01 May 2005

Kidney diseases associated with monoclonal immunoglobulin M-secreting B-cell lymphoproliferative disorders: a case series of 35 patients.

scientific article published on 16 May 2015

Light chain deposition disease without glomerular proteinuria: a diagnostic challenge for the nephrologist.

scientific article

Mesangial cells as amyloid factory: a unique contribution of animal models.

scientific article published in October 2014

Physiological and druggable skipping of immunoglobulin variable exons in plasma cells

scientific article published on 20 August 2018

Premature replacement of mu with alpha immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation.

scientific article

Production of human or humanized antibodies in mice

scientific article published on 01 January 2012

Randall-type monoclonal immunoglobulin deposition disease: From diagnosis to treatment

scientific article published on 21 April 2016

Randall-type monoclonal immunoglobulin deposition disease: novel insights from a nationwide cohort study

scientific article published on 21 December 2018

Role of the monoclonal kappa chain V domain and reversibility of renal damage in a transgenic model of acquired Fanconi syndrome

scientific article published on 16 March 2006

Strategies to model AL amyloidosis in mice.

scientific article

The pathogenesis and diagnosis of acute kidney injury in multiple myeloma

scientific article

Toward understanding renal Fanconi syndrome: step by step advances through experimental models.

scientific article published on 20 January 2011

Unravelling the immunopathological mechanisms of heavy chain deposition disease with implications for clinical management.

scientific article published on 20 October 2016

[Classification and therapeutic management of monoclonal gammopathies of renal significance].

scientific article published on 27 April 2017

[Renal disorders associated with monoclonal gammopathies: diagnostic and therapeutic progress]

scientific article published on 13 January 2012

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