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List of works by Rosa Marina Melillo

A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma.

scientific article published in November 2007

A new germline RET mutation apparently devoid of transforming activity serendipitously discovered in a patient with atrophic autoimmune thyroiditis and primary ovarian failure.

scientific article published in October 2004

AXL Is a Novel Predictive Factor and Therapeutic Target for Radioactive Iodine Refractory Thyroid Cancer

scientific article published on 07 June 2019

Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.

scientific article

BRAF is a therapeutic target in aggressive thyroid carcinoma.

scientific article published in March 2006

Biochemical and molecular characterization of the novel BRAF(V599Ins) mutation detected in a classic papillary thyroid carcinoma.

scientific article published on 27 February 2006

CXC chemokine receptor 4 immunodetection in the follicular variant of papillary thyroid carcinoma: comparison to galectin-3 and hector battifora mesothelial cell-1.

scientific article published in May 2010

Different mutations of the RET gene cause different human tumoral diseases.

scientific article

Differential diagnosis of thyroid nodules using fine-needle aspiration cytology and oncogene mutation screening: are we ready?

scientific article

Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade

scientific article published in July 2001

Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).

scientific article

Genetics: The genomic landscape of papillary thyroid carcinoma

scientific article published on 25 November 2014

Glial cell line-derived neurotrophic factor differentially stimulates ret mutants associated with the multiple endocrine neoplasia type 2 syndromes and Hirschsprung's disease.

scientific article published on August 1998

HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity

scientific article

Helicobacter pylori Hp(2-20) promotes migration and proliferation of gastric epithelial cells by interacting with formyl peptide receptors in vitro and accelerates gastric mucosal healing in vivo.

scientific article

Higher intratumoral expression of CD1a, tryptase, and CD68 in a follicular variant of papillary thyroid carcinoma compared to adenomas: correlation with clinical and pathological parameters

scientific article published on 18 October 2011

Indoleamine 2,3-dioxygenase 1 (IDO1) is up-regulated in thyroid carcinoma and drives the development of an immunosuppressant tumor microenvironment.

scientific article published on 11 February 2014

Mast cells have a protumorigenic role in human thyroid cancer ⬇️

scientific article published on August 23, 2010

Mast cells induce epithelial-to-mesenchymal transition and stem cell features in human thyroid cancer cells through an IL-8-Akt-Slug pathway.

scientific article

Molecular biology of the MEN2 gene.

scientific article published on June 1998

Molecular biomarkers in thyroid FNA samples

scientific article published on 01 December 2012

OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome.

scientific article published on 6 November 2007

Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness.

scientific article

Overexpression of the cytokine osteopontin identifies aggressive laryngeal squamous cell carcinomas and enhances carcinoma cell proliferation and invasiveness.

scientific article published on November 2005

Protein kinase Calpha activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase.

scientific article published on May 2003

RET/PTC1 oncogene signaling in PC Cl 3 thyroid cells requires the small GTP-binding protein Rho.

scientific article

RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase.

scientific article published on January 2007

Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes

scientific article published in January 2003

Recent advances in understanding immune phenotypes of thyroid carcinomas: prognostication and emerging therapies

scientific article published on 28 February 2019

Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells.

scientific article published on June 2004

Serum soluble ST2 and interleukin-33 levels in patients with pulmonary arterial hypertension

The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells

scientific article

The formyl peptide receptor 1 exerts a tumor suppressor function in human gastric cancer by inhibiting angiogenesis.

scientific article published on 29 September 2014

The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret.

scientific article published on January 2001

The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.

scientific article

The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins

scientific article

The ret/ptc1 oncogene is activated in familial adenomatous polyposis-associated thyroid papillary carcinomas

scientific article published on 01 March 1998

Thyroid cancer and inflammation

scientific article published on 14 October 2009

Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas

scientific article published on 19 June 2006

Tyrosine kinase oncoprotein, RET/PTC3, induces the secretion of myeloid growth and chemotactic factors.

scientific article published in July 2003

XB130, a tissue-specific adaptor protein that couples the RET/PTC oncogenic kinase to PI 3-kinase pathway.

scientific article

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