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List of works by R. Luke Wiseman

A new pharmacology--drugging stressed folding pathways.

scientific article

ATF6 activation reduces the secretion and extracellular aggregation of destabilized variants of an amyloidogenic protein

scientific article

ATF6 is essential for human cone photoreceptor development

scientific article published in 2021

An Adaptable Standard for Protein Export from the Endoplasmic Reticulum

article

Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action

scientific article

Broadly applicable methodology for the rapid and dosable small molecule-mediated regulation of transcription factors in human cells.

scientific article published on 21 May 2013

Chaperones in Neurodegeneration

scientific article

Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1.

scientific article

Chemically Targeting the Emergent Properties of a Chaperone Complex

article published in 2011

D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis?

scientific article

Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation Using Targeted RNA Sequencing

scientific article published on 13 March 2019

Defining the Functional Targets of Cap'n'collar Transcription Factors NRF1, NRF2, and NRF3

scientific article published on 21 October 2020

Endoplasmic reticulum quality control and systemic amyloid disease: Impacting protein stability from the inside out

scientific article

Evolving protein stability through genetic selection.

scientific article

Induced pluripotent stem cell modeling of multisystemic, hereditary transthyretin amyloidosis.

scientific article published on 31 October 2013

Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: implications for transthyretin amyloidosis.

scientific article

Lining up for quality control: linear ubiquitin and proteotoxicity

scientific article published on 11 April 2019

Modulating protein quality control

scientific article published on 20 July 2016

Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses.

scientific article

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

scientific article published on 20 May 2019

PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum Stress

scientific article published in Scientific Reports

Partitioning conformational intermediates between competing refolding and aggregation pathways: insights into transthyretin amyloid disease.

scientific article published on December 2005

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

scientific article published on 07 August 2018

Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming

scientific article published on 20 July 2020

Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity

scientific article published on 01 February 2022

Phosphatase Inhibition Delays Translational Recovery ⬇️

scientific article published on April 1, 2011

Premature Activation of Immune Transcription Programs in Autoimmune-Predisposed Mouse Embryonic Stem Cells and Blastocysts

scientific article published on 11 August 2020

Prevention of transthyretin amyloid disease by changing protein misfolding energetics.

scientific article

Protein energetics in maturation of the early secretory pathway.

scientific article published on 7 August 2007

Publisher Correction: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

scientific article published on 01 July 2019

Quantification of transthyretin kinetic stability in human plasma using subunit exchange.

scientific article published on 24 March 2014

R104H may suppress transthyretin amyloidogenesis by thermodynamic stabilization, but not by the kinetic mechanism characterizing T119 interallelic trans-suppression

Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress

scientific article published on 24 February 2016

Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy

scientific article

Regulating extracellular proteostasis capacity through the unfolded protein response

scientific article published on January 2015

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.

scientific article published on 20 July 2016

Small molecule strategies to harness the unfolded protein response: where do we go from here?

scientific article published on 04 September 2020

SnapShot: The Unfolded Protein Response

article

Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments

scientific article published on 11 April 2013

Stress-regulated translational attenuation adapts mitochondrial protein import through Tim17A degradation.

scientific article published on December 2013

Stress-responsive regulation of mitochondria through the ER unfolded protein response.

scientific article

Structural basis for distinct operational modes and protease activation in AAA+ protease Lon

scientific article published on 20 May 2020

Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing.

scientific article

The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress

scientific article published in March 2018

The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer.

scientific article

The pathway by which the tetrameric protein transthyretin dissociates.

scientific article

The unfolded protein response regulator ATF6 promotes mesodermal differentiation.

scientific article published on 13 February 2018

Thioredoxin-related Protein 32 is an arsenite-regulated Thiol Reductase of the proteasome 19 S particle.

scientific article published on 06 April 2009

Understanding and Ameliorating the TTR Amyloidoses

Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis.

scientific article

YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress

scientific article

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