List of works - Klas Wiman

A melanoma-predisposing germline CDKN2A mutation with functional significance for both p16 and p14ARF

scientific article published on 01 June 2002

A splice donor site mutation results in the insertion of five extra amino acids into P53 from SEWA mouse sarcoma cells.

scientific article

A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death

scientific article published on 14 December 2020

APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells

scientific article published on 18 June 2015

APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma

scientific article published on 17 July 2015

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277.

scientific article published on 18 April 2018

APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations

scientific article

APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

scientific article published on 24 October 2013

Abrogation of p53-induced G1 arrest by the HPV 16 E7 protein does not inhibit p53-induced apoptosis.

scientific article published in June 1996

An old acquaintance resurfaces in human mesothelioma

scientific article published on 01 August 1997

Characterization of human buccal epithelial cells transfected with the simian virus 40 T-antigen gene ⬇️

scientific article published on October 1, 1995

Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.

scientific article

Correction: APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

scientific article published on 10 October 2019

Decreased immunoglobulin deposition in tumors and increased immature B cells in p53-null mice.

scientific article published in February 1997

Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells

scientific article published on 01 October 2000

Effects of PRIMA-1 on chronic lymphocytic leukaemia cells with and without hemizygous p53 deletion.

scientific article

Effects of the TP53 p.R249S mutant on proliferation and clonogenic properties in human hepatocellular carcinoma cell lines: interaction with hepatitis B virus X protein.

scientific article published on 10 June 2010

Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog

scientific article published on 07 March 2022

Expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical carcinoma

scientific article

Extract from Asteraceae Brachylaena ramiflora induces apoptosis preferentially in mutant p53-expressing human tumor cells.

scientific article

Genetic landscape of hepatitis B virus-associated diffuse large B-cell lymphoma.

scientific article published on 15 March 2018

Genome-wide identification of Wig-1 mRNA targets by RIP-Seq analysis

scientific article published on 11 December 2015

Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death.

scientific article published on June 2017

Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene

scientific article published on 30 November 2020

Identification of functional p53-binding motifs in the mouse wig-1 promoter

scientific journal article

Immunolocalization of human p14(ARF) to the granular component of the interphase nucleolus

scientific article published on 01 May 2000

Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET.

scientific article published on 25 January 2013

In frame deletion of intron-7 in the p53 gene in a human tonsil tumor

scientific article published on 01 January 1995

Inactivation of Myc-induced p53-dependent apoptosis in human tumors.

scientific article

Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53: functional impact.

scientific article

Induction of the human ARF protein by serum starvation.

scientific article

Infrequent MDM2 gene amplification and absence of gross WAF1 gene alterations in nasopharyngeal carcinoma

article

Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation

scientific article published on 28 March 2017

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

scientific article published in Scientific Reports

Introduction to Nobel Conference: 'The Cell Cycle and Cell Death in Disease'.

scientific article published in May 2017

Is conversion of solid into more anoxic ascites tumors associated with p53 inactivation?

scientific article published on 01 November 1998

Low p14ARF expression in de novo acute myeloid leukemia with normal karyotype is associated with poor survival

scientific article

Mutant p53 protein, master regulator of human malignancies: a report on the Fifth Mutant p53 Workshop

scientific article published on 18 November 2011

Mutant p53 reactivation by small molecules makes its way to the clinic.

scientific article

Mutant p53 rescue and modulation of p53 redox state.

scientific article published on 29 August 2009

Mutant p53 targeting by the low molecular weight compound STIMA-1

scientific article published on 7 March 2008

Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.

scientific article

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

scientific article published on 15 July 2021

Mutated and non-mutated TP53 as targets in the treatment of leukaemia.

scientific article

Novel cancer therapy by reactivation of the p53 apoptosis pathway.

scientific article published on January 2003

PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

scientific article published on May 2009

PRIMA-1(met) radiosensitizes prostate cancer cells independent of their MTp53-status.

scientific article published on 30 January 2008

PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein.

scientific article

PRIMA-1MET inhibits growth of mouse tumors carrying mutant p53.

scientific article

PRIMA-1MET/APR-246 targets mutant forms of p53 family members p63 and p73 ⬇️

scientific article published on September 6, 2010

Polyoma virus middle T and small t antigens cooperate to antagonize p53-induced cell cycle arrest and apoptosis.

scientific article published in January 2000

Proteomic identification of p53-dependent protein phosphorylation.

scientific article

RB-reconstituted human retinoblastoma cells form RB-positive intraocular and intracerebral but not subcutaneous tumors in SCID mice.

scientific article published on May 1995

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

scientific article published on July 2005

Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.

scientific article

Reactivation of mutant p53: a new strategy for cancer therapy.

scientific article

Regulation of tumor suppressor p53 at the RNA level

scientific article published on 21 March 2010

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

scientific article published on 01 June 1997

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

scientific article

Restoration of wild-type p53 function in human tumors: strategies for efficient cancer therapy.

scientific article

Reversible nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 and hsp70 proteins after exposure to heat shock or cell density congestion.

scientific article

Strategies for therapeutic targeting of the p53 pathway in cancer.

scientific article

Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer

scientific article published on 14 May 2016

Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors.

scientific article

TP53: an oncogene in disguise.

scientific article published on 29 May 2015

Targeting mutant p53 for efficient cancer therapy.

scientific article

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

scientific article published on January 2014

Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

scientific article

Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer

scientific article published on 10 September 2012

The EBV-encoded LMP1 protein inhibits p53-triggered apoptosis but not growth arrest

scientific article published on 01 September 1995

The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element

scholarly article

The p53 target Wig-1: a regulator of mRNA stability and stem cell fate?

scientific article published on 11 March 2011

The p53-induced Wig-1 protein binds double-stranded RNAs with structural characteristics of siRNAs and miRNAs.

scientific article published on 17 July 2006

The p53-induced Wig-1 zinc finger protein is highly conserved from fish to man.

scientific article published on June 2004

The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region.

scientific article

Understanding cell cycle and cell death regulation provides novel weapons against human diseases.

scientific article

WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies

scientific article

Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3σ.

scientific article published on 27 January 2014

Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage.

scientific article published in February 2009

bcl-2 inhibits wild-type p53-triggered apoptosis but not G1 cell cycle arrest and transactivation of WAF1 and bax

scientific article published on 01 September 1995

p14ARF deletion and methylation in genetic pathways to glioblastomas.

scientific article published in April 2001

p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53

scientific article published on 01 April 2001

p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain

scientific article

p53 overexpression in normal and dysplastic tissues adjacent to p53 negative squamous cell carcinomas of the head and neck.

scientific article

p53 talks to PARP: the increasing complexity of p53-induced cell death

scientific article published on November 2013

p53 targets identified by protein expression profiling

scholarly article

p53-induced apoptosis as a safeguard against cancer.

scientific article

p53: emergency brake and target for cancer therapy.

scientific article published on November 1997

List of works by Klas Wiman

A melanoma-predisposing germline CDKN2A mutation with functional significance for both p16 and p14ARF

A splice donor site mutation results in the insertion of five extra amino acids into P53 from SEWA mouse sarcoma cells.

A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death

APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells

APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277.

APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations

APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

Abrogation of p53-induced G1 arrest by the HPV 16 E7 protein does not inhibit p53-induced apoptosis.

An old acquaintance resurfaces in human mesothelioma

Characterization of human buccal epithelial cells transfected with the simian virus 40 T-antigen gene ⬇️

Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.

Correction: APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

Decreased immunoglobulin deposition in tumors and increased immature B cells in p53-null mice.

Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells

Effects of PRIMA-1 on chronic lymphocytic leukaemia cells with and without hemizygous p53 deletion.

Effects of the TP53 p.R249S mutant on proliferation and clonogenic properties in human hepatocellular carcinoma cell lines: interaction with hepatitis B virus X protein.

Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog

Expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical carcinoma

Extract from Asteraceae Brachylaena ramiflora induces apoptosis preferentially in mutant p53-expressing human tumor cells.

Genetic landscape of hepatitis B virus-associated diffuse large B-cell lymphoma.

Genome-wide identification of Wig-1 mRNA targets by RIP-Seq analysis

Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death.

Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene

Identification of functional p53-binding motifs in the mouse wig-1 promoter

Immunolocalization of human p14(ARF) to the granular component of the interphase nucleolus

Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET.

In frame deletion of intron-7 in the p53 gene in a human tonsil tumor

Inactivation of Myc-induced p53-dependent apoptosis in human tumors.

Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53: functional impact.

Induction of the human ARF protein by serum starvation.

Infrequent MDM2 gene amplification and absence of gross WAF1 gene alterations in nasopharyngeal carcinoma

Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

Introduction to Nobel Conference: 'The Cell Cycle and Cell Death in Disease'.

Is conversion of solid into more anoxic ascites tumors associated with p53 inactivation?

Low p14ARF expression in de novo acute myeloid leukemia with normal karyotype is associated with poor survival

Mutant p53 protein, master regulator of human malignancies: a report on the Fifth Mutant p53 Workshop

Mutant p53 reactivation by small molecules makes its way to the clinic.

Mutant p53 rescue and modulation of p53 redox state.

Mutant p53 targeting by the low molecular weight compound STIMA-1

Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

Mutated and non-mutated TP53 as targets in the treatment of leukaemia.

Novel cancer therapy by reactivation of the p53 apoptosis pathway.

PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

PRIMA-1(met) radiosensitizes prostate cancer cells independent of their MTp53-status.

PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein.

PRIMA-1MET inhibits growth of mouse tumors carrying mutant p53.

PRIMA-1MET/APR-246 targets mutant forms of p53 family members p63 and p73 ⬇️

Polyoma virus middle T and small t antigens cooperate to antagonize p53-induced cell cycle arrest and apoptosis.

Proteomic identification of p53-dependent protein phosphorylation.

RB-reconstituted human retinoblastoma cells form RB-positive intraocular and intracerebral but not subcutaneous tumors in SCID mice.

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.

Reactivation of mutant p53: a new strategy for cancer therapy.

Regulation of tumor suppressor p53 at the RNA level

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

Restoration of wild-type p53 function in human tumors: strategies for efficient cancer therapy.

Reversible nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 and hsp70 proteins after exposure to heat shock or cell density congestion.

Strategies for therapeutic targeting of the p53 pathway in cancer.

Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer

Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors.

TP53: an oncogene in disguise.

Targeting mutant p53 for efficient cancer therapy.

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer

The EBV-encoded LMP1 protein inhibits p53-triggered apoptosis but not growth arrest

The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element

The p53 target Wig-1: a regulator of mRNA stability and stem cell fate?

The p53-induced Wig-1 protein binds double-stranded RNAs with structural characteristics of siRNAs and miRNAs.

The p53-induced Wig-1 zinc finger protein is highly conserved from fish to man.

The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region.

Understanding cell cycle and cell death regulation provides novel weapons against human diseases.

WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies

Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3σ.

Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage.