List of works - Joaquín Castilla

A Quick Method to Evaluate the Effect of the Amino Acid Sequence in the Misfolding Proneness of the Prion Protein

scientific article published in January 2017

A Single Amino Acid Substitution, Found in Mammals with Low Susceptibility to Prion Diseases, Delays Propagation of Two Prion Strains in Highly Susceptible Transgenic Mouse Models

scientific article published on 07 March 2019

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.

scientific article published on 15 March 2016

A molecular switch controls interspecies prion disease transmission in mice

scientific article

Accelerated high fidelity prion amplification within and across prion species barriers.

scientific article

Amyloid formation modulates the biological activity of a bacterial protein.

scientific article

Amyloids, prions and the inherent infectious nature of misfolded protein aggregates

scientific article

An Amino Acid Substitution Found in Animals with Low Susceptibility to Prion Diseases Confers a Protective Dominant-Negative Effect in Prion-Infected Transgenic Mice

scientific article published on 20 December 2017

An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.

scientific article published on 07 August 2017

Animal models for prion-like diseases.

scientific article published on 20 April 2015

Animal models for testing anti-prion drugs.

scientific article

Autoantibodies against the prion protein in individuals with PRNP mutations

scientific article published on 25 February 2020

Behind the potential evolution towards prion resistant species.

scientific article published in February 2018

Bovine spongiform encephalopathy induces misfolding of alleged prion-resistant species cellular prion protein without altering its pathobiological features.

scientific article published in May 2013

Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.

scientific article

Cell-free propagation of prion strains.

scientific article published on 18 September 2008

Characterization of mesenchymal stem cells in sheep naturally infected with scrapie

scientific article published on 2 October 2015

Chronic wasting disease in bank voles: characterisation of the shortest incubation time model for prion diseases

scientific article

Coenzyme Q and protein/lipid oxidation in a BSE-infected transgenic mouse model.

scientific article

Cofactors influence the biological properties of infectious recombinant prions.

scientific article published in November 2017

Crossing the species barrier by PrP(Sc) replication in vitro generates unique infectious prions.

scientific article published on September 2008

Cyclic amplification of protein misfolding and aggregation

scientific article published on 01 January 2005

De novo induction of amyloid-β deposition in vivo ⬇️

scientific article published on October 4, 2011

Detection of Pathognomonic Biomarker PrPSc and the Contribution of Cell Free-Amplification Techniques to the Diagnosis of Prion Diseases

scientific article published on 19 March 2020

Detection of amyloid fibrils in Parkinson's disease using plasmonic chirality.

scientific article

Detection of prions in blood

scientific article

Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies

scientific article published on 23 October 2019

Different behavior toward bovine spongiform encephalopathy infection of bovine prion protein transgenic mice with one extra repeat octapeptide insert mutation.

scientific article published in March 2004

Dogs are resistant to prion infection, due to the presence of aspartic or glutamic acid at position 163 of their prion protein

scientific article published on 15 January 2020

Elements modulating the prion species barrier and its passage consequences

scientific article (publication date: 2014)

Evaluation of the Influence of Astrocytes on In Vitro Blood-Brain Barrier Models

scientific article published on 02 November 2020

Exploring the risks of a putative transmission of BSE to new species

scientific article

Generation of a new infectious recombinant prion: a model to understand Gerstmann-Sträussler-Scheinker syndrome

scientific article

Genome comparison of a nonpathogenic myxoma virus field strain with its ancestor, the virulent Lausanne strain.

scientific article published on 17 December 2008

Human prion protein sequence elements impede cross-species chronic wasting disease transmission

scientific article published on 11 May 2015

Human prion protein sequence elements impede cross-species chronic wasting disease transmission. ⬇️

scientific article

In Vitro Approach To Identify Key Amino Acids in Low Susceptibility of Rabbit Prion Protein to Misfolding

scientific article published on 4 October 2017

In vitro generation of infectious scrapie prions.

scientific article

In vitro studies of the transmission barrier.

scientific article published on 30 October 2009

In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms

scientific article

Induction of an immune response to transmissible gastroenteritis coronavirus using vectors with enteric tropism.

scientific article published in January 1993

Infectivity versus Seeding in Neurodegenerative Diseases Sharing a Prion-Like Mechanism

scientific article

Insights into the Bidirectional Properties of the Sheep-Deer Prion Transmission Barrier

scientific article published on 27 December 2018

Isolation and characterization of a proteinase K-sensitive PrPSc fraction.

scientific article published on 6 December 2006

Lactogenic immunity in transgenic mice producing recombinant antibodies neutralizing coronavirus.

scientific article published on January 1998

Lipids, a Missing Link in Prion Propagation

scientific article published on 01 November 2011

Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion diseases

scientific article

Molecular mechanisms of neurotoxicity of pathological prion protein

scientific article

Naturally prion resistant mammals: a utopia?

scientific article

Perturbation of endoplasmic reticulum homeostasis facilitates prion replication.

scientific article

Post-translational modifications in PrP expand the conformational diversity of prions in vivo

scientific article

Pre-symptomatic detection of prions by cyclic amplification of protein misfolding.

scientific article published in January 2005

Presymptomatic detection of prions in blood.

scientific article published in July 2006

Prion replication without host adaptation during interspecies transmissions.

scientific article

Prion strain mutation determined by prion protein conformational compatibility and primary structure

scientific article

Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC

scientific article published on January 2014

Prion-like diseases: Looking for their niche in the realm of infectious diseases.

scientific article published on 4 June 2015

Prion-like disorders and Transmissible Spongiform Encephalopathies: An overview of the mechanistic features that are shared by the various disease-related misfolded proteins.

scientific article

Prion-resistant or prion-susceptible species, this is the question.

scientific article published on 8 May 2013

Prionemia and leukocyte-platelet-associated infectivity in sheep transmissible spongiform encephalopathy models.

scientific article published on 7 December 2011

Production of cattle lacking prion protein.

scientific article

Protein Misfolding

Protein misfolding cyclic amplification corroborates the absence of PrPSc accumulation in placenta from foetuses with the ARR/ARQ genotype in natural scrapie.

scientific article published on 6 April 2017

Protein misfolding cyclic amplification for diagnosis and prion propagation studies

scientific article published on January 2006

Proteinase K enhanced immunoreactivity of the prion protein-specific monoclonal antibody 2A11.

scientific article

Rabbits are not resistant to prion infection

scientific article published on 13 March 2012

Recombinant PrP and Its Contribution to Research on Transmissible Spongiform Encephalopathies.

scientific article

Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis.

scientific article published on 31 January 2018

Reduced susceptibility to bovine spongiform encephalopathy prions in transgenic mice expressing a bovine PrP with five octapeptide repeats.

scientific article

Reduction of prion infectivity in packed red blood cells.

scientific article published on 11 October 2008

Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria

scientific article published on 01 September 2018

Sheep-passaged bovine spongiform encephalopathy agent exhibits altered pathobiological properties in bovine-PrP transgenic mice.

scientific article published on November 2006

Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors

scientific article published on 4 October 2017

Spontaneous generation of infectious prion disease in transgenic mice

scientific article published on December 2013

Structure of the β2-α2 loop and interspecies prion transmission

scientific article

Subclinical bovine spongiform encephalopathy infection in transgenic mice expressing porcine prion protein.

scientific article published in May 2004

Susceptibility of European red deer (Cervus elaphus elaphus) to alimentary challenge with bovine spongiform encephalopathy

scientific article

The architecture of prions: how understanding would provide new therapeutic insights

scientific article

The controversial protein-only hypothesis of prion propagation.

scientific article

The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity.

scientific article

Transgenic Mouse Bioassay: Evidence That Rabbits Are Susceptible to a Variety of Prion Isolates

scientific article

Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease

scientific article

Transgenic mice expressing bovine PrP with a four extra repeat octapeptide insert mutation show a spontaneous, non-transmissible, neurodegenerative disease and an expedited course of BSE infection.

scientific article published on 19 October 2005

Ultra-efficient PrP(Sc) amplification highlights potentialities and pitfalls of PMCA technology

scientific article

Ultra-efficient replication of infectious prions by automated protein misfolding cyclic amplification.

scientific article published on 18 September 2006

Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.

scholarly article

Unraveling the key to the resistance of canids to prion diseases

scientific article

Vertical transmission of bovine spongiform encephalopathy prions evaluated in a transgenic mouse model.

scientific article

[Qualitative analysis of the social and family impact of human transmissible spongiform encephalopathies]

scientific article published on 01 September 2019

iPS Cell Cultures from a Gerstmann-Sträussler-Scheinker Patient with the Y218N PRNP Mutation Recapitulate tau Pathology.

scientific article published on 2 May 2017

List of works by Joaquín Castilla

A Quick Method to Evaluate the Effect of the Amino Acid Sequence in the Misfolding Proneness of the Prion Protein

A Single Amino Acid Substitution, Found in Mammals with Low Susceptibility to Prion Diseases, Delays Propagation of Two Prion Strains in Highly Susceptible Transgenic Mouse Models

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.

A molecular switch controls interspecies prion disease transmission in mice

Accelerated high fidelity prion amplification within and across prion species barriers.

Amyloid formation modulates the biological activity of a bacterial protein.

Amyloids, prions and the inherent infectious nature of misfolded protein aggregates

An Amino Acid Substitution Found in Animals with Low Susceptibility to Prion Diseases Confers a Protective Dominant-Negative Effect in Prion-Infected Transgenic Mice

An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.

Animal models for prion-like diseases.

Animal models for testing anti-prion drugs.

Autoantibodies against the prion protein in individuals with PRNP mutations

Behind the potential evolution towards prion resistant species.

Bovine spongiform encephalopathy induces misfolding of alleged prion-resistant species cellular prion protein without altering its pathobiological features.

Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.

Cell-free propagation of prion strains.

Characterization of mesenchymal stem cells in sheep naturally infected with scrapie

Chronic wasting disease in bank voles: characterisation of the shortest incubation time model for prion diseases

Coenzyme Q and protein/lipid oxidation in a BSE-infected transgenic mouse model.

Cofactors influence the biological properties of infectious recombinant prions.

Crossing the species barrier by PrP(Sc) replication in vitro generates unique infectious prions.

Cyclic amplification of protein misfolding and aggregation

De novo induction of amyloid-β deposition in vivo ⬇️

Detection of Pathognomonic Biomarker PrPSc and the Contribution of Cell Free-Amplification Techniques to the Diagnosis of Prion Diseases

Detection of amyloid fibrils in Parkinson's disease using plasmonic chirality.

Detection of prions in blood

Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies

Different behavior toward bovine spongiform encephalopathy infection of bovine prion protein transgenic mice with one extra repeat octapeptide insert mutation.

Dogs are resistant to prion infection, due to the presence of aspartic or glutamic acid at position 163 of their prion protein

Elements modulating the prion species barrier and its passage consequences

Evaluation of the Influence of Astrocytes on In Vitro Blood-Brain Barrier Models

Exploring the risks of a putative transmission of BSE to new species

Generation of a new infectious recombinant prion: a model to understand Gerstmann-Sträussler-Scheinker syndrome

Genome comparison of a nonpathogenic myxoma virus field strain with its ancestor, the virulent Lausanne strain.

Human prion protein sequence elements impede cross-species chronic wasting disease transmission

Human prion protein sequence elements impede cross-species chronic wasting disease transmission. ⬇️

In Vitro Approach To Identify Key Amino Acids in Low Susceptibility of Rabbit Prion Protein to Misfolding

In vitro generation of infectious scrapie prions.

In vitro studies of the transmission barrier.

In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms

Induction of an immune response to transmissible gastroenteritis coronavirus using vectors with enteric tropism.

Infectivity versus Seeding in Neurodegenerative Diseases Sharing a Prion-Like Mechanism

Insights into the Bidirectional Properties of the Sheep-Deer Prion Transmission Barrier

Isolation and characterization of a proteinase K-sensitive PrPSc fraction.

Lactogenic immunity in transgenic mice producing recombinant antibodies neutralizing coronavirus.

Lipids, a Missing Link in Prion Propagation

Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion diseases

Molecular mechanisms of neurotoxicity of pathological prion protein

Naturally prion resistant mammals: a utopia?

Perturbation of endoplasmic reticulum homeostasis facilitates prion replication.

Post-translational modifications in PrP expand the conformational diversity of prions in vivo

Pre-symptomatic detection of prions by cyclic amplification of protein misfolding.

Presymptomatic detection of prions in blood.

Prion replication without host adaptation during interspecies transmissions.

Prion strain mutation determined by prion protein conformational compatibility and primary structure

Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC

Prion-like diseases: Looking for their niche in the realm of infectious diseases.

Prion-like disorders and Transmissible Spongiform Encephalopathies: An overview of the mechanistic features that are shared by the various disease-related misfolded proteins.

Prion-resistant or prion-susceptible species, this is the question.

Prionemia and leukocyte-platelet-associated infectivity in sheep transmissible spongiform encephalopathy models.

Production of cattle lacking prion protein.

Protein Misfolding

Protein misfolding cyclic amplification corroborates the absence of PrPSc accumulation in placenta from foetuses with the ARR/ARQ genotype in natural scrapie.

Protein misfolding cyclic amplification for diagnosis and prion propagation studies

Proteinase K enhanced immunoreactivity of the prion protein-specific monoclonal antibody 2A11.

Rabbits are not resistant to prion infection

Recombinant PrP and Its Contribution to Research on Transmissible Spongiform Encephalopathies.

Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis.

Reduced susceptibility to bovine spongiform encephalopathy prions in transgenic mice expressing a bovine PrP with five octapeptide repeats.

Reduction of prion infectivity in packed red blood cells.

Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria

Sheep-passaged bovine spongiform encephalopathy agent exhibits altered pathobiological properties in bovine-PrP transgenic mice.

Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors

Spontaneous generation of infectious prion disease in transgenic mice

Structure of the β2-α2 loop and interspecies prion transmission

Subclinical bovine spongiform encephalopathy infection in transgenic mice expressing porcine prion protein.

Susceptibility of European red deer (Cervus elaphus elaphus) to alimentary challenge with bovine spongiform encephalopathy

The architecture of prions: how understanding would provide new therapeutic insights

The controversial protein-only hypothesis of prion propagation.