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List of works by Patrick Dansette

A new generation of ferrociphenols leads to a great diversity of reactive metabolites, and exhibits remarkable antiproliferative properties

scientific article published on 16 November 2017

A new intermediate in naphthoquinone and menaquinone biosynthesis

article

Antidepressant efficacy of a selective organic cation transporter blocker in a mouse model of depression

scientific article published on 16 October 2019

Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera.

scientific article published on September 1996

Assay and partial purification of epoxide hydrase from rat liver microsomes

article

Automated multiple analysis of protein structures: application to homology modeling of cytochromes P450.

scientific article published in July 1997

Bioactivation of clopidogrel and prasugrel: factors determining the stereochemistry of the thiol metabolite double bond.

scientific article published on 21 May 2015

Carcinogenicity of benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides on mouse skin ⬇️

scientific article published on January 1, 1976

Comparison of the Substrate Specificities of Human Liver Cytochrome P450s 2C9 and 2C18: Application to the Design of a Specific Substrate of CYP 2C18

scientific article published in 1999

Continuous fluorometric assay of epoxide hydrase activity

article

Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer.

scientific article published on December 2011

Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions

scientific article published on 12 December 2008

Determinants of Cytochrome P450 2C8 Substrate Binding: STRUCTURES OF COMPLEXES WITH MONTELUKAST, TROGLITAZONE, FELODIPINE, AND 9-CIS-RETINOIC ACID

scientific article

Diclofenac and Its Derivatives As Tools for Studying Human Cytochromes P450 Active Sites: Particular Efficiency and Regioselectivity of P450 2Cs

scientific article published on 01 October 1999

Effect of purified epoxide hydrolase on metabolic activa-tion and binding of benzo(a)pyrene to exogenous DNA. Shift of the activation pathway

scientific article published on 01 March 1980

Effects of Inducers and Epoxide Hydrase on the Metabolism of Benzo[ a ]pyrene by Liver Microsomes and a Reconstituted System: Analysis by High Pressure Liquid Chromatography ⬇️

scientific article published on November 1, 1974

Endogenous induction of epoxide hydrolase, benzo(a)pyrene hydroxylase and glutathione-S-transferase in “responsive” C57B16 mice and in “nonresponsive” DBA2 mice during pregnancy

scientific article published on 01 April 1983

Enzymatic characterization of the polynuclear aromatic hydrocarbons activating rat-liver preparations used in the mutagenicity test of Ames ⬇️

scientific article published on February 1, 1984

Epoxide hydrase and glutathione S-transferase activities with selected alkene and arene oxides in several marine species ⬇️

scientific article published on May 1, 1979

Evaluation of Deuterium Labeled and Unlabeled Bis-methyl Glutathione Combined with Nanoliquid Chromatography−Mass Spectrometry to Screen and Characterize Reactive Drug Metabolites

scientific article published on 04 March 2011

Evidence for thiophene-S-oxide as a primary reactive metabolite of thiophene in vivo: formation of a dihydrothiophene sulfoxide mercapturic acid

scientific article published on August 14, 1992

Facile synthesis of arene oxides at the K regions of polycyclic hydrocarbons ⬇️

scientific article published on February 20, 1974

Ferrocenyl Quinone Methide-Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols, and Oxidative Transformation

scientific article

Ferrocenyl quinone methides as strong antiproliferative agents: formation by metabolic and chemical oxidation of ferrocenyl phenols.

scientific article published on January 2009

First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives.

scientific article published on 22 August 2005

Human Anti-Mitochondria Autoantibodies Appearing in Iproniazid-Induced Immunoallergic Hepatitis Recognize Human Liver Monoamine Oxidase B

scientific article published on 01 January 1996

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug

scientific article

Hydroxylation of the thiophene ring by hepatic monooxygenases

scientific article published on 01 March 1990

In vitro metabolism of isaxonine phosphate: formation of two metabolites, 5-hydroxyisaxonine and 2-aminopyrimidine, and covalent binding to microsomal proteins.

scientific article published in May 1992

In vivo administration of hydroxylated phenobarbital metabolites: effect on rat hepatic cytochromes P-450, epoxide hydrolase and udp-glucuronosyltransferase

scientific article published on 01 April 1980

Indirect cytotoxicity of flucloxacillin toward human biliary epithelium via metabolite formation in hepatocytes.

scientific article published in June 2001

Induction of drug metabolizing enzymes in the liver of diabetic mice.

scientific article

Inhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms

scientific article published on 20 July 2017

Iron-porphyrin catalysis of the oxidative dealkylation of para-nitro-anisole and 7-ethoxycoumarin by cumylhydroperoxide: a possible model for the corresponding cytochrome P 450-dependent reactions

article

Lack of effect of trichloropropene oxide on benzo(a)pyrene tumor-initiating activity on mouse skin

scientific article published on January 1, 1979

Mechanism of H2S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes

scientific article published on 18 June 2019

Mechanism of catalysis for the hydration of substituted styrene oxides by hepatic epoxide hydrase

scientific article published on 01 April 1978

Membrane fluidity and drug metabolism in liver microsomes of lean, ob/ob and db/db mice.

scientific article

Metabolic Activation of Prasugrel: Nature of the Two Competitive Pathways Resulting in the Opening of Its Thiophene Ring

scientific article published on 18 April 2012

Metabolic hydroxylation of the thiophene ring: Isolation of 5-hydroxy-tienilic acid as the major urinary metabolite of tienilic acid in man and rat

scientific article published on 01 May 1984

Metabolism of Anethole Dithiolethione by Rat and Human Liver Microsomes: Formation of Various Products Deriving from Its O-Demethylation and S-Oxidation. Involvement of Cytochromes P450 and Flavin Monooxygenases in These Pathways

scientific article published on 17 July 2018

Metabolism of benzo[a]pyrene by brain microsomes of fetal and adult rats and mice. Induction by 5,6 benzoflavone, comparison with liver and lung microsomal activities

article

Mutagenic and cytotoxic activity of benzol[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols ⬇️

scientific article published on August 1, 1975

Opposite Behaviors of Reactive Metabolites of Tienilic Acid and Its Isomer toward Liver Proteins: Use of Specific Anti-Tienilic Acid−Protein Adduct Antibodies and the Possible Relationship with Different Hepatotoxic Effects of the Two Compounds

Oxidation of Tienilic Acid by Human Yeast-Expressed Cytochromes P-450 2C8, 2C9, 2C18 and 2C19. Evidence that this Drug is A Mechanism-Based Inhibitor Specific for Cytochrome P-450 2C9

article

Oxidative activation of the thiophene ring by hepatic enzymes. Hydroxylation and formation of electrophilic metabolites during metabolism of tienilic acid and its isomer by rat liver microsomes.

scientific article published in March 1990

Oxidative metabolism of ferrocene analogues of tamoxifen: characterization and antiproliferative activities of the metabolites.

scientific article published on 16 April 2015

Partial purification of human liver cytochrome P 450 ⬇️

scientific article published on June 13, 1979

Presence of benzo[a]pyrene metabolizing activities in isolated rat liver nucleoli

scientific article published on 01 January 1981

Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2

scholarly article by Pierre Lafite published in July 2018

Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2.

scientific article published on 10 April 2007

Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: identification of a new high affinity substrate common to those enzymes.

scientific article published in June 2003

Sulfenic acids as reactive intermediates in xenobiotic metabolism ⬇️

scientific article published on March 1, 2011

Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily.

scientific article

The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An Approach Using Designed Tienilic Acid Derivatives and Molecular Modeling

article

The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An NMR Study†

scientific article published on 01 October 1997

The effect of some mixed function oxidase inducers on aryl hẏdrocarbon hydroxylase and epoxide hydrase in nuclei and microsomes from rat liver and lung. The effect of cigarette smoke ⬇️

scientific article published on June 1, 1979

The end product of transglutaminase crosslinking: simultaneous quantitation of [Nepsilon-(gamma-glutamyl) lysine] and lysine by HPLC-MS3.

scientific article published in October 2008

The shikimate pathway : II. Stereospecificity of hydrogen transfer catalyzed by NADPH-dehydroshikimate reductase of E. coli

scientific article published in January 1974

The shikimate pathway. I. Preparation of 3-3H, 4-3H and 2,4-3H2 D-shikimic acid.

scientific article published in May 1973

UPD-glucuronosyltransferase, epoxide hydrolase and gultathione S-transferase

scientific article published on 01 August 1981

Unusual regioselectivity and active site topology of human cytochrome P450 2J2

scientific article published on 17 August 2007

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