List of works by Karen Blyth

A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing

scientific article published on 12 July 2019

A full-length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with myc

scientific article published on 01 November 1999

A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of gammaC gene oncogenicity

scientific article published on 31 March 2009

Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation

scientific article published on January 2017

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

scientific article

Activated mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanism

scientific article

Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling

scientific article

Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling

scientific article published on 16 July 2015

An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism

scientific article published on 12 March 2021

Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity

scientific article published on 16 October 2017

Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.

scientific article

Author Correction: CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity.

scientific article published on 13 April 2018

Author Correction: Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori

scientific article published on 01 February 2020

BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration

scientific article published on 18 November 2019

Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas

scientific article published on 11 March 2019

CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma

scientific article published on 16 August 2016

CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity

scientific article published on 4 December 2017

Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function

scientific article published in 2024

Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability

scientific article

Correction: BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration

scientific article published on 01 March 2020

Correction: Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori

scientific article published on 01 December 2018

Corrigendum: Modulating the therapeutic response of tumours to dietary serine and glycine starvation

correction of a scholarly article

Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo

scientific article

Enforced expression of Runx2 perturbs T cell development at a stage coincident with beta-selection

scientific article published on 01 September 2002

Expression of RUNX1 correlates with poor patient prognosis in triple negative breast cancer

scientific article

Fas-independent apoptosis in T-cell tumours induced by the CD2-myc transgene

scientific article published on 01 January 2000

Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes

scientific article

Frequent infection of human cancer xenografts with murine endogenous retroviruses in vivo.

scientific article published on 17 April 2015

Frequent loss of RAF kinase inhibitor protein expression in acute myeloid leukemia

scientific article

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

scientific article

Gene therapy: X-SCID transgene leukaemogenicity

scientific article

Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells.

scientific article published on 21 December 2017

HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia

scientific article

Identification of murine CBF alpha1, a runt domain transcription factor, as a putative Myc collaborator in T cell lymphoma

scientific article published on 01 April 1999

Impact of Formate Supplementation on Body Weight and Plasma Amino Acids

scientific article published on 22 July 2020

Improving the metabolic fidelity of cancer models with a physiological cell culture medium

article

In vivo models in breast cancer research: progress, challenges and future directions ⬇️

scientific article

In-Depth Proteomics Identifies a Role for Autophagy in Controlling Reactive Oxygen Species Mediated Endothelial Permeability.

scientific article published in June 2016

Increased T-cell Infiltration Elicited by Erk5 Deletion in a Pten-Deficient Mouse Model of Prostate Carcinogenesis.

scientific article published on 17 May 2017

Increased formate overflow is a hallmark of oxidative cancer.

scientific article

Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori

scientific article published on 13 August 2018

Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas

scientific article

Introducing SEARCHBreast: a virtual resource to facilitate sharing of surplus animal material developed for breast cancer research ⬇️

scientific article

Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death.

scientific article

Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death

scientific article

Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis

scientific article published on 31 January 2020

MCL-1 is a prognostic indicator and drug target in breast cancer

scientific article published on 16 January 2018

Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization

scientific article published on 31 May 2019

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

scientific article published on 28 August 2017

Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest

scientific article

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

scientific article

Moloney murine leukemia virus-induced lymphomas in p53-deficient mice: overlapping pathways in tumor development?

scientific article published on April 1996

Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels ⬇️

scientific article published in Nature Communications

N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods

scientific article

Oncogene-Expressing Senescent Melanocytes Up-Regulate MHC Class II, a Candidate Melanoma Suppressor Function

scientific article published on 21 June 2017

Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine

scientific article published on 17 December 2015

Polyamine pathway activity promotes cysteine essentiality in cancer cells

scientific article published on 03 August 2020

Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma.

scientific article

Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene

scientific article published on August 1997

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.

scientific article

RIPK3 promotes adenovirus type 5 activity

scientific article

RUNX1 is a driver of renal cell carcinoma correlating with clinical outcome

scientific article published on 10 March 2020

RUNX1 transformation of primary embryonic fibroblasts is revealed in the absence of p53.

scientific article published on July 2004

RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland

scientific article

RUNX2 in mammary gland development and breast cancer.

scientific article published on June 2013

Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis.

scientific article published on 4 December 2015

Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells.

scientific article

Runx Genes in Breast Cancer and the Mammary Lineage.

scientific article published on January 2017

Runx1 Deficiency Protects Against Adverse Cardiac Remodeling After Myocardial Infarction.

scientific article

Runx1 promotes B-cell survival and lymphoma development

scientific article published on 9 March 2009

Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo

scientific article published on 01 February 2006

Runx2 contributes to the regenerative potential of the mammary epithelium

scientific article

Runx2 disruption promotes immortalization and confers resistance to oncogene-induced senescence in primary murine fibroblasts

scientific article published on December 2007

Runx2 in normal tissues and cancer cells: A developing story.

scientific article published on 26 June 2010

Runx2: a novel oncogenic effector revealed by in vivo complementation and retroviral tagging

scientific article published on 01 January 2001

SEARCHBreast Workshop Proceedings: 3D Modelling of Breast Cancer

scientific article published on December 2015

SEARCHBreast: An online resource designed to increase the efficiency of using materials derived from breast cancer studies in animals ⬇️

scientific article published on 6 June 2016

SEARCHBreast: a new online resource to make surplus material from in vivo models of breast cancer visible and accessible to researchers ⬇️

scientific article published on 31 May 2016

SEARCHBreast: a new resource to locate and share surplus archival material from breast cancer animal models to help address the 3Rs. ⬇️

scientific article published on 15 April 2016

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.

scientific article published on 15 February 2017

Sensitivity to myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycER mice

scientific article published on 01 February 2000

Serine one-carbon catabolism with formate overflow

scientific article published on 28 October 2016

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

scientific article published on 16 December 2012

Somatic base editing to model oncogenic drivers in breast cancer

scientific article published on 01 April 2020

Synergy between a human c-myc transgene and p53 null genotype in murine thymic lymphomas: contrasting effects of homozygous and heterozygous p53 loss

scientific article published on 01 May 1995

TIGAR is required for efficient intestinal regeneration and tumorigenesis

scientific journal article

The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis

scientific article published on 2 March 2016

The RUNX genes: gain or loss of function in cancer

scientific article (publication date: May 2005)

The Runx genes as dominant oncogenes

scientific article

The Sharing Experimental Animal Resources, Coordinating Holdings (SEARCH) Framework: Encouraging Reduction, Replacement, and Refinement in Animal Research ⬇️

scientific article

The enigmatic role of RUNX1 in female-related cancers - current knowledge & future perspectives.

scientific article published on 17 March 2017

The in vivo function of TIGAR, a p53 target gene that regulates glucose metabolism.

scientific article

The in vivo function of the p53 target gene TIGAR.

scientific article

The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma

scientific article published on 19 August 2016

The right time, the right place: will targeting human cancer-associated mutations to the mouse provide the perfect preclinical model?

scientific article published on February 2012

The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels

scientific article published in 2023

Tiam1-Rac signaling counteracts Eg5 during bipolar spindle assembly to facilitate chromosome congression

scientific article published on 25 March 2010

Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium.

scientific article

Wnt signaling potentiates nevogenesis

scientific article published on 16 September 2013

iRFP is a sensitive marker for cell number and tumor growth in high-throughput systems.

scientific article published on 31 October 2013

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