List of works - Walter D Fairlie

(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions

scientific article published on 01 January 2007

A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol).

scientific article

A fusion protein system for the recombinant production of short disulfide-containing peptides.

scientific article

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

scientific article

A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma

scientific article

A preliminary assessment of oral monepantel's tolerability and pharmacokinetics in individuals with treatment-refractory solid tumors

scientific article published on 22 September 2020

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

scientific article published on 07 October 2019

A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak

scientific article

A transgenic mouse model to inducibly target prosurvival Bcl2 proteins with selective BH3 peptides in vivo

scientific article published on 12 March 2015

ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types.

scientific article published on 13 June 2017

Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling.

scientific article

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

scientific article published on January 2012

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

scientific article

Antibody-based approach to high-volume genotyping for MIC-1 polymorphism

scientific article

Apoptosis in schistosomes: toward novel targets for the treatment of schistosomiasis

scientific article published on 03 January 2014

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

scientific article

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

scholarly article

BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux

scientific article published on 12 May 2016

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

scientific article published on 24 April 2019

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

scientific article

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

scientific article

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.

scientific article

Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: a nonhormonal contraceptive strategy.

scholarly article

CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13

scientific article published on 01 March 2006

Characterisation of a novel A1-specific monoclonal antibody.

scientific article published on 4 December 2014

Characterisation of the conformational preference and dynamics of the intrinsically disordered N-terminal region of Beclin 1 by NMR spectroscopy

scientific article published on 8 June 2016

Characterization of a novel human BFL-1-specific monoclonal antibody

scientific article published on 12 November 2019

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

scientific article

Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study

scientific article published on 01 June 2002

Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

scientific article

Contribution of specific disulphide bonds to two epitopes of thyrotropin beta-subunit associated with receptor recognition

scientific article published on 01 September 1996

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

scientific article published in November 2017

Crosstalk between apoptosis and autophagy signaling pathways

scientific article published on 05 February 2020

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

scientific article

Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins

scientific article

Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution

scientific article

Delineation of tyrosine-containing epitopes within the beta subunit of bovine thyrotropin

scientific article published on 01 March 1995

Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes

scientific article

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

scientific article published on 26 June 2013

Diversity in the intrinsic apoptosis pathway of nematodes

scientific article published on 28 August 2020

EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency.

scientific article published on 20 June 2008

Epitope mapping of the transforming growth factor-beta superfamily protein, macrophage inhibitory cytokine-1 (MIC-1): identification of at least five distinct epitope specificities

scientific article

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

scientific article

Expression of a TGF-beta superfamily protein, macrophage inhibitory cytokine-1, in the yeast Pichia pastoris

scientific article published on 01 August 2000

Expression of growth differentiation factor-15/ macrophage inhibitory cytokine-1 (GDF-15/MIC-1) in the perinatal, adult, and injured rat brain

scientific article

Functional genomics approaches in parasitic helminths.

scientific article published on February 2012

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

article by Daniel J Klionsky et al published January 2021 in Autophagy

Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM.

scientific article published on 30 September 2016

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

scientific article

Inhibition of malaria parasite development by a cyclic peptide that targets the vital parasite protein SERA5.

scientific article

Lesser degrees of intoxication

scientific article published on 01 January 1946

MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib

scientific article published on 08 December 2016

MIC-1 is a novel TGF-beta superfamily cytokine associated with macrophage activation

scientific article published on 01 January 1999

MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily

scientific article

Macrophage inhibitory cytokine 1 in fetal membranes and amniotic fluid from pregnancies with and without preterm labour and premature rupture of membranes

scientific article published on 01 September 2003

Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins.

scientific article published on 19 February 2018

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

scientific article published on October 2009

Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis

scientific article

Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2.

scientific article published on June 2003

Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins.

scientific article published on 10 September 2009

Peptide inhibitors of the malaria surface protein, apical membrane antigen 1: identification of key binding residues

scientific article

Physiological restraint of Bak by Bcl-xL is essential for cell survival

scientific article published on 19 May 2016

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

scientific article

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

scientific article

Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese hamster ovary cells expressing CLIC1

scientific article (publication date: 19 July 2002)

Relaxin and prostaglandin E(2) regulate interleukin 11 during human endometrial stromal cell decidualization.

scientific article published on 22 March 2005

Repurposing apoptosis-inducing cancer drugs to treat schistosomiasis

scientific article published on January 2015

Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics.

scientific article published on 07 May 2015

Screening procedure for Pichia pastoris clones containing multiple copy gene inserts

scientific article published on 01 June 1999

Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design

scientific article

Structural biology of the intrinsic cell death pathway: what do we know and what is missing?

scientific article published on 16 April 2012

Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1

scientific article published on 09 January 2019

Structural insights into the degradation of Mcl-1 induced by BH3 domains

scientific article

Structural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serine

scientific article

Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1

scientific article

Structure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival Proteins

scientific article

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

scientific article published on January 2014

The BECN1 N-terminal domain is intrinsically disordered

scientific article published on March 2016

The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia.

scientific article published on 30 July 2009

The Structural Biology of Bcl-xL. ⬇️

scientific article

The functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains.

scientific article

The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition

scientific article

The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-beta superfamily member, acts as a quality control determinant for correctly folded MIC-1.

scientific article published on May 2000

The propeptide of the transforming growth factor-beta superfamily member, macrophage inhibitory cytokine-1 (MIC-1), is a multifunctional domain that can facilitate protein folding and secretion

scientific article published on 26 February 2001

The role of BCL-2 family proteins and therapeutic potential of BH3-mimetics in malignant pleural mesothelioma

scientific article published on 26 November 2020

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

scientific article published on 03 August 2009

The transforming growth factor-ss superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women.

scientific article

Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.

scientific article published on 4 November 2007

Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

scientific article

α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells

scientific article published on 28 August 2015

List of works by Walter D Fairlie

(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions

A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol).

A fusion protein system for the recombinant production of short disulfide-containing peptides.

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma

A preliminary assessment of oral monepantel's tolerability and pharmacokinetics in individuals with treatment-refractory solid tumors

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak

A transgenic mouse model to inducibly target prosurvival Bcl2 proteins with selective BH3 peptides in vivo

ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types.

Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling.

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

Antibody-based approach to high-volume genotyping for MIC-1 polymorphism

Apoptosis in schistosomes: toward novel targets for the treatment of schistosomiasis

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.

Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: a nonhormonal contraceptive strategy.

CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13

Characterisation of a novel A1-specific monoclonal antibody.

Characterisation of the conformational preference and dynamics of the intrinsically disordered N-terminal region of Beclin 1 by NMR spectroscopy

Characterization of a novel human BFL-1-specific monoclonal antibody

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study

Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

Contribution of specific disulphide bonds to two epitopes of thyrotropin beta-subunit associated with receptor recognition

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

Crosstalk between apoptosis and autophagy signaling pathways

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins

Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution

Delineation of tyrosine-containing epitopes within the beta subunit of bovine thyrotropin

Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

Diversity in the intrinsic apoptosis pathway of nematodes

EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency.

Epitope mapping of the transforming growth factor-beta superfamily protein, macrophage inhibitory cytokine-1 (MIC-1): identification of at least five distinct epitope specificities

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

Expression of a TGF-beta superfamily protein, macrophage inhibitory cytokine-1, in the yeast Pichia pastoris

Expression of growth differentiation factor-15/ macrophage inhibitory cytokine-1 (GDF-15/MIC-1) in the perinatal, adult, and injured rat brain

Functional genomics approaches in parasitic helminths.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM.

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

Inhibition of malaria parasite development by a cyclic peptide that targets the vital parasite protein SERA5.

Lesser degrees of intoxication

MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib

MIC-1 is a novel TGF-beta superfamily cytokine associated with macrophage activation

MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily

Macrophage inhibitory cytokine 1 in fetal membranes and amniotic fluid from pregnancies with and without preterm labour and premature rupture of membranes

Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins.

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis

Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2.

Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins.

Peptide inhibitors of the malaria surface protein, apical membrane antigen 1: identification of key binding residues

Physiological restraint of Bak by Bcl-xL is essential for cell survival

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese hamster ovary cells expressing CLIC1

Relaxin and prostaglandin E(2) regulate interleukin 11 during human endometrial stromal cell decidualization.

Repurposing apoptosis-inducing cancer drugs to treat schistosomiasis

Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics.

Screening procedure for Pichia pastoris clones containing multiple copy gene inserts

Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design

Structural biology of the intrinsic cell death pathway: what do we know and what is missing?

Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1

Structural insights into the degradation of Mcl-1 induced by BH3 domains

Structural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serine

Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1

Structure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival Proteins

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

The BECN1 N-terminal domain is intrinsically disordered