List of works by Terrance G Johns

A Pre-Clinical Assessment of the Pan-ERBB Inhibitor Dacomitinib in Pediatric and Adult Brain Tumors.

scientific article published on 22 March 2018

A high-affinity ErbB4Fc fusion protein is a potent antagonist of heregulin-mediated receptor activation

scientific article

A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor

scientific article

A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors

scholarly article

A simple guide screw method for intracranial xenograft studies in mice

scientific article published on 26 September 2011

A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo

scientific article published on June 2009

Activation of ERBB4 in Glioblastoma Can Contribute to Increased Tumorigenicity and Influence Therapeutic Response

scientific article published on 25 July 2018

Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism

scientific article published on September 2011

Amino acid substitutions alter the tissue distribution of murine interferon-alpha 1.

scientific article

An automated peptide and protein thiazolidine coupling chemistry for biosensor immobilization giving a unique N-terminal orientation

scientific article published on 26 September 2005

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

scientific article

Antibody response in Lewis rats injected with myelin oligodendrocyte glycoprotein derived peptides

scientific article published on 01 November 1996

Antibody-functionalized porous silicon nanoparticles for vectorization of hydrophobic drugs

scientific article

Antiproliferative potencies of interferons on melanoma cell lines and xenografts: higher efficacy of interferon beta

scientific article published on August 5, 1992

Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478.

scientific article

Axitinib Has Antiangiogenic and Antitumorigenic Activity in Myxoid Liposarcoma

scientific article published on 16 October 2016

Binding of complement component Clq to myelin oligodendrocyte glycoprotein: A novel mechanism for regulating CNS inflammation

scientific article published on 01 January 1997

CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor.

scientific article published on 11 March 2004

Combination gefitinib and methotrexate compared with methotrexate alone to treat ectopic pregnancy

scientific article published in October 2013

Combination gefitinib and methotrexate treatment for non-tubal ectopic pregnancies: a case series

scientific article published on 7 May 2014

Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma.

scientific article published on 15 May 2017

DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implications

scientific article published on 17 March 2015

Development and Biological Evaluation of a Photoactivatable Small Molecule Microtubule-Targeting Agent

scientific article published on 15 March 2017

Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma

scientific article

Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3

scientific article published on 22 June 2018

Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer

scientific article

EGFRvIII-mediated transactivation of receptor tyrosine kinases in glioma: mechanism and therapeutic implications.

scientific article

Effects of gefitinib, an epidermal growth factor receptor inhibitor, on human placental cell growth

scientific article published on October 2013

Enhanced efficacy of radioimmunotherapy with 90Y-CHX-A''-DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478.

scientific article published on October 2005

Epidermal growth factor receptor activation: an upstream signal for transition of quiescent astrocytes into reactive astrocytes after neural injury

scientific journal article

Functional effects of glycosylation at Asn-579 of the epidermal growth factor receptor

scientific article published on November 2005

Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients

scientific article published on 18 August 2009

Gefitinib and Methotrexate to Treat Ectopic Pregnancies with a Pre-Treatment Serum hCG 1000-10,000 IU/L: Phase II Open Label, Single Arm Multi-Centre Trial

scientific article published on 22 June 2018

Generation of anti-idiotype antibodies for application in clinical immunotherapy laboratory analyses

scientific article published on August 2003

Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation

scientific article published on 18 April 2011

Glioma surgical aspirate: a viable source of tumor tissue for experimental research

scientific article published on 03 April 2013

Glioma-specific Domain IV EGFR cysteine mutations promote ligand-induced covalent receptor dimerization and display enhanced sensitivity to dacomitinib in vivo

scientific article published on 21 April 2014

Global protein profiling reveals anti-EGFR monoclonal antibody 806-modulated proteins in A431 tumor xenografts

scientific article published on 20 August 2013

Heparin-binding epidermal growth factor-like growth factor signaling in flow-induced arterial remodeling

scientific article

Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor

scientific article published on 9 April 2004

Immuno-PET quantitation of de2-7 epidermal growth factor receptor expression in glioma using 124I-IMP-R4-labeled antibody ch806.

scientific article

In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.

scientific article published on July 2008

In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.

scientific article published on 17 March 2009

Incomplete target neutralization by the anti-cancer antibody rilotumumab

scientific article published on 11 January 2016

Internalization, intracellular trafficking, and biodistribution of monoclonal antibody 806: a novel anti-epidermal growth factor receptor antibody

scientific article

MAb 806 enhances the efficacy of ionizing radiation in glioma xenografts expressing the de2-7 epidermal growth factor receptor

scientific article published on 16 July 2010

Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny

scientific article

Neurosphere and adherent culture conditions are equivalent for malignant glioma stem cell lines

scientific article

Non-agonistic bivalent antibodies that promote c-MET degradation and inhibit tumor growth and others specific for tumor related c-MET.

scientific article

Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene

scientific article published in March 2002

Pharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signalling

scientific article published on 28 October 2015

Phase II single arm open label multicentre clinical trial to evaluate the efficacy and side effects of a combination of gefitinib and methotrexate to treat tubal ectopic pregnancies (GEM II): study protocol

scientific article published on 19 July 2013

Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis

scientific article published on 7 February 2012

Placental-Specific sFLT-1 e15a Protein Is Increased in Preeclampsia, Antagonizes Vascular Endothelial Growth Factor Signaling, and Has Antiangiogenic Activity.

scientific article published on 28 September 2015

Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase.

scientific article published on 7 March 2006

Quantitative intratumoural microdistribution and kinetics of (131)I-huA33 antibody in patients with colorectal carcinoma

scientific article

Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion.

scientific article published on 16 December 2003

Structural Optimization and Pharmacological Evaluation of Inhibitors Targeting Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases (DYRK) and CDC-like kinases (CLK) in Glioblastoma.

scientific article

Targeted drug delivery using genetically engineered diatom biosilica

scientific article

Targeted nanoparticle delivery of doxorubicin into placental tissues to treat ectopic pregnancies.

scientific article published on 3 January 2013

Targeting a unique EGFR epitope with monoclonal antibody 806 activates NF-kappaB and initiates tumour vascular normalization

scientific article published on 11 May 2009

Targeting the ERBB family in cancer: couples therapy

scientific article published on 16 August 2013

The Efficacy of Epidermal Growth Factor Receptor-Specific Antibodies against Glioma Xenografts Is Influenced by Receptor Levels, Activation Status, and Heterodimerization

scientific article published on 01 March 2007

The Structure and Function of Myelin Oligodendrocyte Glycoprotein

scientific article published on 01 January 1999

The antitumor monoclonal antibody 806 recognizes a high-mannose form of the EGF receptor that reaches the cell surface when cells over-express the receptor

scientific article

The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis

scientific article

The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor AG1478 increases the formation of inactive untethered EGFR dimers. Implications for combination therapy with monoclonal antibody 806.

scientific article published on 8 November 2006

The identification of mitochondrial DNA variants in glioblastoma multiforme

scientific article published on 02 January 2014

The plasticity of oncogene addiction: implications for targeted therapies directed to receptor tyrosine kinases

scientific article published on May 2009

The regulation of mitochondrial DNA copy number in glioblastoma cells

scientific article published on 30 August 2013

The tumor suppressor microRNA, miR-124a, is regulated by epigenetic silencing and by the transcriptional factor, REST in glioblastoma

scientific article published on 26 September 2013

The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR.

scientific article published on August 2004

Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical epidermal growth factor receptor-specific antibody generates enhanced antitumor activity.

scientific article published in September 2005

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

scientific article

Unligated epidermal growth factor receptor forms higher order oligomers within microclusters on A431 cells that are sensitive to tyrosine kinase inhibitor binding.

scientific article published on 24 March 2007

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